• Aortic Valve
    • Martin B Leon
    • Martin B Leon: Influence Statistics

      Martin B Leon

      Martin B Leon

      The Cardiovascular Research Foundation, New York, New York | Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York | Center for ...

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      Martin B Leon:Expert Impact

      Concepts for whichMartin B Leonhas direct influence:Aortic valve,Intravascular ultrasound,Transcatheter aortic,Valve replacement,Coronary artery,Aortic stenosis,Coronary angioplasty,Balloon angioplasty.

      Martin B Leon:KOL impact

      Concepts related to the work of other authors for whichfor which Martin B Leon has influence:Aortic valve,Coronary artery,Myocardial infarction,Heart failure,Intravascular ultrasound,Eluting stents,Stent thrombosis.

      KOL Resume for Martin B Leon


      The Cardiovascular Research Foundation, New York, New York

      Columbia-Presbyterian Hospital University Medical Center, NY (M.B.L., M.A., C.R.S.).

      Université Laval, Quebec, Canada

      Cardiovascular Research Foundation, NY (M.B.L., M.A., D.J.C.).


      Division of Cardiology, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center (M.Z., E.U., M.N., T.F., KN.F., Z.Z., T.M.N., S.A.P., L.E.R., A.J.K., M.B.C., M.B.L., J.W.M., D.K., Z.A.A., G.S.M., A.M.).

      Department of Cardiology, Columbia University Irving Medical Center/New York-Presbyterian Hospital and Cardiovascular Research Foundation, 622 W 168th St, New York, NY 10032, USA.

      Cardiovascular Research Foundation, New York, NY

      NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, USA

      Columbia University Medical Center, New York, New York

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      Sample of concepts for which Martin B Leon is among the top experts in the world.
      Concept World rank
      reasons cli #1
      false angioplasty #1
      nct03222128 #1
      smtavr #1
      tavr coronary ostia #1
      groups sev #1
      balloon post dilatation #1
      device angioplasty #1
      adjunct directional #1
      lumen crosssectional areas #1
      rehospitalization 1 year #1
      complications patients quality #1
      tia tavr #1
      ppmm tavr #1
      tavi patients eohm #1
      oversizing area #1
      30 primary stenting #1
      sstavr #1
      drugeluting stents women #1
      antecedent statin #1
      pvr increased risk #1
      incidence surgical bailout #1
      regression trials #1
      hospital 11 #1
      mismatch downgrades #1
      prohealing stent #1
      debris heterogeneity #1
      tavr clinical #1
      lad restenosis #1
      rates ses #1
      intravalvular spacer #1
      procedural implications #1
      tavi standard therapy #1
      savr 2 years #1
      verapamil diastolic filling #1
      tavr mm #1
      hospital‒19 #1
      glass” adventure #1
      provocation lvpa #1
      gamma vascular brachytherapy #1
      comprehensive acquisition prior #1
      tests tavr #1
      zes pes #1
      incremental cost tavr #1
      p0956 #1
      ctindirect teedirect #1
      partner #1
      ppmm ppm ppmp #1
      dilatation outcomes #1
      intermediate surgical #1
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      Prominent publications by Martin B Leon

      KOL-Index: 25986

      BACKGROUND: Little is known about the incidence of prosthesis-patient mismatch (PPM) and its impact on outcomes after transcatheter aortic valve replacement (TAVR).

      OBJECTIVES: The objectives of this study were: 1) to compare the incidence of PPM in the TAVR and surgical aortic valve replacement (SAVR) randomized control trial (RCT) arms of the PARTNER (Placement of AoRTic TraNscathetER Valves) I Trial cohort A; and 2) to assess the impact of PPM on regression of left ventricular (LV) ...

      Known for Severe Aortic | Ppm Tavr | Savr Patients | Surgical Valve | Partner Trial
      KOL-Index: 24254

      Importance: Transcatheter aortic valve replacement (TAVR) indications are expanding, leading to an increasing number of patients with bicuspid aortic stenosis undergoing TAVR. Pivotal randomized trials conducted to obtain US Food and Drug Administration approval excluded bicuspid anatomy.

      Objective: To compare the outcomes of TAVR with a balloon-expandable valve for bicuspid vs tricuspid aortic stenosis.

