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    • An E Vanhaesebrouck
    • An E Vanhaesebrouck

      An E Vanhaesebrouck

      The Department of Veterinary Medicine, University of Cambridge, Cambridge, UK | Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, ...



      KOL Resume for An E Vanhaesebrouck


      The Department of Veterinary Medicine, University of Cambridge, Cambridge, UK


      Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom


      Department of Veterinary Medicine University of Cambridge Cambridge UK


      Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK


      Department of Veterinary Medicine, Veterinary Medicine School, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.


      The Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK


      Department of Veterinary Medicine, Queen's Veterinary School Hospital, Cambridge University, Madingley Road, Cambridge CB3 0ES, UK


      Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

      Ioannis N Plessas is now at the Royal Veterinary College, University of London, UK

      Anthony C Palmer and Fernando Constantino-Casas contributed equally to this work


      Queen’s Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES

      Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium


      Department of Small Animal Medicine and Clinical Biology


      Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium

      National Veterinary School of Alfort, Maisons-Alfort, France



      An E Vanhaesebrouck: Influence Statistics

      Sample of concepts for which An E Vanhaesebrouck is among the top experts in the world.
      Concept World rank
      argillacea mycosis #2
      rasamsonia argillacea mycosis #2
      neuromyotonia jack #4
      8 jrts #5
      neuromyotonic attack #5
      neuromyotonia clinical signs #5
      neuromyotonia nm #5
      dogs thirty dogs #5
      pnh generalized myokymia #5
      neuromyotonia jack russell #5
      dogs neuromyotonic #5
      jrts neuromyotonia #5
      58 veterinary cases #5
      sep neuromyotonic #5
      terriers myokymia #5
      terriers dysfunction #5
      pnh veterinary #5
      jrts nm #5
      pnh veterinary medicine #5
      generalized myokymia neuromyotonia #5
      healthy jrts #5
      nm jrts #5
      jrts animals #5
      jrts 8 #5
      signs myokymia #5
      medicine myokymia #5
      8 jrts nm #5
      pnh hyperexcitability #5
      macroscopically visible myokymia #5
      neuromyotonia veterinary #5
      unpublished treatment #5
      cramp myokymia #5
      natural occurring pnh #5
      clinical baep #5
      pnh generalized #5
      vermicular muscle contractions #5
      pnh jack russell #5
      veterinary medicine myokymia #5
      latencies tibial #5
      jack russell pnh #5
      hereditary ataxia myokymia #5
      neuromyotonic ataxia #5
      37 jack #5
      neuromyotonia 37 #5
      neuromyotonia veterinary medicine #5
      terriers syndrome #6
      predicted canine orthologs #6
      neuromyotonia spinocerebellar ataxia #6
      episodic muscle rippling #6
      terriers kcna1 #6


      Prominent publications by An E Vanhaesebrouck

      KOL-Index: 7769

      To date there is no evidence-based data for efficacious treatment of neuropathic pain in dogs with Chiari-like malformation (CM) and syringomyelia (SM). The objective of this prospective cross-over study was to compare the effect of gabapentin versus topiramate, as an add-on treatment to carprofen, on quality of life (QoL) of dogs experiencing signs of neuropathic pain due to CM/SM. A visual analogue scale (VAS) was used to assess the QoL: (1) on day 0; (2) after 1 week of carprofen ...

      Known for Neuropathic Pain | Quality Life | Malformation Syringomyelia | Dogs Chiari | Analgesics Animals
      KOL-Index: 7486

      The clinical and clinicopathological characteristics, treatment and outcome of vermicular muscle contractions (myokymia) and generalized muscle stiffness (neuromyotonia) in 37 Jack Russell terriers were evaluated retrospectively. Thirty dogs were affected by both disorders, whereas seven were presented with myokymia and never developed neuromyotonia. Clinical signs started at the mean age of 8 months. Except for signs of myokymia and neuromyotonia, clinical and neurological examination ...

      Known for Jack Russell | Myokymia Neuromyotonia | Clinical Signs | Hereditary Ataxia | Diseases Dogs
      KOL-Index: 6999

      BACKGROUND: Intranasal administration of benzodiazepines has shown superiority over rectal administration for terminating emergency epileptic seizures in human trials. No such clinical trials have been performed in dogs.

