• Disease
  • Gastroesophageal
  • Gastroesophageal Reflux
  • Tom R Demeester

    Prominent publications by Tom R DeMeester

    KOL Index score: 20236

    OBJECTIVE: This study was undertaken to investigate the role of the angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor in the development and progression of Barrett esophagus and adenocarcinomas of the esophagus and gastroesophageal junction.

    METHODS: Vascular endothelial growth factor and basic fibroblast growth factor messenger RNA expression levels, relative to the control gene encoding beta-actin, were measured by using a quantitative reverse ...

    Also Ranks for: Growth Factor |  barrett esophagus |  vascular endothelial |  esophageal adenocarcinoma |  basic fibroblast
    KOL Index score: 18765

    OBJECTIVE: The normal histology at the gastroesophageal junction, and in particular the nature of cardiac mucosa, remains in dispute. Likewise, the relationship of intestinal metaplasia at the gastroesophageal junction (CIM) to Barrett's and intestinal metaplasia of the stomach (GIM) is unclear. The aim of this study was to assess the immunostaining characteristics of cardiac mucosa and CIM and compare their staining pattern with that of other foregut mucosal types. We hypothesized that ...

    Also Ranks for: Cardiac Mucosa |  cim barrett |  gastroesophageal junction |  humans metaplasia |  staining pattern
    KOL Index score: 16173

    OBJECTIVE: The aim of this study was to determine whether antireflux surgery is more effective in producing loss of intestinal metaplasia located only at the gastroesophageal junction than it has been in patients with intestinal metaplasia extending up into the distal esophagus.

    SUMMARY BACKGROUND DATA: Biopsies of a normal appearing gastroesophageal junction will demonstrate cardiac mucosa containing goblet cells--the hallmark of intestinal metaplasia--in 10% to 15% of patients who are ...

    Also Ranks for: Intestinal Metaplasia |  patients cim |  esophagus cardia |  antireflux procedure |  columnar epithelium
    KOL Index score: 16138

    Adenocarcinoma of the distal esophagus and gastroesophageal junction are believed to arise in Barrett's esophagus with intestinal metaplasia. Whether adenocarcinoma can arise in columnar lined esophagus without intestinal metaplasia is in doubt. Whether adenocarcinoma of the gastric cardia arises in intestinal metaplasia of the gastric cardia is also in doubt. We aim to evaluate the relationship of size and stage of adenocarcinoma of the distal esophagus, gastroesophageal junction and ...

    Also Ranks for: Intestinal Metaplasia |  gastric cardia |  distal esophagus |  gastroesophageal junction |  precursor lesion
    KOL Index score: 15556

    Knowledge of the risk of lymph node metastases is critical to planning therapy for T1 esophageal adenocarcinoma. This study retrospectively reviews 75 T1a and 51 T1b tumors and correlates lymph node metastases with depth of tumor invasion, tumor size, presence of lymphovascular invasion, and tumor grade.

    OBJECTIVES: Increasingly, patients with superficial esophageal adenocarcinoma are being treated endoscopically or with limited surgical resection techniques. Since no lymph nodes are ...

    Also Ranks for: Lymph Node Metastases |  tumor size |  poor differentiation |  submucosal invasion |  patients esophageal adenocarcinoma
    KOL Index score: 15417

    Barrett's esophagus is a multistage polyclonal disease that is associated with the development of adenocarcinoma of the esophagus and esophagogastric junction. Telomerase activation is associated with cellular immortality and carcinogenesis, and increased expression of the telomerase reverse transcriptase catalytic subunit (hTERT) has been used for the early detection of malignant diseases. To identify biomarkers associated with each stage of the Barrett's process, relative mRNA ...

    Also Ranks for: Telomerase Reverse |  patients cancer |  barrett esophagus |  neoplastic humans |  intestinal metaplasia
    KOL Index score: 15372

    OBJECTIVE: The purpose of the study was to test the hypothesis that cardiac mucosa, carditis, and specialized intestinal metaplasia at an endoscopically normal-appearing cardia are manifestations of gastroesophageal reflux disease.

