• KOL
    • Intestinal Permeability
    • Ian S Menzies
    • Ian S Menzies: Influence Statistics

      Ian S Menzies

      Ian S Menzies

      King's College School of Medicine and Dentistry, London, UK | King's College School of Medicine and Dentistry, London, United Kingdom | Departments of Child Health and ...

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      Ian S Menzies:Expert Impact

      Concepts for whichIan S Menzieshas direct influence:Intestinal permeability,Cirrhotic patients,Enteral feeding,Coeliac disease,Iron deficiency,Degree relatives,Atopic eczema,Intestinal inflammation.

      Ian S Menzies:KOL impact

      Concepts related to the work of other authors for whichfor which Ian S Menzies has influence:Intestinal permeability,Cardiopulmonary bypass,Enteral nutrition,Cardiac surgery,Small intestine,Coeliac disease,Liver cirrhosis.

      KOL Resume for Ian S Menzies

      Year
      2004

      King's College School of Medicine and Dentistry, London, UK

      2000

      King's College School of Medicine and Dentistry, London, United Kingdom

      1999

      Departments of Child Health and Medicine, Kings College Hospital, Denmark Hill, London SE5 9RS

      St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, UK.

      1996

      Department of Clinical Pharmacology, University of Newcastle upon Tyne.

      1995

      Department of Medicine, Chelsea and Westminster Hospital, London.

      1994

      Gastrointestinal Laboratory, Rayne Institute, and Dept. of Clinical Chemistry, St Thomas' Hospital, London, UK

      Dept. of Clinical Biochemistry, King's College School of Medicine and Dentistry, and Dept. of Chemical Pathology, U.M.D.S. Guy's and St Thomas's Hospital, London, United Kingdom

      Department of Chemical Pathology, St Thomas' Hospital, London, United Kingdon

      1993

      Department of Clinical Biochemistry, Kings College Hospital, London, United Kingdom

      St Thomas's Hospital, London. UK

      1992

      Department of Pediatrics, Rambam Medical Center, and Technion-Faculty of Medicine, Haifa, Israel, and Department of Chemical Pathology, St. Thomas' Hospital Medical School, London, United Kingdom

      Section of Gastroenterology, MRC Clinical Research Centre, Harrow, Middlesex.

      Division of Chemical Pathology, St. Thomas's Hospital Medical School, London, England

      1991

      Section of Gastroenterology, Northwick Park Hospital and MRC Clinical Research Centre, Harrow, Middlesex Dept. of Chemical Pathology, St Thomas Hospital Medical School, London, UK Dept. of Clinical Biochemistry, Kings College School of Medicine and Dentistry, London, UK

      Gastrointestinal Laboratory, St Thomas's Hospital, London.

      1990

      Department of Chemical Pathology and Metabolic Disorders, St Thomas's Hospital, London.

      Depts. of Chemical Pathology and Physiology, and Gastrointestinal Laboratory, St Thomas Hospital, London, UK

      1989

      Department of Chemical Pathology, Metabolic Disorders, St. Thomas's Hospital, London, UK

      Section of Gastroenterology, MRC Clinical Research Centre, Harrow, Middlesex

      1988

      St. Thomas Hospital Medical School, London SW1

      1986

      Departments of Paediatrics and Chemical Pathology, St Thomas’ Hospital, London SE1 7EH, UK

      Department of Chemical Pathology and Metabolic Disorders, and the Gastrointestinal Laboratory, U.M.D.S. Guy's and St Thomas's Hospital, London, and Division of Clinical Sciences and Cell Biology, MRC Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex, U.K.

      1985

      Department of Chemical Pathology and Metabolic Disorders, St. Thomas's Hospital Medical School, London (U.K.)

