Mark D Fleming: Influence Statistics

Mark D Fleming

Mark D Fleming

Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America | Department of Pathology, Boston Children’s Hospital, Harvard ...

Mark D Fleming: Expert Impact

Concepts for which Mark D Fleming has direct influence: Sideroblastic anemia , Iron deficiency , Iron overload , Myelodysplastic syndrome , Iron transport , Hepcidin expression , Acute myeloid leukaemia .

Mark D Fleming: KOL impact

Concepts related to the work of other authors for which for which Mark D Fleming has influence: Cancer cells , Iron metabolism , Gene expression , Pyruvate kinase , Oxidative stress , Ewing sarcoma , Langerhans cell histiocytosis .

KOL Resume for Mark D Fleming

Year
2022

Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America

2021

Boston Children’s Hospital, Boston, MA, USA

2020

Harvard Medical School, Boston, MA, USA

Department of Pathology, Boston Children's Hospital, Boston, MA.

2019

Department of Pathology, Boston Children's Hospital, Boston, Massachusetts

Harvard Medical School, Boston, MA

2018

Department of Pathology, Boston Children's Hospital, Boston, MA

Boston Children Hospital;

2017

Department of Pathology, Boston Children’s Hospital, and

Boston Children’s Hospital, Boston, MA

2016

Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA

2015

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA.

Mayo Clinic, Rochester, Minnesota.

2014

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Boston Children's Hospital, Boston, MA

2013

Department of Pathology, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA

2012

Department of Pathology, Children's Hospital Boston, MA, USA

2011

Pediatrics, and

Departments of Pathology,

Children's Hospital Boston, Boston, MA

2010

Department of Pathology, Children's Hospital, Boston, Massachusetts

Pathology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA,

Enders 1116.1, Children's Hospital, 300 Longwood Ave, Boston, MA 02115

2009

Pathology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA

James V. Neel Distinguished University Professor, Departments of Internal Medicine, Pediatrics and Communicable Diseases, and Human Genetics, Investigator, Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan

Professor of Pediatrics, Edward Wigglesworth Professor of Dermatology, Harvard Medical School, Chief, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts

2008

Department of Pathology, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA

Mark Fleming, Associate Professor of Pathology, Children’s Hospital, Harvard Medical School, Enders 1116.1, 300 Longwood Ave, Boston, MA 02115; e-mail: mark.fleming{at}childrens.harvard.edu ; Mark Fleming, Associate Professor of Pathology, Children’s Hospital, Harvard Medical School, Enders 1116.1, 300 Longwood Ave, Boston, MA 02115; e-mail: mark.fleming{at}childrens.harvard.edu

2007

Department of Pathology, Children's Hospital and Harvard Medical School, Boston, MA;

