![]() | Andrew G Nicholson |
Prominent publications by Andrew G Nicholson
INTRODUCTION: Adenocarcinoma is the most common histologic type of lung cancer. To address advances in oncology, molecular biology, pathology, radiology, and surgery of lung adenocarcinoma, an international multidisciplinary classification was sponsored by the International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society. This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, ...
Also Ranks for: Lung Adenocarcinoma | european respiratory society | international association | small biopsies | resection specimens |
INTRODUCTION: Patients with lung cancer who harbor multiple pulmonary sites of disease have been challenging to classify; a subcommittee of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee was charged with developing proposals for the eighth edition of the tumor, node, and metastasis (TNM) classification to address this issue.
METHODS: A systematic literature review and analysis of the International Association for the Study of Lung ...
Also Ranks for: Multiple Pulmonary Sites | tnm classification | lung cancer | eighth edition | international association |
This article proposes codes for the primary tumor categories of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) and a uniform way to measure tumor size in part-solid tumors for the eighth edition of the tumor, node, and metastasis classification of lung cancer. In 2011, new entities of AIS, MIA, and lepidic predominant adenocarcinoma were defined, and they were later incorporated into the 2015 World Health Organization classification of lung cancer. To fit these ...
Also Ranks for: Tumor Size | lung cancer | subsolid nodules | tnm classification | eighth edition |
INTRODUCTION: The current WHO classification of lung cancer states that a diagnosis of SCLC can be reliably made on routine histological and cytological grounds but immunohistochemistry (IHC) may be required, particularly (1) in cases in which histologic features are equivocal and (2) in cases in which the pathologist wants to increase confidence in diagnosis. However, reproducibility studies based on hematoxylin and eosin-stained slides alone for SCLC versus large cell neuroendocrine ...
Also Ranks for: Differential Diagnosis | cell lung | tumor carcinoma | biopsy specimens | immunohistochemistry ihc |
INTRODUCTION: Small cell lung cancer (SCLC) is commonly classified as either limited or extensive, but the Union for International Cancer Control TNM Classification of Malignant Tumours seventh edition (2009) recommended tumor, node, and metastasis (TNM) staging based on analysis of the International Association for the Study of Lung Cancer (IASLC) database.
METHODS: Survival analyses were performed for clinically and pathologically staged patients presenting with SCLC from 1999 through ...
Also Ranks for: Eighth Edition | international association | cancer staging | patients sclc | small cell |
INTRODUCTION: Application of tumor, node, and metastasis (TNM) classification is difficult in patients with lung cancer presenting as multiple ground glass nodules or with diffuse pneumonic-type involvement. Clarification of how to do this is needed for the forthcoming eighth edition of TNM classification.
METHODS: A subcommittee of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee conducted a systematic literature review to build an ...
Also Ranks for: Tnm Classification | ground glass | forthcoming eighth edition | cancer staging | pneumonic type |
Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.
[ PUBLICATION ]
PURPOSE: To review recent advances in pathology and computed tomography (CT) of lung adenocarcinoma and bronchioloalveolar carcinoma (BAC).
METHODS: A pathology/CT review panel of pathologists and radiologists met during a November 2004 International Association for the Study of Lung Cancer/American Society of Clinical Oncology consensus workshop in New York. The purpose was to determine if existing data was sufficient to propose modification of criteria for adenocarcinoma and BAC as ...
Also Ranks for: Computed Tomography | adenocarcinoma bac | bronchioloalveolar carcinoma | mixed subtype | favorable prognosis |
INTRODUCTION: It can be difficult to distinguish between a second primary and a metastasis in patients with lung cancer who have more than one pulmonary site of cancer.
METHODS: A systematic review of the literature was conducted by a subcommittee of the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee to develop recommendations to identify second primary lung cancers. The process entailed review of knowledge relating to the mechanism of ...
Also Ranks for: Primary Lung | forthcoming eighth edition | cancer staging | background data | metastasis patients |
INTRODUCTION: Separate tumor nodules with the same histologic appearance occur in the lungs in a small proportion of patients with primary lung cancer. This article addresses how such tumors can be classified to inform the eighth edition of the anatomic classification of lung cancer. Separate tumor nodules should be distinguished from second primary lung cancer, multifocal ground glass/lepidic tumors, and pneumonic-type lung cancer, which are addressed in separate analyses.
METHODS: ...
Also Ranks for: Lung Cancer | tnm classification | eighth edition | tumor nodules | background data |
INTRODUCTION: The current T component for malignant pleural mesothelioma (MPM) has been predominantly informed by surgical data sets and consensus. The International Association for the Study of Lung Cancer undertook revision of the seventh edition of the staging system for MPM with the goal of developing recommendations for the eighth edition.