      1984

      St Thomas' Hospital, London, and MRC Clinical Research Centre, Harrow, Middlesex

      1983

      Department of Chemical Pathology, St Thomas' Hospital, London SE1, United Kingdon

      1982

      Institute of Clinical Medicine, University of Naples, Medical School II, Italy;, Department of Chemical Pathology and Metabolic Disorders, St. Thomas’ Hospital Medical School, London, England

      1980

      Clinica Medica, 2nd University Medical School, Naples, and Department of Chemical Pathology and Metabolic Disorders, St. Thomas’s Hospital Medical School, London

      1976

      Fellow American Association for the Advancement of Science, Reader in Biochemical Education, Courtauld Institute, Middlesex Hospital, London, University of London

      1974

      Department of Chemical Pathology, St Thomas's Hospital, London SE1 7EH, U.K

      1973

      Department of Clinical Chemistry, St. Thomas's Hospital, London S.E.1 Great Britain

      1972

      Departments of Clinical Chemistry, St. Thomas's Hospital, London S.E.1, and the Institute of Child Health, London WC1N1EH, U.K

      1969

      Fellow American Association for the Advancement of Science, Senior Lecturer in Biochemistry, Courtauld Institute, Middlesex Hospital, London, Recognised Teacher, University of London

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      Sample of concepts for which Ian S Menzies is among the top experts in the world.
      Concept World rank
      absorbed test sugars #1
      enhanced permeability week #1
      technique infant milk #1
      sodium sulphate absorption #1
      chapter 4 sources #1
      human intestinal permeability #1
      types 114 mmol #1
      sugars ileostomy #1
      mature pattern permeability #1
      lactulose absorbed #1
      continued infusion milks #1
      absorption rhamnose #1
      mucosa lactulose #1
      0001 lactulose #1
      xylose 3omethyldglucose #1
      ingested lactulose absorption #1
      birth temporary period #1
      increased permeability findings #1
      lactulose rhamnose #1
      lactuloserhamnose ratio #1
      intestinal isomaltase activity #1
      byin vitro estimation #1
      error chapter 4 #1
      permeability children #1
      increase 51credta recovery #1
      30methyldglucose #1
      mannitol intestinal uptake #1
      permeability neonatal bowel #1
      lactulose nonabsorbable sugars #1
      intestinal permeability absorption #1
      51credta markers #1
      impaired hydrolysis sucrose #1
      layer disaccharidases layer #1
      disaccharide excretion #1
      disaccharidases assessed #1
      recovery 51cr #1
      lrhamnose #1
      sugar probes #1
      permeability lactulose #1
      lactulose 51credta #1
      mammals immunological implications #1
      isomaltase inborn errors #1
      lrhamnose dxylose 3omethyld #1
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      Prominent publications by Ian S Menzies

      KOL-Index: 12871

      It has been reported that intestinal permeability to polyethylene glycol 400 is increased in patients with Crohn's disease and their apparently unaffected first degree relatives. Because of the implications that these findings have for the aetiology of Crohn's disease these studies were repeated. Patients with Crohn's disease (n = 28) and 32 first degree relatives from 11 families underwent a polyethylene glycol 400 (PEG400) intestinal permeability test and a hyperosmotic (1500 mosmol/l) ...

      Known for Degree Relatives | Intestinal Permeability | Crohns Disease | Polyethylene Glycol | Patients Crohn
      KOL-Index: 12328

      Gastrointestinal dysfunction in patients with cirrhosis may contribute to complications such as malnutrition and spontaneous bacterial peritonitis. To determine whether cirrhotic patients with ascites have altered intestinal function, we compared intestinal permeability and absorption in patients with liver disease and normal subjects. Intestinal permeability and absorption were investigated in 66 cirrhotic patients (48 with ascites, 18 without ascites) and 74 healthy control subjects. ...

      Known for Cirrhotic Patients | Intestinal Permeability | Sugar Probes | Liver Disease | Oral Administration
      KOL-Index: 11723

      BACKGROUND: The frequency with which non-steroidal anti-inflammatory drugs (NSAIDs) increase small intestinal permeability and cause inflammation is uncertain.

