• Disease
  • Functional
  • Functional Dyspepsia
  • Jan F Tack

    Prominent publications by Jan F Tack

    KOL Index score: 21510

    BACKGROUND: The Rome III consensus proposed to subdivide functional dyspepsia (FD) into two groups: meal-related dyspepsia or postprandial distress syndrome (PDS), and meal-unrelated dyspepsia or epigastric pain syndrome (EPS). However, in clinical practice, overlap between both has been reported to be as high as 50%, thereby hampering clinical applicability. Although EPS is referred to as meal-unrelated dyspepsia, relationship of symptoms to meal ingestion in this category is not ...

    Also Ranks for: Pds Eps |  rome iii |  postprandial symptoms |  epigastric pain |  patients overlap
    KOL Index score: 17123

    OBJECTIVES: Studies using ambulatory pH and esophageal bile reflux monitoring (Bilitec) have shown that both acid reflux and duodeno-gastro-esophageal reflux (DGER) frequently occur in patients with gastroesophageal reflux disease (GERD). A subset of patients with GERD has persistent reflux symptoms in spite of standard doses of proton pump inhibitors (PPIs). The aim of the present study was to investigate the role of acid and DGER in patients with reflux disease poorly responsive to ...

    Also Ranks for: Acid Reflux |  dger patients |  proton pump |  illness statistics |  persistent esophagitis
    KOL Index score: 16214

    Background: Patient-rated symptom assessments are needed for evaluating the effectiveness of medical treatments and for monitoring outcomes in gastroparesis. Objective: This paper summarizes the development and psychometric evaluation of a new instrument, the Gastroparesis Cardinal Symptom Index (GCSI), for assessing severity of symptoms associated with gastroparesis. Methods: The GCSI was based on reviews of the medical literature, patient focus groups, and interviews with clinicians. A ...

    Also Ranks for: Gastroparesis Symptoms |  patients gcsi |  symptom severity |  united states |  total score
    KOL Index score: 16081

    OBJECTIVES: The Rome III criteria proposed to subdivide functional dyspepsia (FD) into a postprandial distress syndrome (PDS) group, characterized by the presence of postprandial fullness and/or early satiety, and an epigastric pain syndrome (EPS) group, characterized by the presence of epigastric pain and/or epigastric burning. It has been suggested that different pathophysiological mechanisms underlie the symptom presentations in these subgroups that might determine treatment choices. ...

    Also Ranks for: Rome Iii Criteria |  epigastric pain |  pds eps |  dyspeptic symptoms |  postprandial fullness
    KOL Index score: 15214

    BACKGROUND: Many experts consider laparoscopic Heller's myotomy (LHM) to be superior to pneumatic dilation for the treatment of achalasia, and LHM is increasingly considered to be the treatment of choice for this disorder.

    METHODS: We randomly assigned patients with newly diagnosed achalasia to pneumatic dilation or LHM with Dor's fundoplication. Symptoms, including weight loss, dysphagia, retrosternal pain, and regurgitation, were assessed with the use of the Eckardt score (which ranges ...

    Also Ranks for: Pneumatic Dilation |  2 years |  therapeutic success |  eckardt score |  laparoscopic heller
    KOL Index score: 15039

    BACKGROUND & AIMS: Among patients with functional dyspepsia (FD), there is overlap in symptoms between those in the Rome III subgroups of postprandial distress syndrome (PDS) and those with epigastric pain syndrome (EPS). The Rome IV consensus proposed to incorporate all patients with postprandial symptoms into the PDS group. We aimed to evaluate the assessment of meal-related dyspepsia symptoms in patients with FD according to the Rome III vs Rome IV subdivisions.

    METHODS: Consecutive ...

    Also Ranks for: Pds Eps |  symptoms patients |  rome iii |  breath test |  nausea postprandial
    KOL Index score: 15027

    BACKGROUND AND AIMS: Acid gastro-oesophageal reflux is one of the most important causes of chronic cough. The response to acid suppression in these patients is not as good as in patients with heartburn but improvement with antireflux surgery has been reported, suggesting the involvement of a non-acidic gastric component in the refluxate. Less acidic reflux may produce symptoms such as regurgitation or chest pain. We investigated whether chronic cough might be associated with weakly ...

