• KOL
    • Intestinal Permeability
    • Jon B Meddings
    • Jon B Meddings: Influence Statistics

      Jon B Meddings

      Jon B Meddings

      Department of Medicine, University of Calgary, Calgary, Alberta, Canada | Department of Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, ...

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      Jon B Meddings:Expert Impact

      Concepts for whichJon B Meddingshas direct influence:Intestinal permeability,Sucrose permeability,Nutrient absorption,Glucose transport,Crohns disease,Gastric damage,Intestinal permeability patients,Gastrointestinal permeability.

      Jon B Meddings:KOL impact

      Concepts related to the work of other authors for whichfor which Jon B Meddings has influence:Intestinal permeability,Celiac disease,Gut microbiota,Barrier function,Inflammatory bowel,Tight junctions,Ulcerative colitis.

      KOL Resume for Jon B Meddings

      Year
      2022

      Department of Medicine, University of Calgary, Calgary, Alberta, Canada

      2021

      Department of Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada

      2020

      Department of Medicine, University of Calgary, Alberta, Canada.

      2018

      Department of Surgery, University of Calgary , Calgary, Alberta , Canada.

      Cumming School of Medicine, University of Calgary, Calgary, Alberta, View further author information

      2017

      Faculty of Medicine, University of Calgary, Health Sciences Centre, Calgary, Alberta, Canada; and

      2016

      Cumming School of Medicine, University of Calgary, Calgary, AB, Canada T2N 4Z6

      2015

      Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, AB, Canada;

      Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

      2013

      University of Calgary Department of Medicine Alberta AB Canada

      2011

      Department of Medicine, University of Alberta, Edmonton, Alberta, Canada

      2010

      Division of Gastroenterology, University of Alberta, Zeidler Ledcor Building, T6G 2X8, Edmonton, AB, Canada

      2009

      Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2V2

      2008

      Department of Medicine, University of Alberta, Edmonton, AB, Canada

      2007

      From the Royal Alexandra Hospital, Edmonton, Canada (CA, LG, and DK); the Department of Medicine, Division of Gastroenterology (LG, JM, RF, and KM), and the Department of Agricultural, Food, and Nutritional Science (LM), University of Alberta, Edmonton, Canada

      2006

      Gastrointestinal Research Group, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1

      2005

      Department of Pathology, The University of Chicago, Chicago, Illinois, USA., Department of Medicine, Division of Gastroenterology, Northwestern University, Chicago, Illinois, USA., Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Center for Drug Discovery and Chemical Biology, Northwestern University, Chicago, Illinois, USA., Department of Biomedical Sciences, University of Missouri, Columbia, Missouri, USA., Welsh School of Pharmacy, Cardiff University, Cardiff, Wales, United Kingdom.

      University of Calgary, Alberta, Canada

      2004

      Division of Pediatric General Surgery [D.S.], Alberta Children’s Hospital, Calgary, AB, Canada, T2T 5C7; GI Research Group [D.S., G.M., J.M.], University of Calgary, Health Science Centre, Calgary, AB, Canada, T2N 4N1; Department of Physiology [B.H., J.H.], Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2100 Copenhagen Ø, Denmark

      2002

      Alberta Children's Hospital and University of Calgary, Calgary, Alberta, Canada

      2001

      Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada

      2000

      GI Research Group, University of Calgary, Calgary, Alberta, Canada

      1999

      Department of Medicine, Health Science Centre, Calgary, Alberta, Canada

      Medicine, and

      1998

      Gastrointestinal and Neuroscience Research Groups, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

      1996

      From the Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada

      1995

      Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada.

      1993

      Gastrointestinal Research Group, Health Sciences Centre, University of Calgary, Alberta, Canada.

      1992

      Gastrointestinal Research Group, Faculty of Medicine, University ofCalgary, Alberta, Canada.

      1991

      Departments of Anesthesia and Internal Medicine, University of Calgary, Calgary Canada

      1990

      Gastrointestinal Research Group, University of Calgary, Alberta,Canada.

