Ngolela Esther BabadyShow email address
From the, Infectious Diseases Service | Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA | ...
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Ngolela Esther Babady:Expert Impact
Concepts for whichNgolela Esther Babadyhas direct influence:Influenza virus,Xpert mtb,Lymphoid malignancies,Clonal hematopoiesis,Clostridium difficile,New york city,Difficile infection,Clinical specimens.
Ngolela Esther Babady:KOL impact
Concepts related to the work of other authors for whichfor which Ngolela Esther Babady has influence:Clostridium difficile,Patients cancer,Respiratory viruses,Friedreich ataxia,Influenza virus,Transplant recipients,Fungal infections.
KOL Resume for Ngolela Esther Babady
From the, Infectious Diseases Service
Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Memorial Sloan Kettering Cancer Center, U.S.A. Electronic address:
Authors of equal contribution.
Department Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
Memorial Sloan-Kettering Cancer Center, New York, NY.
Memorial Sloan Kettering Cancer Center, New York, New York, USA
Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States
Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center.
Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
Microbiology Service, Department of Laboratory Medicine at Memorial Sloan Kettering Cancer Center, New York, NY, USA
Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Clinical Microbiology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, S428D, New York, NY, 10044,
Clinical Microbiology Service, Department of Laboratory Medicine,
Memorial Sloan-Kettering Cancer Center, New York, New York, USA
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905
Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York
Clinical Microbiology Service, Department of Clinical Laboratories
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Biochemistry and Molecular Biology and
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|opportunities clinical microbiologist||#1|
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|methodologies increased sensitivity||#1|
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Prominent publications by Ngolela Esther Babady
Rapid and accurate diagnosis of influenza is important for infection control, as well as for patient management. Alere i Influenza A&B is an isothermal nucleic acid amplification-based integrated system for detection and differentiation of influenza virus A and influenza virus B. The performance of the Alere i Influenza A&B was screened using frozen nasopharyngeal-swab specimens collected in viral transport medium (VTM) that were originally tested fresh with the FilmArray Respiratory ...
|Known for Influenza Virus | Rapid Detection | Alere Assay | Patient Management | Infection Control|
Clinical Performance of (1,3) Beta-D Glucan for the Diagnosis of Pneumocystis Pneumonia (PCP) in Cancer Patients Tested With PCP Polymerase Chain Reaction.
[ PUBLICATION ]
BACKGROUND: Serum (1,3)-beta-D glucan (BDG) is increasingly used to guide the management of suspected Pneumocystis pneumonia (PCP). BDG lacks specificity for PCP, and its clinical performance in high-risk cancer patients has not been fully assessed. Polymerase chain reaction (PCR) for PCP detection is highly sensitive, but cannot differentiate between colonization and infection. We evaluated the diagnostic performance of serum BDG in conjunction with PCP PCR on respiratory samples in ...
|Known for Clinical Performance | Pcp Patients | Sensitivity Specificity | Polymerase Chain Reaction | Carinii Pneumonia|
Comparison of the Luminex xTAG RVP Fast Assay and the Idaho Technology FilmArray RP Assay for Detection of Respiratory Viruses in Pediatric Patients at a Cancer Hospital
[ PUBLICATION ]
Respiratory viruses are increasingly recognized as serious causes of morbidity and mortality in immunocompromised patients. The rapid and sensitive detection of respiratory viruses is essential for the early diagnosis and administration of appropriate antiviral therapy, as well as for the effective implementation of infection control measures. We compared the performance of two commercial assays, xTAG RVP Fast (Luminex Diagnostics, Toronto, Canada) and FilmArray RVP (FA RVP; Idaho ...
|Known for Respiratory Viruses | Rvp Fast | Pediatric Patients | Luminex Xtag | Infections Sensitivity|
Evaluation of the Vitek MS v3.0 Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Mycobacterium and Nocardia Species
[ PUBLICATION ]
This multicenter study was designed to assess the accuracy and reproducibility of the Vitek MS v3.0 matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry system for identification of Mycobacterium and Nocardia species compared to DNA sequencing. A total of 963 clinical isolates representing 51 taxa were evaluated. In all, 663 isolates were correctly identified to the species level (69%), with another 231 (24%) correctly identified to the complex or ...
|Known for Mass Spectrometry | Assisted Laser | Nocardia Species | Complex Level | Diagnostic Reproducibility|
Evaluation of the Cepheid Xpert Clostridium difficile Epi Assay for Diagnosis of Clostridium difficile Infection and Typing of the NAP1 Strain at a Cancer Hospital ▿
[ PUBLICATION ]
Clostridium difficile is the most common cause of health care-associated diarrhea. Accurate and rapid diagnosis is essential to improve patient outcome and prevent disease spread. We compared our two-step diagnostic algorithm, an enzyme immunoassay for glutamate dehydrogenase (GDH) followed by the cytotoxin neutralization test (CYT) with a turnaround time of 24 to 48 h, versus the Cepheid Xpert C. difficile Epi assay, a PCR-based assay with a turnaround time of <1 h. In the first phase ...
|Known for Xpert Clostridium | Difficile Infection | Epi Assay | Nap1 Strain | Turnaround Time|
Detection of Blastomyces dermatitidis and Histoplasma capsulatum from Culture Isolates and Clinical Specimens by Use of Real-Time PCR
[ PUBLICATION ]
Blastomyces dermatitidis and Histoplasma capsulatum are dimorphic fungi that often cause self-limited respiratory infections. However, they may also cause severe disseminated disease, depending on the level of the exposure to the organism and the host immune status. In addition, patients with infections caused by these fungi may have very similar clinical presentations. Although microbiologic culture is a standard method for detecting these pathogens, their recovery may require days to ...
|Known for Clinical Specimens | Histoplasma Capsulatum | Blastomyces Dermatitidis | Time Pcr | Culture Isolates|
Potential of real-time PCR threshold cycle (CT) to predict presence of free toxin and clinically relevant C. difficile infection (CDI) in patients with cancer
[ PUBLICATION ]
OBJECTIVES: Clostridium difficile infection (CDI) is a toxin-mediated disease. Oncology patients are at increased risk for developing CDI. Diagnosis of CDI by PCR has led to misclassification of some C. difficile carriers as CDI cases. We determined if an optimized C. difficile PCR cycle threshold value (CT) could reliably predict presence of free toxin, and in turn improve the utility of PCR in detecting clinically relevant CDI in oncology patients.