      OBJECTIVE: To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management option for canine status epilepticus and compare it to rectal administration of diazepam (R-DZP) for controlling status epilepticus ...

      Known for Status Epilepticus | Intranasal Administration | Cessation Time | Randomized Parallel | 5 Minutes
      KOL-Index: 5905

      Brachial plexus trauma is a common clinical entity in small animal practice and prognostic indicators are essential early in the course of the disease. Magnetic stimulation of the radial nerve and consequent recording of the magnetic motor evoked potential (MMEP) was examined in 36 dogs and 17 cats with unilateral brachial plexus trauma. Absence of deep pain perception (DPP), ipsilateral loss of panniculus reflex, partial Horner's syndrome and a poor response to MMEP were related to the ...

      Known for Magnetic Stimulation | Brachial Plexus | Radial Nerve | Dogs Cats | Panniculus Reflex
      KOL-Index: 5679

      BACKGROUND: Seizures are a common presenting sign in dogs with brain tumors.

      HYPOTHESIS/OBJECTIVES: To investigate the effect of radiotherapy on freedom from brain tumor-associated seizures and survival time in dogs.

      ANIMALS: Thirty-two client-owned dogs with brain tumor-associated seizures; 18 received medical treatment and radiotherapy, 14 received medical treatment alone.

      METHODS: Multicenter retrospective study. Baseline characteristics (seizure semiology, magnetic resonance imaging ...

      Known for Brain Tumors | Seizures Dogs | Retrospective Studies | Glioma Humans | Neoplasms Diseases
      KOL-Index: 5461

      A 14-year-old male domestic shorthair cat presented with an acute onset of aggressive behaviour, fear and hypersalivation. Neurological examination revealed bilateral mydriasis and left-sided facial twitching and hemiparesis. Magnetic resonance imaging (MRI) showed moderate bilateral symmetrical T2-hyperintensity along the entire hippocampus and bilateral asymmetric T2-hyperintensity in the pyriform lobes. Marked bilateral contrast enhancement of the hippocampus was evident on ...

      Known for Temporal Lobe | Hippocampal Necrosis | Acute Onset | Medical Treatment | Magnetic Resonance Imaging
      KOL-Index: 5197

      PURPOSE OF REVIEW: Congenital myasthenic syndromes (CMS) are a group of heterogeneous inherited disorders caused by mutations in genes encoding proteins whose function is essential for the integrity of neuromuscular transmission. This review updates the reader on the expanding phenotypic spectrum and suggested improved treatment strategies.

      RECENT FINDINGS: As next-generation sequencing is taken into the clinic, its use is both continuing to unearth new causative genes in which mutations ...

      Known for Congenital Myasthenic | Genes Mutations | Neuromuscular Transmission | Central Nervous | Syndromes Cms
      KOL-Index: 5158

      KEY POINTS: The physiological significance of the developmental switch from fetal to adult acetylcholine receptors in muscle (AChRs) and the functional impact of AChR clustering by rapsyn are not well studied. Using patch clamp experiments, we show that recovery from desensitization is faster in the adult AChR isoform. Recovery from desensitization is determined by the AChR isoform-specific cytoplasmic M3-M4 domain. The co-expression of rapsyn in muscle cells induced AChR clustering and ...

      Known for Adult Achrs | Acetylcholine Receptors | Neuromuscular Junction | Hek293 Cells | Achr Clustering
      KOL-Index: 5123

      BACKGROUND: Generalized myokymia and neuromyotonia (M/NM) in Jack Russell Terriers (JRTs) is related to peripheral nerve hyperexcitability syndrome in humans, a symptom complex resulting from diverse etiologies.

      OBJECTIVE: Clinical and electrodiagnostic evaluation is used to narrow the list of possible etiological diagnoses in JRTs with M/NM.

      ANIMALS: Nine healthy JRTs and 8 affected JRTs.

      METHODS: A prospective study was conducted comparing clinical and electrophysiological ...

      Known for Jack Russell Terriers | Hereditary Ataxia | Clinical Signs | Generalized Myokymia | Neuromyotonic Discharges
      KOL-Index: 5049

      A questionnaire-based study was used to investigate the association between the findings on magnetic resonance imaging (MRI) screening for syringomyelia (SM) in 79 asymptomatic Cavalier King Charles spaniels (CKCS) and the subsequent development of clinical signs consistent with SM in later life. Owners reported clinical signs consistent with SM in 13/79 (16%) dogs at the time of the questionnaire. A significantly greater proportion of CKCS with a syrinx visible on MRI screening showed ...

