• KOL
    • Intestinal Permeability
    • Analysis Of Genetic...
    • Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease.: Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Intestinal permeability,Degree relatives,Crohns disease,Gut permeability,Patients crohns disease,Altered gut permeability,Crohn disease,Intestinal barrier dysfunction.

      Key People For Intestinal Permeability

      Top KOLs in the world
      #1
      Ingvar T Bjarnason
      intestinal permeability ulcerative colitis coeliac disease
      #2
      Ian S Menzies
      intestinal permeability coeliac disease cirrhotic patients
      #3
      Jerrold R Turner
      tight junction barrier function epithelial cells
      #4
      Jon B Meddings
      intestinal permeability crohns disease nutrient absorption
      #5
      ANdrew J Macpherson
      intestinal permeability blood loss cardiopulmonary bypass
      #6
      Alessio Fasano
      celiac disease intestinal permeability zonula occludens toxin

      Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease.

      Abstract

      Excessive intestinal permeability or intestinal barrier dysfunction as measured by various assays has been observed in various diseases. However, little is known about the factors contributing to altered gut permeability in these diseases. Our objective was to determine the genetic determinants of altered gut permeability as measured by the lactulose mannitol fractional excretion ratio (LacMan ratio) in 1075 healthy first-degree relatives of patients with Crohn's disease (CD). In a targeted analysis of single nucleotide polymorphisms (SNPs) located in genes associated with intestinal barrier function related or not to inflammatory bowel disease, we did not find a significant association with intestinal permeability. In an untargeted genome-wide association analysis, the top 100 associations were located in 22 genomic loci, although they were not statistically significant after correction for multiple testing (raw P values [1.8 × 10-7 - 1.4 × 10-5]. The lowest P value was obtained for rs9616637 (22q13.33, C22orf34), for which the minor allele A was associated with a decreased LacMan ratio. These results suggest that host genetic background has limited contribution toward intestinal permeability. Despite this, our study is currently the largest of its kind assessing gut permeability in vivo. It remains possible that smaller genetic effect sizes on LacMan ratio are not detectable in this sized cohort. Larger studies are warranted to identify the potential genetic contribution to intestinal permeability.

      Sign-in to see all concepts, it's free!

       

    Download on the App StoreGet it on Google Play

    Copyright © 2023 Key Opinion Leaders, LLC.