• Disease
  • Aortic
  • Aortic Aneurysm
  • Alan B Lumsden

    Prominent publications by ALAN B Lumsden

    KOL Index score: 17858

    PURPOSE: Intimal hyperplasia and graft thrombosis are major causes of graft failure. Heparin prolongs graft patency and inhibits neointimal hyperplasia in animal models. The purpose of this study was to evaluate the effect of a heparin-coated expanded polytetrafluoroethylene (ePTFE) graft on platelet deposition and anastomotic neointimal hyperplasia after aortoiliac bypass grafting in a baboon model.

    METHODS: Heparin-coated ePTFE grafts (4-mm diameter) were incorporated into exteriorized ...

    Also Ranks for: Neointimal Hyperplasia |  eptfe grafts |  platelet deposition |  heparin coated |  bypass graft
    KOL Index score: 16263

    OBJECTIVE: Homocysteine (Hcy) is an independent risk factor for atherosclerosis. This study investigates the effects of ginsenoside Rb1, a major constituent of ginseng, on Hcy-induced endothelial dysfunction and molecular changes in porcine coronary arteries.

    METHODS: The coronary arteries were harvested from pig hearts and cut into 5-mm ring segments, which were then divided into six groups, including control, Hcy alone (50 microM), low-dose (1 microM) or high-dose (10 microM) Rb1 ...

    Also Ranks for: Ginsenoside Rb1 |  endothelial dysfunction |  coronary arteries |  superoxide anion |  ginseng compounds
    KOL Index score: 16053

    BACKGROUND: Carotid artery stenting (CAS) has emerged as an acceptable treatment alternative in patients with carotid bifurcation disease. Although early results of CAS have been promising, long-term clinical outcomes remain less certain. We report herein the frequency, management, and clinical outcome of in-stent restenosis (ISR) after CAS at a single academic institution.

    METHODS: Clinical records of 208 CAS procedures in 188 patients with carotid stenosis of 80% or greater, including ...

    Also Ranks for: Cas Patients |  balloon angioplasty |  carotid artery |  recurrent stenosis |  stent placement
    KOL Index score: 15862

    BACKGROUND: While aggressive endoluminal therapy for superficial femoral artery (SFA) occlusive disease is commonplace, the implications of runoff on long-term outcomes of these interventions in patients with rest pain and tissue loss is unclear. Runoff is known to negatively effect graft patency. The aim of this study is to examine the impact of distal runoff on long-term outcomes of SFA interventions for critical ischemia.

    METHODS: A prospective database of patients undergoing ...

    Also Ranks for: Rest Pain |  tissue loss |  femoral artery |  limb salvage |  critical ischemia
    KOL Index score: 13625

    PURPOSE: As a minimally invasive strategy for the treatment of patients with abdominal aortic aneurysm (AAA), endovascular repair has been embraced with enthusiasm because of the promise of achieving a durable result with a reduced risk of perioperative morbidity and mortality. Our mid-term experience with endovascular AAA repair was assessed by examining early and late clinical outcome in concurrent cohorts of patients stratified either as low-risk or as at increased-risk for ...

    Also Ranks for: Endovascular Repair |  abdominal aortic aneurysm |  patients increased risk |  perioperative morbidity |  prosthesis failure
    KOL Index score: 13402

    INTRODUCTION: Bypass graft failure due to acute thrombosis and intimal hyperplasia remains a major challenge in small-diameter vascular prosthetic graft reconstruction. Heparin has been shown to prevent thrombus formation and inhibit intimal antithrombotic in animal studies. In this study, we evaluated the effect of small-caliber heparin-coated expanded polytetrafluoroethylene (ePTFE) grafts on platelet deposition and intimal hyperplasia in a canine model of femoral artery bypass ...

    Also Ranks for: Intimal Hyperplasia |  eptfe grafts |  artery bypass |  heparin coated |  graft patency
    KOL Index score: 13287

    BACKGROUND: Hemodynamic forces play a crucial role in regulating vascular cell phenotype. However, the underlying molecular mechanisms are largely unknown. The objective of this study was to test our hypothesis that cyclic strain could affect smooth muscle cell (SMC) differentiation.

    METHODS: A murine embryonic mesenchymal progenitor cell line (C3H/10T1/2) was cultured with or without cyclic strain for 6 days. Changes in cell morphology were studied with fluorescence dye Calcein-AM ...

    Also Ranks for: Cyclic Strain |  smooth muscle |  cell differentiation |  vascular myocytes |  mesenchymal progenitor
    KOL Index score: 13208

    BACKGROUND: Metabolic syndrome (MetS) is rapidly increasing in prevalence and is associated with carotid plaque development and is a risk factor for stroke. The aim of this study is to describe the outcomes for patients with MetS after carotid revascularization (carotid endarterectomy [CEA] and carotid stenting [CAS]).

    METHODS: A database of patients undergoing carotid revascularization for primary atherosclerotic lesions was queried from 1996 to 2006. MetS was defined as the presence of ...

    Also Ranks for: Patients Mets |  metabolic syndrome |  carotid revascularization |  adverse outcomes |  stroke myocardial infarction
    KOL Index score: 12938

    OBJECTIVES: Covered stents have been proposed as an endovascular option for recalcitrant cases of hemodialysis-related central venous occlusive disease (CVOD). This study evaluated the efficacy and durability of covered stents in treating CVOD to preserve a functional dialysis access circuit.

    METHODS: A retrospective review was performed of all patients with clinically significant CVOD who were treated by placement of covered stents from April 2007 to September 2010. Demographics, lesion ...

