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    • Jinghua Chen

      Jinghua Chen

      The School of Pharmacy, Fujian Medical University, 350108, Fuzhou, Fujian, People’s Republic of China | Key Laboratory of Gene Editing Screening and R&D of Digestive System ...



      KOL Resume for Jinghua Chen


      The School of Pharmacy, Fujian Medical University, 350108, Fuzhou, Fujian, People’s Republic of China


      School of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, PR China.

      Model Animal Research Center of State Key Laboratory of Reproductive Medicine, Jiangsu Laboratory Animal Center, Jiangsu Animal Experimental Center of Medicine and Pharmacy, Jiangsu Animal of Model, Department of Cell Biology, Animal Core facility, Key Laboratory of Model Animal, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing 211166, China

      Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

      Xiamen University Affiliated Chenggong Hospital


      Department of Biophysics & Center of Cryo-Electron Microscopy, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

      Engineering Research & Design Dept., CNOOC Research Institute


      Department of Radiology,The Second Affiliated Hospital of Nanchang University, Jiangxi Province, PR China.

      Jiangxi Province Key Laboratory of Preventive Medicine, Nanchang University, 330006, Nanchang, People’s Republic of China


      Medicinal Biopolymer Laboratory of College of Pharmacy, Jiangnan University, Wuxi Jiangsu, 214000, P.R.China.

      Key Laboratory of Aquaculture Nutrition and Feed (Ministry of Agriculture) and the Key Laboratory of Mariculture (Education Ministry of China), Ocean University of China, Qingdao 266003, PR China


      Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China


      School of Medicine and Pharmaceautics, Jiangnan University, Wuxi, Jiangsu Province 214122, China


      College of Publishing and Printing, University of Shanghai for Science and Technology, 200093, Shanghai, China


      The Key Laboratory of Mariculture (Ministry of Education), Ocean University of China, Fishery College of Ocean University of China, 5 Yushan Road, Qingdao 266003, China


      Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030, P.R. China


      College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China


      Department of Chemistry, Wuhan University


      § Medicine, Albert Einstein College of Medicine, Bronx, New York 10461



      Jinghua Chen: Influence Statistics

      Sample of concepts for which Jinghua Chen is among the top experts in the world.
      Concept World rank
      abdominal restraint #7
      mercaptobenzothiazole copper #11
      responses farreri #12
      farreri scallops #14
      body dictyophora #16
      secondary iah #19
      iah model #23
      025 licl #24
      metablastin #26
      lls viscometry #31
      length granulosa #34
      camouflaging glycans #38
      prosolin #38
      secondary intra #50
      farreri jones #51
      waterinsoluble polysaccharides #51
      1→3α glucan #63
      ivf treatment outcomes #69
      jones preston #69
      serine stathmin #77


      Prominent publications by Jinghua Chen

      KOL-Index: 11781

      A 12-week feeding trial was conducted to investigate the effects of dietary arginine (Arg), glutamine (Gln), and their interactions on growth performance, nonspecific immunity, disease resistance, and Arg catabolism in juvenile turbot (Scophthalmus maximus L.). The basal diet was formulated with white fish meal, soybean meal, and corn gluten meal to contain 50% crude protein and 12% crude lipid. Nine isoproteic and isolipidic experimental diets were formulated by supplementing the basal ...

      Known for Juvenile Turbot | Dietary Arg | Growth Performance | Scophthalmus Maximus | Glutamine Gln
      KOL-Index: 9208

      This experiment investigated the effects of dissolved oxygen (DO) on the survival and immune responses of scallop Chlamys farreri. The scallops (initial mean dry weight of soft tissue 1.52+/-0.10 g) were cultivated in the seawater with different DO levels (8.5, 6.5, 4.5, and 2.5mg l(-1), respectively) for 21 d. Each treatment had triplicate groups of 35 animals. During the experimental period, the scallops were fed with Spirulina maxima, and water temperature ranged from 15.2 degrees C ...

