• KOL
    • Intractable Epilepsy
    • Kenji Sugai
    • Kenji Sugai: Influence Statistics

      Kenji Sugai

      Kenji Sugai

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      4Department of Child Neurology, National Center Hospital, NCNP, Kodaira, Tokyo. | Clinical Department, Soleil Kawasaki Medical Center for the Handicapped, Kawasaki, Japan | ...

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      Kenji Sugai:Expert Impact

      Concepts for whichKenji Sugaihas direct influence:Intractable epilepsy,Status epilepticus,Focal cortical dysplasia,Cortical dysplasia,Mechanical ventilation,Adaptive behavior,Seizure imitators,Localized megalencephaly.

      Kenji Sugai:KOL impact

      Concepts related to the work of other authors for whichfor which Kenji Sugai has influence:Status epilepticus,Epilepsy surgery,Cytochrome p450,Febrile seizures,Intellectual disability,Epileptic encephalopathies,Acute encephalopathy.

      KOL Resume for Kenji Sugai

      Year
      2021

      4Department of Child Neurology, National Center Hospital, NCNP, Kodaira, Tokyo.

      2020

      Clinical Department, Soleil Kawasaki Medical Center for the Handicapped, Kawasaki, Japan

      4Child Neurology, Epilepsy Center, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo.

      2019

      Epilepsy Center, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan

      2018

      Department of Child Neurology, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan. Electronic address:

      2017

      Department of Child Neurology (A.I., Y.S., E.N., H.K, K.S., M.S.), National Center Hospital; Department of Neuromuscular Research (A.I., S.N., S.M., Y.E., Y.K.H., I. Nonaka, I. Nishino.), National Institute of Neuroscience; Department of Mental Retardation and Birth Defect Research (C.S., Y.M., Y.-i.G.), National Institute of Neuroscience; Department of Radiology (N.S.), National Center Hospital, National Center of Neurology and Psychiatry, Tokyo; Department of Pharmacology (A.I.), Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi; and Department of Pathophysiology (Y.K.H), Tokyo Medical University, Japan.

      Epilepsy Center, National Center of Neurology and Psychiatry, National Institute of Neuroscience, Kodaira, Japan

      2016

      Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan

      2015

      Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan

      2014

      Department of Child Neurology, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

      2013

      Department of Child Neurology, National Center Hospital, NCNP, Kodaira, Tokyo, Japan

      2012

      Department of Child Neurology, National Center of Neurology and Psychiatry, 4-1-1 Kodaira, 187-8551, Tokyo, Japan

      Epilepsy Center, National Center of Neurology and Psychiatry, Tokyo

      3Child Neurology,

      2011

      Department of Child Neurology, National Centre of Neurology and Psychiatry, Kodaira, Tokyo.

      2010

      Department of Child Neurology, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187-8551, Japan

      2009

      Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo, 187-8511 Japan

      2008

      National Hospital for Mental, Nervous and Muscular Disorders, Tokyo, Japan

      2007

      Department of Child Neurology, National Center Hospital for Mental. Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan.

      2005

      Department of Pediatric Neurology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

      2004

      Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

      2003

      National Center Hospital for Mental, Nervous, Muscular Disorders, National Center of Neurology and Psychiatry, 4-1-1, Tokyo, Japan

      2002

      Department of Child Neurology; National Center Hospital for Mental, Nervous and Muscular Disorders; National Center of Neurology and Psychiatry; Kodaira, Tokyo, Japan

      2001

      National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo, Japan

      2000

      National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo, 187-855 1, Japan

      1999

      Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan

      1998

      Department of Child Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo, Japan

      1997

      Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi-cho, Kodaira, Tokyo 187, Japan

      1996

      Division of Child Neurology National Center Hospital for Mental, Nervous and Muscular Disorders National Center of Neurology and Psychiatry (NCNP) Kodaira, Tokyo 187, Japan

      1995

      Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo 187, Japan

      1994

      Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders

      1993

      Division of Child Neurology; National Center Hospital for Mental, Nervous and Muscular Disorders; National Center of Neurology and Psychiatry; Kodaira, Tokyo; Japan.

