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    • Katherine Samaras

      Katherine Samaras

      Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia | Adipose Biology, Clinical Obesity and Nutrition Laboratory, Garvan Institute of Medical Research, ...



      KOL Resume for Katherine Samaras


      Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia


      Department of Endocrinology, St Vincent's Hospital, Darlinghurst, NSW, Australia.


      St Vincent's Clinic School, St Vincent's Hospital, Sydney, New South Wales, Australia


      Department of Endocrinology, St Vincent’s Hospital, 2010, Sydney, New South Wales, Australia


      Diabetes & Metabolism Division, Garvan Institute of Medical Research, Sydney, Department of Endocrinology, St Vincent's Hospital, Darlinghurst, NSW, Australia.

      Department of Endocrinology, St Vincent's Hospital, Sydney, NSW, Australia


      Diabetes and Metabolism Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

      St Vincent's Hospital Department of Endocrinology Darlinghurst Australia

      Department of Endocrinology.


      Department of Endocrinology St Vincent's Hospital Darlinghurst NSW Australia


      Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, Australia

      Garvan Institute of Medical Research, Sydney, NSW.


      Diabetes & Obesity Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia


      St Vincent's Hospital Department of Endocrinology Darlinghurst NSW Australia


      Department of Endocrinology, St Vincent's Hospital

      Clinical Diabetes and Obesity Research Group, Garvan Medical Research Institute, Sydney, Australia

      Faculty of Medicine, University of NSW


      Diabetes Program, Garvan Institute of Medical Research

      Department of Endocrinology, St Vincent's Hospital, Sydney, Australia



      Katherine Samaras: Influence Statistics

      Sample of concepts for which Katherine Samaras is among the top experts in the world.
      Concept World rank
      complications hivdm #1
      treatment disparities review #1
      hivdm dmcontrols #1
      people hivinfection #1
      vat t2d #1
      cart rising #1
      hivdm compared #1
      infection hivdm #1
      diabetes complications rates #1
      schizophrenia start #1
      diabetes complications hivdm #1
      metformin psychiatric populations #1
      scientific effort #1
      immune cellmediated inflammation #1
      hivdm hba1c targets #1
      diabetes psychiatric inpatients #1
      diseases new challenges #1
      acromegaly longstanding hirsutism #1
      metformin cardiometabolic protection #1
      vat expression #1
      clozapine instigation #1
      pathways antiretroviral therapy #1
      early intervention vulnerable #1
      treated hiv #1
      setting menstrual irregularity #1
      aix insulin #1
      energy underreporters #1
      review double jeopardy #1
      cardiometabolic youth #1
      untreated primary disease #1
      hivdm standards #1
      incarcerated indigenous youth #1
      gradual medication switch #1
      investigations active exclusion #1
      central abdominal adiposity #1
      incident glucose disorders #1
      hivinfected haart recipients #1
      active exclusion patients #1
      relative short term #1
      mellitus hiv1 infection #1
      gain rising #1
      tears hirsutism #1
      perfect storm hydroxymethylglutarylcoa #1
      double jeopardy diabetes #1
      hivdm dm #1
      case diabetes control #1


      Prominent publications by Katherine Samaras

      KOL-Index: 18549

      OBJECTIVE: Metabolic syndrome is a cluster of risk factors for cardiovascular disease and type 2 diabetes. Definitions exist to identify those "at risk." Treatment of HIV infection with highly active antiretroviral therapy can induce severe metabolic complications including lipodystrophy, dyslipidemia, and insulin resistance. The purpose of this study was to report the prevalence of metabolic syndrome in HIV-infected patients and compare insulin resistance and total body, limb, and ...

      Known for Metabolic Syndrome | Insulin Resistance | Active Antiretroviral | Infected Patients | Body Fat
      KOL-Index: 17281

      OBJECTIVE: To describe a syndrome of peripheral lipodystrophy (fat wasting of the face, limbs and upper trunk), hyperlipidaemia and insulin resistance in patients receiving potent HIV protease inhibitor therapy.

      DESIGN: Cross-sectional study.

      SETTING: Outpatient clinic of a university teaching hospital.

