Prominent publications by Robin Lemmens

KOL Index score: 18820

BACKGROUND: Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes) was the first trial with ticagrelor in patients with ...

Known for Transient Ischemic Attack |  Acute Stroke |  Ticagrelor Aspirin |  Major Bleeding |  Antiplatelet Therapy
KOL Index score: 18776

BACKGROUND: Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral ...

Known for Ischaemic Stroke |  Cerebral Microbleeds |  Intracranial Haemorrhage |  Pooled Analysis |  Individual Patient Data
KOL Index score: 13555

BACKGROUND AND PURPOSE: Among patients with a transient ischemic attack or minor ischemic strokes, those with ipsilateral atherosclerotic stenosis of cervicocranial vasculature have the highest risk of recurrent vascular events.

METHODS: In the double-blind THALES (The Acute Stroke or Transient Ischemic Attack Treated With Ticagrelor and ASA for Prevention of Stroke and Death) trial, we randomized patients with a noncardioembolic, nonsevere ischemic stroke, or high-risk transient ...

Known for Ischemic Stroke |  Ticagrelor Aspirin |  Hazard Ratio |  Attack Transient |  30 Patients
KOL Index score: 12537

BACKGROUND: The value of administering intravenous alteplase before endovascular treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian populations.

METHODS: We performed an open-label, multicenter, randomized trial in Europe involving patients with stroke who presented directly to a hospital that was capable of providing EVT and who were eligible for intravenous alteplase and EVT. Patients were randomly assigned in a 1:1 ratio to receive ...

Known for Intravenous Alteplase |  Endovascular Treatment |  Evt Patients |  Modified Rankin Scale |  Functional Outcome
KOL Index score: 8822

BACKGROUND: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers.

METHODS: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults ...

Known for Intravenous Alteplase |  Patients Stroke |  Functional Outcome |  Time Onset |  Dwi Flair
KOL Index score: 7856

AIMS: To provide contemporary data on the implementation of European guideline recommendations for lipid-lowering therapies (LLTs) across different settings and populations and how this impacts low-density lipoprotein cholesterol (LDL-C) goal achievement.

METHODS AND RESULTS: An 18 country, cross-sectional, observational study of patients prescribed LLT for primary or secondary prevention in primary or secondary care across Europe. Between June 2017 and November 2018, data were collected ...

Known for Secondary Primary |  Patients Llt |  Sectional Observational |  Vinci Study |  2019 Goals
KOL Index score: 7766

OBJECTIVES: To assess the association between cerebral microbleeds (CMBs) and future spontaneous intracerebral hemorrhage (ICH) risk in ischemic stroke patients with nonvalvular atrial fibrillation (AF) taking oral anticoagulants.

METHODS: This was a meta-analysis of cohort studies with >50 patients with recent ischemic stroke and documented AF, brain MRI at baseline, long-term oral anticoagulation treatment, and ≥6 months of follow-up. Authors provided summary-level data on stroke ...

Known for Hemorrhage Risk |  Presence Cmb |  Brain Microbleeds |  Ischemic Stroke |  Oral Anticoagulants
KOL Index score: 7603

OBJECTIVE: For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms.

METHODS: We first sought to identify genetic associations with white matter hyperintensities in a stroke population, and then examined whether genetic loci previously linked to WMHV in community ...

Known for White Matter |  Stroke Patients |  Genetic Associations |  Genome Wide |  Disease Mechanisms
KOL Index score: 6890

OBJECTIVE: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods.

METHODS: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.

RESULTS: There ...

Known for Global Impact |  Covid19 Stroke |  6 Continents |  70 Countries |  Retrospective Studies
KOL Index score: 6266

Amyotrophic lateral sclerosis (ALS) is a spontaneous, relentlessly progressive motor neuron disease, usually resulting in death from respiratory failure within 3 years. Variation in the genes SOD1 and TARDBP accounts for a small percentage of cases, and other genes have shown association in both candidate gene and genome-wide studies, but the genetic causes remain largely unknown. We have performed two independent parallel studies, both implicating the RNA polymerase II component, ELP3, ...

Known for Elongator Protein |  Neuron Degeneration |  Elp3 Gene |  Male Mice Mice |  Aged Motor
KOL Index score: 6213

BACKGROUND: S44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitability in a transcranial magnetic stimulation study in healthy volunteers. The Randomized Efficacy and Safety Trial of Oral GABAA α5 antagonist S44819 after Recent ischemic Event (RESTORE BRAIN) aimed to evaluate the safety and efficacy of S44819 for enhancing clinical recovery of patients ...

Known for Stroke Treatment |  Antagonist S44819 |  Gabaa Α5 |  Tonic Inhibition |  Brain Ischemia
KOL Index score: 5835

RATIONALE: Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome.