METHODS: Data elements including detailed T descriptors were developed by consensus. Tumor thickness at three pleural levels was also recorded. ...
Also Ranks for: Pleural Mesothelioma | eighth edition | tnm classification | tumor thickness | clinical staging |
INTRODUCTION: Nodal categories for malignant pleural mesothelioma are derived from the lung cancer staging system and have not been adequately validated. The International Association for the Study of Lung Cancer developed a multinational database to generate evidence-based recommendations to inform the eighth edition of the TNM classification of malignant pleural mesothelioma.
METHODS: Data from 29 centers were entered prospectively (n = 1566) or by transfer of retrospective data (n = ...
Also Ranks for: Pleural Mesothelioma | tnm classification | eighth edition | lung cancer | clinical staging |
High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury
[ PUBLICATION ]
Mechanical ventilation has been demonstrated to exacerbate lung injury, and a sufficiently high tidal volume can induce injury in otherwise healthy lungs. However, it remains controversial whether injurious ventilation per se, without preceding lung injury, can initiate cytokine-mediated pulmonary inflammation. To address this, we developed an in vivo mouse model of acute lung injury produced by high tidal volume (Vt) ventilation. Anesthetized C57BL6 mice were ventilated at high Vt (34.5 ...
Also Ranks for: Lung Injury | tidal volume | vivo mouse | lavage fluid | tnf alpha |
INTRODUCTION: Revisions to the TNM stage classifications for lung cancer, informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external validation. The objective was to externally validate the revisions by using the National Cancer Data Base (NCDB) of the American College of Surgeons.
METHODS: Cases presenting from 2000 through 2012 were drawn from the NCDB and reclassified ...
Also Ranks for: Eighth Edition | lung cancer | external validation | tnm classification | stage groupings |
INTRODUCTION: Stage classification provides a consistent language to describe the anatomic extent of disease and is therefore a critical tool in caring for patients. The Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer developed proposals for revision of the classification of lung cancer for the eighth edition of the tumor, node, and metastasis (TNM) classification, which takes effect in 2017.
METHODS: An international database of ...
Also Ranks for: Lung Cancer | stage classification | tumor node | eighth edition | international association |
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus
[ PUBLICATION ]
Motile cilia move body fluids and gametes and the beating of cilia lining the airway epithelial surfaces ensures that they are kept clear and protected from inhaled pathogens and consequent respiratory infections. Dynein motor proteins provide mechanical force for cilia beating. Dynein mutations are a common cause of primary ciliary dyskinesia (PCD), an inherited condition characterized by deficient mucociliary clearance and chronic respiratory disease coupled with laterality ...
Also Ranks for: Situs Inversus | motile cilia | dnah9 mutations | outer dynein arm | heavy chain |
Andrew G Nicholson: Influence Statistics
Concept | World rank |
---|---|
consensus statement definition | #1 |
lung adenocarcinoma clinical | #3 |
lung adenocarcinoma relevance | #3 |
relevance lung adenocarcinoma | #3 |
disorders lymphocytic | #4 |
single category | #4 |
pn0 tumors | #5 |
lung cancer limitations | #5 |
pulmonary sites | #5 |
pn2 tumors | #5 |
thickness pleural | #5 |
sclc immunohistochemistry | #5 |
pn1 pn2 tumors | #5 |
diffuse pneumonic | #5 |
distinguish separate | #6 |
dnah9 mutations | #6 |
interstitial societies | #6 |
lepidic features | #6 |
pneumonic type | #7 |
forthcoming eighth edition | #7 |
bac pattern | #7 |
forthcoming eighth | #7 |
sqcc large | #7 |
organization pathologic | #8 |
diagnosis sqcc | #8 |
relevance 2004 | #8 |
limitations development | #8 |
category tumor | #8 |
solid adc | #8 |
separate primary | #9 |
cancer iaslc | #9 |
ais lepidic | #9 |
adenocarcinoma mixed subtype | #9 |
Key People For Lung Cancer
Andrew G Nicholson:Expert Impact
Concepts for whichAndrew G Nicholsonhas direct influence:Lung cancer, Tnm classification, Forthcoming eighth edition, Eighth edition, Cancer staging, International association, Lung adenocarcinoma, Separate tumor nodules.
Andrew G Nicholson:KOL impact
Concepts related to the work of other authors for whichfor which Andrew G Nicholson has influence:Lung cancer, Small cell, Idiopathic pulmonary fibrosis, Acute exacerbation, Egfr mutations, Computed tomography, Tumor size.
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