      Known for Clinical Signs | Magnetic Resonance | King Charles | Questionnaires Syringomyelia | Imaging Mri
      KOL-Index: 4873

      SeSAME/EAST syndrome is a multisystemic disorder in humans, characterised by seizures, sensorineural deafness, ataxia, developmental delay and electrolyte imbalance. It is exclusively caused by homozygous or compound heterozygous variations in the KCNJ10 gene. Here we describe a similar syndrome in two families belonging to the Malinois dog breed, based on clinical, neurological, electrodiagnostic and histopathological examination. Genetic analysis detected a novel pathogenic KCNJ10 ...

      Known for Malinois Dogs | Hearing Loss | Kcnj10 Gene | Electrolyte Imbalance | Canine Phenotype
      KOL-Index: 4830

      Acetylcholine receptor deficiency is the most common form of the congenital myasthenic syndromes, a heterogeneous collection of genetic disorders of neuromuscular transmission characterized by fatiguable muscle weakness. Most patients with acetylcholine receptor deficiency respond well to acetylcholinesterase inhibitors; however, in some cases the efficacy of acetylcholinesterase inhibitors diminishes over time. Patients with acetylcholine receptor deficiency can also benefit from the ...

      Known for Neuromuscular Junction | Myasthenic Syndromes | Β2adrenergic Agonists | Acetylcholine Receptor | Synaptic Transmission
      KOL-Index: 4775

      KCNA1, KCNA2, KCNA6 and KCNQ2 are associated with peripheral nerve hyperexcitability in humans. In order to determine if these genes are also involved in Jack Russell Terriers with a similar syndrome characterized by myokymia and neuromyotonia, their predicted canine orthologs were first validated experimentally. They were found either incompletely or even incorrectly annotated, mainly due to gaps in the canine genomic sequence and insufficient transcript data. Canine KCNQ2 was found to ...

      Known for Jack Russell Terriers | Peripheral Nerve | Hyperexcitability Syndrome | Potassium Channel | Myokymia Neuromyotonia
      KOL-Index: 4731

      A 4-month-old female entire domestic shorthair cat presented with an acute onset of blindness, tetraparesis and subsequent generalised seizure activity. Haematology and serum biochemistry demonstrated a moderate, poorly regenerative anaemia, hypoalbuminaemia and hyperglobulinaemia with a low albumin:globulin ratio. Serology for feline coronavirus antibody was positive with an elevated alpha-1 acid glycoprotein. Analysis of cisternal cerebrospinal fluid (CSF) demonstrated markedly ...

      Known for Feline Infectious Peritonitis | Cerebrospinal Fluid | Csf Macrophages | Cats Coronavirus | Antemortem Diagnosis
      KOL-Index: 4670

      Involuntary muscle hyperactivity can result from muscle or peripheral nerve hyperexcitability or central nervous system dysfunction. In humans, diseases causing hyperexcitability of peripheral nerves are grouped together under the term 'peripheral nerve hyperexcitability' (PNH). Hyperexcitability of the peripheral motor nerve can result into five different phenotypic main variants, i.e. fasciculations, myokymia, neuromyotonia, cramps and tetany, each with their own clinical and ...

      Known for Myokymia Neuromyotonia | Jack Russell | Peripheral Nerve | Potassium Channel | Isaacs Syndrome

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      An E Vanhaesebrouck:Expert Impact

      Concepts for whichAn E Vanhaesebrouckhas direct influence:Jack russell terriers,  Clinical signs,  Jack russell,  Status epilepticus,  Labrador retrievers,  Veterinary medicine,  Spinal epidural empyema,  Magnetic stimulation.

      An E Vanhaesebrouck:KOL impact

      Concepts related to the work of other authors for whichfor which An E Vanhaesebrouck has influence:Clinical signs,  Myasthenia gravis,  Neuromuscular junction,  Feline infectious peritonitis,  Spinocerebellar ataxia,  Neuropathic pain,  Congenital myasthenic syndrome.



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      The Department of Veterinary Medicine, University of Cambridge, Cambridge, UK | Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK | Department of Veterinary Medicine, U

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