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    • Yan Li: Influence Statistics

      Yan Li

      Yan Li

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      Informatics, Knowledge Services, Public Health Ontario, Toronto, ON, Canada | Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic ...

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      Yan Li:Expert Impact

      Concepts for whichYan Lihas direct influence:Influenza virus,Influenza vaccine,British columbia,Viral genome,Vaccine effectiveness,Influenza viruses,Signal sequence,Human metapneumovirus.

      Yan Li:KOL impact

      Concepts related to the work of other authors for whichfor which Yan Li has influence:Influenza virus,Vaccine effectiveness,United states,Neutralizing antibodies.

      KOL Resume for Yan Li

      Year
      2022

      Informatics, Knowledge Services, Public Health Ontario, Toronto, ON, Canada

      Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

      2021

      Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada

      Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road. Atlanta, Georgia, United States

      2020

      Public Health Ontario, Toronto and Ottawa, ON, Canada

      Poxvirus and Rabies Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA;,

      Pox and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA

      2019

      Public Health Ontario, Toronto, Ontario, Canada.

      U.S. Centers for Disease Control and Prevention, Poxvirus and Rabies Branch, Atlanta, Georgia, USA.

      2018

      Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States

      Centers for Disease Control and Prevention, NCIRD, DVD, Atlanta, Georgia 30329, USA;

      National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba

      Public Health Ontario, 480 University Avenue, Suite 300, Toronto, ON M5G 1V2 Canada

      2017

      Poxvirus and Rabies Branch, and

      National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.

      Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, M5T 1P8 Canada

      2016

      Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Enteric and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

      University of Manitoba, Winnipeg, Canada

      Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention (CCID/CDC), Atlanta, 30329-4027 GA, USA;, (G.L.E.);, (S.S.);, (M.F.);, (D.G.);, (M.O.-R.);, (C.S.G.);, (Y.L.);, (D.C.)

      The National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

      2015

      National Microbiology Laboratory, Winnipeg, Canada

      Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30333, USA; E-Mails:, (M.R.M.);, (G.L.E.);, (M.G.R.);, (R.R.L.);, (J.G.);, (H.Z.);, (Y.L.);, (K.L.K.);, (I.K.D.);, (D.S.C.)

      University of Manitoba

      From the Epidemic Intelligence Service (N.M.V.), Division of High-Consequence Pathogens and Pathology (N.M.V., Y.L., G.L.E., P.S.S., N.G.-R., C.S.G., M.G.M., I.D., M.G.R., D.S.C.), and the Division of Global Health Protection (N.M.V., M.G., E.F.M., J.M.), Centers for Disease Control and Prevention (CDC), Atlanta

      2014

      University of Manitoba, Winnipeg, MB, Canada

      Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia

      National Microbiology Laboratory, Winnipeg

      Poxvirus and Rabies Branch, US Centers for Disease Control and Prevention, Atlanta, USA

      Analytic Services, Knowledge Services, Public Health Ontario, Toronto, Ontario

      2013

      Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333

      Author affiliations: Centre hospitalier universitaire Dr-Georges-L.-Dumont, Moncton, New Brunswick, Canada (G. Girouard, R. Garceau, L. Thibault, Y. Oussedik);

      Public Health Agency of Canada National Microbiology Laboratory 1015 Arlington Street, Winnipeg, Manitoba, R3E 3R2

      National Microbiology Laboratory (NML), Winnipeg, Manitoba, Canada

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      Sample of concepts for which Yan Li is among the top experts in the world.
      Concept World rank
      assays genus avipoxvirus #1
      vesiculopustular rash illnesses #1
      20062007 tiv influenza #1
      opx assay #1
      burgdorferi pathogens #1
      expressed apv protein #1
      combination np antigens #1
      conserved sequence members #1
      colombia volume #1
      gagc2v3 #1
      genome alaskapox virus #1
      joint tissues pcr #1
      immunossupressed patients pathogens #1
      skingraft harvest #1
      human mutation phylogeny #1
      submission hot spots #1
      genomespanning assay #1
      study common marmosets #1
      shrews case #1
      ancestral varv #1
      human metapneumovirus pneumonia #1
      lineage match viruses #1
      456 505 #1
      signs poxvirus infection #1
      canadian sampled viruses #1
      mpxv assays #1
      deer parapoxvirus #1
      papvs #1
      ancient divergence north #1
      recovery male vaccinia #1
      sudan congo basin #1
      h3n2 viruses canada #1
      28 aa positions #1
      historical relics #1
      parapoxvirus species #1
      mpx assay #1
      1998–2001 period isolates #1
      interaction sarscov #1
      human metapneumovirus attachment #1
      componentspecific effectiveness #1
      probable swine origin #1
      republic congo monkeypox #1
      parapoxviruses domestic ruminants #1
      disseminated ulcers cows #1
      viability variola #1
      opxv phylogeny #1
      pediatric hmpv hospitalization #1
      canadian canadaab #1
      colombia vaccinia #1
      experienced failure 10 #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Yan Li

