Prominent publications by ChangYue Gao

KOL Index score: 17850

Vascular smooth muscle cell (VSMC) foam cell formation is an important hallmark, especially in advanced atherosclerosis lesions. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) promotes foam cell formation by promoting intracellular cholesteryl ester synthesis. The present study tests the hypothesis that oxidized low-density lipoprotein (oxLDL) increases the ACAT1 expression by activating the Toll-like receptor 4 (TLR4)-mediated inflammation, and ultimately promotes VSMC foam cell ...

Known for Foam Cell |  Acat1 Expression |  Vascular Smooth |  Knockout Muscle |  Oxldl Induced
KOL Index score: 15631

Vascular smooth muscle cells (VSMCs) are an important origin of foam cells besides macrophages. The mechanisms underlying VSMC foam cell formation are relatively little known. Activation of transient receptor potential vanilloid subfamily 1 (TRPV1) and autophagy have a potential role in regulating foam cell formation. Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin ...

Known for Foam Cell Formation |  Trpv1 Activation |  Smooth Muscle |  Cation Channels |  Vascular Myocytes
KOL Index score: 15474

AIMS: Peroxisome proliferator-activated receptor γ (PPARγ) has been reported to attenuate intimal hyperplasia. This study aimed to test the hypothesis that PPARγ inhibits intimal hyperplasia through suppressing Toll-like receptor 4 (TLR4)-mediated inflammation in vascular smooth muscle cells.

METHODS AND RESULTS: TLR4(-/-) mice on a C57BL/6J background were used. Increased TLR4 and pro-inflammatory cytokines were observed in wire-injury-induced carotid neointima and in platelet-derived ...

Known for Intimal Hyperplasia |  Smooth Muscle |  Tlr4mediated Inflammation |  Vascular Myocytes |  Proliferation Cells
KOL Index score: 14642

Increasing evidence showed that abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are common event in the pathophysiology of many vascular diseases, including atherosclerosis and restenosis after angioplasty. Among the underlying mechanisms, oxidative stress is one of the principal contributors to the proliferation and migration of VSMCs. Oxidative stress occurs as a result of persistent production of reactive oxygen species (ROS). Recently, the protective ...

Known for Oxidative Stress |  Migration Vsmcs |  Vsmc Proliferation |  Smooth Muscle |  Vascular Diseases
KOL Index score: 12574

OBJECTIVE: Growing evidence suggests that vascular risk factors (VRF) contribute to cognitive decline. The aim of this study was to investigate the impact of VRF on the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD) dementia.

METHODS: A total of 837 subjects with MCI were enrolled at baseline and followed up annually for 5 years. The incidence of AD dementia was investigated. A mixed random effects regression model was used to analyze the association between ...

Known for Vascular Risk Factors |  Mci Dementia |  Alzheimer Disease |  Mild Cognitive Impairment |  Diabetes Hypercholesterolemia
KOL Index score: 12090

BACKGROUND: Meta-analysis in European population found no association between rs12425791/rs11833579 and ischemic stroke. Several studies focused on East Asians have evaluated the association between this two SNPs and risk of ischemic stroke, but the results have been inconsistent. The aim of this study was to perform a meta-analysis to investigate a more authentic association between rs12425791 and rs11833579 G>A mutation and ischemic stroke in East Asian population, as well as in ...

Known for Ischemic Stroke |  Asian Population |  Ninj2 Gene |  Association Rs11833579 |  Snps Risk
KOL Index score: 11907

BACKGROUND: Frequency of poststroke cognitive impairment is high in western countries, and the risk factors of poststroke cognitive impairment have not been fully understood yet. We sought to examine the frequency and risk factors of cognitive impairment after ischemic stroke in a large stroke cohort of China.

METHODS: A total of 434 consecutive patients with ischemic stroke were enrolled. The cognitive status before and 3 months after stroke was evaluated using the Informant ...

Known for Cognitive Impairment |  Ischemic Stroke |  3 Months |  Disorders Cohort |  Neuropsychological Tests
KOL Index score: 11628

The activation of Toll-like receptor 4 (TLR4) signaling has an important role in promoting lipid accumulation and pro-inflammatory effects in vascular smooth muscle cells (VSMCs), which facilitate atherosclerosis development and progression. Previous studies have demonstrated that excess lipid accumulation in VSMCs is due to an inhibition of the expression of ATP-binding cassette transporter A1 (ABCA1), an important molecular mediator of lipid efflux from VSMCs. However, the underlying ...

Known for Lipid Accumulation |  Tlr4 Knockout |  Irak1 Expression |  Effects Hfd |  Induced Abca1
KOL Index score: 11433

Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. In a previous study, we found that peripheral tissues and organs play important roles in clearing brain-derived Aβ, suggesting that the peripheral approach of removing Aβ from the blood may also be effective for AD therapy. Here, we investigated whether ...

Known for Peritoneal Dialysis |  Aβ Brain |  App Ps1 Mice |  Plasma Levels |  Alzheimer Disease
KOL Index score: 10877

BACKGROUND: The association between polymorphism -1131T/C in the promoter region of apolipoprotein A5 (APOA5) and ischemic stroke and plasma triglyceride (TG) levels remains controversial. To better clarify the association between APOA5-1131T/C and risk of ischemic stroke and plasma TG levels, we performed a meta-analysis to examine the allele and genotype of APOA5-1131T/C polymorphism in ischemic stroke cases and controls.

METHODS: Based on the search of PubMed, Embase, MEDLINE, CNKI ...

