Prominent publications by W Donald Shields

Vigabatrin: 2008 Update

KOL Index score: 15139

Vigabatrin (VGB) is a structural analogue of gamma-aminobutyric acid (GABA) that irreversibly inhibits GABA-transaminase (GABA-T), increasing brain levels of GABA. VGB is under assessment for treatment of infantile spasms (IS) and refractory complex partial seizures (CPS). Response can be rapid with spasm cessation following approximately 2 weeks of therapy. Patients with symptomatic tuberous sclerosis (TS) and other patients have achieved spasm cessation. Comparison with ACTH has been ...

Also Ranks for: Vgb Patients |  12 weeks |  adults cps |  treatment infantile spasms |  visual field
KOL Index score: 13817

PURPOSE: To assess the efficacy and safety of levetiracetam (LEV) as adjunctive therapy in children with treatment-resistant partial-onset seizures.

METHODS: Children (aged 6-12 years) with treatment-resistant partial-onset seizures receiving one standard antiepileptic drug (AED) were eligible. After a 4-week baseline period, children received LEV in a 6-week titration phase (target dose, 40 mg/kg/day) followed by an 8-week evaluation phase. Seizure frequency during the evaluation period ...

Also Ranks for: Partial Seizures |  lev children |  efficacy safety |  combination epilepsies |  seizure frequency
KOL Index score: 13284

PURPOSE: Vigabatrin used to treat infantile spasms (IS) has been associated with transient magnetic resonance imaging (MRI) abnormalities. We carried out a retrospective review to better characterize the frequency of those abnormalities in IS and in children and adults treated with vigabatrin for refractory complex partial seizures (CPS).

METHODS: Medical records and 332 cranial MRIs from 205 infants (aged 16 years) with CPS were re-reviewed. Prespecified MRI abnormalities were defined ...

Also Ranks for: Magnetic Resonance |  mri abnormalities |  vigabatrin cps |  children adults |  infants prevalence
KOL Index score: 11728

PURPOSE: This study examined the role of cognition, language, seizure-related, and demographic variables in the psychopathology of children with complex partial seizure disorder (CPS) of average intelligence.

METHODS: One-hundred one CPS and 102 normal children, aged 5.1 to 16.9 years, had a structured psychiatric interview and cognitive and language testing. Parents provided demographic, perinatal, and seizure-related information, as well as behavioral information through the Child ...

Also Ranks for: Complex Partial |  linguistic variables |  psychopathology children |  disorders child |  cognitive deficits
KOL Index score: 11495

OBJECTIVE: This investigation examined psychopathology in 48 children with complex partial seizures (CPS), 39 children with primary generalized epilepsy with absence (PGE), and 59 nonepileptic children, aged 5 to 16 years, by comparing the Child Behavior Checklist (CBCL) and the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS).

METHOD: The CBCL was completed by parents and the K-SADS was administered to both parent and child.


Also Ranks for: Complex Partial Seizures |  absence epilepsy |  psychopathology children |  cps pge |  primary generalized
KOL Index score: 11423

OBJECTIVE: Patients with cortical dysplasia (CD) are difficult to treat because the MRI abnormality may be undetectable. This study determined whether fluorodeoxyglucose (FDG)-PET/MRI coregistration enhanced the recognition of CD in epilepsy surgery patients.

METHODS: Patients from 2004-2007 in whom FDG-PET/MRI coregistration was a component of the presurgical evaluation were compared with patients from 2000-2003 without this technique. For the 2004-2007 cohort, neuroimaging and clinical ...

Also Ranks for: Cortical Dysplasia |  type patients |  mri coregistration |  presurgical evaluation |  fluorodeoxyglucose pet
KOL Index score: 11007

OBJECTIVE: To determine the current best practice for treatment of infantile spasms in children.

METHODS: Database searches of MEDLINE from 1966 and EMBASE from 1980 and searches of reference lists of retrieved articles were performed. Inclusion criteria were the documented presence of infantile spasms and hypsarrhythmia. Outcome measures included complete cessation of spasms, resolution of hypsarrhythmia, relapse rate, developmental outcome, and presence or absence of epilepsy or an ...

Also Ranks for: Infantile Spasms |  insufficient evidence |  medical treatment |  adrenocorticotropic hormone acth |  developmental outcome
KOL Index score: 10151

PURPOSE: This study compared frontotemporal brain volumes in children with childhood absence epilepsy (CAE) to age- and gender-matched children without epilepsy. It also examined the association of these volumes with seizure, demographic, perinatal, intelligence quotient (IQ), and psychopathology variables.

METHODS: Twenty-six children with CAE, aged 7.5-11.8 years, and 37 children without epilepsy underwent brain magnetic resonance imaging (MRI) scans at 1.5 Tesla. Tissue was segmented, ...

