Prominent publications by Robert B Couch

KOL Index score: 15520

BACKGROUND: Severe acute respiratory syndrome (SARS) emerged in China in 2002 and spread to other countries before brought under control. Because of a concern for reemergence or a deliberate release of the SARS coronavirus, vaccine development was initiated. Evaluations of an inactivated whole virus vaccine in ferrets and nonhuman primates and a virus-like-particle vaccine in mice induced protection against infection but challenged animals exhibited an immunopathologic-type lung ...

Also Ranks for: Sars Virus |  pulmonary immunopathology |  inbred balb mice |  protection infection |  cov vaccines
KOL Index score: 13208

The emergence of Middle East respiratory syndrome-coronavirus (MERS-CoV) in the Middle East since 2012 has caused more than 900 human infections with ∼40% mortality to date. Animal models are needed for studying pathogenesis and for development of preventive and therapeutic agents against MERS-CoV infection. Nonhuman primates (rhesus macaques and marmosets) are expensive models of limited availability. Although a mouse lung infection model has been described using adenovirus vectors ...

Also Ranks for: Middle East |  mouse model |  coronavirus infection |  mers mice |  respiratory syndrome
KOL Index score: 12897

BACKGROUND: Serum antibody responses in humans to inactivated influenza A (H5N1), (H9N2) and A (H7) vaccines have been varied but frequently low, particularly for subunit vaccines without adjuvant despite hemagglutinin (HA) concentrations expected to induce good responses.

DESIGN: To help understand the low responses to subunit vaccines, we evaluated influenza A (H5N1), (H9N2), (H7N7) vaccines and 2009 pandemic (H1N1) vaccines for antigen uptake, processing and presentation by dendritic ...

Also Ranks for: Influenza Vaccines |  virus h5n1 |  antibody responses |  low immunogenicity |  h9n2 subtype
KOL Index score: 12406

It is generally accepted that human influenza viruses bind glycans containing sialic acid linked α2-6 to the next sugar, that avian influenza viruses bind glycans containing the α2-3 linkage, and that mutations that change the binding specificity might change the host tropism. We noted that human H3N2 viruses showed dramatic differences in their binding specificity, and so we embarked on a study of representative human H3N2 influenza viruses, isolated from 1968 to 2012, that had been ...

Also Ranks for: Influenza Viruses |  human h3n2 |  sialic acid |  binding specificity |  mdck cells
KOL Index score: 12338

Rhesus and cynomolgus monkey kidney tissue cultures and two continuous lines, Madin-Darby canine kidney (MDCK) and LLC-MK2, were compared in titrations and isolations of influenza and parainfluenza viruses. Tube cultures were inoculated with laboratory virus strains or stored patient specimens and observed for hemadsorption. Trypsin was added to the medium of the continuous lines to increase sensitivity. All four tissue cultures gave similar titers of influenza A/USSR (H1N1), A/Texas ...

Also Ranks for: Parainfluenza Viruses |  tissue cultures |  mdck llcmk2 |  influenza virus influenza |  continuous lines
KOL Index score: 12128

BACKGROUND: Serum antibody to the hemagglutinin (HA) surface protein of influenza virus induced by influenza vaccination is a correlate of protection against influenza. The neuraminidase (NA) protein is also on the surface of the virus; antibody to it has been shown to impair virus release from infected cells and to reduce the intensity of influenza infections in animal models and in humans challenged with infectious virus. Recently we have shown that NA inhibiting antibody can ...

Also Ranks for: Antibody Responses |  inactivated vaccines |  influenza vaccine |  hemagglutinin glycoproteins |  healthy adults
KOL Index score: 11750

Community respiratory viruses, such as respiratory syncytial virus (RSV), influenza viruses, parainfluenza viruses, adenoviruses, and picornaviruses, are an important cause of respiratory disease in the immunocompromised adult with cancer. Recent studies have demonstrated that a minimum of 31% of adult bone marrow transplant (BMT) recipients and 18% of adults with leukemia who are hospitalized with an acute respiratory illness have a community respiratory virus infection. The temporal ...

Also Ranks for: Immunocompromised Patients |  respiratory virus |  rsv infections |  early therapy |  viral pneumonia
KOL Index score: 11467

We performed virus isolation tests for respiratory viruses on combined nasal wash-throat swab specimens collected from infants and children with acute respiratory illnesses presenting to a hospital clinic during a 3-month period of concurrent epidemics of respiratory syncytial virus (RSV) and influenza A virus (Flu A) infections. Virus isolation results were used to assess the utility of commercially available rapid diagnostic kits for these two viruses. The kits employed direct ...

