• KOL
    • Knee Arthroplasty
    • Henrik Kehlet
    • Henrik Kehlet: Influence Statistics

      Henrik Kehlet

      Henrik Kehlet

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      Surgical Pathophysiology Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark | Section of Surgical Pathophysiology 7621, Rigshospitalet, Copenhagen | ...

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      Henrik Kehlet:Expert Impact

      Concepts for whichHenrik Kehlethas direct influence:Knee arthroplasty,Chronic pain,Epidural analgesia,Postoperative pain,Hip arthroplasty,Persistent pain,Hip fracture,Hip arthroplasty replacement.

      Henrik Kehlet:KOL impact

      Concepts related to the work of other authors for whichfor which Henrik Kehlet has influence:Postoperative pain,Enhanced recovery,Epidural analgesia,General anesthesia,Hip fracture,Colorectal surgery,Total knee arthroplasty.

      KOL Resume for Henrik Kehlet

      Year
      2022

      Surgical Pathophysiology Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

      2021

      Centre for Fast-track Hip and Knee Arthroplasty, , Rigshospitalet, , Copenhagen, 2100, , Denmark

      St. Joseph’s Hospital, McMaster University, Hamilton, Ontario, Canada (H.S.).,

      2020

      Professor, Section of Surgical Pathophysiology 7621, Copenhagen University Hospital, Denmark.

      Section for Surgical Pathophysiology, Rigshospitalet, , Copenhagen, , Denmark

      Members of the PROSPECT Working Group, see Appendix, 1, .

      Lundbeck Foundation Centre for Fast-track Hip and Knee Arthroplasty, ;

      2019

      Section of Surgical Pathophysiology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark

      Department of Cardiovascular Sciences KULeuven Leuven Belgium

      2018

      Section of Surgical Pathophysiology, Rigshospitalet, Copenhagen University, Denmark and The Lundbeck; ; Foundation Centre for Fast-track Hip and Knee replacement, Copenhagen, Denmark.,

      The Lundbeck Foundation Centre for Fast-Track Hip and Knee Arthroplasty, Copenhagen, Denmark.

      Rigshospitalet Copenhagen University, Copenhagen, Denmark

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      Sample of concepts for which Henrik Kehlet is among the top experts in the world.
      Concept World rank
      laparoscopic colonic surgery #1
      preoperative alcoholism #1
      mechanical stimuli burn #1
      tonsillectomy pain management #1
      vats ppp #1
      4 women pain #1
      blood plasmareduced blood #1
      analgesia analgesia #1
      discharge median #1
      skin temperature p00005 #1
      stay middle #1
      epigastric repair 95 #1
      pain osteoarthritis sensitization #1
      patients ejaculatory pain #1
      nerves block #1
      survival ranitidine #1
      tka fasttrack setup #1
      dexamethasone burn #1
      heparin prophylaxis hysterectomy #1
      ngml1 #1
      increased odds 4 #1
      transfusion risk 95 #1
      femoral humans #1
      skin erythema humans #1
      24 96 injections #1
      pregabalin prevalence #1
      fasttrack protocol #1
      66y #1
      preoperative electrical #1
      denmark 2004–2007 #1
      knee replacement tka #1
      clinical trials considerations #1
      hyperalgesia riluzole #1
      additional analgesic lia #1
      local ketamine #1
      time mobilization #1
      readmissions tka #1
      analgesics opioid anesthesia #1
      26 304 herniorrhaphies #1
      tka bmi groups #1
      study analgesic effects #1
      walk nociceptive function #1
      cpk glucose #1
      patients fasttrack #1
      continuous epidural analgesia #1
      colloid surgery #1
      severe persistent pain #1
      human burn injury #1
      p00005 erythema #1
      cleveland hamilton #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Henrik Kehlet

      KOL-Index: 16658

      BACKGROUND: Quantitative reviews of postoperative pain management have demonstrated that the number of patients needed to treat for one patient to achieve at least 50% pain relief (NNT) is 2.7 for ibuprofen (400 mg) and 4.6 for paracetamol (1000 mg), both compared with placebo. However, direct comparisons between paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) have not been extensively reviewed. The aims of this review are (i) to compare the analgesic and adverse effects ...

