• Disease
  • Intestinal
  • Intestinal Permeability
  • Anthony Otley

    Prominent publications by Anthony Otley

    KOL Index score: 4612

    Excessive intestinal permeability or intestinal barrier dysfunction as measured by various assays has been observed in various diseases. However, little is known about the factors contributing to altered gut permeability in these diseases. Our objective was to determine the genetic determinants of altered gut permeability as measured by the lactulose mannitol fractional excretion ratio (LacMan ratio) in 1075 healthy first-degree relatives of patients with Crohn's disease (CD). In a ...

    Also Ranks for: Intestinal Permeability |  degree relatives |  crohns disease |  lactulose mannitol |  altered gut
    KOL Index score: 4507

    BACKGROUND & AIMS: Increased intestinal permeability has been associated with Crohn's disease (CD), but it is not clear whether it is a cause or result of the disease. We performed a prospective study to determine whether increased intestinal permeability is associated with future development of CD.

    METHODS: We assessed the intestinal permeability, measured by the urinary fractional excretion of lactulose-to-mannitol ratio (LMR) at recruitment in 1420 asymptomatic first-degree relatives ...

    Also Ranks for: Intestinal Permeability |  crohn disease |  future development |  lactulose mannitol |  barrier function
    KOL Index score: 207

    BACKGROUND & AIMS: Case-control studies have shown that patients with Crohn's disease (CD) have a microbial composition different from healthy individuals. Although the causes of CD are unknown, epidemiologic studies suggest that diet is an important contributor to CD risk, potentially via modulation of bacterial composition and gut inflammation. We hypothesized that long-term dietary clusters (DCs) are associated with gut microbiome compositions and gut inflammation. Our objectives were ...

    Also Ranks for: Fecal Calprotectin |  crohn disease


    Anthony Otley: Influence Statistics

    Sample of concepts for which Anthony Otley is among the top experts in the world.
    Concept World rank
    2289 healthy fdrs #56
    dc3 diet #56
    dc3 mediterranean diet #56
    clusters dc3 #56
    longterm dietary clusters #56
    compositions subclinical #56
    gut inflammation cohort #56
    lmr abnormal #64
    abnormal lmr diagnosis #64
    items fecal #65
    abnormal lmr #66
    defined fecal #76
    baseline lmr #87

    Key People For Intestinal Permeability

    Top KOLs in the world
    Ingvar T Bjarnason
    intestinal permeability ulcerative colitis coeliac disease
    Ian S Menzies
    intestinal permeability coeliac disease cirrhotic patients
    Jerrold R Turner
    tight junction barrier function epithelial cells
    Jon B Meddings
    intestinal permeability crohns disease nutrient absorption
    ANdrew J Macpherson
    intestinal permeability blood loss cardiopulmonary bypass
    Alessio Fasano
    celiac disease intestinal permeability zonula occludens toxin

    Anthony Otley:Expert Impact

    Concepts for whichAnthony Otleyhas direct influence:Intestinal permeability,  Crohns disease,  Gut inflammation,  Microbial composition,  Dietary patterns,  Increased intestinal,  Fecal calprotectin,  Gut microbiome.

    Anthony Otley:KOL impact

    Concepts related to the work of other authors for whichfor which Anthony Otley has influence:Intestinal permeability,  Inflammatory bowel disease,  Gut microbiome,  Healthy cotwins,  Dietary patterns,  Unrelated patients,  Multiple sclerosis prodrome.



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