      Known for Immune Responses | Dissolved Oxygen | Chlamys Farreri | Sod Activity | Water Temperature
      KOL-Index: 8779

      A water-soluble glucan, namely, PD3, was isolated from the fruiting body of Dictyophora indusiata as the method reported previously. Its chemical structure was characterized by GC, FTIR, and (13)C NMR. The results indicated that PD3 is a (1-->3)-beta-D-glucan, with (1-->6)-beta-glucopyranoside side branches. The chain conformation and morphology of PD3 in aqueous solution were investigated by viscometry, rheometer, and laser light scattering (LLS) measurements, atomic force microscopy ...

      Known for Chain Conformation | Dictyophora Indusiata | Structural Characterization | Fruiting Body | Aqueous Solution
      KOL-Index: 6185

      INTRODUCTION: The extent of optimal gastric resection for proximal gastric cancer (PGC) continues to remain controversial, and a final consensus is yet to be met. The current study aimed to compare the perioperative outcomes, postoperative complications, and overall survival (OS) of proximal gastrectomy (PG) versus total gastrectomy (TG) in the treatment of PGC through a meta-analysis.

      METHODS: We systematically searched PubMed, Embase, The Cochrane Library, and Web of Science for ...

      Known for Proximal Gastrectomy | Gastric Cancer | Postoperative Complications | Pg Tg | Perioperative Outcomes
      KOL-Index: 5736

      Metablastin (also called p19, stathmin, prosolin, p18, Lap18, and oncoprotein 18) is a highly conserved, cytosolic 149-amino acid polypeptide that is expressed in immature vertebrate cells and undergoes extracellular factor- and cell cycle-regulated serine phosphorylation. The protein was shown recently to destabilize microtubules in vitro (Belmont, L., and Mitchison, T. J. (1996) Cell 84, 623-631). Here we demonstrate that microinjection of recombinant metablastin induces a loss of ...

      Known for Destabilizing Activity | Antineoplastic Agents | Microtubule Proteins | Phosphorylation Sites | Intact Cells
      KOL-Index: 5522

      Our previous study has demonstrated that luteinized granulosa cells (GCs) have the potential to proliferate and that the telomerase activity (TA) of luteinized GCs may predict the clinical outcomes of IVF treatment. However, in the field of telomere research, there have always been different opinions regarding the significance of TA and telomere length (TL). Thus, in the present study, we compared the effects of these two parameters on IVF treatment outcomes in the same individuals. TL ...

      Known for Telomerase Activity | Granulosa Cells | Telomere Length | Ivf Treatment | Pregnancy Outcomes
      KOL-Index: 4611

      BACKGROUND: To build a new and appropriate model of secondary intra-abdominal hypertension (IAH) in rats.

      METHODS: A total of 32 female Sprague-Dawley rats were randomized into four groups. Group I: the rats were hemorrhaged to a mean arterial pressure (MAP) of 40 mm Hg for 1 h and portal hypertension was induced by partial ligation of the portal vein 1 h later; Group II: after inducing portal hypertension, hemorrhagic shock of MAP of 40 mm Hg was induced and maintained for 1 h; Group ...

      Known for Abdominal Hypertension | Secondary Iah | Arterial Pressure | Shock Hemorrhagic | Sprague Dawley
      KOL-Index: 4480

      The coronavirus disease 2019 (COVID-19) pandemic has led to worldwide efforts to understand the biological traits of the newly identified human coronavirus (HCoV-19) virus. In this mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spike protein (S protein), 20 are completely occupied by N-glycans, predominantly of the oligomannose type. All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be ...

      Known for Spike Protein | Mass Spectrometry | Human Ace2 | Worldwide Efforts | Posttranslational Modifications
      KOL-Index: 4358

      Water-soluble and water-insoluble polysaccharide fractions were isolated from fruiting bodies of Ganoderma lucidum (rheishi) by extraction with phosphate buffer and 1 N sodium hydroxide solutions at different temperatures and investigated by high-performance liquid chromatography (HPLC), one- and two-dimensional 1H and 13C NMR, infrared (IR) spectroscopy, and other techniques. This work was prompted by Sone et al.’s earlier conclusion that similarly extracted, water-insoluble ...