Also Ranks for: Childhood Absence Epilepsy |  frontal lobe |  brain volumes |  children cae |  intelligence tests
KOL Index score: 10048

PURPOSE: This study examined affective disorders, anxiety disorders, and suicidality in children with epilepsy and their association with seizure-related, cognitive, linguistic, family history, social competence, and demographic variables.

METHODS: A structured psychiatric interview, mood self-report scales, as well as cognitive and language testing were administered to 100 children with complex partial seizures (CPSs), 71 children with childhood absence epilepsy (CAE), and 93 normal ...

Also Ranks for: Anxiety Disorders |  pediatric epilepsy |  suicidal ideation |  social competence |  suicide attempt
KOL Index score: 10006

OBJECTIVE: To examine whether formal thought disorder and psychopathology occurred in children with complex partial seizures (CPS) rather than children with primary generalized epilepsy with absences (PGE) or nonepileptic children.

METHOD: Formal thought disorder was coded in 30 children with CPS, 24 children with PGE, and 61 nonepileptic children, and structured interview-based psychiatric diagnoses were obtained for the epileptic subjects.

RESULTS: The CPS subjects had significantly ...

Also Ranks for: Complex Partial Epilepsy |  formal thought disorder |  cps pge |  illogical thinking |  primary generalized
KOL Index score: 9968

BACKGROUND: The unambiguous identification of the epileptogenic tubers in individuals with tuberous sclerosis complex (TSC) can be challenging. We assessed whether magnetic source imaging (MSI) and coregistration of (18)fluorodeoxyglucose PET (FDG-PET) with MRI could improve the identification of the epileptogenic regions noninvasively in children with TSC.

METHODS: In addition to standard presurgical evaluation, 28 children with intractable epilepsy from TSC referred from 2000 to 2007 ...

Also Ranks for: Seizure Freedom |  children tsc |  intractable epilepsy |  tuberous sclerosis |  younger age
KOL Index score: 9738

PURPOSE: Young children with refractory symptomatic epilepsy are at risk for developing neurologic and cognitive disabilities. Stopping the seizures may prevent these disabilities, but it is unclear whether resective surgery is associated with adequate long-term seizure control.

METHODS: This study determined pre- and postsurgery seizure frequency and antiepileptic drug (AED) use (6 months to 10 years) in children with symptomatic seizures from unilateral cortical dysplasia (CD; n = 64) ...

Also Ranks for: Seizure Control |  surgery patients |  antiepileptic drug |  ucla experience |  5 years
KOL Index score: 9534

PURPOSE: This study investigated the short-term response to a standardized hormonal therapy protocol for treatment of infantile spasms.

METHODS: Twenty-seven children with video electroencephalography (EEG)-confirmed infantile spasms received very high dose (8 mg/kg/day, max 60 mg/day) oral prednisolone for 2 weeks. Response (absence of both hypsarrhythmia and spasms) to prednisolone was ascertained by repeat overnight video-EEG. Responders were tapered over 2 weeks and nonresponders ...

Also Ranks for: Infantile Spasms |  dose prednisolone |  adrenocorticotropic hormone |  2 weeks |  acth initial treatment
KOL Index score: 9467

PURPOSE: Evidence for a poor psychiatric, social, and vocational adult outcome in childhood absence epilepsy (CAE) suggests long-term unmet mental health, social, and vocational needs. This cross-sectional study examined behavioral/emotional, cognitive, and linguistic comorbidities as well as their correlates in children with CAE.

METHODS: Sixty-nine CAE children aged 9.6 (SD = 2.49) years and 103 age- and gender-matched normal children had semistructured psychiatric interviews, as well ...

Also Ranks for: Children Cae |  childhood absence epilepsy |  child behavior |  anxiety disorders |  psychiatric interviews

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W Donald Shields:Expert Impact

Concepts for whichW Donald Shieldshas direct influence:Infantile spasms,  Pertussis immunization,  Thought disorder,  Complex partial,  Complex partial epilepsy,  Pediatric epilepsy,  Status epilepticus,  Complex partial seizures.

W Donald Shields:KOL impact

Concepts related to the work of other authors for whichfor which W Donald Shields has influence:Infantile spasms,  Epilepsy surgery,  West syndrome,  Antiepileptic drugs,  Cortical dysplasia,  Status epilepticus,  Tuberous sclerosis.



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UCLA Medical Center, Los Angeles, CA, USA | David Geffen School of Medicine at UCLA Pediatric Epilepsy Program Los Angeles California U.S.A | Mattel Children's Hospital and David Geffen School of Medicine at UCLA Division of Neurology Department of P