Also Ranks for: Respiratory Syncytial |  virus rsv |  human sensitivity |  enzyme immunoassay |  young children
KOL Index score: 11464

Characterized animal models are needed for studying the pathogenesis of and evaluating medical countermeasures for persisting Middle East respiratory syndrome-coronavirus (MERS-CoV) infections. Here, we further characterized a lethal transgenic mouse model of MERS-CoV infection and disease that globally expresses human CD26 (hCD26)/DPP4. The 50% infectious dose (ID50) and lethal dose (LD50) of virus were estimated to be <1 and 10 TCID50 of MERS-CoV, respectively. Neutralizing antibody ...

Also Ranks for: Middle East |  respiratory syndrome |  coronavirus infection |  mouse model |  neutralizing antibodies
KOL Index score: 11384

BACKGROUND: Matrix protein 2 (M2) is an integral tetrameric membrane protein of influenza A virus (IAV). Its ectodomain (M2e) shows remarkably little diversity amongst human IAV strains. As M2e-specific antibodies (Abs) have been shown to reduce the severity of infection in animals, M2e is being studied for its capability of providing protection against a broad range of IAV strains. Presently, there is little information about the concentration of M2e-specific Abs in humans. Two previous ...

Also Ranks for: Matrix Protein |  virus infection |  m2e specific |  viral blotting |  influenza human
KOL Index score: 11248

Two attenuated influenza A donor viruses, the A/Udorn/72 ts-1A2 and the A/Ann Arbor/6/60 cold-adapted (ca) viruses, are being evaluated for their ability to reproducibly attenuate each new variant of influenza A virus to a specific and desired level by the transfer of one or more attenuating genes. Each of these donor viruses has been able to attenuate influenza A viruses belonging to the H3N2 subtype by the transfer of one or more attenuating genes. To determine whether these two donor ...

Also Ranks for: Recombinant Viruses |  influenza virus |  seronegative adult |  h3n2 subtype |  vaccines attenuated
KOL Index score: 11050

BACKGROUND: Immune responses after influenza immunization are reduced in elderly individuals, the group at greatest risk for complications and death after influenza. Improved vaccines are needed to address this problem.

METHODS: Ambulatory individuals 65 years and older (N = 202) were assigned randomly to receive a single intramuscular injection of the 2001-2002 formulation of trivalent inactivated influenza vaccine containing 15, 30, or 60 microg of hemagglutinin per strain (up to 180 ...

Also Ranks for: Antibody Responses |  elderly persons |  influenza vaccine |  human injections |  60 microg
KOL Index score: 10873

CONTEXT: While hospitalization rates have declined overall, hospitalizations for acute lower respiratory tract infections have increased steadily since 1980. Development of new approaches for prevention of acute respiratory tract conditions requires studies of the etiologies of infections and quantification of the risk of hospitalization for vulnerable patients.

OBJECTIVE: To determine the frequency of specific virus infections associated with acute respiratory tract conditions leading ...

Also Ranks for: Respiratory Virus |  hospitalization patients |  chronic underlying |  tract infections |  viral etiology
KOL Index score: 10750

Using paired serum samples obtained from patients with illness associated with increases in anti-human coronavirus OC43 (HCoV-OC43) or anti-HCoV-229E antibodies, we examined the possibility of false-positive results detected in a recombinant severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein immunoglobulin G enzyme-linked immunosorbent assay (ELISA). Three of the 21 and 1 of the 7 convalescent-phase serum samples from persons with increases in ...

Also Ranks for: Western Blotting |  respiratory syndrome |  linked immunosorbent |  recombinant sars |  cov spike
KOL Index score: 10473

From 1 November 1992 through 1 May 1993 and from 1 November 1993 through 1 May 1994, we conducted a prospective surveillance study at the University of Texas M.D. Anderson Cancer Center (Houston) to evaluate the role of community respiratory virus infections in hospitalized adult bone marrow transplant (BMT) recipients, Respiratory secretions were obtained from all adult BMT recipients with acute respiratory illnesses. During these two winters, a community respiratory virus was isolated ...

Also Ranks for: Respiratory Virus |  bone marrow |  transplant recipients |  viral infections |  rsv infection

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Robert B Couch:Expert Impact

Concepts for whichRobert B Couchhas direct influence:Influenza virus,  Influenza vaccine,  Virus influenza,  Elderly persons,  Serum antibody,  Influenza vaccines,  Antibody responses,  Influenza viruses.

Robert B Couch:KOL impact

Concepts related to the work of other authors for whichfor which Robert B Couch has influence:Influenza virus,  Immune response,  Respiratory syncytial,  Neutralizing antibodies,  Common cold.



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Department of Internal Medicine, Division of Infectious Disease, University of Texas Medical Branch, Galveston. | Internal Medicine, Division of Infectious Disease, University of Texas Medical Branch, Galveston, TX, USA | Department of Internal Medic