      KOL-Index: 16247

      BACKGROUND: Influenza vaccine effectiveness (VE) is generally interpreted in the context of vaccine match/mismatch to circulating strains with evolutionary drift in the latter invoked to explain reduced protection. During the 2012-13 season, however, detailed genotypic and phenotypic characterization shows that low VE was instead related to mutations in the egg-adapted H3N2 vaccine strain rather than antigenic drift in circulating viruses.

      METHODS/FINDINGS: Component-specific VE against ...

      Known for Circulating Viruses | Influenza Vaccine | Antigenic Drift | Virus Canada | Eggadapted Strain
      KOL-Index: 15811

      Rapid methods for the detection and confirmatory identification of pandemic influenza A virus (also known as pandemic [H1N1] 2009) are of utmost importance. In this study, a conventional reverse transcriptase PCR (RT-PCR) assay for the detection of influenza A virus and the hemagglutinin of swine lineage H1 (swH1) was designed, optimized, and validated. Nucleic acids were extracted from 198 consecutive nasopharyngeal, nasal, or throat swab specimens collected early in the outbreak (127 ...

      Known for Influenza Virus | Pcr Assay | Simultaneous Detection | Pandemic H1n1 | Reverse Transcriptase
      KOL-Index: 15536

      Before 2003, only occasional case reports of human H7 influenza virus infections occurred as a result of direct animal-to-human transmission or laboratory accidents; most of these infections resulted in conjunctivitis. An increase in isolation of avian influenza A H7 viruses from poultry outbreaks and humans has raised concerns that additional zoonotic transmissions of influenza viruses from poultry to humans may occur. To better understand the pathogenesis of H7 viruses, we have ...

      Known for Avian Influenza | H7n7 Virus | Enhanced Virulence | Mice Ferrets | Human Respiratory
      KOL-Index: 15069

      We identified ticks submitted by the public from 2008 through 2012 in Ontario, Canada, and tested blacklegged ticks Ixodes scapularis for Borrelia burgdorferi and Anaplasma phagocytophilum. Among the 18 species of ticks identified, I. scapularis, Dermacentor variabilis, Ixodes cookei and Amblyomma americanum represented 98.1% of the 14,369 ticks submitted. Rates of blacklegged tick submission per 100,000 population were highest in Ontario's Eastern region; D. variabilis in Central West ...

      Known for Blacklegged Ticks | Ixodes Scapularis | Ontario Canada | Tick Surveillance | Animals Borrelia
      KOL-Index: 14988

      CPG 7909, a 24-mer B-Class CpG oligodeoxynucleotide (ODN), was tested for safety, tolerability and its ability to augment the immunogenicity of a commercial trivalent killed split influenza vaccine (Fluarix containing A/Beijing/262/95, A/Sydney/5/97 and B/Harbin/7/94; SmithKline Beecham) in a phase Ib blinded, randomized, controlled clinical trial. Sixty healthy volunteers were recruited in two consecutive cohorts of 30 subjects, who were randomly assigned to receive Fluarix plus 1mg CPG ...

      Known for Cpg 7909 | Influenza Vaccine | Safety Immunogenicity | Interferon Gamma | Subjects Receiving
      KOL-Index: 14554

      BACKGROUND: Trivalent inactivated influenza vaccine (TIV) is reformulated annually to contain representative strains of 2 influenza A subtypes (H1N1 and H3N2) and 1 B lineage (Yamagata or Victoria). We describe a sentinel surveillance approach to link influenza variant detection with component-specific vaccine effectiveness (VE) estimation.

      METHODS: The 2006-2007 TIV included A/NewCaledonia/20/1999(H1N1)-like, A/Wisconsin/67/2005(H3N2)-like, and B/Malaysia/2506/2004(Victoria)-like ...

      Known for Sentinel Surveillance | Influenza Virus | H1n1 H3n2 | Specific Effectiveness | Hemagglutination Inhibition
      KOL-Index: 14153

      BACKGROUND: Neuraminidase (NA) inhibitors (NAIs) are currently the only antivirals effective against influenza infections due to widespread resistance to M2 inhibitors.

      METHODS: Influenza A and B viruses (n = 1079) collected worldwide between April 01, 2011, and September 30, 2011, were assessed for susceptibility to FDA-approved NAIs, oseltamivir and zanamivir, and investigational peramivir, using the fluorescent-based NA-Fluor™ Influenza Neuraminidase Assay Kit. A subset of viruses (n ...

