Haruaki Tomioka: Influence Statistics

Haruaki Tomioka

Haruaki Tomioka

Department of Basic Medical Science for Nursing, Department of Primary Education, Yasuda Women’s University, Hiroshima 731-0153, Japan | Department of Microbiology and ...

Haruaki Tomioka: Expert Impact

Concepts for which Haruaki Tomioka has direct influence: Mycobacterium avium , Mycobacterium tuberculosis , Avium complex , Therapeutic efficacy , Complex mycobacterium , Mycobacterium avium complex , Mycobacterial infections .

Haruaki Tomioka: KOL impact

Concepts related to the work of other authors for which for which Haruaki Tomioka has influence: Mycobacterium tuberculosis , Avium complex , Nitric oxide , Antitubercular agents , Vitro activity , Human macrophages , Therapeutic efficacy .

KOL Resume for Haruaki Tomioka

Year
2019

Department of Basic Medical Science for Nursing, Department of Primary Education, Yasuda Women’s University, Hiroshima 731-0153, Japan

2018

Department of Basic Medical Sciences for Nursing, Yasuda Women’s University, Hiroshima, Japan

2017

Department of Basic Medical Sciences for Nursing, Department of Primary Education, Yasuda Women's University, Hiroshima 731-0153, Japan

2016

Department of Basic Medical Sciences for Nursing, Yasuda Women’s University, Hiroshima 731-0153, Japan

2015

Faculty of Nursing, Yasuda Women's University, Hiroshima 231-0153, Japan

2014

Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan

2013

Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan.

2012

Department of Microbiology and Immunology, Shimane University School of Medicine.

2011

Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Japan

2010

Department of Microbiology and Immunology, Shimane University School of Medicine, 89-1, Enyacho, Izumo-shi, Shimane 693-8501, Japan.

2008

Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, Japan.

2007

Department of Microbiology and Immunology, Shimane University School of Medicine, Enya-cho 89-1, Izumo, Shimane 693-8501, Japan

2006

Shimane University School of Medicine Department of Microbiology and Immunology Izumo Shimane Japan

2005

Department of Microbiology and Immunology,

2004

Department of Microbiology and Immunology, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan.

2003

Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane, Japan.

2002

Department of Microbiology and Immunology, Shimane Medical University, Izumo, 693-8501, Japan

2001

Department of Microbiology and Immunology, Shimane Medical University

2000

Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan.

1999

Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane 693, Japan

1998

From the Department of Microbiology and Immunology, Shimane Medical University

1997

Department of Microbiology and Immunology, Shimane Medical University, Japan.

1996

島根医科大学微生物・免疫

Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane, Japan,

1995

Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan

1994

Department of Microbiology and Immunology, Shimane Medical University, Izumo 693, Japan

1993

Department of Microbiology and Immunology, Japan

島根医科大学微生物・免疫学教室

1992

Department of Microbiology and Immunology, Shimane Medical University, 693, Izumo, Shimane, Japan

1991

Department of Microbiology and Immunology, Shimane Medical University, Shimane, Japan

1990

Shimane Medical University Department of Alicrobiology and Immunology Izumo Shimane

1989

Shimane Medical University Department of Microbiology and Immunology Izumo Shimane

1987

Shimane Medical University Department of Microbiology and Immunology Izumo, Shimane

1983

Shimane Medical University Department of Microbioloyg and Immunology Izumo, Shimane

1979

Department of Microbiology and Immunology, Shimane Medical University, Izumo 693, Shimane, Japan