      PATIENTS: HIV-infected patients either receiving at least one protease inhibitor (n=116) or protease inhibitor-naive (n=32), and healthy men (n=47).


      Known for Peripheral Lipodystrophy | Insulin Resistance | Hiv Protease | Triglyceride Levels | Body Composition
      KOL-Index: 12633

      BACKGROUND: Metabolic syndrome (MS) identifies individuals at risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Little is known about MS and its consequences following initiation of antiretroviral therapy (ART).

      METHODS: HIV-infected adults (881) initiating ART were evaluated for prevalence and incidence of MS and subsequent diagnosis of CVD and T2DM over a 3-year period. MS was defined by criteria of the National Cholesterol Education Program Expert Panel on ...

      Known for Diabetes Mellitus | Cardiovascular Disease | Antiretroviral Therapy | Metabolic Syndrome | Hiv Infection
      KOL-Index: 12450

      BackgroundFTO gene variants are linked to obesity. We tested for site-specific differences in FTO gene expression in subcutaneous and visceral adipose tissue (SAT and VAT, respectively) from individuals with and without type 2 diabetes mellitus (T2D) and the relationships between fasting glucose, in vivo insulin action, and measures of adiposity with FTO gene expression in adipose tissue.MethodsPaired subcutaneous and visceral fat were excised at elective surgery in n = 16 subjects (six ...

      Known for Gene Expression | Insulin Action | Adipose Tissue | Type 2 | Diabetes Mellitus
      KOL-Index: 11854

      This study addresses the paucity of research on the prospective relationship between a range of inflammatory markers and symptoms of depression and anxiety during aging. In the Sydney Memory and Aging Study, the relationships between remitted depression, current and first onset of symptoms of depression or anxiety (Geriatric Depression Scale and Goldberg Anxiety Scale (GDS, GAS), and markers of systemic inflammation (C-reactive protein (CRP), interleukins-1β, -6, -8, -10, -12, ...

      Known for Anxiety Symptoms | Inflammatory Biomarkers | Sydney Memory | Tumor Necrosis Factoralpha | Systemic Inflammation
      KOL-Index: 11410

      BACKGROUND: The prevalence and severity of lipodystrophy syndrome with long-term therapy for HIV-1 infection that includes a protease inhibitor is unknown. We studied the natural course of the syndrome to develop diagnostic criteria and identifying markers that predict its severity.

      METHODS: We assessed 113 patients who were receiving HIV-1 protease inhibitors (mean 21 months) and 45 HIV-1-infected patients (28 with follow-up) never treated with a protease inhibitor. Lipodystrophy was ...

      Known for Diabetes Mellitus | Physical Examination | Protease Inhibitor | Prevalence Severity | Therapy Hiv1
      KOL-Index: 11364

      OBJECTIVE: To investigate 1). associations between environmental factors (alcohol consumption, hormone replacement therapy [HRT], and physical activity) and insulin resistance and secretion, independent of genetic influences; 2). the contribution of abdominal adiposity to these relationships; and 3). whether gene-environment interactions mediate these associations.

      RESEARCH DESIGN AND METHODS: Reported effects of lifestyle factors on insulin resistance and secretion are inconsistent, ...

      Known for Moderate Alcohol Consumption | Insulin Sensitivity | Physical Activity | Estrogen Replacement | Dizygotic Twins
      KOL-Index: 11363

      BACKGROUND: Nucleoside reverse-transcriptase inhibitors (NRTIs), which are used to treat human immunodeficiency virus (HIV) infection, can cause mitochondrial dysfunction and have been associated with lipoatrophy. The effects of this mitochondrial dysfunction on lipid metabolism, at a molecular level in vivo, have not been described.

      METHODS: We examined early changes (by 2 weeks after initiation of therapy) in expression of mitochondrial and nuclear genes in adipose tissue from 20 ...

      Known for Mitochondrial Dna | Lipid Metabolism | Transcriptase Inhibitors | Adipose Tissue | Nucleoside Reverse
      KOL-Index: 10964

      CONTEXT: Obesity-related chronic inflammation is implicated in the pathogenesis of type 2 diabetes (T2D).

      OBJECTIVE: The objective of the study was to determine the effects of weight loss on immune cells in T2D and prediabetes.

