Lisa R. Young

Lisa R. Young

Division Of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Oh 45229-3039, Usa

Direct Impact

Concepts for which Lisa R Young has direct influence:

interstitial lung
pulmonary fibrosis
hermansky-pudlak syndrome
trial participation
neuroendocrine hyperplasia
tuberous sclerosis complex
β1 integrin

External impact

Concepts related to the work of other authors for which Lisa R Young has influence:

renal cancer
hermansky-pudlak syndrome
interstitial lung
pulmonary fibrosis
bronchial dysplasia
systemic juvenile idiopathic arthritis
abca3 mutations

Prominent publications by Lisa R. Young

KOL-Index: 76 Hermansky-Pudlak syndrome (HPS) is a multisystemic autosomal recessive disorder characterized by oculocutaneous albinism, bleeding diathesis, and lethal pulmonary fibrosis (PF) in some HPS subtypes. During middle adulthood, ground-glass opacities, reticulation, and traction bronchiectasis develop with progression of PF. HPS is an orphan disease occurring in 1 in 500,000 to 1,000,000 ...
Known for
Hermansky | Pudlak | Syndrome Hps
KOL-Index: 73 OBJECTIVE: To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). METHODS: In a multicentre retrospective study, 61 cases were investigated using physician-reported clinical information and centralised analyses of radiological, pathological and genetic data. RESULTS: LD was ...
KOL-Index: 55 BACKGROUND: There is growing recognition and understanding of the entities that cause interstitial lung disease (ILD) in infants. These entities are distinct from those that cause ILD in older children and adults. METHODS: A multidisciplinary panel was convened to develop evidence-based guidelines on the classification, diagnosis, and management of ILD in children, focusing on neonates and ...
Known for
Pathologic Classification Scheme | Evidence-Based Guidelines | Childhood Ild | Familys
KOL-Index: 47 RATIONALE: Asymptomatic relatives of patients with familial interstitial pneumonia (FIP), the inherited form of idiopathic interstitial pneumonia, carry increased risk for developing interstitial lung disease. OBJECTIVES: Studying these at-risk individuals provides a unique opportunity to investigate early stages of FIP pathogenesis and develop predictive models of disease onset. METHODS: ...
Known for
Increased Interstitial | Asymptomatic Fip | Predictive Models | Minor Allele Frequency
KOL-Index: 45 Childhood interstitial lung diseases (ILDs) are a heterogeneous group of disorders characterized by common clinical features and diffuse radiographic abnormalities. There are important differences between the types and prognosis of ILD in children than in adults. Additionally, several unique disease entities occur only in infants and young children, including pulmonary interstitial ...
Known for
Pulmonary Interstitial Glycogenosis | Surgical Lung Biopsy | Lung Childhood | Ild Children
KOL-Index: 42 Alveolar type II (AT2) epithelial cells are uniquely specialized to produce surfactant in the lung and act as progenitor cells in the process of repair after lung injury. AT2 cell injury has been implicated in several lung diseases, including idiopathic pulmonary fibrosis and bronchopulmonary dysplasia. The inability to maintain primary AT2 cells in culture has been a significant barrier in ...
Known for
Injury At2 | Direct Contact | Conventional Two-Dimensional 2d Culture | Proliferation Marker Ki67
KOL-Index: 42 RATIONALE: Hermansky-Pudlak syndrome (HPS) is a family of recessive disorders of intracellular trafficking defects that are associated with highly penetrant pulmonary fibrosis. Naturally occurring HPS mice reliably model important features of the human disease, including constitutive alveolar macrophage activation and susceptibility to profibrotic stimuli. OBJECTIVES: To decipher which cell ...
Known for
Bone Marrow Chimeras | Epithelial Apoptosis | Chediak-Higashi Mouse Models | Naturally Occurring Hps Mice
KOL-Index: 42 Pulmonary inflammation, abnormalities in alveolar type II cell and macrophage morphology, and pulmonary fibrosis are features of Hermansky-Pudlak Syndrome (HPS). We used the naturally occurring "pearl" HPS2 mouse model to investigate the mechanisms of lung inflammation observed in HPS. Although baseline bronchoalveolar lavage (BAL) cell counts and differentials were similar in pearl and ...
Known for
Markedly Increased Production | Baseline Bronchoalveolar Lavage | Wt Ams | Alpha Responses
KOL-Index: 40 BACKGROUND: Recommendations regarding key aspects related to the diagnosis and pharmacological treatment of lymphangioleiomyomatosis (LAM) were recently published. We now provide additional recommendations regarding four specific questions related to the diagnosis of LAM and management of pneumothoraces in patients with LAM. METHODS: Systematic reviews were performed and then discussed by a ...
Known for
Additional Confirmatory Features | Lam Management | Burdens | Diagnostic Tool
KOL-Index: 36 INTRODUCTION: The Multicenter International Lymphangioleiomyomatosis (LAM) Efficacy of Sirolimus (MILES) trial revealed that sirolimus stabilised lung function in patients with moderately severe LAM. The purpose of this study was to further examine the MILES cohort for the effects of racial, demographic, clinical and physiological patient characteristics on disease progression and treatment ...
Known for
Baseline Fev1 Tsc | Initial Forced Expiratory Volume | Miles Effects | Stratum

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA

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