Prominent publications by Alberto Martini

KOL Index score: 16018

OBJECTIVES: To validate the previously proposed classification criteria for Henoch-Schönlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).

METHODS: Step 1: retrospective/prospective web-data collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis consensus panel of a representative sample of 280 cases. Step 3: statistical (sensitivity, ...

Known for Classification Criteria |  Childhood Takayasu |  Henoch–schönlein Purpura |  Ankara 2008 |  Polyarteritis Nodosa
KOL Index score: 15181

BACKGROUND: Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF antibody, in children with polyarticular-course juvenile rheumatoid arthritis.

METHODS: Patients 4 to 17 years of age with active juvenile rheumatoid arthritis who had previously received treatment with nonsteroidal antiinflammatory drugs underwent stratification according to methotrexate use and received 24 ...

Known for Juvenile Rheumatoid Arthritis |  Adalimumab Methotrexate |  Monoclonal Antibodies |  Acr Pedi |  Treatment Children
KOL Index score: 14879

OBJECTIVE: To develop response criteria for juvenile dermatomyositis (DM).

METHODS: We analyzed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to ...

Known for Major Clinical |  Core Measures |  Juvenile Dermatomyositis |  Rheumatology International |  Response Criteria
KOL Index score: 14540

OBJECTIVE: To validate and promulgate a core set of outcome measures for the evaluation of response to treatment in patients with juvenile systemic lupus erythematosus (SLE).

METHODS: In 2001, a preliminary consensus-derived core set of measures for evaluating the response to therapy in juvenile SLE was established. In the present study, the core set was validated through an evidence-based, large-scale data collection process that led to the enrollment of 557 patients from 39 different ...

Known for Response Therapy |  Lupus Erythematosus |  Prospective Validation |  Juvenile Systemic |  International Trials
KOL Index score: 14464

BACKGROUND: Some children with juvenile idiopathic arthritis either do not respond, or are intolerant to, treatment with disease-modifying antirheumatic drugs, including anti-tumour necrosis factor (TNF) drugs. We aimed to assess the safety and efficacy of abatacept, a selective T-cell costimulation modulator, in children with juvenile idiopathic arthritis who had failed previous treatments.

METHODS: We did a double-blind, randomised controlled withdrawal trial between February, 2004, ...

Known for Juvenile Idiopathic Arthritis |  Patients Abatacept |  6 Months |  Withdrawal Trial |  Illness Treatment Outcome
KOL Index score: 14461

BACKGROUND: Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human, anti-interleukin-1β monoclonal antibody, in two trials.

METHODS: In trial 1, we randomly assigned patients, 2 to 19 years of age, with systemic JIA and active systemic features (fever; ≥2 active joints; C-reactive protein, >30 mg per liter; and glucocorticoid dose, ≤1.0 mg per kilogram of body weight per ...

Known for Canakinumab Patients |  Monoclonal Antibodies |  Systemic Jia |  Humanized Arthritis |  Juvenile Child Child
KOL Index score: 14258

OBJECTIVE: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent cells characterized by immunomodulatory properties and are therefore considered a promising tool for the treatment of immune-mediated diseases. This study was undertaken to assess the influence of murine BM-MSCs on the activation of B cells in (NZB × NZW)F(1) mice as an animal model of systemic lupus erythematosus (SLE).

METHODS: We evaluated the in vitro effects of BM-MSCs on the proliferation and ...

Known for Bone Marrow |  Systemic Lupus Erythematosus |  Murine Model |  Cell Activation |  Mesenchymal Stem
KOL Index score: 13763

OBJECTIVE: To investigate the level of agreement between patients, mothers, fathers, and physicians in rating pain intensity in juvenile idiopathic arthritis (JIA), and to identify factors explaining discrepancies between raters.

METHODS: Ninety-four children with JIA and their mothers and fathers were asked to rate independently the intensity of present pain and pain in the previous week on a visual analog scale. The physicians rated pain intensity after physical examination. Agreement ...

Known for Pain Children |  Juvenile Idiopathic Arthritis |  Mothers Fathers |  Level Agreement |  Parents Physicians
KOL Index score: 13620

OBJECTIVE: To use the Pediatric Rheumatology International Trials Organization (PRINTO) core set of outcome measures to develop a validated definition of improvement for the evaluation of response to therapy in juvenile systemic lupus erythematosus (SLE).

METHODS: Thirty-seven experienced pediatric rheumatologists from 27 countries, each of whom had specific experience in the assessment of juvenile SLE patients, achieved consensus on 128 patient profiles as being clinically improved or ...

Known for Lupus Erythematosus |  Provisional Criteria |  Juvenile Systemic |  Rheumatology International |  Prospective Validation
KOL Index score: 13416

OBJECTIVE: To analyze the long-term impact of the R92Q mutation of TNFRSF1A in children with periodic fever, in comparison with children with tumor necrosis factor receptor-associated periodic syndrome (TRAPS) with TNFRSF1A structural mutations and children with periodic fever of unknown origin fulfilling the criteria for periodic fever, aphthosis, pharyngitis, and adenitis syndrome (PFAPA).