      DESIGN AND SETTING: Thirteen obese subjects with T2D or prediabetes underwent 24 wk dietary energy restriction with gastric banding surgery at 12 wk.

      MAIN OUTCOME MEASURES: Measures included weight, waist, and insulin resistance; surface activation marker ...

      Known for Weight Loss | Type 2 Diabetes | Gastric Banding | Immune Cells | Chronic Inflammation
      KOL-Index: 10843

      OBJECTIVE: To determine the phenotypic and dietary characteristics of energy underreporters in a healthy population of middleaged women using accurate body composition measures.DESIGN: Cross-sectional study of 436 healthy middleaged female volunteers, unaware of any hypotheses regarding diet and body fat: mean age 58 y (39–70 y), body mass index (BMI) 24.3 kg/m2 (17.0–41.9 kg/m2). The prevalence of overweight (25.0>BMI>29.9 kg/m2) and obesity (BMI>30 kg/m2) were 30% and 5% ...

      Known for Body Fat | Dietary Underreporting | Physical Activity | Reported Energy | Mass Bmi
      KOL-Index: 10597

      BACKGROUND/AIMS: Raised low-grade systemic inflammation has been associated with dementia, and preliminary studies suggest an association with mild cognitive impairment (MCI). This study examines the relationship between systemic inflammation and MCI subtypes.

      METHODS: We measured the inflammatory markers C-reactive protein, interleukins (IL)-1β, -6, -8, -10 and -12, plasminogen activator inhibitor-1 (PAI-1), serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and vascular adhesion ...

      Known for Systemic Inflammation | Mci Higher Levels | Inflammatory Markers | Il1β Tnfα | Cognition Disorders
      KOL-Index: 10194

      ObjectivesWhile obesity has been linked with lower quality of life in the general adult population, the prospective effects of present obesity on future quality of life amongst the elderly is unclear. This article investigates the cross-sectional and longitudinal relationships between obesity and aspects of quality of life in community-dwelling older Australians.MethodA 2-year longitudinal sample of community dwellers aged 70–90 years at baseline, derived from the Sydney Memory and ...

      Known for Waist Circumference | Quality Life | Bmi Wc | Independent Living | Longitudinal Studies
      KOL-Index: 9976

      Type 2 diabetes mellitus (T2D) is predicted by central obesity and circulating adipokines regulating inflammation. We hypothesized that visceral adipose tissue (VAT) in T2D expresses greater levels of proinflammatory molecules. Paired samples of subcutaneous (SAT) and VAT were excised at elective surgery (n = 16, 6 with T2D, n = 8 age- and gender- matched controls). Metabolic parameters were measured in the fasted state: body composition by dual-energy X-ray absorptiometry and insulin ...

      Known for 2 Diabetes | Gene Expression | Visceral Adipose Tissue | Insulin Resistance | Proinflammatory Molecules
      KOL-Index: 9872

      BACKGROUND: C-reactive protein (CRP) values predict atherothrombotic cardiovascular disease and type 2 diabetes mellitus. Associations between CRP and obesity, predominantly assessed anthropometrically, may partly explain these observations. Previous studies have been unable to control for genetic influences on CRP and obesity. The aim of this study was to examine the relationship between CRP and accurately measured body fat, lipids, apolipoproteins, blood pressure, and environmental and ...

      Known for Monozygotic Twins | Blood Pressure | Genetic Influences | Body Fat | Reactive Protein

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      Katherine Samaras:Expert Impact

      Concepts for whichKatherine Samarashas direct influence:Insulin resistance,  Metabolic syndrome,  Weight gain,  Bariatric surgery,  Central adiposity,  Physical activity,  Severe mental illness,  Treated hiv.

      Katherine Samaras:KOL impact

      Concepts related to the work of other authors for whichfor which Katherine Samaras has influence:Antiretroviral therapy,  Insulin resistance,  Metabolic syndrome,  Hiv infection,  Dna methylation,  Adipose tissue,  Protease inhibitors.



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      Department of Endocrinology, St Vincent’s Hospital, Sydney, NSW, Australia | Adipose Biology, Clinical Obesity and Nutrition Laboratory, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia | St Vincent’s Clinical School, University of

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