Prominent publications by David B Dunger

KOL Index score: 17742

Diabetes insipidus is a well-recognized complication of Langerhans-cell histiocytosis (histiocytosis X), but its frequency and natural history are not well defined. Of 52 children with histiocytosis whom we studied, 12 (23 percent) had diabetes insipidus. Only two children had diabetes insipidus at presentation with histiocytosis, but the cumulative risk that it would develop during the first four years after the presentation and diagnosis of histiocytosis was found to be 42 percent. ...

闻名 Diabetes Insipidus |  posterior pituitary |  cell histiocytosis |  multisystem disease |  cumulative risk
KOL Index score: 17508

BACKGROUND: The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump therapy in people with suboptimally controlled type 1 diabetes aged 6 years and older.

METHODS: In this open-label, multicentre, multinational, single-period, parallel randomised controlled trial, participants were recruited from diabetes outpatient clinics at four ...

闻名 Loop Insulin |  1 diabetes |  difference 95 |  randomised trial |  sensoraugmented pump therapy
KOL Index score: 17149

Aims/hypothesisType 2 diabetes risk is associated with low birth weight, rapid weight gain during childhood, and shorter stature and lower circulating IGF-I levels in adults. The largest variations in growth rates occur during the first postnatal years. We hypothesised that early postnatal variations in height and weight gain and IGF-I levels may be associated with risk markers for adult disease.MethodsWe measured the fasting insulin sensitivity (Homeostasis model) and insulin secretion ...

闻名 Insulin Sensitivity |  postnatal growth |  normal children |  8 years |  size birth
KOL Index score: 16310

OBJECTIVE: To compare blood glucose control and incidence of nocturnal hypoglycemia in adolescents with type 1 diabetes on multiple injection regimens managed with either an insulin analog combination or NPH insulin plus regular human insulin.

RESEARCH DESIGN AND METHODS: In a randomized cross-over study, 28 adolescents with type 1 diabetes on multiple injection therapy received either insulin glargine prebedtime plus lispro preprandially (LIS/GLAR) or NPH insulin prebedtime plus regular ...

闻名 Nph Insulin |  type 1 diabetes |  nocturnal hypoglycemia |  regular human |  blood glucose
KOL Index score: 16234

OBJECTIVE: To determine the prevalence of polycystic ovaries as identified by ultrasound in a group of young, postmenarcheal women in the normal population, and to investigate how polycystic ovaries are related to the spectrum of clinical and biochemical symptoms associated with the polycystic ovary syndrome (PCOS).

DESIGN: Cross-sectional observational study.

SUBJECTS AND METHODS: Volunteers were recruited from two universities and two general practice surgeries in Oxford. 230 women ...

闻名 Polycystic Ovaries |  prevalence pcos |  biochemical features |  acne hirsutism |  young women
KOL Index score: 15975

1. The effects of insulin-like growth factor I (IGF-I) on the rates of glucose transport and utilization and its interaction with insulin were investigated in rat soleus muscle in vitro. IGF-I increased the rates of glucose transport, lactate formation, glycogen synthesis and the flux of glucose to hexose monophosphate, but it had no effect on the rate of glucose oxidation or glycogenolysis. 2. In the absence of insulin, low levels of IGF-I (0-30 ng/ml) increased the rate of glycolysis ...

闻名 Glucose Transport |  growth factor |  skeletal muscle |  igfi insulin |  lactate formation
KOL Index score: 15969

OBJECTIVE: Untreated GH-deficient adults are predisposed to insulin resistance and excess cardiovascular mortality. We showed previously that short-term treatment with a very low GH dose (LGH) enhanced insulin sensitivity in young healthy adults. The present study was therefore designed to explore the hypothesis that LGH, in contrast to the standard GH dose titrated to normalize serum IGF-I levels (SGH), may have differing effects on insulin sensitivity, body composition, and ...

闻名 Insulin Sensitivity |  cardiovascular risk markers |  body composition |  gh deficiency |  growth hormone
KOL Index score: 15367

BACKGROUND: Hypoglycemia and hyperglycemia during closed-loop insulin delivery based on subcutaneous (SC) glucose sensing may arise due to (1) overdosing and underdosing of insulin by control algorithm and (2) difference between plasma glucose (PG) and sensor glucose, which may be transient (kinetics origin and sensor artifacts) or persistent (calibration error [CE]). Using in silico testing, we assessed hypoglycemia and hyperglycemia incidence during over-night closed loop. ...

闻名 Loop Insulin |  simulation studies |  model predictive control |  overnight closed |  statistical pancreas
KOL Index score: 15230

BACKGROUND: Rapid early postnatal weight gain predicts increased subsequent obesity and related disease risks. However, the exact timing of adverse rapid postnatal weight gain is unclear.

OBJECTIVE: The objective was to examine the associations between rapid weight gain in infancy and in early childhood in relation to body composition at age 17 y.

DESIGN: This prospective cohort study was conducted in 248 (103 males) singletons and their mothers. Height and weight were measured at birth, ...

闻名 Early Childhood |  fat mass |  weight gain infancy |  body height |  gestational age
KOL Index score: 15041

OBJECTIVE: Polycystic ovaries are a common ultrasound finding, yet few of these women have many clinical features of polycystic ovary syndrome. Clinical presentation may relate to degree of insulin resistance, common polymorphism at the insulin gene VNTR, and birth weight. We therefore examined the relationship between insulin sensitivity, insulin gene VNTR genotype, birth weight and presence of polycystic ovaries/features of polycystic ovary syndrome in a normal population study.


闻名 Polycystic Ovaries |  birth weight |  insulin gene |  ovary syndrome |  women clinical
KOL Index score: 14921

OBJECTIVE: To identify predictors of postnatal catch-up growth from birth to two years and its relation to size and obesity at five years.

DESIGN: Regional prospective cohort study.

SETTING: Avon longitudinal study of pregnancy and childhood, United Kingdom.

SUBJECTS: 848 full term singletons from a 10% random sample of the Avon longitudinal study of pregnancy and childhood.

MAIN OUTCOME MEASURES: Maternal birth weight, prepregnancy weight, pregnancy weight gain, height, smoking, and ...

闻名 Years Children |  prospective cohort |  postnatal catch |  growth birth |  pregnancy childhood

关键人物 Type 1 Diabetes

John * ******
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David ******* ******
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William * **********
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Patricia * ******
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George * **********
type 1 diabetes nod mice celiac disease
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David B Dunger:专家影响

哪个概念David B Dunger具有直接影响:Type 1 diabetes,  1 diabetes,  Type 1,  Insulin sensitivity,  Growth hormone,  Growth factor,  Insulin resistance,  Diabetes mellitus.

David B Dunger:KOL的影响

与其他作者的工作有关的概念for which David B Dunger 有影响力:Type 1 diabetes,  Insulin resistance,  Birth weight,  Growth hormone,  Gestational age,  Diabetic ketoacidosis,  Polycystic ovary syndrome.



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Institute of Metabolic Science, University of Cambridge, Cambridge, UK | Department of Paediatrics, Addenbrooke's Hospital, University of Cambridge, Cambridge, U.K. | Department of Paediatrics, University of Cambridge, Cambridge, UK | Wellcome Trust-