Prominent publications by Haruaki Tomioka

KOL-Index: 14216 . We assessed the role of free fatty acids (FFA) in the expression of the activity of macrophages against Mycobacterium tuberculosis in relation to the roles of two major anti-microbial effectors, reactive nitrogen intermediates (RNI) and reactive oxygen intermediates (ROI). Intracellular growth of M. tuberculosis residing inside macrophages was accelerated by treatments of macrophages with ...
Known for Mycobacterium Tuberculosis | Reactive Nitrogen Intermediates | Free Fatty Acids | Nitric Oxide
KOL-Index: 14188 . We attempted to identify the Mycobacterium avium complex (MAC) isolated in Japan by using DNA probes specific for M. avium or Mycobacterium intracellulare (Gen-Probe Rapid Diagnostic System for MAC; Gen-Probe, Inc., San Diego, Calif.). The source and drug susceptibility distributions were examined. This assay system proved to be rapid, sensitive, specific, and reliable for identification ...
Known for Mycobacterium Intracellulare | Dna Probes | Reagent Kits | Identification Mac
KOL-Index: 13805 . In order to verify the participation of some cytokines in the expression of the suppressor activity of splenic macrophages (M phi s) induced by Mycobacterium avium complex (MAC) infection, we studied whether anticytokine antibodies were capable of blocking their suppressor activity against concanavalin A (ConA)-induced mitogenesis of splenocytes (SPCs). When either anti-tumor necrosis ...
Known for Nitric Oxide | Mycobacterium Avium | Suppressor Activity | Growth Factor
KOL-Index: 12419 . Newly synthesized benzoxazinorifamycin, KRM-1648, was studied for its in vivo anti-Mycobacterium avium complex (MAC) activities. When the MICs were determined by the agar dilution method with Middlebrook 7H11 agar medium, KRM-1648 exhibited similarly potent in vitro antimicrobial activities against the MAC isolated from AIDS and non-AIDS patients, indicating possible usefulness of KRM-1648 ...
Known for Mycobacterium Avium | Complex Infection | Therapeutic Efficacy | Bacterial Loads
KOL-Index: 12409 . Reference strains of the Mycobacterium avium complex (MAC) belonging to serovars 1 to 28 were examined with DNA probes (Gen Probe Rapid Diagnostic System for the MAC; Gen Probe Inc., San Diego, Calif.) specific for either M. avium or Mycobacterium intracellulare. This study revealed that the earlier designations of the MAC serovars, in which serovars 1 to 3 and 4 to 28 were regarded as M. ...
Known for Dna Probes | Mycobacterium Avium | Mac Serovars | Gen Probe
KOL-Index: 11964 . In this study, we evaluated the roles of reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI), and free fatty acids (FFA) as effectors of the macrophage-mediated host defence mechanism against Mycobacterium avium complex (MAC). First, M. avium (three strains) and M. intracellulare (two strains) were treated with the H2O2-Fe2+-mediated halogenation system, acidified ...
Known for Reactive Oxygen Intermediates | Free Fatty Acids | Mycobacterium Avium | Antimicrobial Activity
KOL-Index: 11905 . The in-vitro activities of KRM-1648, a new benzoxazinorifamycin, clarithromycin and levofloxacin against clinical isolates of Mycobacterium avium complex (MAC) were measured using various methods of assay and compared with their in-vivo therapeutic activities against MAC infection in mice. The MICs varied according to drug in the order KRM-1648 << clarithromycin < levofloxacin. However, ...
Known for Mycobacterium Avium | Antimicrobial Activities | Murine Peritoneal Macrophages | Therapeutic Efficacy Drugs
KOL-Index: 11756 . The in vitro and in vivo activities of a new benzoxazinorifamycin, KRM-1648 (KRM), against Mycobacterium tuberculosis were studied. The MIC at which 50% of the isolates are inhibited (MIC50) and the MIC90 of KRM for 30 fresh isolates of M. tuberculosis measured by the BACTEC 460 TB System were 0.016 and 2 micrograms/ml, respectively. These values were much lower than those for rifampin ...
Known for Mycobacterium Tuberculosis | Krm Rbt | New Benzoxazinorifamycin | Lung Mice
KOL-Index: 11420 . Although various antimicrobial agents exhibit appreciable microbicidal activity in the early phase (weeks 2 t0 4) of Mycobacterium avium complex (MAC) infection induced in mice, progressive bacterial regrowth subsequently occurs. To clarify the reason for this pattern of changes, we studied changes in the levels of various cytokines in tissue at sites of infection (spleens and lungs) of ...
Known for Mycobacterium Avium | Complex Infection | Early Phase | Tgf Beta
KOL-Index: 10765 . MICs of a newly developed benzoxazinorifamycin derivative, KRM-1648, for Mycobacterium avium complex (MAC) were determined by the BACTEC 460 TB system and compared with those of other known antimicrobial agents. The radiometric method gave a fast, accurate, and reproducible MIC for each antimicrobial agent. MICs of KRM-1648 for 30 strains of MAC (10 strains each of M. avium isolated from ...
Known for Mycobacterium Avium | Nonaids Patients | Rifampin Rifabutin | Vitro Antimicrobial Activity
KOL-Index: 10731 . We studied the activities of clarithromycin and fluoroquinolones (gatifloxacin, sitafloxacin, levofloxacin) in combination with other antimycobacterial drugs against extracellular and intramacrophage Mycobacterium avium complex (MAC). Clarithromycin potentiated the activities of rifampicin and rifalazil against both extracellular and intramacrophage MAC. In contrast, all the test ...
Known for Antimycobacterial Drugs | Mycobacterium Avium | Antimicrobial Activities | Fluoroquinolones Gatifloxacin
KOL-Index: 10561 . The anti-mycobacterial activities of IFN-gamma and TNF-alpha-treated murine peritoneal macrophages were determined. Resident macrophages pretreated with IFN-gamma or TNF-alpha for 2 days were infected with test organisms and subsequently cultured for up to 7 days. First, the early-phase growth of Mycobacterium tuberculosis (days 0-3) was strongly suppressed in IFN-gamma-treated ...
Known for Murine Peritoneal Macrophages | Reactive Nitrogen | Tumour Necrosis Factor‐alpha | Mycobacterium Tuberculosis

Key People For Mycobacterium Avium

Top KOLs in the world
#1
Luiz Eduardo M Bermudez
mycobacterium avium epithelial cells human macrophages
#2
Richard J Wallace
nontuberculous mycobacteria mycobacterium abscessus united states
#3
Charles Fordham von Reyn
united states mycobacterium avium hiv infection
#4
Michael D Iseman
mycobacterium avium resistant tuberculosis pulmonary disease
#5
Joseph Oliver Falkinham
mycobacterium avium nontuberculous mycobacteria united states
#6
Charles Robert Horsburgh
united states south africa mycobacterium avium

Department of Basic Medical Science for Nursing, Department of Primary Education, Yasuda Women’s University, Hiroshima 731-0153, Japan | Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo 693-8501, Japan | Departm