METHODS: The extracellular region of TNFRSF1A was analyzed in 720 consecutive children with ...

Known for R92q Mutation |  Tnfrsf1a Gene |  Periodic Fever |  Traps Patients |  Tumor Necrosis Factor
KOL Index score: 13279

The aim of the study was to characterise CCR7+ and CCR7- memory T cells infiltrating the inflamed joints of patients with juvenile idiopathic arthritis (JIA) and to investigate the functional and anatomical heterogeneity of these cell subsets in relation to the expression of the inflammatory chemokine receptors CXCR3 and CCR5. Memory T cells freshly isolated from the peripheral blood and synovial fluid (SF) of 25 patients with JIA were tested for the expression of CCR7, CCR5, CXCR3 and ...

Known for Juvenile Idiopathic Arthritis |  Memory Cells |  Patients Jia |  Ccr7 Receptors |  Ccr5 Cxcr3
KOL Index score: 13155

CONTEXT: Novel therapies have improved the remission rate in chronic inflammatory disorders including juvenile idiopathic arthritis (JIA). Therefore, strategies of tapering therapy and reliable parameters for detecting subclinical inflammation have now become challenging questions.

OBJECTIVES: To analyze whether longer methotrexate treatment during remission of JIA prevents flares after withdrawal of medication and whether specific biomarkers identify patients at risk for flares.


Known for 12 Months |  Methotrexate Withdrawal |  Patients Jia |  Juvenile Idiopathic Arthritis |  Clinical Trial
KOL Index score: 13026

CC chemokine ligand 1 (CCL1; I-309) is a CC chemokine that interacts with CC chemokine receptor 8, which is preferentially expressed in polarized T helper cell type 2 and Tc2 cells, in eosinophils, and in T regulatory cells. The present study, prompted by transcriptional profiling of human monocytes undergoing different forms of activation, was designed to characterize the production of CCL1 in monocytes compared with the production of other chemokines (CCL2, CCL22, and CCL18) ...

Known for Human Monocytes |  Chemokine Production |  Type 2 |  Fcγ Receptor |  Arthritis Juvenile


Alberto Martini: Influence Statistics

Sample of concepts for which Alberto Martini is among the top experts in the world.
Concept World rank
antiphospholipid paediatrics #1
italian jia patients #1
oligoarticular jia #1
jca pdi #1
mv ree #1
multifaceted presentation #1
jadas71crp #1
year 1year visit #1
tertiary center sample #1
administration canakinumab #1
igfbp3 il6 #1
separate category #1
jia flare week #1
jadie instrument validation #1
fair responsiveness #1
chaq juvenile attitude #1
placebo spid #1
indices hrqol #1
gc jdm #1
step hsp #1
jia activity #1
psa eojia #1
time paediatric practice #1
parents assessment physician #1
polyarticularcourse jia #1
discriminative ability chaq #1
cd5 cell levels #1
hda cutoffs #1
canakinumab clinical remission #1
paediatric rheumatology clinical #1
jia 6 years #1
rates periods #1
cwg criteria #1
5 years responders #1
abatacept median time #1
adults medicines #1
jca responsiveness #1
chaq moderate responsiveness #1
physician global rating #1
beta humans jia #1
hepcidin management #1
patients baseline methotrexate #1
therapy major prd #1
interleukin female follow #1
cwg cta #1
caps phenotype #1
fmf nlrp3 #1
adapted shs score #1
igg acls #1
inclusion growth failure #1

Key People For Juvenile Idiopathic Arthritis

Top KOLs in the world
Ross Edward Petty
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Anne Marie Prieur
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Taunton R Southwood
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David N Glass
juvenile rheumatoid arthritis gene expression calcium supplementation
Alberto Martini
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Prudence Joan Manners
juvenile arthritis growing pains severe hemophilia

Alberto Martini:Expert Impact

Concepts for whichAlberto Martinihas direct influence:Juvenile idiopathic arthritis,  Idiopathic arthritis,  Juvenile idiopathic,  Inactive disease,  Juvenile dermatomyositis,  Juvenile child child,  Radiographic progression,  Arthritis juvenile.

Alberto Martini:KOL impact

Concepts related to the work of other authors for whichfor which Alberto Martini has influence:Juvenile idiopathic arthritis,  Lupus nephritis,  Macrophage activation syndrome,  Autoimmune diseases,  Familial mediterranean fever,  Patients jia.



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Dipartimento di Neuroscienze, Genetica e Scienze Materno-Infantili (DiNOGMI), Genoa, ITALY | Università degli Studi di Genova, Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-Infantili (DiNOGMI), Genova, Italy |

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