Division of Oncology,Children's National Medical Center. | Children's National Health System, Washington, DC, USA. | Center for Cancer and Immunology, Brain Tumor Institute, ...
KOL Resume for Roger Packer
Division of Oncology,Children's National Medical Center.
Children's National Health System, Washington, DC, USA.
Children’s National Health System, Washington, DC, USA
Center for Neuroscience and Behavioural Medicine, Children's National Medical Center, Washington, DC.
Lindsey M. Hoffman and Nicholas K. Foreman, University of Colorado Denver; Lindsey M. Hoffman and Nicholas K. Foreman, Children’s Hospital Colorado, Aurora, CO; Sophie E.M. Veldhuijzen van Zanten, Esther Hulleman, Gertjan J.L. Kaspers, Esther Sanchez, and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; William P. Vandertop, Academy of Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Niclas Colditz, Marion Hoffmann, Brigitte Bison, Monika Warmuth...
Children's National Medical Center, Washington, DC, USA
From the Divisions of Neurology (JCH, RP) and Infectious Diseases (SP), The Children's Hospital of Philadelphia, Philadelphia, PA, and the Division of Viral Diseases, Center for Infectious Diseases (SGM, MP, LBS), and Division of Immunization, Center for Prevention Services (KMK), Centers for Disease Control, Atlanta, GA.
Roger Packer: Influence Statistics
|poliomyelitislike paralysis enterovirus||#5|
|poliomyelitislike paralysis children||#5|
|focally exophytic morphology||#14|
|reliable imaging distinction||#14|
|enterovirus united states||#14|
|dipg pontine tumors||#14|
|histopathologic diagnoses dipg||#14|
|routine tissue acquisition||#14|
|50 pontine involvement||#14|
|dipg baseline mri||#15|
|mri features reviewers||#15|
|histone mutation status||#15|
|local diagnosis dipg||#15|
|idipgr local diagnosis||#15|
|imaging features age||#15|
|reviewers multivariable analysis||#15|
|age distant disease||#16|
|diagnostic brain mris||#17|
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Prominent publications by Roger Packer
Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society fo
[ PUBLICATION ]
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry databases included patients from North America, Australia, Germany, Austria, Switzerland, the ...
|Known for Molecular Characteristics | Intrinsic Pontine | Longterm Survivors | Pediatric Oncology | 1 Year|
MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry.
[ PUBLICATION ]
BACKGROUND: This study describes imaging features of diffuse intrinsic pontine glioma (DIPG) and correlates with overall survival (OS) and histone mutation status in the International DIPG Registry (IDIPGR).
METHODS: Four hundred cases submitted to the IDIPGR with a local diagnosis of DIPG and baseline MRI were evaluated by consensus review of 2 neuroradiologists; 43 cases were excluded (inadequate imaging or alternative diagnoses). Agreement between reviewers, association with histone ...
|Known for International Dipg Registry | Diffuse Intrinsic | Pontine Glioma | Imaging Features | Central Review|
PURPOSE: Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes with current chemoradiotherapy strategies. Our aim was to study the role of targeted BRAF inhibition in these tumors.
PATIENTS AND METHODS: We collected clinical, imaging, molecular, and outcome information from patients with BRAF V600E-mutated glioma treated with BRAF inhibition across 29 centers from multiple countries.
RESULTS: Sixty-seven patients were treated with BRAF inhibition (pediatric ...
|Known for Pediatric Gliomas | Braf V600e | Patients Plgg | Objective Responses | Poor Outcomes|
In the summer of 1987 five children were seen at The Children's Hospital of Philadelphia because of acute onset of flaccid paralysis of an arm or leg(s). Although there were documented exposures to oral poliovirus vaccine and coxsackievirus B3 in some of the cases, the clinical, epidemiologic and laboratory findings indicate that enterovirus 71 was the common etiologic agent for this unusual outbreak of poliomyelitis-like paralysis. Of the five children three recovered completely; the ...
|Known for Enterovirus 71 | Spinal Cord | Residual Paralysis | Publication Child Diagnosis | Childrens Hospital|
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes
[ PUBLICATION ]
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histologic review, methylation profiling, and custom panel, genome, or exome sequencing. After excluding tumors representing other established entities or subgroups, we identified 130 cases to be part of an "intrinsic" spectrum of ...
|Known for Gene Fusions | Grade Gliomas | Alk Ros1 | Targeted Agents | Older Children|
Accuracy of Central Neuro-Imaging Review of DIPG Compared with Histopathology in the International DIPG Registry.
[ PUBLICATION ]
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential.
METHODS: Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two ...
|Known for Grade Gliomas | Dipg Compared | Pontine Glioma | Diffuse Intrinsic|
Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation
[ PUBLICATION ]
PURPOSE: Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are genetically distinct tumor predisposition syndromes with overlapping phenotypes. We sought to update the diagnostic criteria for NF2 and SWN by incorporating recent advances in genetics, ophthalmology, neuropathology, and neuroimaging.
METHODS: We used a multistep process, beginning with a Delphi method involving global disease experts and subsequently involving non-neurofibromatosis clinical experts, patients, and ...
|Known for Neurofibromatosis Type | Nf2 Schwannomatosis|
Key People For International Dipg Registry
Roger Packer:Expert Impact
Concepts for whichRoger Packerhas direct influence:International dipg registry, Pediatric gliomas, Imaging features, Nf1 patients, Gene fusions, Grade gliomas, Mek inhibitors, Intrinsic pontine.
Roger Packer:KOL impact
Concepts related to the work of other authors for whichfor which Roger Packer has influence:Mouth disease, Intrinsic pontine, Brain tumors, Enterovirus 71, Acute flaccid paralysis, Midline glioma, Young children.
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