      Known for Paracetamol Nsaids | Postoperative Pain Management | Analgesic Effects | Cochrane Library | Direct Comparisons
      KOL-Index: 15223

      BACKGROUND: Elderly patients are at risk of increased length of hospital stay (LOS), postoperative complications, readmission, and discharge to destinations other than home after elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). Recent studies have found that enhanced recovery protocols or fast-track surgery can be safe for elderly patients undergoing these procedures and may result in reduced LOS. However, detailed studies on preoperative comorbidity and ...

      Known for Postoperative Morbidity | Knee Arthroplasty | Discharge Destination | Track Hip | Tka Patients
      KOL-Index: 14733

      Background and purpose - Body mass index (BMI) outside the normal range possibly affects the perioperative morbidity and mortality following total hip arthroplasty (THA) and total knee arthroplasty (TKA) in traditional care programs. We determined perioperative morbidity and mortality in such patients who were operated with the fast-track methodology and compared the levels with those in patients with normal BMI. Patients and methods - This was a prospective observational study involving ...

      Known for Tka Bmi | Hip Arthroplasty | Replacement Length | Obese Patients | Knee Body
      KOL-Index: 14654

      BackgroundRepair for a small (≤2 cm) umbilical and epigastric hernia is a minor surgical procedure. The most common surgical repair techniques are a sutured repair or a repair with mesh reinforcement. However, the optimal repair technique with regard to risk of reoperation for recurrence is not well documented. The aim of the present study was in a nationwide setup to investigate the reoperation rate for recurrence after small open umbilical and epigastric hernia repairs using either ...

      Known for Epigastric Hernias | Small Umbilical | Reoperation Rate | Sutured Repair | Mesh Reinforcement
      KOL-Index: 14382

      The aim of the study was to examine the presence of hyperalgesia to heat stimuli within the zone of secondary hyperalgesia to punctate mechanical stimuli. A burn was produced on the medial part of the non-dominant crus in 15 healthy volunteers with a 50 x 25 mm thermode (47 degrees C, 7 min), and assessments were made 70 min and 40 min before, and 0, 1, and 2 h after the burn injury. Hyperalgesia to mechanical and heat stimuli were examined by von Frey hairs and contact thermodes (3.75 ...

      Known for Secondary Hyperalgesia | Heat Stimuli | Burn Injury | Pain Response | 15 Healthy Volunteers
      KOL-Index: 14089

      In recent years, there has been an increasing interest in local infiltration analgesia (LIA) as a technique to control postoperative pain. We conducted a systematic review of randomized clinical trials investigating LIA for total knee arthroplasty (TKA) and total hip arthroplasty (THA) to evaluate the analgesic efficacy of LIA for early postoperative pain treatment. In addition, the analgesic efficacy of wound catheters and implications for length of hospital stay (LOS) were evaluated. ...

      Known for Analgesic Efficacy | Local Infiltration Analgesia | Replacement Hip Arthroplasty | Tha Tka | Knee Humans
      KOL-Index: 13819

      BACKGROUND: Preoperative anemia has been associated with increased risk of allogeneic blood transfusion and postoperative morbidity and mortality. The prevalence of preoperative anemia and its association with postoperative outcomes has not previously been reported in relation to fast-track elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). We aimed to evaluate the prevalence of preoperative anemia in elective fast-track THA and TKA and its association with risk of ...