    Also Ranks for: Acidic Reflux |  impedance monitoring |  patients chronic cough |  weakly alkaline |  24 hour
    KOL Index score: 14682

    BACKGROUND: Severe duodeno-gastro-oesophageal reflux (DGOR) is a risk factor for oesophagitis and Barrett's oesophagus. Patients with non-erosive reflux disease (NERD) have a slight increase in DGOR. Patients with gastro-oesophageal reflux disease (GORD), who are taking proton pump inhibitors (PPIs), still have reflux but of weakly acidic pH and persistence of bile. In these two groups of patients, heartburn might be due to increased oesophageal mucosal permeability and dilated ...

    Also Ranks for: Bile Acids |  oesophageal mucosa |  intercellular spaces |  acidic conditions |  patients nerd
    KOL Index score: 14371

    BACKGROUND: In animals, activation of 5-HT(1) like receptors causes a relaxation of the gastric fundus through the activation of intrinsic inhibitory neurones.

    AIMS: To investigate the effect of sumatriptan, an agonist at enteric neuronal 5-HT(1) receptors, on fasting fundus tone and sensitivity to gastric distension in man.

    METHODS: A gastric barostat was used to study the effect of placebo and sumatriptan, 6 mg subcutaneously, on basal fundic tone in healthy subjects. In addition, ...

    Also Ranks for: Gastric Fundus |  perception sumatriptan |  muscle relaxation |  ht1 receptor |  administration placebo
    KOL Index score: 13987

    BACKGROUND: Fluctuations in motilin plasma levels have been implicated in the control of the migrating motor complex (MMC). A plasma peak of motilin is present before a gastric phase III. Furthermore, not only exogenous administration of motilin but also ghrelin induces a gastric phase III in man. Aim of this study was to investigate the role of endogenous ghrelin in the regulation of the MMC.

    METHODS: Plasma samples for motilin and ghrelin were taken in between two consecutive phases ...

    Also Ranks for: Phase Iii |  migrating motor complex |  plasma levels |  motilin ghrelin
    KOL Index score: 13920

    BACKGROUND: Oesophageal clearance of acid reflux consists of an initial volume clearance followed by neutralisation of the acidified mucosa by swallowed saliva (chemical clearance). Ineffective oesophageal motility (IOM), a frequent finding in patients with gastro-oesophageal reflux disease (GORD), has been claimed to underlie prolonged acid clearance by affecting oesophageal emptying and saliva transport. Intraluminal impedance allows non-radiological monitoring of movement of ...

    Also Ranks for: Oesophageal Motility |  volume clearance |  severe iom |  acid reflux |  upright supine positions
    KOL Index score: 13558

    OBJECTIVE: The relationship between functional dyspepsia and delayed gastric emptying of solids or liquids is still unclear. The aim of the present study was to investigate in dyspeptic patients the prevalence of delayed gastric emptying for solids or for liquids and to investigate the relationship to the dyspepsia symptom pattern.

    METHODS: In 392 and 330 patients with functional dyspepsia, the solid and liquid gastric emptying, respectively, was measured using breath tests, and the ...

    Also Ranks for: Functional Dyspepsia |  gastric emptying |  solids liquids |  postprandial fullness |  breath tests
    KOL Index score: 13551

    BACKGROUND: It remains controversial as to whether delayed gastric emptying in functional dyspepsia is associated with a specific symptom pattern, and it is unknown if gastric emptying in functional dyspepsia is a driver of impaired health related quality of life (HRQOL). We aimed to evaluate the relationship between functional dyspepsia symptoms, gastric emptying, and HRQOL.

    METHODS: US patients (n=864; mean age 44 years (range 18-82); 74% female) with functional dyspepsia, as defined ...