    Also Ranks for: Covered Stent |  hemodialysis patients |  central venous |  12 months |  occlusive disease
    KOL Index score: 12896

    The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent. Human umbilical vein endothelial cells (HUVECs) treated with TNF-alpha (2.0 ng/ml) showed reduced TM mRNA levels by 80%, 97%, 94%, and 97% at 3, 6, 12, and 24 h, respectively ...

    Also Ranks for: Human Endothelial Cells |  endothelial protein |  expression epcr |  messenger receptors |  tnf alpha
    KOL Index score: 12601

    PURPOSE: In-stent restenosis (ISR) is a known complication following carotid artery stenting (CAS). However, ultrasound criteria determining ISR are not well established. We evaluated alternative ultrasound velocity criteria for >70% ISR in our institution.

    METHODS: Clinical records of 256 patients undergoing 282 consecutive CAS procedures over a 42-month period were reviewed. Follow-up ultrasounds were available for analysis in 237 patients. Selective angiograms and repeat interventions ...

    Also Ranks for: Ultrasound Criteria |  carotid artery |  psv edv |  severe isr |  ica cca
    KOL Index score: 12554

    PURPOSE: Human immune deficiency virus (HIV) infection is often associated with chronic diseases, including atherosclerosis. However, the molecular mechanisms are largely unknown. We examined the effect of Tat protein, an HIV regulatory protein, on endothelial function in porcine coronary arteries.

    METHODS: Porcine coronary arteries were dissected from nine pig hearts and cut into 5-mm ring segments, which were incubated as controls or with Tat protein (10(-7), 10(-9), 10(-11) mol/L) or ...

    Also Ranks for: Tat Protein |  porcine coronary arteries |  endothelial dysfunction |  sodium nitroprusside |  vascular gene products
    KOL Index score: 12401

    BACKGROUND: Hyperhomocysteinemia is an independent risk factor of coronary artery disease. Clinical studies have indicated that moderate red wine consumption is associated with a reduction of incidence of coronary artery disease. In this study, we determined the effect of red wine on homocysteine- induced endothelial dysfunction in porcine coronary arteries.

    MATERIALS AND METHODS: Porcine coronary arteries were dissected from 6 pig hearts and cut into 5-mm ring segments, which were ...

    Also Ranks for: Induced Endothelial |  coronary arteries |  nitric oxide |  protein levels |  treated homocysteine
    KOL Index score: 11838

    Endoluminal therapy for superficial femoral artery (SFA) occlusive disease for claudication is commonplace, but the implications of tibial vessel runoff on long-term outcomes of these interventions in patients with claudication are unclear. Runoff is known to negatively affect graft patency, but no data are available on the impact of runoff on percutaneous SFA interventions and their implications during follow-up. We examined the impact of distal popliteal and tibial runoff on long-term ...

    Also Ranks for: Femoral Artery |  patients poor runoff |  sfa interventions |  recurrent symptoms |  pathologic databases


    ALAN B Lumsden: Influence Statistics

    Sample of concepts for which ALAN B Lumsden is among the top experts in the world.
    Concept World rank
    implantation catheterization #1
    pseudoaneurysms treated #1
    1 9 slices #1
    ampfree survival #1
    patients endotension #1
    80 greater isr #1
    307 standard eptfe #1
    hybrid procedures range #1
    intimal thrombus #1
    patients arteriovenous grafts #1
    primary patency studies #1
    removal vein #1
    thrombolytic therapy urokinase #1
    surgical sealant time #1
    intra‐operative tcd monitoring #1
    24f 17f microcatheters #1
    antegrade endograft deployment #1
    clamp release hemostasis #1
    percutaneous bedside #1
    cyanoacrylate surgical sealant #1
    posterior gate quality #1
    pulsatile devices differences #1
    surgical sealant control #1
    grx robotic #1
    iliac artery complication #1
    002 primary #1
    iliac artery rupture #1
    renal embolization nephrectomy #1
    amputation bmac #1
    total arch debranching #1
    navigation user #1
    occluded renal #1
    patient ima graft #1
    pseudoaneurysm utilizing #1
    successful endovascular repair #1
    endovascular robotics #1
    corpath grx robotic #1
    virtual landmarks mra #1
    successful stentgraft exclusion #1
    anastomosis sites patients #1
    introduction endovascular surgery #1
    endovascular neurointerventions #1
    41 local anesthesia #1
    angiograms vessel cannulation #1
    human vein allografts #1
    angiograms cannulation #1
    lesions flexible catheter #1
    harvest saphenous vein #1
    vessel cannulation #1
    surgical sealant hemostasis #1

    Key People For Aortic Aneurysm

    Top KOLs in the world
    Janet T Powell
    aortic aneurysm endovascular repair saphenous vein
    Roger M Greenhalgh
    aortic aneurysm carotid endarterectomy endovascular repair
    Jan D Blankensteijn
    aortic aneurysm endovascular repair intimal hyperplasia
    Michel S Makaroun
    aortic aneurysm endovascular repair united states
    Simon G Thompson
    aortic aneurysm angina pectoris heart failure
    Frank Junior VEITH
    aortic aneurysm vascular surgery limb salvage

    ALAN B Lumsden:Expert Impact

    Concepts for whichALAN B Lumsdenhas direct influence:Aortic aneurysm,  Porcine coronary arteries,  Carotid artery,  Renal artery,  Platelet deposition,  Intimal hyperplasia,  Vena cava,  Neointimal hyperplasia.

    ALAN B Lumsden:KOL impact

    Concepts related to the work of other authors for whichfor which ALAN B Lumsden has influence:Aortic aneurysm,  Endovascular repair,  Carotid artery,  Fibromuscular dysplasia,  Vascular access,  Endothelial cells,  Metabolic syndrome.



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    Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston, Texas. | 1Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston. | Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston,