 | Andrew J Thomson |
Prominent publications by Andrew J Thomson
Cell Adhesion Molecule Expression in the Cervix and Myometrium During Pregnancy and Parturition
[ PUBLICATION ]
OBJECTIVE: To determine the expression and localization of cell adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin, platelet-endothelial cell adhesion molecule (PECAM), and vascular cell adhesion molecule (VCAM) in the cervix and myometrium during pregnancy and labor.
METHODS: Biopsies of myometrium and cervix were obtained from non-pregnant women and from pregnant women before and after onset of spontaneous labor at term. Cell adhesion molecule mRNA expression was ...
| Also Ranks for: Cell Adhesion | myometrium cervix | molecule expression | pregnancy labor | pregnant women |
Accumulating evidence suggests that human parturition represents an inflammatory process. Leukocytes are known to infiltrate uterine tissues but the exact timing, nature and quantity of these cells has not been formally characterized. We have previously demonstrated an apparent increase in pro-inflammatory cytokines within tissues of the labouring uterus. The aims of this study were to quantify and compare the leukocyte subpopulations before and during labour in fetal membranes, decidua ...
| Also Ranks for: Mrna Expression | myometrium cervix | leukocyte density | inflammatory process | onset labour |
Immunolocalization of Proinflammatory Cytokines in Myometrium, Cervix, and Fetal Membranes During Human Parturition at Term1
[ PUBLICATION ]
Each of the proinflammatory cytokines interleukin (IL)-1beta, IL-6, IL-8, and tumor necrosis factor (TNF) alpha has been identified in reproductive tissues during labor. The cellular origin of these cytokines is unclear. The aim of this study was to localize these proinflammatory cytokines in myometrium (upper and lower segment), cervix, and fetal membranes at term. Biopsies were taken from women undergoing cesarean section either before or after the onset of labor. Immunohistochemistry ...
| Also Ranks for: Fetal Membranes | proinflammatory cytokines | myometrium cervix | human parturition | infiltrating leukocytes |
Superoxide, an agent which attenuates the half-life of nitric oxide, is metabolized and synthesized by superoxide dismutase (SOD) and xanthine oxidase, respectively. Over the last few years much work has focused on the role of nitric oxide in human parturition. The aim of this study was to determine whether the onset of human parturition is associated with a change in the expression of copper/zinc superoxide dismutase (Cu/Zn SOD), manganese superoxide dismutase (Mn SOD) or xanthine ...
| Also Ranks for: Xanthine Oxidase | superoxide dismutase | fetal membranes | zn sod | nitric oxide |
Nitric oxide donors induce ripening of the human uterine cervix: a randomised controlled trial
[ PUBLICATION ]
OBJECTIVE: To determine whether nitric oxide donors can induce cervical ripening before surgical termination of pregnancy in the first trimester.
DESIGN: Prospective, randomised controlled trial.
SETTING: Department of Obstetrics and Gynaecology, Royal Infirmary, Glasgow.
PARTICIPANTS: Forty-eight primigravid women undergoing surgical termination of pregnancy before 12 weeks of gestation.
METHODS: The women were randomised to receive per vaginam before surgery either the nitric oxide ...
| Also Ranks for: Nitric Oxide Donors | induced administration | human uterine cervix | pregnancy trimester | cumulative force |
OBJECTIVE: To determine whether a combined therapy with isosorbide mononitrate (40mg) and misoprostol (400 microg) for pre-operative cervical ripening in the first trimester would result in improved clinical effectiveness, and fewer side effects compared with each agent used alone.
DESIGN: Randomised controlled trial.
SETTING: Glasgow Royal Infirmary.
POPULATION: Sixty-six primigravid women scheduled for suction termination of pregnancy.
METHODS: Women were randomly assigned to receive ...
| Also Ranks for: Isosorbide Mononitrate | combination therapy | cervical ripening | nonsteroidal abortion | 400 microg |
Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process
[ PUBLICATION ]
Inflammatory mediators in the cervix, placenta and fetal membranes play a crucial role in human parturition. The aim of this study was to determine whether the upper and lower segments of the myometrium are infiltrated by inflammatory cells during pregnancy and parturition. Myometrial biopsies were obtained from non-pregnant women, and pregnant women at term before and after the onset of spontaneous labour. Subpopulations of inflammatory cells were identified using immunocytochemistry. ...
| Also Ranks for: Human Parturition | inflammatory process | spontaneous labour | pregnant women | cell adhesion |
Changes in the expression of nitric oxide synthase in the human uterine cervix during pregnancy and parturition
[ PUBLICATION ]
Nitric oxide (NO) has been proposed as a mediator of cervical ripening. We investigated the expression, using Western blotting, and localization, using immunohistochemistry, of the nitric oxide synthase (NOS) enzymes, inducible NOS (iNOS), endothelial NOS (eNOS) and neuronal NOS (bNOS) in the human cervix during pregnancy and parturition. Cervical biopsies were obtained from non-pregnant women, women in the first trimester of pregnancy, and pregnant women at term before and after the ...
| Also Ranks for: Oxide Synthase | human uterine cervix | trimester pregnancy | inos expression | cervical ripening |
BACKGROUND: Accidental out-of-hospital (OHD) deliveries are associated with high rates of perinatal morbidity and mortality. The ability of health care workers to identify women at risk of out-of-hospital delivery is limited. The purpose of this study was to determine the prevalence of these deliveries in our population and to quantify the neonatal morbidity and mortality associated with such births. Further we aimed to determine whether women at risk of accidental out-of-hospital ...
| Also Ranks for: Hospital Deliveries | case control | women risk | perinatal morbidity | delivery obstetric |
Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium: regulation by interferon-γ
[ PUBLICATION ]
The purpose of this study was to localize intercellular adhesion molecule (ICAM)-1 and ICAM-2 in human endometrium and myometrium throughout the menstrual cycle, and to determine whether the expression of these molecules is regulated by interferon (IFN)-gamma. ICAM-1 and ICAM-2 distribution was examined in endometrial biopsies by immunocytochemistry, and Northern blotting was used to quantify ICAM-1 and ICAM-2 mRNA expression in isolated endometrial glands. Stromal fibroblast cultures ...
| Also Ranks for: Intercellular Adhesion | expression icam1 | human endometrium | menstrual cycle | vascular endothelium |
Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy
[ PUBLICATION ]
BACKGROUND: Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix. We investigated whether this drug is associated with fewer side-effects than prostaglandins when used to ripen the cervix before first-trimester surgical termination of pregnancy, and assessed whether the extent of cervical ripening it induces is clinically sufficient.
METHODS: 66 primigravid women scheduled for surgical termination were assigned to ...
| Also Ranks for: Isosorbide Mononitrate | trimester termination | nitric oxide donor | nonsteroidal abortion | cervical resistance |
Expression and localization of cell adhesion molecules in human fetal membranes during parturition
[ PUBLICATION ]
There is increasing evidence to support the view that human parturition represents an inflammatory process. We have previously demonstrated that parturition is associated with leukocyte invasion and pro-inflammatory cytokine production in the cervix and myometrium. Furthermore, we have shown that several cell adhesion molecules are upregulated in these tissues during labor. In fetal membranes, previous studies have shown intercellular adhesion molecule-1 (ICAM-1) upregulation in ...
| Also Ranks for: Adhesion Molecules | fetal membranes | inflammatory process | human parturition | pregnant women |
Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process
[ PUBLICATION ]
Inflammatory mediators in the cervix, placenta and fetal membranes play a crucial role in human parturition. The aim of this study was to determine whether the upper and lower segments of the myometrium are infiltrated by inflammatory cells during pregnancy and parturition. Myometrial biopsies were obtained from non-pregnant women, and pregnant women at term before and after the onset of spontaneous labour. Subpopulations of inflammatory cells were identified using immunocytochemistry. ...
| Also Ranks for: Human Parturition | inflammatory process | spontaneous labour | pregnant women | leukocytes myometrium |
Low molecular weight heparin for the treatment of venous thromboembolism in pregnancy: a case series
[ PUBLICATION ]
OBJECTIVES: To assess the use of low molecular weight heparin for the treatment of venous thromboembolism in pregnancy.
DESIGN: A prospective observational study.
SETTING: The maternity units in two university teaching hospitals and one district general teaching hospital.
POPULATION: Thirty-six consecutive women presenting with objectively diagnosed venous thromboembolism during pregnancy and the immediate puerperium.
METHODS: Treatment with the low molecular weight heparin enoxaparin, ...
| Also Ranks for: Venous Thromboembolism | weight heparin | low molecular | regional anaesthesia | pregnancy puerperium |
Andrew J Thomson: Influence Statistics
| Concept | World rank |
|---|---|
| underlying pte | #2 |
| profound haemorrhage | #2 |
| nonhaemorrhagic obstetric shock | #2 |
| donors isosorbide | #2 |
| pregnancy pulmonary thromboembolism | #2 |
| heparin amniotic | #2 |
| mononitrate ripen | #2 |
| chapter 27 advances | #2 |
| mononitrate 40 | #2 |
| heparin objective testing | #2 |
| labor human myometrium | #2 |
| lower binding properties | #2 |
| cardiovascular pregnancy doppler | #2 |
| 27 advances | #2 |
| inversion sepsis | #2 |
| haemorrhagic obstetric | #2 |
| vcam localized | #3 |
| women isosorbide mononitrate | #3 |
| pecam vascular | #3 |
| postlaboring amnion | #3 |
| women pecam | #3 |
| upregulated myometrium | #3 |
| upregulated cervix | #3 |
| doppler lowmolecularweight humans | #3 |
| choriodecidua cell types | #3 |
| 337 94 microg | #3 |
| women vcam | #3 |
| labor vcam | #3 |
| conclusionsenoxaparin | #3 |
| icam1 mrna cervix | #3 |
| ripening dose | #3 |
| vaginam isosorbide | #3 |
| pecam localized | #3 |
| parturition intercellular adhesion | #3 |
| icam1 localized | #3 |
| molecules cervix labor | #3 |
| 01 labor | #3 |
| cervix myometrium | #3 |
| vcam vascular endothelium | #3 |
| daily complication | #3 |
| settingthe maternity units | #3 |
| labor pecam | #3 |
| biopsies myometrium | #3 |
| pecam mrna myometrium | #3 |
Key People For Isosorbide Mononitrate
Andrew J Thomson:Expert Impact
Concepts for whichAndrew J Thomsonhas direct influence:Isosorbide mononitrate, Nitric oxide, Venous thromboembolism, Xanthine oxidase, Fetal membranes, Human parturition, Nitric oxide donors, Human pregnancy.
Andrew J Thomson:KOL impact
Concepts related to the work of other authors for whichfor which Andrew J Thomson has influence:Preterm birth, Nitric oxide, Fetal membranes, Venous thromboembolism, Isosorbide mononitrate, Pregnant women, Cervical ripening.
Tools
Is this your profile? Claim your profile Copy URL Embed Link to your profile |