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    • Roger Packer

      Roger Packer

      Division of Oncology,Children's National Medical Center. | Children's National Health System, Washington, DC, USA. | Center for Cancer and Immunology, Brain Tumor Institute, ...



      KOL Resume for Roger Packer


      Division of Oncology,Children's National Medical Center.

      Children's National Health System, Washington, DC, USA.


      Children’s National Health System, Washington, DC, USA

      Center for Neuroscience and Behavioural Medicine, Children's National Medical Center, Washington, DC.


      Lindsey M. Hoffman and Nicholas K. Foreman, University of Colorado Denver; Lindsey M. Hoffman and Nicholas K. Foreman, Children’s Hospital Colorado, Aurora, CO; Sophie E.M. Veldhuijzen van Zanten, Esther Hulleman, Gertjan J.L. Kaspers, Esther Sanchez, and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; William P. Vandertop, Academy of Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Niclas Colditz, Marion Hoffmann, Brigitte Bison, Monika Warmuth...


      Children's National Medical Center, Washington, DC, USA


      From the Divisions of Neurology (JCH, RP) and Infectious Diseases (SP), The Children's Hospital of Philadelphia, Philadelphia, PA, and the Division of Viral Diseases, Center for Infectious Diseases (SGM, MP, LBS), and Division of Immunization, Center for Prevention Services (KMK), Centers for Disease Control, Atlanta, GA.



      Roger Packer: Influence Statistics

      Sample of concepts for which Roger Packer is among the top experts in the world.
      Concept World rank
      poliomyelitislike paralysis enterovirus #5
      poliomyelitislike paralysis children #5
      children nervous #10
      inconsistent dipg #12
      review dipg #13
      mris neuro #14
      focally exophytic morphology #14
      reliable imaging distinction #14
      dipg histopathology #14
      enterovirus united states #14
      sharplydefined margins #14
      extrapontine extension #14
      impression histopathology #14
      centrallyreviewed mri #14
      dipg pontine tumors #14
      dipg pontine #14
      classified dipg #14
      histopathologic diagnoses dipg #14
      routine tissue acquisition #14
      nonpontine origin #14
      dipg alternative #14
      50 pontine involvement #14
      dipg baseline mri #15
      mri features reviewers #15
      histone mutation status #15
      idipgr local #15
      histopathology centrally #15
      local diagnosis dipg #15
      assessed idipgr #15
      idipgr 95 #15
      reviewers multivariable #15
      idipgr local diagnosis #15
      imaging features age #15
      reviewers multivariable analysis #15
      consistent dipg #16
      age distant disease #16
      diagnostic brain mris #17
      reviewers association #20
      features univariable #22
      univariable age #23
      features reviewers #24
      poliomyelitislike paralysis #24
      clinicoradiologic diagnosis #24
      diagnostic mris #24
      included pontine #25
      pontine origin #27
      histopathology international #28
      diagnoses inconsistent #28
      central neuro #28
      dipg baseline #29


      Prominent publications by Roger Packer

      KOL-Index: 8002

      Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry databases included patients from North America, Australia, Germany, Austria, Switzerland, the ...

      Known for Molecular Characteristics | Intrinsic Pontine | Longterm Survivors | Pediatric Oncology | 1 Year
      KOL-Index: 7773

      BACKGROUND: This study describes imaging features of diffuse intrinsic pontine glioma (DIPG) and correlates with overall survival (OS) and histone mutation status in the International DIPG Registry (IDIPGR).

      METHODS: Four hundred cases submitted to the IDIPGR with a local diagnosis of DIPG and baseline MRI were evaluated by consensus review of 2 neuroradiologists; 43 cases were excluded (inadequate imaging or alternative diagnoses). Agreement between reviewers, association with histone ...

      Known for International Dipg Registry | Diffuse Intrinsic | Pontine Glioma | Imaging Features | Central Review
      KOL-Index: 5140

      PURPOSE: Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes with current chemoradiotherapy strategies. Our aim was to study the role of targeted BRAF inhibition in these tumors.

      PATIENTS AND METHODS: We collected clinical, imaging, molecular, and outcome information from patients with BRAF V600E-mutated glioma treated with BRAF inhibition across 29 centers from multiple countries.

      RESULTS: Sixty-seven patients were treated with BRAF inhibition (pediatric ...

      Known for Pediatric Gliomas | Braf V600e | Patients Plgg | Objective Responses | Poor Outcomes
      KOL-Index: 4551

      In the summer of 1987 five children were seen at The Children's Hospital of Philadelphia because of acute onset of flaccid paralysis of an arm or leg(s). Although there were documented exposures to oral poliovirus vaccine and coxsackievirus B3 in some of the cases, the clinical, epidemiologic and laboratory findings indicate that enterovirus 71 was the common etiologic agent for this unusual outbreak of poliomyelitis-like paralysis. Of the five children three recovered completely; the ...

      Known for Enterovirus 71 | Spinal Cord | Residual Paralysis | Publication Child Diagnosis | Childrens Hospital
      KOL-Index: 4056

      Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histologic review, methylation profiling, and custom panel, genome, or exome sequencing. After excluding tumors representing other established entities or subgroups, we identified 130 cases to be part of an "intrinsic" spectrum of ...

      Known for Gene Fusions | Grade Gliomas | Alk Ros1 | Targeted Agents | Older Children
      KOL-Index: 1615

      BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential.

      METHODS: Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two ...

      Known for Grade Gliomas | Dipg Compared | Pontine Glioma | Diffuse Intrinsic
      KOL-Index: 658

      PURPOSE: Neurofibromatosis type 2 (NF2) and schwannomatosis (SWN) are genetically distinct tumor predisposition syndromes with overlapping phenotypes. We sought to update the diagnostic criteria for NF2 and SWN by incorporating recent advances in genetics, ophthalmology, neuropathology, and neuroimaging.

      METHODS: We used a multistep process, beginning with a Delphi method involving global disease experts and subsequently involving non-neurofibromatosis clinical experts, patients, and ...

      Known for Neurofibromatosis Type | Nf2 Schwannomatosis

      Key People For International Dipg Registry

      Top KOLs in the world
      David T W Jones
      dna methylation protein structure pilocytic astrocytoma
      David W Ellison
      central nervous young children situ hybridization
      Cynthia E Hawkins
      central nervous cortical dysplasia brain tumor
      Amar J Gajjar
      brain tumors radiation therapy pediatric patients
      Suzanne J Baker
      p53 gene pten mutations cell death
      Chris Jones
      pediatric glioblastoma wilms tumor situ hybridization
      Select a search phrase   international dipg registry

      Roger Packer:Expert Impact

      Concepts for whichRoger Packerhas direct influence:International dipg registry,  Pediatric gliomas,  Imaging features,  Nf1 patients,  Gene fusions,  Grade gliomas,  Mek inhibitors,  Intrinsic pontine.

      Roger Packer:KOL impact

      Concepts related to the work of other authors for whichfor which Roger Packer has influence:Mouth disease,  Intrinsic pontine,  Brain tumors,  Enterovirus 71,  Acute flaccid paralysis,  Midline glioma,  Young children.



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      Division of Oncology,Children's National Medical Center. | Children's National Health System, Washington, DC, USA. | Center for Cancer and Immunology, Brain Tumor Institute, Children's National Health System, Washington, District of Columbia. | Child

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