      1990

      Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Kodaira, Tokyo

      1989

      Division of Pediatrics, National Nishi-Kofu Hospital, Kofu

      Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, 4-1-1, Ogawahigashi-cho, Kodaira, 187, Tokyo, Japan

      1986

      Department of Child Neurology, National Musashi Institute for Mental and Nervous Disorders

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      Sample of concepts for which Kenji Sugai is among the top experts in the world.
      Concept World rank
      megalencephaly clinical #1
      frontal megalencephaly #1
      hemimegalencephaly humans #1
      seizures 2015 #1
      aecsee #1
      2015 gl2015 #1
      ldc cse #1
      age spasms #1
      gl2015 questionnaire #1
      topic seizures japan #1
      abnormalities prolongation #1
      diazepam suppositories simple #1
      ldc drugs #1
      atypical seizures epilepsy #1
      seizures japan #1
      ipsilateral genu #1
      bic cwg #1
      initially intravenous midazolam #1
      task committee conference #1
      diazepam febrile #1
      hemiparesis enlargement #1
      fss gl2015 #1
      gl2015 #1
      limbs minutes #1
      response relationship infantile #1
      15 recurrent seizures #1
      prophylactic dzp children #1
      phenobarbital spasms #1
      88 07 years #1
      nephronophthisis joubert‐related cerebello #1
      lobe hemimegalencephaly humans #1
      abundant spikewave complexes #1
      cse secondline treatment #1
      patients frontal megalencephaly #1
      postoperative dq #1
      new guidelines march #1
      oral anticonvulsants #1
      clinical practices pediatricians #1
      blood examinations diazepam #1
      dzp seizures #1
      childhood neurodegeneration #1
      joubert cdk #1
      dose phenobarbital #1
      febrile seizures japan #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Kenji Sugai

      KOL-Index: 10040

      Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA) is a recently established disorder that is a subtype of neurodegeneration with brain iron accumulation (NBIA). We presented the first case report of SENDA of a 39-year-old female. She had psychomotor retardation from childhood and remained static for two decades. Then, at the age of 30, she developed severe dystonia and parkinsonism. Brain MRI revealed T2-weighted hypointensity signal in the globus pallidus ...

      Known for Static Encephalopathy | Tensor Imaging | Childhood Neurodegeneration | Adulthood Senda | Substantia Nigra
      KOL-Index: 9476

      PURPOSE: KCNQ2 mutations have been found in patients with benign familial neonatal seizures, myokymia, or early onset epileptic encephalopathy (EOEE). In this study, we aimed to delineate the clinical spectrum of EOEE associated with KCNQ2 mutation.

      METHODS: A total of 239 patients with EOEE, including 51 cases with Ohtahara syndrome and 104 cases with West syndrome, were analyzed by high-resolution melting (HRM) analysis or whole-exome sequencing. Detailed clinical information including ...

      Known for Clinical Spectrum | Kcnq2 Mutation | Early Onset | Ohtahara Syndrome | Tonic Seizures
      KOL-Index: 8992

      OBJECTIVE: We conducted a nationwide multicenter study in Japan to elucidate the clinical and laboratory characteristics of acute encephalitis with refractory, repetitive partial seizures (AERRPS).

      MATERIALS AND METHODS: Clinical and laboratory features, treatment, and outcome were assessed using a structured questionnaire.

      RESULTS: Twenty-nine children were enrolled in the study. Refractory and repetitive partial seizures accompanied by fever were the cardinal clinical features. Partial ...

      Known for Acute Encephalitis | Repetitive Partial Seizures | Intractable Epilepsy | Anticonvulsants Atrophy | Child Preschool
      KOL-Index: 8475

      OBJECTIVE: To review the EEG features of ring 20 syndrome in two patients and determine the characteristic pattern of this syndrome. The features of our cases and 24 patients reported in the literature will be discussed.

      SUBJECTS AND METHODS: Report of two patients and review of literature.

      RESULTS: The two patients had intractable epilepsy since childhood. Their clinical seizures were mostly complex partial seizures. Often the patients seizures were of prolonged duration. Ictal EEG ...

      Known for 20 Syndrome | Eeg Findings | Human Pair | Slow Waves | Ring Chromosomes
      KOL-Index: 7385

      In 2015, the Japanese Society of Child Neurology released new guidelines for the management of febrile seizures, the first update of such guidelines since 1996. In 1988, the Conference on Febrile Convulsions in Japan published "Guidelines for the Treatment of Febrile Seizures." The Task Committee of the Conference proposed a revised version of the guidelines in 1996; that version released in 1996 was used for the next 19years in Japan for the clinical management of children with febrile ...

      Known for Febrile Seizures | Japanese Society | Child Neurology | Guidelines Management | Humans Japan
      KOL-Index: 7356

      In order to identify genetic polymorphisms and haplotype frequencies of CYP1A2 in a Japanese population, the enhancer and promoter regions, all the exons with their surrounding introns, and intron 1 were sequenced from genomic DNA from 250 Japanese subjects. Thirty-three polymorphisms were found, including 13 novel ones: 2 in the enhancer region, 5 in the exons, and 6 in the introns. The most common single nucleotide polymorphism (SNP) was -163C>A (CYP1A2*1F allele) with a 0.628 ...