      Design, Setting, and Participants: Registry-based prospective cohort study of ...

      Known for Aortic Stenosis | Valve Replacement | Patients Bicuspid | 1 Year | Mortality Stroke
      KOL-Index: 23382

      OBJECTIVES: The aim of this study was to assess, after 2 years of follow-up, the safety, efficacy, and cost-effectiveness of a zotarolimus-eluting stent (ZES) compared with a paclitaxel-eluting stent (PES) in patients with native coronary lesions.

      BACKGROUND: Early drug-eluting stents were associated with a small but significant incidence of very late stent thrombosis (VLST), occurring >1 year after the index procedure. The ZES has shown encouraging results in clinical trials.

      METHODS: ...

      Known for Coronary Stent | Medtronic Endeavor Drug | Zes Pes | 2 Years | Artery Lesions
      KOL-Index: 20903

      BACKGROUND: Subclinical leaflet thrombosis of bioprosthetic aortic valves after transcatheter valve replacement (TAVR) and surgical aortic valve replacement (SAVR) has been found with CT imaging. The objective of this study was to report the prevalence of subclinical leaflet thrombosis in surgical and transcatheter aortic valves and the effect of novel oral anticoagulants (NOACs) on the subclinical leaflet thrombosis and subsequent valve haemodynamics and clinical outcomes on the basis ...

      Known for Subclinical Leaflet Thrombosis | Aortic Valves | Tavr Savr | Transcatheter Bioprosthetic | Patients Anticoagulants
      KOL-Index: 20497

      Importance: In patients with severe aortic stenosis (AS) at intermediate surgical risk, treatment with transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) results in similar 2-year survival. The effect of TAVR vs SAVR on health status in patients at intermediate surgical risk is unknown.

      Objective: To compare health-related quality of life among intermediate-risk patients with severe AS treated with either TAVR or SAVR.

      Design, Setting, and ...

      Known for Intermediate Surgical Risk | Tavr Patients | Severe Aortic Stenosis | Aortic Valve | 2 Years
      KOL-Index: 19023

      BACKGROUND: Prosthetic valve endocarditis (PVE) is a rare but critical mechanism of valve failure and death after transcatheter and surgical aortic valve replacement (TAVR, SAVR) warranting further analysis in modern aortic valve replacement experience. We characterize the incidence, risk factors, microbiological profile and outcomes of PVE from the PARTNER trials and registries (Placement of Aortic Transcatheter Valve).

      METHODS: We analyzed a pooled cohort of all patients in PARTNER 1 ...

      Known for Pve Tavr | Prosthetic Valve Endocarditis | Aortic Valve | 1 Year | Incidence Risk Factors
      KOL-Index: 18881

      To determine the effects of verapamil on left ventricular (LV) systolic function and diastolic filling in patients with coronary artery disease (CAD), we performed gated radionuclide angiography at rest and during exercise in 16 symptomatic patients before and during oral verapamil therapy (480 mg/day). Twelve patients were also studied during oral propranolol (160--320 mg/day). LV ejection fraction at rest was normal in 13 patients, but abnormal diastolic filling at rest, defined as ...

      Known for Diastolic Filling | Coronary Artery Disease | Rest Exercise | Systolic Function | Time Pfr
      KOL-Index: 18755

      OBJECTIVES: The purpose of this study was to identify predictors and clinical implications of permanent pacemaker (PPM) implantation after transcatheter aortic valve replacement (TAVR).

      BACKGROUND: Cardiac conduction disturbances requiring PPM are a frequent complication of TAVR. However, limited data is available regarding this complication after TAVR with a balloon-expandable valve.

      METHODS: The study included patients without prior pacemaker who underwent TAVR in the PARTNER ...

      Known for Ppm Tavr | Aortic Valve | 1 Year | Pacemaker Implantation | Partner Trial
      KOL-Index: 18706

      BACKGROUND: Transcatheter mitral valve replacement using aortic transcatheter heart valves has recently become an alternative for patients with degenerated mitral bioprostheses, failed surgical repairs with annuloplasty rings or severe mitral annular calcification who are poor surgical candidates. Outcomes of these procedures are collected in the Society of Thoracic Surgeons/American College of Cardiology/Transcatheter Valve Therapy Registry. A comprehensive analysis of mitral ...

