 | Anthony Otley |
Prominent publications by Anthony Otley
Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease.
[ PUBLICATION ]
Excessive intestinal permeability or intestinal barrier dysfunction as measured by various assays has been observed in various diseases. However, little is known about the factors contributing to altered gut permeability in these diseases. Our objective was to determine the genetic determinants of altered gut permeability as measured by the lactulose mannitol fractional excretion ratio (LacMan ratio) in 1075 healthy first-degree relatives of patients with Crohn's disease (CD). In a ...
| Also Ranks for: Intestinal Permeability | degree relatives | crohns disease | lactulose mannitol | altered gut |
Increased Intestinal Permeability Is Associated With Later Development of Crohn’s Disease
[ PUBLICATION ]
BACKGROUND & AIMS: Increased intestinal permeability has been associated with Crohn's disease (CD), but it is not clear whether it is a cause or result of the disease. We performed a prospective study to determine whether increased intestinal permeability is associated with future development of CD.
METHODS: We assessed the intestinal permeability, measured by the urinary fractional excretion of lactulose-to-mannitol ratio (LMR) at recruitment in 1420 asymptomatic first-degree relatives ...
| Also Ranks for: Intestinal Permeability | crohn disease | future development | lactulose mannitol | barrier function |
Mediterranean-like dietary pattern associations with gut microbiome composition and sub-clinical gastrointestinal inflammation
[ PUBLICATION ]
BACKGROUND & AIMS: Case-control studies have shown that patients with Crohn's disease (CD) have a microbial composition different from healthy individuals. Although the causes of CD are unknown, epidemiologic studies suggest that diet is an important contributor to CD risk, potentially via modulation of bacterial composition and gut inflammation. We hypothesized that long-term dietary clusters (DCs) are associated with gut microbiome compositions and gut inflammation. Our objectives were ...
| Also Ranks for: Fecal Calprotectin | crohn disease |
Anthony Otley: Influence Statistics
| Concept | World rank |
|---|---|
| 2289 healthy fdrs | #56 |
| dc3 diet | #56 |
| dc3 mediterranean diet | #56 |
| clusters dc3 | #56 |
| longterm dietary clusters | #56 |
| compositions subclinical | #56 |
| gut inflammation cohort | #56 |
| lmr abnormal | #64 |
| abnormal lmr diagnosis | #64 |
| items fecal | #65 |
| abnormal lmr | #66 |
| defined fecal | #76 |
| baseline lmr | #87 |
Key People For Intestinal Permeability
Anthony Otley:Expert Impact
Concepts for whichAnthony Otleyhas direct influence:Intestinal permeability, Crohns disease, Gut inflammation, Microbial composition, Dietary patterns, Increased intestinal, Fecal calprotectin, Gut microbiome.
Anthony Otley:KOL impact
Concepts related to the work of other authors for whichfor which Anthony Otley has influence:Intestinal permeability, Inflammatory bowel disease, Gut microbiome, Healthy cotwins, Dietary patterns, Unrelated patients, Multiple sclerosis prodrome.
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