Prominent publications by Olivier Dulac†

KOL Index score: 12711

PURPOSE: Presurgical language mapping in dominant hemisphere epilepsy to evaluate the risk of postoperative deficit is particularly difficult in children. Extraoperative invasive cortical stimulation can show some areas critical to language, but not all of them, due to scarce sampling, poor cooperation, cortical immaturity, or network reorganization, whereas functional magnetic resonance imaging (fMRI) displays entire networks involved in, but not necessarily critical to, language. In a ...

Also Ranks for: Language Mapping |  cortical stimulation |  magnetic resonance |  children epilepsy |  postoperative deficit
KOL Index score: 12679

BACKGROUND: Stiripentol is an inhibitor of cytochrome P450 that showed antiepileptic efficacy in severe myoclonic epilepsy in infancy (SMEI) in association with clobazam and valproate in an open study. To confirm these results, 41 children with SMEI were included in a randomised, placebo-controlled, add-on trial.

METHODS: After a baseline period of 1 month, placebo (n=20) or stiripentol (n=21) was added to valproate and clobazam during a double-blind period of 2 months. Patients then ...

Also Ranks for: Severe Myoclonic Epilepsy |  stiripentol placebo |  combination epilepsies |  infancy smei |  doubleblind period
KOL Index score: 12677

Frontal lobe dysfunction in adults has been associated with impairments of planning abilities, working memory, impulse control, attention and certain aspects of motor coordination. However, very few studies have attempted to assess these functions in children suffering from frontal lobe epilepsy. The aim of the present study was to determine whether some or all of the components of the frontal lobe syndrome are present in children with this disorder. For this purpose, a ...

Also Ranks for: Lobe Epilepsy |  motor coordination |  executive functions |  fle children |  neuropsychological tests
KOL Index score: 11915

PURPOSE: Fever induced refractory epileptic encephalopathy in school age children (FIRES) is a devastating condition initiated by prolonged perisylvian refractory status epilepticus (SE) triggered by fever of unknown cause. SE may last more than 1 month, and this condition may evolve into pharmacoresistant epilepsy associated with severe cognitive impairment. We aimed to report the effect of ketogenic diet (KD) in this condition.

METHODS: Over the last 12 years we collected data of nine ...

Also Ranks for: Ketogenic Diet |  refractory status |  school age children |  patients fires |  epileptic encephalopathy
KOL Index score: 11438

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene are responsible for a severe encephalopathy with early epilepsy. So far, the electroclinical phenotype remains largely unknown and no clear genotype-phenotype correlations have been established.

PURPOSE: To characterize the epilepsy associated with CDKL5 mutations and to look for a relationship between the genotype and the course of epilepsy.

METHODS: We retrospectively analyzed the electroclinical phenotypes of 12 ...

Also Ranks for: Cdkl5 Mutations |  epilepsy patients |  preschool chromosomes |  infantile spasms |  electroclinical phenotype
KOL Index score: 10670

To evaluate the efficacy and tolerability of topiramate (TPM) as add-on therapy in children less than 12 years of age with refractory epilepsy, according to epilepsy syndromes, we conducted an open, prospective, pragmatic and multicenter study in France. Efficacy was assessed, especially according to epilepsy syndromes, as well as tolerability. We included 207 children (41 of whom were less than 4 years of age). TPM was effective (responders with >50% decrease in seizure frequency) in ...

Also Ranks for: Epilepsy Syndromes |  children age |  efficacy tolerability |  infantile spasms |  4 years
KOL Index score: 10406

Phenobarbital produces its anti-epileptic actions by increasing the inhibitory drive of γ-aminobutyric acid. However, following recurrent seizures, γ-aminobutyric acid excites neurons because of a persistent increase of chloride raising the important issue of whether phenobarbital could aggravate persistent seizures. Here we compared the actions of phenobarbital on initial and established ictal-like events in an in vitro model of mirror focus. Using the in vitro three-compartment chamber ...

Also Ranks for: Excitatory Actions |  γaminobutyric acid |  potassium chloride |  mirror focus |  recurrent seizures
KOL Index score: 10311

To assess the efficacy and tolerability of steroids in epileptic syndromes with continuous spike-waves during slow-wave sleep (CSWS), charts of 44 children (25 boys) who received corticosteroids for cognitive and/or behavioral deterioration associated with CSWS were retrospectively reviewed. Awake and sleep electroencephalography (EEG) records, clinical and neuropsychological assessments were available before, during, and after corticosteroid therapy. Evaluation focused on effects on ...

Also Ranks for: Epileptic Syndromes |  slow‐wave sleep |  corticosteroids csws |  positive response |  epilepsy female humans
KOL Index score: 10037

PURPOSE: Stiripentol (STP) is a new antiepileptic drug (AED) that inhibits cytochrome P450, resulting in increased plasma concentrations of concomitant AEDs. The efficacy and tolerability of STP as an add-on therapy in children were assessed.