      Known for Ganoderma Lucidum | Chemical Structure | Molecular Weight | Infrared Spectroscopy | Fruiting Bodies
      KOL-Index: 4189

      The treatment of triple-negative breast cancer (TNBC) relies largely on chemotherapies. However, it is frequent that TNBC patients develop resistance to the chemotherapy drugs. Generation of drug-resistant cell lines facilitates the identification of drug resistance. Here, we established two paclitaxel (PTX)-resistant TNBC cancer cell lines using an intermittent and stepwise method and found that long non-coding RNA long intergenic non-protein-coding RNA p53-induced transcript ...

      Known for Negative Breast | Coding Rna | Cancer Cells | Linc Pint | Tnbc Patients
      KOL-Index: 3944

      BackgroundAlzheimer’s disease has become a public health crisis globally due to its increasing incidence. The purpose of this study was to establish an early warning model using artificial neural network (ANN) for early diagnosis of AD and to explore early sensitive markers for AD.MethodsA population based nested case-control study design was used. 89 new AD cases with good compliance who were willing to provide urine and blood specimen were selected from the cohort of 2482 ...

      Known for Artificial Neural Network | Alzheimer Disease | Sensitivity Specificity | Ann Model | Applied Develop
      KOL-Index: 2306

      A label-free electrochemical biosensor based on the triplex DNA-templated Ag/Pt bimetallic nanoclusters (triplex-Ag/PtNCs) and locked nucleic acid (LNA) modified X-shaped DNA probe was developed for the detection of single-nucleotide variant (SNV) related to β-thalassemia. Firstly, using triplex DNA as template, a site-specific and homogeneous Ag/PtNCs was prepared, which can effectively catalyze the 3,3,5,5-tetramethylbenzidine-H2O2 system and thus be employed as a signal reporter in ...

      Known for Electrochemical Biosensor | Nucleic Acid | Single Nucleotide | Dna Probes | Biosensing Techniques
      KOL-Index: 2207

      RATIONALE AND OBJECTIVES: To investigate whether iodine quantification extracted from enhanced dual energy-computed tomography (DE-CT) is useful for distinguishing lung squamous cell carcinoma from adenocarcinoma and to evaluate whether a single scan evaluated during the venous phase (VP) can be substituted for scans evaluated during other phases.

      MATERIALS AND METHODS: Sixty-two patients with lung cancer (32 squamous cell carcinomas; 30 adenocarcinomas) underwent enhanced dual-phase ...

      Known for Sensitivity Specificity | Venous Phase | Computed Tomography | Cell Lung | Dual Energy
      KOL-Index: 1819

      PurposeTo compare the neonatal birthweight of singletons derived from ICSI cycles with fresh or frozen–thawed epididymal sperm in patients with obstructive azoospermia.MethodsA total of 436 singletons derived from ICSI cycles with fresh (n = 220) or frozen–thawed (n = 216) epididymal sperm in obstructive azoospermia evaluated from 2012 to 2018 in the retrospective study. Multivariate generalized linear model was used to analyze the association between epididymal sperm cryopreservation ...

      Known for Sperm Cryopreservation | Icsi Frozen | Patients Obstructive
      KOL-Index: 1772

      The corrosion inhibition behavior of mercaptobenzothiazole (MBT) on copper in 0.1 M H2SO4 solutions was investigated by bulk acoustic wave (BAW) sensor under open-circuit condition in this paper. The growth process of Cu-MBT complex film was monitored by the BAW sensor and the frequency shift curves were acquired. The frequency shift curves were fitted with a proposed model and the maximum frequency shift and the apparent rate constant of film formation were obtained. The relations ...

      Known for Mercaptobenzothiazole Mbt | Corrosion Inhibition

      Key People For Juvenile Turbot

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      Jinghua Chen:Expert Impact

      Concepts for whichJinghua Chenhas direct influence:Juvenile turbot,  Dietary arg,  Growth performance,  Chain conformation,  Proximal gastrectomy,  Fruiting body,  Dictyophora indusiata,  Telomerase activity.

      Jinghua Chen:KOL impact

      Concepts related to the work of other authors for whichfor which Jinghua Chen has influence:Microtubule dynamics,  Dictyophora indusiata,  Stathmin expression,  Telomere length,  Proximal gastrectomy,  Telomerase activity,  Granulosa cells.



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      The School of Pharmacy, Fujian Medical University, 350108, Fuzhou, Fujian, People’s Republic of China | Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs, Chinese Academy of Medical Sciences and Peking Union Medical Col

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