      AIMS: To examine small intestinal permeability and inflammation in a large number of patients on long term NSAIDs.

      METHODS: Sixty eight patients receiving six different NSAIDs for over six months underwent combined absorption-permeability tests at three different test dose osmolarities (iso-, hypo-, and hyperosmolar). Two hundred ...

      Known for Intestinal Permeability | Patients Nsaids | Antiinflammatory Agents | Small Bowel | Steroidal Anti
      KOL-Index: 10389

      BACKGROUND: Controversy surrounds the issue of intestinal permeability in patients with coeliac disease, polyethylene glycol 400 indicating reduced and di-/mono-saccharide urine excretion ratios and 51Cr-labeled ethylenediaminetetraacetic acid (EDTA) indicating increased permeability.

      METHODS: We assessed the suitability of polyethylene glycol 400, L-rhamnose, lactulose, and 51Cr-EDTA as markers of intestinal permeability by assessing urine excretions after simultaneous intravenous ...

      Known for Coeliac Disease | Intestinal Permeability | Polyethylene Glycol | Lactulose Rhamnose | 51cr Edta
      KOL-Index: 10124

      Increased small intestinal permeability caused by non-steroidal anti-inflammatory drugs (NSAIDs) is probably a prerequisite for NSAID enteropathy, a source of morbidity in patients with rheumatoid arthritis. This increased small intestinal permeability may be a summation of a local effect during drug absorption, a systemic effect after absorption, and a local effect of the drug excreted in bile, but the relative contribution made by these factors is unknown. We assessed the effect of ...

      Known for Intestinal Permeability | Steroidal Anti | Drug Absorption | Nsaid Enteropathy | Rheumatoid Arthritis
      KOL-Index: 9157

      Total parenteral nutrition is used for nutritional support in patients undergoing orthotopic liver transplantation but is associated with complications. We compared the efficacy and tolerability of early enteral feeding with total parenteral nutrition after liver transplantation. 24 patients were studied: 14 received enteral feeding and 10 total parenteral nutrition. A double-lumen enteral tube was used to deliver the feed directly into the jejunum with the second lumen of the tube being ...

      Known for Enteral Feeding | Liver Transplantation | Nutrition Total | Intestinal Mucosal Integrity | Early Postoperative
      KOL-Index: 8956

      Small intestinal absorptive function can be disturbed in iron deficiency. We examined the permeability behavior of the small intestinal mucosa toward lactulose and rhamnose in 26 otherwise healthy children with iron deficiency. Their (mean +/- SD) age was 21 +/- 8.6 months; hemoglobin 7.9 +/- 0.9 g/dl, mean corpuscular volume (MCV) 60.1 +/- 3.4 fl, serum iron 2.72 +/- 0.66 mumol/L, serum ferritin 7.3 +/- 1.6 micrograms/L. After an isotonic oral load of both sugars, their 5-h urinary ...

      Known for Iron Deficiency | Intestinal Permeability | Lactulose Rhamnose | Mucosa Intestine | Urinary Recovery
      KOL-Index: 8884

      Gastrointestinal damage occurs in 0.6% to 2% of patients after cardiopulmonary bypass (CPB), and carries a mortality of 12% to 67%. The incidence of subclinical gastrointestinal damage may be much greater. We examined the effects of nonpulsatile, hypothermic CPB on intestinal absorption and permeability in 41 patients. Bowel mucosal saccharide transport and permeation were evaluated using 100 mL of an oral solution containing 3-O-methyl-D-glucose (0.2 g), D-xylose (0.5 g), L-rhamnose ...