METHODS: 183 consecutive patients ...
|Known for Difficile Infection | Cdi Pcr | Free Toxin | Threshold Cycle | Predict Presence|
Monitoring of Cytomegalovirus Viral Loads by Two Molecular Assays in Whole-Blood and Plasma Samples from Hematopoietic Stem Cell Transplant Recipients
[ PUBLICATION ]
Cytomegalovirus (CMV) viral loads in hematopoietic stem cell transplant (HSCT) recipients are typically monitored using quantitative molecular assays. The Roche Cobas AmpliPrep/Cobas TaqMan CMV test (Cobas CMV) has recently been cleared by the FDA for the monitoring of CMV viral loads in plasma samples from transplant patients. In this study, we compare and correlate the viral loads obtained by a laboratory-developed test (LC CMV) (using Roche analyte-specific reagents [ASR] on the ...
|Known for Viral Loads | Stem Cell | Plasma Blood | Transplant Recipients | Cmv Assay|
BACKGROUND: The sensitivity of the MVista Histoplasma antigen enzyme immunoassay (MiraVista Diagnostics) has been evaluated in disseminated histoplasmosis in patients with AIDS and in the "epidemic" form of acute pneumonia. Moreover, there has been no evaluation of the sensitivity of antigenemia detection in disseminated histoplasmosis after the implementation of methods to dissociate immune complexes and denature released antibodies. The goal of this study was to determine the ...
|Known for Disseminated Histoplasmosis | Fungal Antigens | Immunocompromised Patients | Sensitivity Antigen Detection | Lung Diseases|
Multicenter Evaluation of the ePlex Respiratory Pathogen Panel for the Detection of Viral and Bacterial Respiratory Tract Pathogens in Nasopharyngeal Swabs
[ PUBLICATION ]
The performance of the new ePlex Respiratory Pathogen (RP) panel (GenMark Diagnostics) for the simultaneous detection of 19 viruses (influenza A virus; influenza A H1 virus; influenza A 2009 H1 virus; influenza A H3 virus; influenza B virus; adenovirus; coronaviruses [HKU1, OC43, NL63, and 229E]; human rhinovirus/enterovirus; human metapneumovirus; parainfluenza viruses 1, 2, 3, and 4; and respiratory syncytial virus [RSV] [RSV subtype A and RSV subtype B]) and 2 bacteria (Mycoplasma ...
|Known for Eplex Respiratory | Multicenter Evaluation | Influenza Virus | Pathogen Panel | Nasopharyngeal Swabs|
[ PUBLICATION ]
Invasive fungal infections are an important cause of morbidity and mortality affecting primarily immunocompromised patients. While fungal identification to the species level is critical to providing appropriate therapy, it can be slow and laborious and often relies on subjective morphological criteria. The use of matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry has the potential to speed up and improve the accuracy of identification. In this ...
|Known for Filamentous Fungi | Multicenter Evaluation | Vitek V30 | Species Level | Fungal Identification|
Clinical and Laboratory Characteristics of Clostridium difficile Infection in Patients with Discordant Diagnostic Test Results
[ PUBLICATION ]
The aim of this study was to compare the clinical and laboratory characteristics of Clostridium difficile infection (CDI) in patients with discordant test results for the cytotoxin assay (CYT) and PCR assays. A retrospective study from May to August 2008 and March to May 2010 was performed. CDI was diagnosed in 128 patients. PCR increased the yield of C. difficile cases by 2-fold compared to that of the CYT assay. Fifty-six cases (44%) were detected by PCR only (CYT negative). Forty-nine ...
|Known for Clostridium Difficile | Cdi Patients | Cyt Pcr | Diagnostic Test | Preschool Clostridioides|
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hospitalized for COVID-19, patients with hematologic cancer had higher mortality relative to patients with solid cancer. In two additional cohorts, flow cytometric and serologic analyses demonstrated that patients with solid cancer and patients without cancer had a similar immune ...
|Known for Patients Cancer | Cd8 Cells | Cellular Immunity | Acute Covid19 | Humoral Responses|
PURPOSE: A circulating tumor DNA (ctDNA) test to detect plasma Epstein-Barr viral DNA can be used to screen for early nasopharyngeal cancers; however, the reported sensitivity of viral ctDNA tests to detect human papillomavirus (HPV)-associated cancers is modest. We assessed the utility of droplet digital polymerase chain reaction (ddPCR) to detect early-stage HPV-associated cancers using sequential HPV16 and HPV33 assays that account for HPV subtype distribution and subtype sequence ...
|Known for Liquid Biopsy | Human Papillomavirus | Hpv Ctdna | Squamous Cell | Tumor Dna|
As of 10 April 2020, New York State had 180,458 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% of deceased individuals1. Population-based studies from China and Italy suggested a higher coronavirus disease 2019 (COVID-19) death rate in patients with cancer2,3, although there is a knowledge gap as to which aspects of cancer and its treatment confer risk of severe COVID-194. This information is critical ...
|Known for Patients Cancer | Hospitalization Severe Disease | Severe Outcomes | Mechanical Ventilation | Symptomatic Covid19|