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    • Intracranial Pressure
    • John Douglas Pickard
    • John Douglas Pickard: Influence Statistics

      John Douglas Pickard

      John Douglas Pickard

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      Division of Neurosurgery, Addenbrooke’s Hospital, Cambridge, United Kingdom | Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom | ...

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      John Douglas Pickard:Expert Impact

      Concepts for whichJohn Douglas Pickardhas direct influence:Intracranial pressure,Head injury,Cerebral autoregulation,Traumatic brain injury,Subarachnoid hemorrhage,Intracranial pressure icp,Blood flow,Subarachnoid haemorrhage.

      John Douglas Pickard:KOL impact

      Concepts related to the work of other authors for whichfor which John Douglas Pickard has influence:Traumatic brain injury,Intracranial pressure,Subarachnoid hemorrhage,Decompressive craniectomy,Cerebral autoregulation,Blood flow,Magnetic resonance.

      KOL Resume for John Douglas Pickard

      Year
      2022

      Division of Neurosurgery, Addenbrooke’s Hospital, Cambridge, United Kingdom

      Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

      2021

      Department of Neurosurgery, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom.

      Division of Neurosurgery, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Rd, CB2 0SP, Cambridge, United Kingdom

      2020

      Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom

      Department of Clinical Neurosciences, Division of Neurosurgery, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK

      2019

      Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK,

      United Kingdom Shunt Registry, Cambridge, UK

      2018

      Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom

      NIHR Brain Injury Healthcare Technology Co-operative, Cambridge, UK

      2017

      University of Cambridge, UK

      Academic Division of Neurosurgery, Department of Clinical Neurosciences, Department of Neurosurgery, Box 167, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom

      2016

      Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke’s Hospital & University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

      Academic Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, England.

      Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany

      2015

      Addenbrooke's Hospital Division of Neurosurgery, University of Cambridge Cambridge United Kingdom

      Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

      2014

      Division of Neurosurgery, University of Cambridge CambridgeUK

      Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

      1Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge;

      Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, England

      2013

      Division of Neurosurgery, University of Cambridge, Box 167, Level 4, A Block, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK

      Wolfson Brain Imaging Center, University of Cambridge, Cambridge, United Kingdom, .

      Academic Neurosurgical Unit, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom

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      Sample of concepts for which John Douglas Pickard is among the top experts in the world.
      Concept World rank
      head injuries administration #1
      hospital reporting systems #1
      mca normal autoregulation #1
      ccp scans #1
      sxa doppler #1
      bih controls #1
      bwave presence #1
      ptcs csfp #1
      107 3 106 #1
      optimal cpp cpp #1
      fall icp #1
      co2 reactivity ariabp #1
      sodium nitroprusside cbf #1
      vasospasm mx #1
      syndrome iih #1
      ampicp patients #1
      ccpicp #1
      correlation ccp #1
      acute pravastatin #1
      bedside enzyme analyzer #1
      outcome lower wt #1
      hyperemic response patients #1
      csf pressure pcsf #1
      abp males #1
      iihwop iih #1
      autoregulation head trauma #1
      ncc gbms #1
      trueicp #1
      dti responsiveness #1
      anesthesia normal pressure #1
      slow icp waves #1
      lx mx #1
      sources prospective reports #1
      25 cpp #1
      cbf csf pressure #1
      tbi brain growth #1
      icp infusion test #1
      cortical regions data #1
      jun patients #1
      reports head injury #1
      earlier resuscitation #1
      brain slump #1
      outcome blood pressure #1
      amplitude compliance #1
      τ abp #1
      interhemispheric difference autoregulation #1
      codman hakim 0005 #1
      prosa horizontal position #1
      omnishunt hakim valve #1
      hb icp #1
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      Prominent publications by John Douglas Pickard

      KOL-Index: 18720

      OBJECTIVES: To define optimal cerebral perfusion pressure (CPPOPT) in individual head-injured patients using continuous monitoring of cerebrovascular pressure reactivity. To test the hypothesis that patients with poor outcome were managed at a cerebral perfusion pressure (CPP) differing more from their CPPOPT than were patients with good outcome.

      DESIGN: Retrospective analysis of prospectively collected data.

      SETTING: Neurosciences critical care unit of a university hospital.

      PATIENTS: A ...