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      Sample of concepts for which Jon B Meddings is among the top experts in the world.
      Concept World rank
      groups baseline lactulose #1
      crohns disease relatives #1
      rats dendritic cells #1
      correlation 30 absorption #1
      convalescence mucosa humans #1
      cd19 cells subset #1
      scores alendronate #1
      colonic damage probes #1
      abnormal permeability consequence #1
      correlation protein absorption #1
      endoscopically normal controls #1
      age bowel length #1
      increased gastrointestinal #1
      uc patients cd45ro #1
      subset relatives #1
      blood cd45ro #1
      consequence mucosal inflammation #1
      gastrointestinal permeability convalescence #1
      symptom scores alendronate #1
      disease pathogenesis illness #1
      30 marker #1
      intestinal permeability findings #1
      proportion dendritic cells #1
      autoimmune disease description #1
      zonulin intestinal permeability #1
      concept intestinal permeability #1
      place pathogenesis #1
      cancer sucrose #1
      gastrointestinal permeability treatment #1
      mannitol pilot #1
      class 3 probes #1
      severe malaria day #1
      abnormal gut barrier #1
      mln zn rats #1
      lactulose malaria #1
      coacquisition crohns disease #1
      small intestine class #1
      lactulose leukocyte #1
      zd rats mln #1
      repeat attg #1
      treatment endoscopic scores #1
      excretion diseases #1
      nutrient absorption length #1
      mln zd rats #1
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      Prominent publications by Jon B Meddings

      KOL-Index: 12965

      Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined. We utilized a murine model of T cell-mediated acute diarrhea to investigate the role of the epithelial barrier in diarrheal disease. We show that epithelial barrier dysfunction is required for the development of diarrhea. This diarrhea is characterized by reversal of net water flux, from ...

      Known for Barrier Dysfunction | Cell Activation | Myosin Light | Chain Kinase | Epithelial Mlck
      KOL-Index: 11192

      OBJECTIVE: To evaluate the use of sucrose permeability testing to detect ulcers in the gastric squamous mucosa of horses.

      ANIMALS: 13 adult horses ranging from 5 to 19 years of age.

      PROCEDURE: Following induction of gastric ulcers by intermittent feed deprivation, horses underwent sucrose permeability testing (administration of sucrose by nasogastric intubation followed by collection of urine at 2 and 4 hours after intubation) and gastric endoscopy. Squamous ulcers were assigned a ...

      Known for Gastric Ulcers | Sucrose Concentration | Ulcer Severity | Permeability Testing | Horses Omeprazole
      KOL-Index: 10184

      BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a multifactorial disease thought to be caused by alterations in epithelial function, innate and adaptive immunity, and luminal microbiota. The specific role of epithelial barrier function remains undefined, although increased activity of intestinal epithelial myosin light chain kinase (MLCK), which is the primary mechanism of tumor necrosis factor-induced barrier dysfunction, occurs in human IBD. Our aim was to determine whether, in ...

      Known for Experimental Colitis | Epithelial Tight | Immune Activation | Tg Mice | Intestinal Disease
      KOL-Index: 9566

      Glucagon Like Peptide 2 (GLP-2) has been proposed as an important regulatory hormone in nutrient absorption. The present study was conducted in human infants with intestinal dysfunction undergoing surgery, correlating postprandial GLP-2 levels with intestinal length, nutrient absorption, and patient outcome. We hypothesized that GLP-2 levels would be inversely related to nutrient absorption; we further hypothesized that post prandial GLP-2 levels would be predictive of the ability to ...

      Known for Glp2 Levels | Nutrient Absorption | Sbs Infants | Total Parenteral Nutrition | Enteral Feeding
      KOL-Index: 9564

      BACKGROUND & AIMS: Transfer of T helper cells from DBA/2 mice to irradiated allogeneic B6D2F1 mice leads to development of colonic graft-versus-host disease with pathological features of inflammatory bowel disease. To examine the role of tumor necrosis factor (TNF) in graft-versus-host disease enteropathy, an adenoviral vector encoding a TNF inhibitor protein was administered.

      METHODS: Irradiated B6D2F1 mice were infused with DBA/2 bone marrow and spleen cells. Mice then received either ...

      Known for Host Disease | Necrosis Factor | Dba 2 | Tnf Inhibitor | Mucosal Permeability
      KOL-Index: 9515

      BACKGROUND/AIMS: Increased intestinal permeability is observed in Crohn's disease and a subset of first-degree relatives. An alteration in isoform expression of the common leukocyte antigen (CD45) is also found in a significant fraction of patients. Because this alteration may be a measure of antigen exposure, the hypothesis of the study was that this alteration would be observed in both patients and relatives of patients with Crohn's disease and that this would correlate with increased ...

      Known for Intestinal Permeability | Crohns Disease | Relatives Patients | Cd45ro Expression | Cd19 Cells
      KOL-Index: 9358

      BACKGROUND: Alterations in intestinal permeability have been implicated in the pathogenesis of Crohn disease (CD). We have reported that granulocyte macrophage-colony-stimulating factor (GM-CSF) is required for mucosal barrier function in mice, and elevated neutralizing GM-CSF autoantibodies (Ab) are associated with stricturing ileal disease and surgery in patients with CD. We hypothesized that children with CD with elevated GM-CSF Ab would exhibit increased intestinal ...

