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  • Hiroshi Kawaguchi

    Prominent publications by Hiroshi Kawaguchi

    KOL Index score: 22251

    We previously reported that fibroblast growth factor-2 (FGF-2) acts not only on osteoblasts to stimulate osteoclastic bone resorption indirectly but also on mature osteoclasts directly. In this study, we investigated the mechanism of this direct action of FGF-2 on mature osteoclasts using mouse and rabbit osteoclast culture systems. FGF-2 stimulated pit formation resorbed by isolated rabbit osteoclasts moderately from low concentrations (>/=10(-12) m), whereas at high concentrations ...

    Also Ranks for: Fibroblast Growth Factor |  map kinase |  receptor 1 |  mature osteoclasts |  pit formation
    KOL Index score: 18189

    STUDY DESIGN: A retrospective study of the long-term results from double-door laminoplasty (Kurokawa's method) for patients with myelopathy caused by ossification of the posterior longitudinal ligament and cervical spondylosis was performed.

    OBJECTIVE: To know whether the short-term results from double-door laminoplasty were maintained over a 10-year period and, if not, the cause of late deterioration.

    SUMMARY OF BACKGROUND DATA: There are few long-term follow-up studies on the outcome ...

    Also Ranks for: Patients Ossification |  cervical stenotic myelopathy |  doubledoor laminoplasty |  longitudinal ligament |  athetoid cerebral palsy
    KOL Index score: 17784

    This study investigated the mechanism of direct and indirect actions of fibroblast growth factor 2 (FGF-2) on osteoclast differentiation using two mouse cell culture systems. In the coculture system of osteoblasts and bone marrow cells, FGF-2 stimulated osteoclast formation. This effect was decreased markedly by osteoprotegerin (OPG) or NS-398, a selective cyclo-oxygenase 2 (COX-2) inhibitor. FGF-2 (> or = 10(-9) M) stimulated receptor activator of nuclear factor kappaB ligand/osteoclast ...

    Also Ranks for: Fibroblast Growth Factor |  osteoclast differentiation |  receptor activator |  2 fgf2 |  macrophage cell
    KOL Index score: 17404

    This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged ≥ 60 years; 321 men, 642 women). Locomotive syndrome, sarcopenia, and frailty were defined using three tests proposed by Japanese Orthopaedic Association, Asian Working Group for ...

    Also Ranks for: Locomotive Syndrome |  frailty sarcopenia |  osteoarthritis osteoporosis |  stage 2 |  disability road study
    KOL Index score: 16934

    This study investigated the involvement of cell cycle factors in RANKL-induced osteoclast differentiation. Among the G1 cell cycle factors, Cdk6 was found to be a key molecule in determining the differentiation rate of osteoclasts as a downstream effector of the NF-kappaB signaling.

    INTRODUCTION: A temporal arrest in the G1 phase of the cell cycle is a prerequisite for cell differentiation, making it possible that cell cycle factors regulate not only the proliferation but also the ...

    Also Ranks for: Osteoclast Differentiation |  dependent kinase |  cell cycle |  g1 phase |  rankl induced
    KOL Index score: 16305

    The signaling through receptor tyrosine kinases expressed on mature osteoclasts has recently been suggested to be involved in osteoclastic bone resorption. This study investigated the mechanism and the possible physiological relevance of Gas6/Tyro 3, a receptor tyrosine kinase signaling pathway in osteoclasts in stimulating osteoclastic bone resorption using several mouse culture systems. Gas6, expressed ubiquitously in bone cells, did not affect the differentiation or the survival of ...

    Also Ranks for: Osteoclastic Bone Resorption |  tyrosine kinase |  mature osteoclasts |  gas6 tyro |  bone cells
    KOL Index score: 15463

    We tested the hypothesis that induction of cyclo-oxygenase (COX) 2 mediates some effects of bone morphogenetic protein (BMP) 2 on bone. BMP-2 induced COX-2 mRNA and prostaglandin (PG) production in cultured osteoblasts. BMP-2 increased luciferase activity in calvarial osteoblasts from mice transgenic for a COX-2 promoter-luciferase reporter construct (Pluc) and in MC3T3-E1 cells transfected with Pluc. Deletion analysis identified the -300/-213-bp region of the COX-2 promoter as necessary ...

    Also Ranks for: Bone Morphogenetic Protein |  cox2 mice |  binding site |  bmp2 stimulation |  osteoclast formation
    KOL Index score: 15412

    OBJECTIVE: To clarify the association between the occurrence and progression of knee osteoarthritis (KOA) with components of metabolic syndrome (MS), including overweight (OW), hypertension (HT), dyslipidaemia (DL), and impaired glucose tolerance (IGT), in a general population.

    DESIGN: From the large-scale population-based cohort study entitled Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) initiated in 2005, 1,690 participants (596 men, 1,094 women) residing in ...

    Also Ranks for: Knee Osteoarthritis |  progression koa |  road study |  impaired glucose tolerance |  metabolic risk
    KOL Index score: 15103

    OBJECTIVE: There is little information on falls by sex and age strata in Japan, and few factors associated with falls have been established. However, the association between bone and joint diseases and falls remains unclear. We examined prevalence of falls by sex and age strata, determined its association with radiographic osteoarthritis (OA) of the knee and lumbar spine, and determined knee and lower back pain after single and multiple falls.

    METHODS: A questionnaire assessed the number ...

    Also Ranks for: Knee Osteoarthritis |  falls women |  lumbar spondylosis |  lower pain |  sex factors
    KOL Index score: 14853

    STUDY DESIGN: Retrospective multicenter study.