Children’s Hospital Boston, Harvard Medical School, Boston, MA, USA

Prominent publications by Mark D Fleming

KOL-Index: 13922 . Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iron overload disorders, collectively termed hereditary hemochromatosis. Conversely, chronic ...
Known for Bmp Type | Iron Overload | Hepcidin Expression | Alk2 Alk3
KOL-Index: 13796 . Iron-refractory, iron-deficiency anemia (IRIDA) is a familial disorder characterized by iron deficiency anemia unresponsive to oral iron treatment but partially responsive to intravenous iron therapy. Previously, we showed that IRIDA patients harbor loss-of-function mutations in TMPRSS6, a type II transmembrane serine protease primarily expressed by the liver. Both humans and mice with ...
Known for Systemic Iron Homeostasis | Bmp Smad | Mice Tmprss6 | Hepcidin Expression
KOL-Index: 12673 . The Belgrade (b) rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal reticulocyte iron uptake and gastrointestinal iron absorption. The b reticulocyte defect appears to be failure of iron transport out of endosomes within the transferrin cycle. Aspects of this phenotype are similar to those reported for the microcytic anemia (mk) mutation in ...
Known for Iron Transport | Nramp2 Protein | Mk Mouse | Microcytic Anemia
KOL-Index: 12387 . It has been suggested that a switch in chemokine receptor expression underlies Langerhans cell migration from skin to lymphoid tissue. Activated cells are thought to down-regulate CCR6, whose ligand macrophage inflammatory protein-3 alpha (MIP-3 alpha)/CCL20 is expressed in skin, and up-regulate CCR7, whose ligands are in lymphoid tissues. In Langerhans cell histiocytosis (LCH), pathologic ...
Known for Langerhans Cell Histiocytosis | Chemokine Receptors | Ccr6 Ccr7 | Skin Bone
KOL-Index: 12297 . Patients with hematologic malignancies undergoing allogeneic stem cell transplantation (HSCT) commonly have an elevated serum ferritin prior to HSCT, which has been associated with increased mortality after transplantation. This has led to the suggestion that iron overload is common and deleterious in this patient population. However, the relationship between serum ferritin and parenchymal ...
Known for Acute Leukemia | Iron Overload | Cell Transplantation | Serum Ferritin
KOL-Index: 12173 . BACKGROUND: Sideroblastic anemias are heterogeneous congenital and acquired bone marrow disorders characterized by pathologic iron deposits in mitochondria of erythroid precursors. Among the congenital sideroblastic anemias (CSAs), the most common form is X-linked sideroblastic anemia, due to mutations in 5-aminolevulinate synthase (ALAS2). A novel autosomal recessive CSA, caused by ...
Known for Congenital Sideroblastic Anemia | Sideroblastic Child Child | Alas2 Slc25a38 | Mitochondrial Membrane
KOL-Index: 11723 . KRAS is often mutated in human hematopoietic malignancies, including juvenile myelomonocytic leukemia (JMML) and T-cell lymphoblastic leukemia/lymphoma (TLL/L). However, the exact role and function of oncogenic KRAS mutations in the initiation and progression of JMML and TLL/L remain elusive. Here, we report the use of a mouse bone marrow transplantation model to study oncogenic ...
Known for Oncogenic Kras | Stem Cell | Myeloid Progenitors | Solid Tumors
KOL-Index: 11251 . We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73. p63 was detected in a variety of human and mouse tissues, including proliferating basal cells of epithelial layers in the epidermis, cervix, urothelium, and prostate. Unlike p53, the p63 gene encodes multiple isotypes with remarkably divergent ...
Known for P53 Homolog | Tumor Suppressor Genes | Situ Hybridization | Encodes Multiple
KOL-Index: 11201 . Hereditary hemochromatosis, which is characterized by inappropriately low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been associated with mutations in the HFE, transferrin receptor-2 (TfR2), and hemojuvelin (HJV) genes. However, it is still not clear whether these molecules intersect in vivo with bone morphogenetic protein 6 (BMP6)/mothers ...
Known for Iron Phenotype | Morphogenetic Protein | Bmp6 Hjv | Hepcidin Expression Response
KOL-Index: 11083 . Proteins with iron-sulfur (Fe-S) clusters participate in multiple metabolic pathways throughout the cell. The mitochondrial ABC half-transporter Abcb7, which is mutated in X-linked sideroblastic anemia with ataxia in humans, is a functional ortholog of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosolic Fe-S cluster assembly. Using an ...
Known for Cytosolic Iron | Sulfur Cluster | Binding Cassette | Mitochondrial Atp
KOL-Index: 11033 . A number of genetic mutations have been identified in human breast cancers, yet the specific combinations of mutations required in concert to form breast carcinoma cells remain unknown. One approach to identifying the genetic and biochemical alterations required for this process involves the transformation of primary human mammary epithelial cells (HMECs) to carcinoma cells through the ...
Known for Human Breast | Mammary Epithelial | Oncogenic Transformation | Cells Tumors
KOL-Index: 10744 . Although the physiological role of tissue-specific translational control of gene expression in mammals has long been suspected on the basis of biochemical studies, direct evidence has been lacking. Here, we report on the targeted disruption of the gene encoding the heme-regulated eIF2alpha kinase (HRI) in mice. We establish that HRI, which is expressed predominantly in erythroid cells, ...
Known for Erythroid Precursors | Translational Regulation | Iron Deficiency | Eif2α Kinase
KOL-Index: 10743 . Microcytic anemia (mk) mice and Belgrade (b) rats have severe iron deficiency anemia due to defects in intestinal iron transport and erythroid iron utilization. Both animal mutants carry the same missense mutation in Nramp2, the first mammalian iron transporter to be identified. This mutation, in which glycine 185 is changed to arginine (G185R), occurs within predicted transmembrane domain ...
Known for Iron Transport | G185r Mutation | Cultured Cloning | Transmembrane Domain
KOL-Index: 10620 . Oncogenic NRAS mutations are frequently identified in myeloid diseases involving monocyte lineage. However, its role in the genesis of these diseases remains elusive. We report a mouse bone marrow transplantation model harboring an oncogenic G12D mutation in the Nras locus. Approximately 95% of recipient mice develop a myeloproliferative disease resembling the myeloproliferative variant of ...
Known for Oncogenic Nras | Chronic Myelomonocytic | Csf Signaling | Murine Model

Key People For Sideroblastic Anemia

Top KOLs in the world
#1
Sylvia S Bottomley
sideroblastic anemia iron overload heme biosynthesis
#2
David F Bishop
fabry disease uroporphyrinogen iii synthase acute intermittent porphyria
#3
Alison May
sideroblastic anaemia prenatal diagnosis iron overload
#4
Mark D Fleming
sideroblastic anemia iron deficiency myelodysplastic syndrome
#5
Philip D Cotter
situ hybridization prenatal diagnosis human pair
#6
Dean R Campagna
sideroblastic anemia gata2 mutations iron deficiency

Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America | Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, MA; | Department of Pathology, Boston Children's Hosp