      Known for Continuous Monitoring | Cpp Cppopt | Cerebrovascular Pressure | Map Icp | Optimal Cerebral
      KOL-Index: 15502

      OBJECTIVE: To determine the efficacy of oral nimodipine in reducing cerebral infarction and poor outcomes (death and severe disability) after subarachnoid haemorrhage.

      DESIGN: Double blind, placebo controlled, randomised trial with three months of follow up and intention to treat analysis. To have an 80% chance with a significance level of 0.05 of detecting a 50% reduction in an incidence of cerebral infarction of 15% a minimum of 540 patients was required.

      SETTING: Four regional ...

      Known for Cerebral Infarction | Subarachnoid Haemorrhage | Oral Nimodipine | Computed Tomography | Poor Outcomes
      KOL-Index: 14567

      OBJECT: The goal of this study was to examine the relationship between cerebral autoregulation, intracranial pressure (ICP), arterial blood pressure (ABP), and cerebral perfusion pressure (CPP) after head injury by using transcranial Doppler (TCD) ultrasonography.

      METHODS: Using ICP monitoring and TCD ultrasonography, the authors previously investigated whether the response of flow velocity (FV) in the middle cerebral artery to spontaneous variations in ABP or CPP provides reliable ...

      Known for Head Injury | Cerebral Autoregulation | Abp Cpp | Intracranial Pressure Icp | Tcd Ultrasonography
      KOL-Index: 14444

      OBJECTIVE: Cerebrovascular vasomotor reactivity reflects changes in smooth muscle tone in the arterial wall in response to changes in transmural pressure or the concentration of carbon dioxide in blood. We investigated whether slow waves in arterial blood pressure (ABP) and intracranial pressure (ICP) may be used to derive an index that reflects the reactivity of vessels to changes in ABP.

      METHODS: A method for the continuous monitoring of the association between slow spontaneous waves ...

      Known for Head Injury | Abp Icp | Continuous Assessment | Cerebral Vasomotor | Slow Waves
      KOL-Index: 14420

      Objective. Although intracranial hypertension is one of the important prognostic factors after head injury, increased intracranial pressure (ICP) may also be observed in patients with favourable outcome. We have studied whether the value of ICP monitoring can be augmented by indices describing cerebrovascular pressure-reactivity and pressure-volume compensatory reserve derived from ICP and arterial blood pressure (ABP) waveforms.Method. 96 patients with intracranial hypertension were ...

      Known for Intracranial Hypertension | Head Injury | Slow Waves | Patients Icp | Female Glasgow
      KOL-Index: 13865

      OBJECTIVE: In this study we have used O positron emission tomography, brain tissue oxygen monitoring, and cerebral microdialysis to assess the effects of cerebral perfusion pressure augmentation on regional physiology and metabolism in the setting of traumatic brain injury.

      DESIGN: Prospective interventional study.

      SETTING: Neurosciences critical care unit of a university hospital.

      PATIENTS: Eleven acutely head-injured patients requiring norepinephrine to maintain cerebral perfusion ...

      Known for Cerebral Perfusion Pressure | Head Injury | Brain Tissue Oxygen | Positron Emission Tomography | Mm Hg
      KOL-Index: 13848

      OBJECTIVE: Cerebral critical closing pressure (CCP) has been defined as an arterial pressure threshold below which arterial vessels collapse. Hypothetically this is equal to intracranial pressure (ICP) plus the contribution from the active tone of cerebral arterial smooth muscle. The correlation of CCP with ICP, cerebral autoregulation, and other clinical and haemodynamic modalities in patients with head injury was evaluated.

      METHOD: intracranial pressure, arterial blood pressure (ABP) ...

      Known for Critical Closing Pressure | Cerebrovascular Circulation | Ccp Icp | Cerebral Autoregulation | Head Injury
      KOL-Index: 13639

      OBJECT: The authors studied the reliability of a new method for noninvasive assessment of cerebral perfusion pressure (CPP) in head-injured patients in which mean arterial blood pressure (ABP) and transcranial Doppler middle cerebral artery mean and diastolic flow velocities are measured.

      METHODS: Cerebral perfusion pressure was estimated (eCPP) over periods of continuous monitoring (20 minutes-2 hours, 421 daily examinations) in 96 head-injured patients (Glasgow Coma Scale score < 13) ...