      Known for Single Nucleotide | Japanese Population | Genetic Polymorphisms | Haplotype Frequencies | Genomic Dna
      KOL-Index: 7141

      We report a surgically treated case of early infantile epileptic encephalopathy (EIEE) with suppression-bursts associated with focal cortical dysplasia. Tonic-clonic seizures followed by a series of spasms occurred about a hundred times a day at a few days of age. Interictal electroencephalogram (EEG) revealed a suppression-burst pattern that was predominant in the left hemisphere. Magnetic resonance imaging (MRI) suggested focal cortical dysplasia in the left prefrontal area. ...

      Known for Focal Cortical Dysplasia | Surgical Treatment | Epileptic Encephalopathy | Early Infantile | Psychomotor Development
      KOL-Index: 7068

      BACKGROUND AND PURPOSE: In hemimegalencephaly, MR imaging often reveals midsagittal bandlike structures between the 2 lateral ventricles. To determine whether these structures are aberrant midsagittal fibers, we retrospectively reviewed them on conventional MR imaging and prospectively examined them by diffusion tensor MR and fiber tract (FT) reconstruction imaging.

      MATERIALS AND METHODS: We retrospectively reviewed conventional MR images of 26 consecutive patients with ...

      Known for Patients Hemimegalencephaly | Diffusion Tensor Imaging | Aberrant Midsagittal Fibers | Fiber Tracts | Corpus Callosum
      KOL-Index: 6991

      Focal cortical dysplasia (FCD) and hemimegalencephaly (HME) are major causes of intractable epilepsy in children. The probable pathogenesis of FCD and HMG is the abnormal migration and differentiation of neurons. The aim of the present study was to clarify the abnormal cytoarchitecture, based on neuronal immaturation. Tissue samples were obtained from 16 FCD and seven HME patients, aged between 2 months and 12 years, who had been diagnosed as typical FCD and HME, following surgical ...

      Known for Focal Cortical Dysplasia | Intractable Epilepsy | Infant Male Malformations | Abnormal Migration | Hemimegalencephaly Hme
      KOL-Index: 6963

      A retrospective multicenter study was conducted, designed to evaluate the efficacy and safety of midazolam for the treatment of status epilepticus. The subjects were 358 inpatients who received intravenous midazolam therapy for status epilepticus. The mean age was 48.6 +/- 46.5 months. The underlying disorder was epilepsy in 195 cases, and acute symptomatic diseases in 163 (encephalitis or encephalopathy in 88 cases). Midazolam was administered as a bolus dose (0.25 +/- 0.21 mg/kg), ...

      Known for Status Epilepticus | Intravenous Midazolam | Seizure Onset | Continuous Infusion | 10 Patients
      KOL-Index: 6805

      Hirotomo Saitsu, Noboru Mizushima, Naomichi Matsumoto and colleagues report the identification of de novo mutations in WDR45 that cause static encephalopathy of childhood with neurodegeneration in adulthood. WDR45 encodes a homolog of the yeast autophagy protein Atg18.

      Known for Novo Mutations | Static Encephalopathy | Autophagy Gene | Wdr45 Encodes | Intellectual Disability
      KOL-Index: 6738

      Mutations in the Aristaless-related homeobox (ARX) gene are associated with pleiotropic phenotypes including infantile spasms, mental retardation and dystonia. However, relatively consistent genotype-phenotype correlations have been emphasized in prior reports. We report a boy presenting with mental retardation, tonic seizures and dystonia but without infantile spasms. Gene sequencing detected an additional seven GCG repeats in the first polyalanine tract of the ARX gene, a mutation ...

      Known for Arx Gene | Infantile Spasms | Polyalanine Tract | Mental Retardation | Intellectual Disability
      KOL-Index: 6700

      Transmantle dysplasia is a rare type of focal cortical dysplasia (FCD) characterized by expansion of the cortex from the deep white matter to the surface and in which there is a FCD IIA or IIB pathologic pattern. To characterize possible mechanisms underlying this regional disorder of radial migrating cells, we studied the expression patterns of neocortical layer-specific markers using immunohistochemistry in surgical specimens from 5 FCD IIA and 4 FCD IIB cases in children. All neuronal ...

      Known for Focal Cortical Dysplasia | Transmantle Sign | Specific Marker | White Matter | Iia Iib

      Key People For Intractable Epilepsy

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      4Department of Child Neurology, National Center Hospital, NCNP, Kodaira, Tokyo. | Clinical Department, Soleil Kawasaki Medical Center for the Handicapped, Kawasaki, Japan | Department of Child Neurology, National Center Hospital, National Center of N

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