      Known for Preoperative Anemia | Knee Arthroplasty | Risk Transfusion | Postoperative Morbidity | Total Hip
      KOL-Index: 13752

      BackgroundThis prospective study aimed to evaluate the impact of transabdominal preperitoneal patch plasty (TAPP) with implantation of a lightweight mesh (<50 g/m²) fixed by fibrin glue on the occurrence of chronic pain and sexual dysfunction in hernia patients.MethodsPatients were examined before TAPP, early and late postoperatively. The primary end point of the study was pain-related functional impairment 6 months after the operation as assessed by the validated assessment scale (AAS). ...

      Known for Chronic Pain | Lightweight Mesh | Hernia Repair | Sexual Dysfunction | Inguinal Humans
      KOL-Index: 13735

      CONTEXT: Persistent pain and sensory disturbances following surgical treatment for breast cancer is a significant clinical problem. The pathogenic mechanisms are complex and may be related to patient characteristics, surgical technique, and adjuvant therapy.

      OBJECTIVE: To examine prevalence of and factors associated with persistent pain after surgical treatment for breast cancer.

      DESIGN, SETTING, AND PATIENTS: A nationwide cross-sectional questionnaire study of 3754 women aged 18 to 70 ...

      Known for Persistent Pain | Cancer Surgery | Sensory Disturbances | Prevalence Factors | Surgical Treatment
      KOL-Index: 13673

      Objective: With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system that both reflects contemporary mechanistic insights and helps guide future research and treatment. Existing classifications of acute pain conditions are limiting, with a predominant focus on the sensory experience (e.g., pain intensity) and pharmacologic consumption. Consequently, there is a need to more broadly characterize and ...

      Known for Acute Pain | Common Features | Aps Aapm | Modulating Factors | 1 Core Criteria
      KOL-Index: 13558

      Pain is the dominant complaint after laparoscopic cholecystectomy. No study has examined the combined effects of a somato-visceral blockade during laparoscopic cholecystectomy. Therefore, we investigated the effects of a somato-visceral local anesthetic blockade on pain and nausea in patients undergoing elective laparoscopic cholecystectomy. In addition, all patients received multi-modal prophylactic analgesic treatment. Fifty-eight patients were randomized to receive a total of 286 mg ...

      Known for Patients Laparoscopic Cholecystectomy | Local Anesthetics | Pain Nausea | Opioid Anesthesia | Postoperative Week
      KOL-Index: 13503

      IntroductionWith the implementation of fast-track surgery with optimization of both logistical and clinical features, the postoperative convalescence has been reduced as functional milestones have been achieved earlier and consequently length of stay (LOS) in hospital has been reduced. However, it has been speculated that a decrease in LOS may be associated with an increase in readmissions in general, including risk of dislocation after total hip arthroplasty (THA) or manipulation after ...

      Known for Tha Tka | Knee Arthroplasty | Track Hip | Stay Replacement | Increase Readmissions
      KOL-Index: 13404

      OBJECTIVE: With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system that both reflects contemporary mechanistic insights and helps guide future research and treatment. Existing classifications of acute pain conditions are limiting, with a predominant focus on the sensory experience (eg, pain intensity) and pharmacologic consumption. Consequently, there is a need to more broadly characterize and ...

      Known for Acute Pain | Common Features | Aps Aapm | Modulating Factors | Multidimensional Approach
      KOL-Index: 13393

      BACKGROUND: Total knee arthroplasty (TKA) is associated with severe pain and inflammation despite an extensive multimodal analgesic approach, but the effect of high-dose glucocorticoid administration has not been studied.

      METHODS: Forty-eight patients undergoing unilateral TKA were included in a randomized, double-blind, placebo-controlled trial receiving preoperative methylprednisolone (MP) 125 mg i.v. or saline. All surgery was performed under lumbar spinal anaesthesia and patients ...

      Known for Preoperative Methylprednisolone | Total Knee Arthroplasty | Opioid Anesthesia | 24 Surgery | Controlled Trial

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      Surgical Pathophysiology Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark | Section of Surgical Pathophysiology 7621, Rigshospitalet, Copenhagen | Section of Surgical Pathophysiology, Copenhagen University Hospital, Rigshospi

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