      Known for Cardiopulmonary Bypass | Patients Cpb | Small Intestinal | Lactulose Rhamnose | Aged Permeability
      KOL-Index: 8110

      Intestinal function is poorly defined in patients with HIV infection. Absorptive capacity and intestinal permeability were assessed using 3-O-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose in 88 HIV infected patients and the findings were correlated with the degree of immunosuppression (CD4 counts), diarrhoea, wasting, intestinal pathogen status, and histomorphometric analysis of jejunal biopsy samples. Malabsorption of 3-O-methyl-D-glucose and D-xylose was prevalent in all groups ...

      Known for Intestinal Permeability | Absorptive Capacity | Hiv Patients | Coeliac Disease | Cd4 Lymphocyte
      KOL-Index: 7570

      This study examined whether indomethacin-induced increases in small intestinal permeability in man are prevented by concomitant administration of a prostaglandin analog (misoprostol). Twelve male volunteers were tested as baseline, following misoprostol alone (200 Μg, at −16, −12, −8.5, −4, −1.5, and +4 hr); following indomethacin alone (75 mg, at −8; 50 mg, −1 hr); and following coadministration of misoprostol and indomethacin as specified above. A 100-ml test solution containing ...

      Known for Small Intestinal | Misoprostol Indomethacin | Paracellular Permeability | Male Volunteers | Rhamnose Xylose
      KOL-Index: 6895

      BACKGROUND/AIMS: Mean arterial pressure is reduced during hypothermic cardiopulmonary bypass. The aim of this study was to assess whether this was associated with intestinal hypoperfusion and whether it affected intestinal absorption and permeability.

      METHODS: Twenty-six patients undergoing coronary artery bypass grafting underwent an intestinal absorption-permeability test involving ingestion of 3-O-methyl-D-glucose, D-xylose, L-rhamnose, and lactulose. Ingestion took place 2 days ...

      Known for Intestinal Absorption | Cardiopulmonary Bypass | Arterial Pressure | Postoperative Day | Aged Permeability
      KOL-Index: 6823

      BACKGROUND: We have previously shown that small oral doses of poorly absorbed solute can significantly reduce absorption of test sugars in normal volunteers. To confirm these results and investigate the underlying mechanism, the effects of lactulose on absorption of three test sugars in subjects with ileostomies were studied.

      METHODS: Ten fasted subjects with ileostomies ingested an isosmolar test solution containing 2.5 g 3-O-methyl-D-glucose, 5.0 g D-xylose, 1.0 g L-rhamnose, and 50 ...

      Known for Test Solution | Rhamnose Xylose | Crohn Disease | 3 Methylglucose | Lactulose Male
      KOL-Index: 6742

      Nonsteroidal anti-inflammatory drug (NSAID)-induced increased intestinal permeability appears to be a prerequisite for NSAID enteropathy. It has been suggested that early metabolic events leading to the permeability changes may involve inhibition of glycolysis and the tricarboxylic acid cycle, in which case the coadministration of glucose and citrate (the substrates for these metabolic pathways) with indomethacin may afford some protection. The present study, using a combined intestinal ...

      Known for Indomethacin Intestinal Permeability | Nsaid Enteropathy | Small Intestinal | Metabolic Pathways | Citric Acid

      Key People For Intestinal Permeability

      Top KOLs in the world
      #1
      Ingvar T Bjarnason
      intestinal permeability ulcerative colitis coeliac disease
      #2
      Ian S Menzies
      intestinal permeability coeliac disease cirrhotic patients
      #3
      Jerrold R Turner
      tight junction barrier function epithelial cells
      #4
      Jon B Meddings
      intestinal permeability crohns disease nutrient absorption
      #5
      ANdrew J Macpherson
      intestinal permeability blood loss cardiopulmonary bypass
      #6
      Alessio Fasano
      celiac disease intestinal permeability zonula occludens toxin

      King's College School of Medicine and Dentistry, London, UK | King's College School of Medicine and Dentistry, London, United Kingdom | Departments of Child Health and Medicine, Kings College Hospital, Denmark Hill, London SE5 9RS | St Thomas's Hospi

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