      Known for United States | Mitral Valve | Annular Calcification | Society Thoracic Surgeons | Mvir Vimac
      KOL-Index: 18482

      OBJECTIVES: This study sought to compare the influence of the extent of multidetector computed tomography (MDCT) area oversizing on the incidence of paravalvular aortic regurgitation (PAR) between the Sapien 3 and the Sapien XT transcatheter heart valve (THV) to define a new MDCT sizing guideline suitable for the Sapien 3 platform.

      BACKGROUND: The inverse relationship of PAR occurrence and oversizing has been demonstrated for the Sapien XT but the incidence of PAR with comparable ...

      Known for Sapien 3 | Heart Valve | Computed Tomography | Area Oversizing | Aortic Regurgitation
      KOL-Index: 18437

      OBJECTIVES: The study aimed to investigate the difference in major adverse cardiac event (MACE) at 1-year after double kissing (DK) crush versus Culotte stenting for unprotected left main coronary artery (UPLMCA) distal bifurcation lesions.

      BACKGROUND: DK crush and Culotte stenting were reported to be effective for treatment of coronary bifurcation lesions. However, their comparative performance in UPLMCA bifurcation lesions is not known.

      METHODS: A total of 419 patients with UPLMCA ...

      Known for Culotte Stenting | Bifurcation Lesions | Double Kissing Crush | Iii Study | 1 Year
      KOL-Index: 17871

      Importance: Moderate/severe and even mild paravalvular regurgitation (PVR) are associated with increased mortality following transcatheter aortic valve replacement (TAVR) with first and second generations of transcatheter valves.

      Objective: To examine the incidence, evolution, and effect on 1-year outcomes of PVR following TAVR with a third-generation balloon-expandable transcatheter heart valve.

      Design, Setting, and Participants: Prespecified analysis of PVR in the Placement of Aortic ...

      Known for Sapien 3 Valve | Paravalvular Regurgitation | Transcatheter Aortic | 1 Year | Pvr Patients
      KOL-Index: 17255

      OBJECTIVES: This study sought to compare late safety and efficacy outcomes following percutaneous coronary revascularization with zotarolimus-eluting stents (ZES) and sirolimus-eluting stents (SES).

      BACKGROUND: Despite higher late lumen loss and binary restenosis with ZES compared with SES, it is uncertain whether differences in early angiographic measures translate into more disparate late clinical events.

      METHODS: Clinical outcomes were prospectively evaluated through 5 years in the ...

      Known for Eluting Coronary | Endeavor Iii | Ses Zes | Randomized Controlled Trial | 5 Years
      KOL-Index: 17204

      BACKGROUND: Transcatheter aortic valve replacement (TAVR) with the SAPIEN 3 valve demonstrates good 30 day clinical outcomes in patients with severe aortic stenosis who are at intermediate risk of surgical mortality. Here we report longer-term data in intermediate-risk patients given SAPIEN 3 TAVR and compare outcomes to those of intermediate-risk patients given surgical aortic valve replacement.

      METHODS: In the SAPIEN 3 observational study, 1077 intermediate-risk patients at 51 sites in ...

      Known for Aortic Valve | Intermediaterisk Patients | Propensity Score Analysis | Tavr Sapien | 1 Year
      KOL-Index: 17097

      CONTEXT: Coronary computed tomographic (CT) angiography is a noninvasive anatomic test for diagnosis of coronary stenosis that does not determine whether a stenosis causes ischemia. In contrast, fractional flow reserve (FFR) is a physiologic measure of coronary stenosis expressing the amount of coronary flow still attainable despite the presence of a stenosis, but it requires an invasive procedure. Noninvasive FFR computed from CT (FFR(CT)) is a novel method for determining the ...

      Known for Ffr Ffrct | Fractional Flow Reserve | Stenosis Ischemia | Specificity Tomography | Suspected Cad

      Key People For Aortic Valve

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      The Cardiovascular Research Foundation, New York, New York | Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, New York | Center for Interventional Vascular Therapy, Columbia University Irving Medical Center, NewYork-

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