      Known for Noninvasive Assessment | Cerebral Perfusion Pressure | Doppler Ultrasonography | Cpp Ecpp | Injured Patients
      KOL-Index: 13316

      AIMS: We compared the vasoconstrictor effects of 5-HT with those of the selective 5-HT1B/1D-receptor agonists sumatriptan and rizatriptan in human isolated cranial (middle meningeal) arteries. In addition selective 5-HT1B- or 5-HT1D-receptor antibodies were used in combination with semiquantitative immunohistochemical techniques to compare the levels of expression of these receptors in human middle meningeal and coronary arteries.

      METHODS: Middle meningeal and coronary arteries were ...

      Known for Vasoconstrictor Effects | Middle Meningeal | Human Isolated | Coronary Arteries | Rizatriptan Sumatriptan
      KOL-Index: 13261

      OBJECT: Cerebrovascular pressure reactivity is the ability of cerebral vessels to respond to changes in transmural pressure. A cerebrovascular pressure reactivity index (PRx) can be determined as the moving correlation coefficient between mean intracranial pressure (ICP) and mean arterial blood pressure.

      METHODS: The authors analyzed a database consisting of 398 patients with head injuries who underwent continuous monitoring of cerebrovascular pressure reactivity. In 298 patients, the ...

      Known for Pressure Reactivity | Continuous Monitoring | Head Injury | Optimal Cpp | Physiologic Ultrasonography
      KOL-Index: 13205

      BACKGROUND AND PURPOSE: The goal of this study was to examine the effects of hypertonic saline on cerebral blood flow (CBF) in poor-grade patients with subarachnoid hemorrhage.

      METHODS: We administered 23.5% hypertonic saline (2 mL/kg IV) 1 time to 10 patients, 2 times to 7 patients, and 3 times to 1 patient. All patients had transcranial Doppler (TCD), intracranial pressure (ICP) monitoring, and analysis of serum sodium and osmolality; 6 had xenon CT (XeCT). Data were used to ...

      Known for Subarachnoid Hemorrhage | Hypertonic Saline | Cerebral Blood Flow | Cpp Icp | Grade Patients
      KOL-Index: 12849

      Clinical audits have highlighted the many challenges and dilemmas faced by clinicians assessing persons with disorders of consciousness (vegetative state and minimally conscious state). The diagnostic decision-making process is highly subjective, dependent upon the skills of the examiner and invariably dictated by the patients' ability to move or speak. Whilst a considerable amount has been learnt since Jennett and Plum coined the term 'vegetative state', the assessment process remains ...

      Known for Brain Imaging | Disorders Consciousness | Vegetative State | Behavioural Assessment | Clinical Audits
      KOL-Index: 12815

      BACKGROUND AND PURPOSE: Statins may improve cerebral vasomotor reactivity through cholesterol-dependent and -independent mechanisms. A phase II randomized controlled trial was conducted to examine the hypothesis that acute pravastatin treatment could improve cerebrovascular autoregulation and reduce vasospasm-related complications after aneurysmal subarachnoid hemorrhage (SAH).

      METHODS: A total of 80 aneurysmal SAH (aSAH) patients (18 to 84 years of age) within 72 hours from the ictus ...

      Known for Acute Treatment | Cerebral Vasospasm | Ischemic Deficits | Aneurysmal Subarachnoid | Impaired Autoregulation
      KOL-Index: 12733

      BackgroundCerebral autoregulation assessed using transcranial Doppler (TCD) mean flow velocity (FV) in response to various physiological challenges is predictive of outcome after traumatic brain injury (TBI). Systolic and diastolic FV have been explored in other diseases. This study aims to evaluate the systolic, mean and diastolic FV for monitoring autoregulation and predicting outcome after TBI.Methods300 head-injured patients with blood pressure (ABP), intracranial pressure (ICP), ...

      Known for Transcranial Doppler | Cerebral Autoregulation | Flow Velocity | Cpp Abp | Head Injury

      Key People For Intracranial Pressure

      Top KOLs in the world
      #1
      John Douglas Pickard
      intracranial pressure head injury cerebral autoregulation
      #2
      Marek Czosnyka
      intracranial pressure cerebral autoregulation traumatic brain injury
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      Anthony P Marmarou
      brain edema head injury intracranial pressure
      #4
      Donald P Becker
      brain injury intracranial pressure cerebral ischemia
      #5
      Lawrence F Marshall
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      David Krishna Menon
      traumatic brain injury intracranial pressure magnetic resonance

      Division of Neurosurgery, Addenbrooke’s Hospital, Cambridge, United Kingdom | Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom | Neurosurgical Division, Department of Clinical Neurosciences, University of Cambr

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