METHODS: Two hundred twelve patients with refractory epilepsy, aged from 1 month to 20.5 years, received STP either in a single-blind, placebo-controlled trial (108 patients) or in a further open trial (104 other patients selected by epilepsy ...

Also Ranks for: Partial Epilepsy |  stiripentol stp |  combination epilepsies |  efficacy tolerability |  cytochrome p450
KOL Index score: 9980

PURPOSE: In severe myoclonic epilepsy of infancy (SME), multiple drug-resistant focal and generalized seizure types occur. Lamotrigine (LTG), found effective in many generalized and partial seizures, has been little used in severe childhood epilepsy syndromes with multiple seizure types. We studied the effects of LTG in SME.

METHODS: Twenty-one patients with SME, aged 2-18 years, were treated with LTG, 20 in add-on and one in monotherapy. LTG was started at 0.2-2.5 mg/kg/day and ...

Also Ranks for: Severe Myoclonic Epilepsy |  seizure aggravation |  myoclonic epilepsies |  lamotrigine ltg |  18 patients
KOL Index score: 9964

X linked subcortical laminar heterotopia and lissencephaly syndrome (XSCLH/ LIS) is an intriguing disorder of cortical development, which causes classical lissencephaly with severe mental retardation and epilepsy in hemizygous males, and subcortical laminar heterotopia (SCLH) associated with milder mental retardation and epilepsy in heterozygous females. Here we report an exclusion mapping study carried out in three unrelated previously described families in which males are affected with ...

Also Ranks for: Subcortical Laminar Heterotopia |  lissencephaly syndrome |  dominant genetic |  cortical development |  chromosome mapping
KOL Index score: 9792

Myoclonic astatic epilepsy (MAE) is a genetically determined condition of childhood onset characterized by multiple generalized types of seizures including myoclonic astatic seizures, generalized spike waves and cognitive deterioration. This condition has been reported in a few patients in generalized epilepsy with febrile seizures plus (GEFS+) families and MAE has been considered, like severe myoclonic epilepsy of infancy (SMEI), to be a severe phenotype within the GEFS+ spectrum. Four ...

Also Ranks for: Myoclonic Astatic Epilepsy |  gated sodium channel |  febrile seizures |  cognitive deterioration |  mae patients
KOL Index score: 9676

Vigabatrin (VGB) has demonstrated high efficacy in infantile spasms (IS) due to tuberous sclerosis. Our first objective was to evaluate the cognitive long term effect outcome of children whose refractory spasms definitely disappeared when VGB was given as an add on drug. Our second objective was to determine the response of generalized epilepsy (infantile spasms) compared to partial epilepsy on cognitive impairment. A non selected series of 13 children underwent psychometric and ...

Also Ranks for: Tuberous Sclerosis |  partial epilepsy |  infantile spasms |  vigabatrin vgb |  behavioural outcome
KOL Index score: 9629

PURPOSE: Idiopathic generalized epilepsy (IGE) accounts for approximately 20% of all epilepsies and affects about 0.2% of the general population. The etiology of IGE is genetically determined, but the complex pattern of inheritance suggests an involvement of a large number of susceptibility genes. The objective of the present study was to explore the genetic architecture of common IGE syndromes and to dissect out susceptibility loci predisposing to absence or myoclonic seizures.


Also Ranks for: Absence Epilepsy |  human pair |  generalized epilepsies |  susceptibility loci |  myoclonic seizures

Key People For Infantile Spasms

Top KOLs in the world
Richard * ********
infantile spasms neonatal seizures tetanus toxin
James * *****
infantile spasms neonatal seizures video recordings
W ****** *******
infantile spasms pertussis immunization thought disorder
Raili ****** ********
infantile spasms rett syndrome cerebrospinal fluid
Orlando ****** ****** *****
infantile spasms absence seizures epilepsy surgery
John * *******
tuberous sclerosis infantile spasms hormonal treatment

Olivier Dulac†:Expert Impact

Concepts for whichOlivier Dulac†has direct influence:Infantile spasms,  West syndrome,  Dravet syndrome,  Ketogenic diet,  Tuberous sclerosis,  Status epilepticus,  Basal ganglia,  Myoclonic epilepsy.

Olivier Dulac†:KOL impact

Concepts related to the work of other authors for whichfor which Olivier Dulac† has influence:Infantile spasms,  Dravet syndrome,  Status epilepticus,  Tuberous sclerosis,  Antiepileptic drugs,  Ketogenic diet,  Febrile seizures.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

AdPueriVitam, Antony, France | AdPuerivitam, Antony, France | AdPueriVitam, Antony, France. | Department of Pediatrics, Paris Descartes University, Paris, France | INSERM U1129, Paris, France; Paris Descartes University, CEA, Gif-sur-Yvette, France.