    SUMMARY BACKGROUND DATA: In the absence of esophageal mucosal injury, the diagnosis of gastroesophageal reflux disease currently rests on 24-hour pH monitoring. Histologic examination of the esophagus is not useful. The recent identification of specialized ...

    Also Ranks for: Reflux Disease |  cardiac mucosa |  intestinal metaplasia |  patients carditis |  gastroesophageal junction
    KOL Index score: 15161

    OBJECTIVE: The Siewert classification system differentiates between adenocarcinoma of the gastroesophageal junction and that of the distal esophagus. The purpose of this study was to evaluate whether there were differences in the location and prevalence of lymph node metastases, type of recurrence, and survival with these tumors that warrant distinguishing between them in clinical practice.

    METHODS: Records of all patients who underwent resection for adenocarcinoma of the distal ...

    Also Ranks for: Gastroesophageal Junction |  distal esophagus |  patients adenocarcinoma |  survival esophagectomy |  lymph node metastases
    KOL Index score: 14626

    OBJECTIVE: To investigate the prevalence of Barrett's esophagus in patients with adenocarcinomas located at the gastroesophageal junction.

    DESIGN: A case series of patients who underwent esophagogastrectomy for adenocarcinoma was retrospectively reviewed. Tumors were grouped by location as esophageal, cardiac, and subcardiac, and the prevalence of specialized intestinal metaplasia in the histological specimens was determined.

    SETTING: A university department of surgery that specializes ...

    Also Ranks for: Cardiac Adenocarcinomas |  patients adenocarcinoma |  barretts metaplasia |  barrett esophagus |  cardia prevalence
    KOL Index score: 14624

    OBJECTIVE: To assess the long-term outcome of antireflux surgery in patients with Barrett's esophagus.

    SUMMARY BACKGROUND DATA: The prevalence of Barrett's esophagus is increasing, and its treatment is problematic. Antireflux surgery has the potential to stop reflux and induce a quiescent mucosa. Its long-term outcome, however, has recently been challenged with reports of poor control of reflux and the inability to prevent progression to cancer.

    METHODS: The outcome of antireflux surgery ...

    Also Ranks for: Antireflux Surgery |  patients barrett esophagus |  reflux symptoms |  intestinal metaplasia |  5 years
    KOL Index score: 14332

    The significance of finding specialized intestinal epithelium localized to the region of the gastroesophageal junction is unclear. We tested the hypothesis that short segments of specialized intestinal epithelium are a consequence of gastroesophageal reflux disease and are premalignant. Two hundred forty-one patients with reflux symptoms underwent gastroscopy with rigorous biopsy. Barrett's esophagus was diagnosed when specialized intestinal epithelium was present on biopsy. Patients ...

    Also Ranks for: Gastroesophageal Reflux Disease |  segment barrett |  esophagus patients |  specialized intestinal |  reflux symptoms
    KOL Index score: 14256

    BACKGROUND: The CDX2 (caudal-related homeobox gene 2) and PITX1 (pituitary homeobox 1) genes have essential roles in human development. Forced expression of Cdx2 alone in the murine stomach results in gastric intestinal metaplasia (IM). This study was undertaken to investigate the expression pattern of these critical morphogenesis genes in the Barrett's multistage carcinogenesis model.

    METHODS: CDX2 and PITX1 messenger RNA (mRNA) expression levels, relative to the control gene ...

    Also Ranks for: Gene Expression |  barretts esophagus |  pitx1 homeobox |  esophageal neoplasms |  cdx2 mrna
    KOL Index score: 14173

    OBJECTIVE: To compare the frequency and spectrum of p53 gene mutations in adenocarcinomas of the esophagus and cardia and to compare clinical and pathologic features in patients with p53 mutant and nonmutant cancers.