OBJECTIVE: Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date.

METHODS AND RESULTS: A 12-cohort, 2-phase ...

Known for Functional Outcome |  Ischemic Stroke |  Genetic Factors |  Genome Wide |  Common Variants
KOL Index score: 5547

OBJECTIVE: To examine etiologic stroke subtypes and vascular risk factor profiles and their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic stroke (AIS).

METHODS: For the MRI Genetics Interface Exploration (MRI-GENIE) study, we systematically assembled brain imaging and phenotypic data for 3,301 patients with AIS. All cases underwent standardized web tool-based stroke subtyping with the Causative Classification of Ischemic Stroke ...

Known for Ischemic Stroke |  White Matter |  Hyperintensity Burden |  Diabetes Mellitus |  Deep Learning
KOL Index score: 5451

OBJECTIVE: To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study.

METHODS: The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to 190 days, evaluated as 2 dichotomous variables (0-2 vs 3-6 and 0-1 vs 2-6) and subsequently ...

Known for Functional Outcome |  Ischemic Stroke |  Genome Wide |  Genetic Variant |  Brain Ischemia
KOL Index score: 4534

BACKGROUND: Within randomized clinical trials (RCTs), coiling of the ruptured aneurysm to prevent rebleeding results in better outcomes than clipping in patients with aneurysmal subarachnoid hemorrhage (aSAH).

OBJECTIVE: To study the association of coiling and clipping with outcome after aSAH in daily clinical practice.

METHODS: In this controlled, nonrandomized study, we compared outcomes after endovascular coiling and neurosurgical clipping of ruptured intracranial aneurysms in an ...

Known for Subarachnoid Hemorrhage |  Clipping Coiling |  Aneurysm Ruptured |  Endovascular Procedures |  Humans Intracranial


Robin Lemmens: Influence Statistics

Sample of concepts for which Robin Lemmens is among the top experts in the world.
Concept World rank
attainment belgium #9
prescribed llt regimen #9
497 enrolled patients #9
belgium vinci #9
observational vinci #9
goals 59 #9
eas levels #9
esc eas belgium #9
achieved 2016 #15
belgium cvd #16
attainment 2019 #17
goals 2016 #18
prescribed llt #21
vinci observational #22
vinci observational study #22
oxazoles stroke #27
achieved 2019 #27
guidelines 41 #29
riskbased ldlc goals #29
α5 antagonist #32
doubleblind thales #33
ipsilateral atherosclerosis #33
illness ticagrelor aspirin #33
stenosis cervicocranial #33
34 95 patients #34
brainresident tregs #34
adam23 log #35
total 5876 #35
2p251 2q312 #35
gria1 enriched #35
humans excitotoxicity #35
analyses nominated #35
δnihss total #35
2q312 2q333 #35
suggested gria1 #35
smr adam23 #35
87 δnihss #35
5q332 locus #35
mapping smr #35
ischemic stroke ticagrelor #36
acute nonsevere #37
δnihss variance #38
parenchymal haematoma type #38
cervicocranial vasculature #39
deteriorate early #39
treat 34 #39
δnihss adam23 #40
6q26 7p211 #40
studied ancestry #40
excitotoxic genes #40

Key People For Ischaemic Stroke

Top KOLs in the world
Harold P Jr Adams
ischemic stroke cerebral infarction subarachnoid hemorrhage
Ralph L Sacco
ischemic stroke northern manhattan study carotid plaque
Laurens Jaap Kappelle
ischemic stroke type 2 diabetes cognitive impairment
Hanschristoph C Diener
atrial fibrillation cluster headache chronic migraine
Graeme J Hankey
atrial fibrillation global burden ischemic stroke
José Biller
ischemic stroke cerebral infarction neurologic complications

Robin Lemmens:Expert Impact

Concepts for whichRobin Lemmenshas direct influence:Ischaemic stroke,  Intravenous alteplase,  Ischemic stroke,  Cerebral microbleeds,  Functional outcome,  Stroke patients,  Transient ischemic attack,  Cerebral venous thrombosis.

Robin Lemmens:KOL impact

Concepts related to the work of other authors for whichfor which Robin Lemmens has influence:Ischemic stroke,  Cerebral microbleeds,  Amyotrophic lateral sclerosis,  Atrial fibrillation,  Bempedoic acid,  Intravenous thrombolysis,  Cerebrovascular disease.



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Department of Neurology, University Hospitals Leuven, Leuven, Belgium | Department of Neuroscience, Katholieke Universiteit Leuven, Campus Gasthuisberg O&N2; Leuven (BE-3000), Belgium. | KU Leuven - Department of Neurosciences, Leuven 3000, Belgium |

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