Known for Ischemic Stroke |  Apolipoprotein A5 |  Triglyceride Levels |  Dominant Model |  Genetic Risk
KOL Index score: 9881

The formation of fat-laden foam cells, contributing to the fatty streaks of the plaques of atheroma, is the critical early process in atherosclerosis. The previous study demonstrated that vascular smooth muscle cells (VSMCs) contain a much larger burden of the excess cholesterol in comparison with monocyte-derived macrophages in human coronary atherosclerosis, as the main origin of foam cells. It is noteworthy that VSMC-derived foam cells are deposited in subintima but not media, where ...

Known for Foam Cells |  Smooth Muscle |  Cell Formation |  1 Trpv1 |  Nf Κb
KOL Index score: 9755

Abstract.Objective:We studied a large hospitalized cohort of patients aged 55

years and over with acute ischemic stroke to identify the

frequency and predictors of poststroke dementia.Methods:A total of 434 consecutive patients with ischemic stroke

were enrolled in this study. During admission, the demographic

data, vascular risk factors, stroke features, and neurological

status information were collected. All subjects were examined by

a battery of neuropsychological tests during ...

Known for Ischemic Stroke |  Dementia Patients |  Atrial Fibrillation |  Frequency Predictors |  3 Months
KOL Index score: 9678

Accumulation of toxic amyloid-β (Aβ) in the cerebral cortex and hippocampus is a major pathological feature of Alzheimer's disease (AD). The neurotrophin receptor p75NTR has been proposed to mediate Aβ-induced neurotoxicity; however, its role in the development of AD remains to be clarified. The p75NTR/ExonIII-/- mice and APPSwe/PS1dE9 mice were crossed to generate transgenic AD mice with deletion of p75NTR gene. In APPSwe/PS1dE9 transgenic mice, p75NTR expression was localized in the ...

Known for Aβ Production |  Extracellular Domain |  Transgenic Mice |  P75ntr Expression |  Precursor Protein
KOL Index score: 9665

The report focused on investigating the relationship between cigarette smoking and dementia in elderly people through prospective studies. We did a 2-year follow-up study of elderly people. A total of 2820 participants aged 60 years old and over from six communities of Chongqing agreed to take part. Dementia was diagnosed with MMSE (Mini-Mental State Examination) and DSM-III-R (Diagnostic and Statistical Manual of Mental Disorders). Participants were classified as never smokers, past ...

Known for Cigarette Smoking |  Risk Dementia |  Alzheimers Disease |  Current Smokers |  Mental Disorders
KOL Index score: 9371

Reactive oxygen species (ROS) are associated with inflammation and vasculature dysfunction. This study aimed to investigate the potential role of the ROS on vascular Toll-like receptor 4 (TLR4)-mediated proinflammatory and proliferative phenotype of vascular smooth muscle cells (VSMCs). A wire-induced carotid injury model was used in male TLR4-deficient (TLR4−/−) and wild-type C57BL/6J mice to induce neointima formation. In the presence or absence of the ROS scavenger apocynin for 14 ...

Known for Smooth Muscle |  Reactive Oxygen |  Proliferative Phenotype |  Vascular Myocytes |  Intimal Hyperplasia


ChangYue Gao: Influence Statistics

Sample of concepts for which ChangYue Gao is among the top experts in the world.
Concept World rank
deterioration serum #1
p75ecd neuroprotective function #1
gene k469e polymorphism #1
association neurological deterioration #1
k469e polymorphism stroke #1
sdinduced cognitive dysfunction #1
cbmdisc cnki #1
science cbmdisc #1
admission neurological deterioration #1
aβ p75ecd #1
association icam1 gene #1
selectin neurological #1
highdose p75ecdfc #1
prospective preventive measure #1
models allelic #1
predictors poststroke dementia #1
peripheral supplementation p75ecdfc #1
models allelic model #1
cbmdisc #1
p75ecd induced #1
ectodomain ameliorates #1
mice p75ecd #1
mice p75ecdfc #1
current study p75ecdfc #1
sicam1 admission #1
fragment immunoglobulin igg1 #1
p75ecdfc pathologies #1
peripheral supplementation #1
svcam1 admission #1
chinese population conclusion #1
vsmc functions atherosclerosis #2
tlr4mediated proinflammatory #2
sirt1 vsmc functions #2
tlr4mediated inflammation #2
asians combined ors #2
upregulating ucp2 expression #2
smooth vascular sirtuin #2
interesting link trpv1 #2
hypertension cardiovascular models #2
upregulation acat1 #2
polymorphism ischemic #2
critical early process #2
vsmcs upregulating #2
c344t gene polymorphism #2
capsaicin cumulative studies #2

Key People For Ischemic Stroke

Top KOLs in the world
Ralph L Sacco
ischemic stroke northern manhattan study carotid plaque
Harold P Jr Adams
ischemic stroke cerebral infarction subarachnoid hemorrhage
José Biller
ischemic stroke cerebral infarction neurologic complications
Laurens Jaap Kappelle
ischemic stroke type 2 diabetes cognitive impairment
Geoffrey Alan Donnan
ischemic stroke atrial fibrillation intracerebral haemorrhage
Jeffrey L Saver
acute ischemic stroke endovascular thrombectomy united states

ChangYue Gao:Expert Impact

Concepts for whichChangYue Gaohas direct influence:Ischemic stroke,  Chinese population,  Cognitive impairment,  Lipid accumulation,  Peritoneal dialysis,  Vascular risk,  Stroke patients,  Cerebrovascular disease.

ChangYue Gao:KOL impact

Concepts related to the work of other authors for whichfor which ChangYue Gao has influence:Cognitive impairment,  Alzheimer disease,  Ischemic stroke,  Vascular dementia,  Smooth muscle,  Leisure activities,  Alcohol consumption.



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Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, 10 Changjiang Branch Road, Yu-Zhong District, 400042 Chongqing, China. Electronic address: | Chongqing Key Laboratory of Aging and Brain Disease

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