    SUMMARY BACKGROUND DATA: The p53 gene is commonly mutated in human cancers, and a p53 mutation is reported to be present in more than 50% of esophageal adenocarcinomas. Although many studies have investigated the frequency of p53 protein overexpression in adenocarcinomas of ...

    Also Ranks for: P53 Mutations |  esophagus cardia |  clinical significance |  esophagogastric junction |  female genes
    KOL Index score: 13514

    Background and AimsGastroesophageal reflux disease (GERD) is a spectrum of disease that includes nonerosive reflux disease (NERD), erosive reflux disease (ERD), and Barrett’s esophagus (BE). Treatment outcomes for patients with different stages have differed in many studies. In particular, acid suppressant medication therapy is reported to be less effective for treating patients with NERD and Barrett’s esophagus. The aims of this study were to investigate (1) the role of mechanical ...

    Also Ranks for: Hiatal Hernia |  nissen fundoplication |  reflux disease |  lower esophageal |  nerd patients


    Tom R DeMeester: Influence Statistics

    Sample of concepts for which Tom R DeMeester is among the top experts in the world.
    Concept World rank
    1288 reflux episodes #1
    adenocarcinomas distal esophagus #1
    early progressive disease #1
    juice esophagus #1
    refluxinduced strictures #1
    systemic disease followup #1
    gim barrett #1
    presence highgrade dysplasia #1
    intraoperative assessment perfusion #1
    triple antibiotics surgery #1
    chest pain nadir #1
    respiratory symptoms fundoplication #1
    squamous mucosa patients #1
    robust perfusion laa #1
    34 gm #1
    station pull #1
    esophagectomy life #1
    pharyngoesophageal patients #1
    29 patients metastases #1
    abdomen interaction #1
    esophagectomy eating #1
    potential duodenal origin #1
    endoscopic augmentation cardia #1
    reflux gastric dilatation #1
    laryngopharyngeal reflux threshold #1
    biopsies cervical esophagus #1
    interposition patients #1
    postoperative elevation levels #1
    n0 patients eradication #1
    hiatal hernia eae #1
    reflux admixture #1
    91 dysphagia #1
    ischemic gastric #1
    disease adenocarcinoma #1
    gastroesophageal junction length #1
    nissen fundoplication nissen #1
    patients marketing campaign #1
    patients surveillance programs #1
    eac role #1
    fold dysplasia #1
    partial fundoplication outcome #1
    cancer expression levels #1
    barretts esophagus followup #1
    pill entrapment #1
    bravo catheter #1
    patients resting pressure #1
    anastomotic breakdown esophagectomy #1
    esophagus barretts #1
    resting characteristics #1
    patients muscular invasion #1

    Key People For Gastroesophageal Reflux

    Top KOLs in the world
    John Dent
    reflux disease gastric emptying pyloric motility
    Donald O Castell
    gastroesophageal reflux chest pain esophageal manometry
    Peter James Kahrilas
    esophagogastric junction chicago classification gastroesophageal reflux disease
    Tom R DeMeester
    gastroesophageal reflux intestinal metaplasia esophageal adenocarcinoma
    Joel E Richter
    chest pain gastroesophageal reflux eosinophilic esophagitis
    Hashem B EL‐SERAG
    united states hepatocellular carcinoma veterans affairs

    Tom R DeMeester:Expert Impact

    Concepts for whichTom R DeMeesterhas direct influence:Gastroesophageal reflux,  Gastroesophageal reflux disease,  Intestinal metaplasia,  Esophageal adenocarcinoma,  Nissen fundoplication,  Reflux disease,  Antireflux surgery,  Barretts esophagus.

    Tom R DeMeester:KOL impact

    Concepts related to the work of other authors for whichfor which Tom R DeMeester has influence:Gastroesophageal reflux,  Esophageal cancer,  Eosinophilic esophagitis,  Barrett esophagus,  Nissen fundoplication,  Hiatal hernia,  Intestinal metaplasia.



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    Keck School of Medicine, University of Southern California, Los Angeles, CA, USA | University of Southern California, Los Angeles, CA, USA | Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electroni