      Known for Influenza Viruses | Susceptibility Surveillance | Oseltamivir Zanamivir | Inhibitors Nais | Neuraminidase Inhibitor
      KOL-Index: 14136

      OBJECTIVE: To assess the effectiveness of the pandemic influenza A/H1N1 vaccine used in Canada during autumn 2009.

      DESIGN: Test negative incident case-control study based on sentinel physician surveillance system.

      SETTING: Community based clinics contributing to sentinel networks in British Columbia, Alberta, Ontario, and Quebec, Canada.

      PARTICIPANTS: 552 patients who presented to a sentinel site within seven days of onset of influenza-like illness during the primary analysis period ...

      Known for Pandemic H1n1 | Sentinel Surveillance | Influenza Vaccine | As03 Adjuvanted | Single Dose
      KOL-Index: 14123

      The human coronavirus, associated with severe acute respiratory syndrome (SARS-CoV), was identified and molecularly characterized in 2003. Sequence analysis of the virus indicates that there is only 20% amino acid (aa) identity with known coronaviruses. Previous studies indicate that protein-protein interactions amongst various coronavirus proteins are critical for viral assembly. Yet, little sequence homology between the newly identified SARS-CoV and those previously studied ...

      Known for Protein Interaction | Sars Coronavirus | Viral Assembly | Cov Nucleocapsid | Molecular Mechanism
      KOL-Index: 13987

      BACKGROUND: The blacklegged tick Ixodes scapularis transmits Borrelia burgdorferi (sensu stricto) in eastern North America; however, the agent of Lyme disease is not the sole pathogen harbored by the blacklegged tick. The blacklegged tick is expanding its range into areas of southern Canada such as Ontario, an area where exposure to blacklegged tick bites and tick-borne pathogens is increasing. We performed a systematic review to evaluate the public health risks posed by expanding ...

      Known for Blacklegged Tick | Human Pathogens | Ixodes Scapularis | Burgdorferi Borrelia | Sensu Stricto
      KOL-Index: 13480

      Secretory proteins and most membrane proteins are synthesized with a signal sequence that is usually cleaved from the nascent polypeptide chain, during its transport, into the lumen of the endoplasmic reticulum (ER). We have analyzed the kinetics of the cleavage of the HIV-1 Env protein signal sequence from gp160 and gp120 in HeLa, BHK, and Jurkat cells. Furthermore, we have determined the effects of this cleavage on the association of the gp160 and gp120 glycoproteins with the ER ...

      Known for Signal Sequence | Protein Folding | Hiv1 Env | Cleavage Gp160 | Endoplasmic Reticulum
      KOL-Index: 12812

      OBJECTIVES: To describe the experience of Ontario long-term care facilities that used oseltamivir during influenza outbreaks in 1999/2000.

      DESIGN: Case series.

      SETTING: Ten Ontario long-term care facilities for older people and their residents.

      PARTICIPANTS: Older residents of long-term care facilities.

      INTERVENTION: Oseltamivir for treatment or prophylaxis during 11 influenza outbreaks in 1999/2000.

      MEASUREMENTS: Control of outbreaks; pneumonia, hospitalization, and death complicating ...

      Known for Influenza Outbreaks | Oseltamivir Treatment | Nursing Homes | Amantadine Prophylaxis | Term Facilities
      KOL-Index: 12086

      BACKGROUND: In late spring 2009, concern was raised in Canada that prior vaccination with the 2008-09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of pandemic influenza A (H1N1) (pH1N1) illness. Several epidemiologic investigations were conducted through the summer to assess this putative association.

      METHODS AND FINDINGS:

      STUDIES INCLUDED: (1) test-negative case-control design based on Canada's sentinel vaccine effectiveness monitoring system in ...

      Known for Observational Studies | Seasonal Influenza | Pandemic H1n1 | Quebec Canada | 200809 Tiv
      KOL-Index: 12050

      BACKGROUND: During the 2010-2011 winter, a large number of outbreaks due to influenza A/H3N2 at long-term care facilities, including higher-than-expected attack rates among vaccinated staff, were reported in some regions of Canada. Interim analysis from the community-based sentinel surveillance system showed circulating H3N2 variants and suboptimal vaccine effectiveness (VE), assessed here for the entire season's data set.

      METHODS: Nasal/nasopharyngeal swabs and epidemiologic details ...

      Known for Influenza Vaccine | Canada Child Child | Virus H3n2 | Polymerase Chain | Sentinel Surveillance

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      Informatics, Knowledge Services, Public Health Ontario, Toronto, ON, Canada | Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ge

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