      Known for Intestinal Permeability | Crohn Disease | Factor Autoantibodies | Granulocyte Macrophage | Gm Csf
      KOL-Index: 8399

      BACKGROUND: Patients with Crohn's disease have increased intestinal permeability, which may precede the development of clinical disease and be involved in disease pathogenesis. Subsequent studies have suggested that, as a group, first-degree relatives of patients with Crohn's disease do not have significantly increased small intestinal permeability rates. The present study proposes that conventional data analysis, used in these studies, may be inappropriate and has overlooked an ...

      Known for Intestinal Permeability | Patients Crohns Disease | Firstdegree Relatives | Increased Small | Lactulose Mannitol
      KOL-Index: 8126

      BACKGROUND & AIMS: Abnormal presentation of luminal constituents to the mucosal immune system, caused by dysfunction of the intestinal epithelial barrier, is a candidate theory for the cause of Crohn's disease. Increased epithelial permeability is found in subgroups of patients at high risk for the development of Crohn's disease and has been found to precede disease recurrence. Clinical observations have suggested that disease recurrence can follow times of increased psychological ...

      Known for Gastrointestinal Permeability | Environmental Stress | Crohns Disease | Endogenous Glucocorticoids | Mucosal Immune
      KOL-Index: 8093

      BACKGROUND/AIMS: The aim of this exploratory trial was to establish if the probiotic Bifidobacterium natren life start (NLS) strain strain may affect the clinical course and pathophysiological features of patients with untreated celiac disease (CD). Positive findings would be helpful in directing future studies.

      METHODS: Twenty-two adult patients having 2 positives CD-specific tests were enrolled. Patients were randomized to receive 2 capsules before meals for 3 weeks of either ...

      Known for Bifidobacterium Infantis | Super Strain | Natren Life | Celiac Disease | Intestinal Permeability
      KOL-Index: 8062

      Disaccharides do not cross intact gastrointestinal mucosa to any appreciable extent unless there is damage to the epithelium. Furthermore, since sucrose is rapidly broken down in the small intestine, the absorption of intact sucrose implies damage to proximal epithelium. We have reported that measurement of sucrose permeability detects gastric damage in animals. Whilst such a non-specific test could not replace endoscopy, it might represent a clinically useful technique to identify ...

      Known for Gastric Damage | Sucrose Permeability | Small Intestine | Endoscopic Findings | Mild Gastritis

      Mind The Gaps


      [ PUBLICATION ]
      KOL-Index: 8049

      OBJECTIVES: Confocal endomicroscopy can be used to image intestinal mucosa. Epithelial gaps resulting from shedding of epithelial cells have been reported in patients. We hypothesize that the rate of epithelial cell shedding increases in patients with Crohn's disease, leading to more epithelial gaps and barrier dysfunction. In this study, we used probe-based confocal laser endomicroscopy to quantify epithelial cells and gaps in patients with Crohn's disease compared with controls. We ...

      Known for Epithelial Gaps | Crohns Disease | 1000 Cells | Gap Density | Mouse Model
      KOL-Index: 8001

      BACKGROUND: Inert carbohydrate probes are commonly used to assess intestinal permeability; we have previously shown that the actively transported moiety 3-0 methylglucose (3-0 MG) is a useful marker of intestinal surface area and nutrient absorption in animal models of short bowel syndrome (SBS). This study examines the correlation of 3-0 MG absorption with nutrient absorption, bowel length, and the tolerance of enteral feeds in pediatric patients.

      METHODS: Fifteen children (1 month to ...

      Known for Nutrient Absorption | Pediatric Patients | Bowel Length | Intestinal Permeability | Enteral Feeds
      KOL-Index: 7981

      OBJECTIVES: First-degree relatives of patients with celiac disease are at high risk for developing the disease themselves. Detection of serum antibodies and intestinal permeability tests have been useful to identify candidates for intestinal biopsies. Recently it was demonstrated that abnormal sucrose permeability is a very sensitive marker of active disease. Our objectives in this prospective study were (1) to assess the screening value of permeability tests, and (2) to compare the ...

      Known for Celiac Disease | Degree Relatives | Sucrose Permeability | Lactulose Mannitol | Liquid Chromatography

      Key People For Intestinal Permeability

      Top KOLs in the world
      #1
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      #4
      Jon B Meddings
      intestinal permeability crohns disease nutrient absorption
      #5
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      Department of Medicine, University of Calgary, Calgary, Alberta, Canada | Department of Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada. | Division of Gastroenterology, University

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