    Also Ranks for: Functional Dyspepsia |  gastric emptying |  impaired quality |  life hrqol |  patients delayed
    KOL Index score: 13511

    BACKGROUND & AIMS: Patients with achalasia are treated with either pneumatic dilation (PD) or laparoscopic Heller myotomy (LHM), which have comparable rates of success. We evaluated whether manometric subtype was associated with response to treatment in a large population of patients treated with either PD or LHM (the European achalasia trial).

    METHODS: Esophageal pretreatment manometry data were collected from 176 patients who participated in the European achalasia trial. Symptoms ...

    Also Ranks for: Manometric Subtype |  patients type achalasia |  type iii lhm |  success rates |  eckardt score
    KOL Index score: 13504

    BACKGROUND & AIMS: Gastroparesis is a complication of diabetes with few treatment options. Relamorelin (also referred to as RM-131) is a selective, prokinetic agonist of ghrelin. We aimed to evaluate the efficacy of relamorelin on symptoms and gastric emptying (GE) in a 12-week, phase 2B study of diabetic patients with moderate to severe gastroparesis symptoms (DG).

    METHODS: We performed a study of 393 patients with DG (37.7% male; 9.9% with type 1 diabetes; median age, 58.2 years [range ...

    Also Ranks for: Symptoms Gastroparesis |  vomiting frequency |  efficacy safety |  gastrointestinal agents |  patients dg


    Jan F Tack: Influence Statistics

    Sample of concepts for which Jan F Tack is among the top experts in the world.
    Concept World rank
    rectal sensorimotor #1
    slikfunctie #1
    150±095 #1
    placebo oral intake #1
    monitoring bilitec #1
    esophageal activity #1
    acid peptic diseases #1
    role erythromycin #1
    sri aspiration #1
    apical solvent #1
    bowel symptoms impact #1
    safety zzkz #1
    transient relaxations sumatriptan #1
    intestinal permeation indinavir #1
    fd hvs #1
    r137696 #1
    increased exposure acid #1
    amprenavir fed state #1
    fatty acids octanoylation #1
    enrd erosive oesophagitis #1
    nutrient infusion #1
    itopride domperidone #1
    absence mechanical obstruction #1
    non‐constipating #1
    nutrient tolerance children #1
    oic opioids #1
    oesophageal manometry diagnosis #1
    reflux episodes cough #1
    hydroxytryptamine1 #1
    rome iii consensus #1
    supersaturation hif #1
    satiety drinking #1
    placebo mntx #1
    proximal stomach dysfunction #1
    duodenogastric reflex #1
    symptoms dyspeptic symptoms #1
    acotiamide pds symptoms #1
    erythromycin 40 #1
    δigp #1
    european achalasia trial #1
    gastric accommodation fd #1
    coadministration cocacola #1
    symptom relapse ibs #1
    dyspepsia postprandial #1
    lipid removal ultrastructure #1
    constipation symptoms pacsym #1
    pfa metrics #1
    nausea belching #1
    pdsmethodsin #1
    accommodation reflex #1

    Key People For Functional Dyspepsia

    Top KOLs in the world
    Nicholas Joseph Talley
    functional dyspepsia irritable bowel syndrome emergency action
    Vincenzo Stanghellini
    irritable bowel syndrome functional dyspepsia gastric emptying
    Jan F Tack
    functional dyspepsia irritable bowel syndrome chronic constipation
    Camilleri Camilleri
    irritable bowel syndrome colonic transit gastric emptying
    Gerald J Holtmann
    functional dyspepsia irritable bowel syndrome inflammatory bowel disease
    Juan‐R Malagelada
    functional dyspepsia abdominal bloating intestinal gas

    Jan F Tack:Expert Impact

    Concepts for whichJan F Tackhas direct influence:Functional dyspepsia,  Irritable bowel syndrome,  Chronic constipation,  Gastric emptying,  Bowel syndrome,  Food intake,  Gastric accommodation,  Esophageal sensitivity.

    Jan F Tack:KOL impact

    Concepts related to the work of other authors for whichfor which Jan F Tack has influence:Irritable bowel syndrome,  Functional dyspepsia,  Gastroesophageal reflux disease,  Gastric emptying,  Helicobacter pylori,  Chronic constipation,  Abdominal pain.



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    Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; | Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium | Rome Foun