Direct Impact

Concepts for which Thewarach Laha has direct influence:

opisthorchis viverrini
liver fluke
lao pdr
southeast asia
advanced periductal fibrosis
clonorchis sinensis
hepatobiliary abnormalities

External impact

Concepts related to the work of other authors for which Thewarach Laha has influence:

clonorchis sinensis
opisthorchis viverrini
lao pdr
liver fluke
northeast thailand
hepatobiliary abnormalities
luang prabang

Prominent publications by Thewarach Laha

KOL-Index: 79 Liver flukes, such as Clonorchis sinensis and Opisthorchis viverrini, are food-borne parasites that have a major impact on the health of humans and animals, particularly in Asia. However, the impact of C. sinensis and O. viverrini, in particular, is exacerbated in that these parasites can induce a malignant, untreatable cancer (cholangiocarcinoma, CCA) in chronically infected people. As a ...
Known for
Chronically Infected People | Next-Generation Technologies | Unique Biological Biotechnological Prospects | 1 Carcinogens
KOL-Index: 60 Recent work has found urine analysis to be as sensitive as serology for diagnosis of strongyloidiasis. Here, we examined the daily variation of Strongyloides-specific IgG in urine by qualitative and quantitative ELISA and its effects on diagnostic accuracy and reliability. In the first part of the study, matched urine and fecal samples were collected from project participants in northeast ...
Known for
Matched Urine | Northeast Thailand | Methods Consecutive | Elisa Strongyloides
KOL-Index: 54 The ability of the parasitic blood fluke Schistosoma mansoni and other parasitic helminths to manipulate host biology is well recognised, but the mechanisms that underpin these phenomena are not well understood. An emerging paradigm is that helminths transfer their biological cargo to host cells by secretion of extracellular vesicles (EVs). Herein, we show that two populations of S. mansoni ...
Known for
Cells Huvecs | Mansoni Evs
KOL-Index: 42 Crosstalk between malignant and neighboring cells contributes to tumor growth. In East Asia, infection with the liver fluke is a major risk factor for cholangiocarcinoma (CCA). The liver fluke Opisthorchis viverrini secretes a growth factor termed liver fluke granulin, a homologue of the human progranulin, which contributes significantly to biliary tract fibrosis and morbidity. Here, ...
Known for
Granulin | Evs | Δhupgrn-H69 | Naïve Recipient Cells
KOL-Index: 41 The omics technologies have improved our understanding of the molecular events that underpin host-parasite interactions and the pathogenesis of parasitic diseases. In the last decade, proteomics and genomics in particular have been used to characterize the surface and secreted products of the carcinogenic liver fluke Opisthorchis viverrini and revealed important roles for proteins at the ...
Known for
Viverrini | Fluke Opisthorchis | Interactions Pathogenesis | Roles Proteins
KOL-Index: 40 Background: Sensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the Schistosoma haematobium secretome to find antibody biomarkers of schistosome infection, validate their diagnostic performance in samples from endemic populations, and evaluate their utility ...
Known for
Antibody Biomarkers | Proteome Array | Haematobium Infection | Serum Urine
KOL-Index: 35 The liver fluke Opisthorchis viverrini sensu lato causes serious public-health problems in Northeast Thailand and Southeast Asian countries. A hypothesis has been proposed that O. viverrini represents a species complex with varying levels of genetic differentiation in Thailand and Lao PDR. This study aimed to clarify whether O. viverrini populations can be genetically divided into separate ...
Known for
Cryptic Species | Cf-Int6 | Localities | Mitochondrial Nuclear Dna
KOL-Index: 32 OBJECTIVES: To isolate and characterize an asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and evaluate its expression profile, biochemical activity, and potential as an immunodiagnostic antigen. METHODS: The full length mRNA encoding an asparaginyl endopeptidase (family C13), Ov-aep-1, was isolated by immunoscreening of a cDNA bacteriophage library of ...
Known for
Carcinogenic Liver | Opisthorchis Viverrini | Immunodiagnosis | Worms
KOL-Index: 31 The infection dynamics of Opisthorchis viverrini metacercariae was analyzed in cyprinid fish from endemic areas in Mukdahan Province, Thailand, and Khammouane Province, Lao PDR. The fish were collected during the cool-dry (November-February), hot-dry (March-May), and rainy (June-October) seasons in 2017. They were examined by the digestion method, and the infection status was statistically ...
Known for
Host Environmental | Metacercarial Intensities | Digestion Method | Puntius Brevis
KOL-Index: 29 Infection by the small liver fluke, Opisthorchis viverrini, causes serious public health problems, including cholangiocarcinoma, in Thailand and southeastern Asian countries. Previous studies have reported that O. viverrini represents a species complex with varying levels of genetic differentiation in Thailand and Lao PDR. In this study, we re-examined population genetic structure and ...
Known for
Localities Lao | Structure Genetic | Cluster Time | Populations Thailand

Parasitology, Khon Kaen University, Khon Kaen, Thailand

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