Chang-Yue Gao

Chang-Yue Gao

Department Of Neurology, Institute Of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, 400042, Chongqing, ...

Direct Impact

Concepts for which Chang-Yue Gao has direct influence:

ischemic stroke
cognitive impairment
lipid accumulation
peritoneal dialysis
intimal hyperplasia
east asian
neurological deterioration

External impact

Concepts related to the work of other authors for which Chang-Yue Gao has influence:

ischemic stroke
cerebral infarction
ntrk2 gene
cognitive impairment
plasma lipid
single nucleotide polymorphisms
phenotypic expression

Prominent publications by Chang-Yue Gao

KOL-Index: 45 Abstract.Objective:We studied a large hospitalized cohort of patients aged 55 years and over with acute ischemic stroke to identify the frequency and predictors of poststroke dementia.Methods:A total of 434 consecutive patients with ischemic stroke were enrolled in this study. During admission, the demographic data, vascular risk factors, stroke features, and neurological status information ...
KOL-Index: 38 Amyloid precursor protein (APP) is cleaved by β-secretase and γ-secretase complex, and subsequently generates amyloid-β peptide (Aβ). The Aβ cascade is widely accepted as playing a role in the pathogenesis Alzheimer’s disease (AD). Meanwhile, procession of APP by α-secretase (mainly a disintegrin and metalloproteinase 10, ADAM10) precludes Aβ production, and produces soluble APP-α which is ...
Known for
Aβ Cascade | Polymorphism Sad | Ligase Reaction Method | 243
KOL-Index: 36 BACKGROUND: The association between aldosterone synthase (CYP11B2) C-344T gene polymorphism and ischemic stroke remains controversial and ambiguous. To better explain the association between CYP11B2 polymorphism and ischemic stroke risk, a meta-analysis was performed. METHODS: Based on comprehensive searches of Medline, Embase, Web of Science, CNKI and CBM databases, we identified and ...
Known for
Model Asians | C-344 Polymorphism | Aldosterone Synthase | Cbm
KOL-Index: 30 BACKGROUND: Epidemiological studies have evaluated the association between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22(phox) C242T polymorphism and risk of ischemic cerebrovascular disease (ICVD), but the results remain inconclusive. This meta-analysis was therefore designed to clarify these controversies. METHODOLOGY/PRINCIPAL FINDINGS: Systematic searches of electronic ...
Known for
Size Subgroup | Nicotinamide | Meta Nadph | Stroke Small
KOL-Index: 28 Despite advancements in diagnosis and treatment of cardiovascular diseases (CVDs), the morbidity and mortality of CVDs are still rising. Atherosclerosis is a chronic inflammatory disease contributing to multiple CVDs. Considering the complexity and severity of atherosclerosis, it is apparent that exploring the mechanisms of atherosclerotic formation and seeking new therapies for patients ...
Known for
Functional Structural | Functions Atherosclerosis | Cholesterol Metabolism | Atherogenic
KOL-Index: 28 The association between large-artery atherosclerosis and leukoaraiosis (LA) has been increasingly reported with inconsistent conclusion. This systematic review examines the relationship between LA and carotid atherosclerosis, manifested as atherosclerotic stenosis, plaques and increased intima-media thickness (IMT). PubMed, Embase, and Web of Science were searched for articles published up ...
Known for
Atherosclerosis Leukoaraiosis | Stenosis Plaques | Meta Carotid | Plaque Reporting
KOL-Index: 26 INTRODUCTION: Epidemiological studies have evaluated the association between factor XIII-A (FXIII-A) Val34Leu polymorphism and risk of ischemic stroke, but the results remain inconclusive. This meta-analysis was therefore designed to clarify these controversies. METHODS: Systematic searches of electronic databases Embase, PubMed and Web of Science, as well as hand searching of the references ...
Known for
Fxiii | Stroke Lack
KOL-Index: 25 Increasing evidence showed that abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are common event in the pathophysiology of many vascular diseases, including atherosclerosis and restenosis after angioplasty. Among the underlying mechanisms, oxidative stress is one of the principal contributors to the proliferation and migration of VSMCs. Oxidative stress occurs as ...
Known for
Carotid Injury | Attenuating Oxidative | Prospective Target | Induced Vsmc
KOL-Index: 24 STUDY QUESTION: Does maternal smoking in early pregnancy affect metallothionein 1 and 2 (MT1 and MT2) mRNA and protein expression in first trimester placenta or embryonic/fetal liver? SUMMARY ANSWER: In the first trimester, MT protein expression is seen only in liver, where smoking is associated with a significantly reduced expression. WHAT IS KNOWN ALREADY: Zinc homeostasis is altered by ...
Known for
Fetal Liver | Western Blot | Maternal Smoking | Mrna Protein
KOL-Index: 22 BACKGROUND: The association between methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism and adult stroke remains controversial. The present article was designed to clarify this relationship through pooled analysis of the numerous epidemiological studies focusing on this association. METHODS: We comprehensively searched all published papers in electronic database including ...
Known for
Meta Asian | Potential Publication Bias | China Knowledge Infrastructure | Methylenetetrahydrofolate Reductase Mthfr Gene

Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, 400042, Chongqing, People’s Republic of China

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