    OBJECTIVE: To review the clinical characteristics of traumatic cervical spinal cord injury (SCI) associated with ossification of the posterior longitudinal ligament (OPLL).

    SUMMARY OF BACKGROUND DATA: Despite its potentially devastating consequences, there is a lack of information about acute cervical SCI complicated by OPLL.

    METHODS: This study included consecutive patients with acute traumatic cervical SCI (Frankel A, B, and C) who were ...

    Also Ranks for: Patients Opll |  bone injury |  spinal cord |  longitudinal ligament |  acute cervical
    KOL Index score: 14667

    Musculoskeletal diseases, especially osteoarthritis (OA) and osteoporosis (OP), impair activities of daily life (ADL) and quality of life (QOL) in the elderly. Although preventive strategies for these diseases are urgently required in an aging society, epidemiological data on these diseases are scant. To clarify the prevalence of knee osteoarthritis (KOA), lumbar spondylosis (LS), and osteoporosis (OP) in Japan, and estimate the number of people with these diseases, we started a ...

    Also Ranks for: Lumbar Spondylosis |  knee osteoarthritis |  disability study |  osteoporosis japan |  femoral neck
    KOL Index score: 14240

    OBJECTIVE: Although hip osteoarthritis (OA) is a major cause of hip pain and disability in elderly people, few epidemiologic studies have been performed. We investigated the prevalence of radiographic hip OA and its association with hip pain in Japanese men and women using a large-scale population of a nationwide cohort study, Research on Osteoarthritis/osteoporosis Against Disability (ROAD).

    METHODS: From the baseline survey of the ROAD study, 2975 participants (1043 men and 1932 ...

    Also Ranks for: Radiographic Hip |  road study |  japanese women |  aged osteoarthritis |  baseline survey
    KOL Index score: 13932

    The present cross-sectional study investigated the prevalence of sarcopenia and clarified its associated factors in 1,000 elderly participants of Japanese population-based cohorts. Exercise habit in middle age was associated with low prevalence of sarcopenia in older age, suggesting that it is a protective factor against sarcopenia in older age.IntroductionThe present study investigated the prevalence of sarcopenia using the European Working Group on Sarcopenia in Older People (EWGSOP) ...

    Also Ranks for: Middle Age |  exercise habits |  road study |  prevalence sarcopenia |  physical performance
    KOL Index score: 13787

    OBJECTIVE: To examine the incidence and progression of radiographic knee osteoarthritis (OA) and the incidence of knee pain, and their risk factors in Japan, using the large-scale population of the nationwide cohort study ROAD (Research on Osteoarthritis/osteoporosis Against Disability).

    METHODS: Subjects from the ROAD study who had been recruited in 2005-2007 were followed up with knee radiography 3 years later. A total of 2,262 paired radiographs (74.4% of the original sample) were ...

    Also Ranks for: Knee Pain |  women incidence |  road study |  aged osteoarthritis |  factors radiographic
    KOL Index score: 13688

    STUDY DESIGN: Cross-sectional surveys of health-related quality of life (QOL) in subjects with low back pain and knee pain using a population-based cohort.

    OBJECTIVE: The purpose of the present study was to clarify the impact of low back pain and knee pain on QOL in men. In addition, we analyzed the impacts of vertebral fracture (VFx), lumbar spondylosis, and knee osteoarthritis (OA) on the magnitude of QOL loss in men with low back pain and knee pain.


    Also Ranks for: Knee Pain |  life qol |  lumbar spondylosis |  based cohort |  healthrelated quality


    Hiroshi Kawaguchi: Influence Statistics

    Sample of concepts for which Hiroshi Kawaguchi is among the top experts in the world.
    Concept World rank
    prevention chondrocyte apoptosis #1
    hcd marked hypercholesterolemia #1
    bglap2 mineralization #1
    calvarial cultures tnfalpha #1
    joints surgically induced #1
    bmp nanog homeobox #1
    lipid glomerular injury #1
    patients propensitymatched analysis #1
    preschool glomerulosclerosis fsgs #1
    ribosomes rer #1
    ahcs klotho gene #1
    medical interview sheets #1
    s100b endochondral ossification #1
    systemic abnormality #1
    runx2 cooperate #1
    role endogenous opg #1
    dhfr bmyb #1
    chronic organ size #1
    127 months outcomes #1
    bearing couplings #1
    disease onset initiation #1
    exogenous aa bfgf #1
    recombinant fibroblast #1
    osteoblastic cells bfgf #1
    difference clinical condition #1
    cohort osteoarthritis #1
    k6h d1h #1
    inbred c57bl gli1 #1
    physiological skeletal growth #1
    daily physical therapies #1
    osteoblasts irs2 #1
    glomerular infiltration exhc #1
    kbrunx2p1lacz transgenic mice #1
    fgf18 adult rats #1
    cyclin d1 effects #1
    bglap2 osteopenia #1
    prostaglandin dpa #1
    indefinite wholebody symptoms #1
    postoperative plasmapheresis #1
    male methods life #1
    qol prehdf #1
    plasmapheresis sole therapy #1
    rtks erk #1
    ossification study #1
    coronary atherosclerosis relation #1
    bmp2 luciferase activity #1
    japan aged cross #1
    classic kl #1
    western blotting bfgf #1
    hd ihdf #1

    Key People For Road Study

    Top KOLs in the world
    Kozo Nakamura
    road study knee pain spinal cord
    Hiroshi Kawaguchi
    road study knee pain lumbar spondylosis
    Noriko Yoshimura
    road study knee pain bone loss
    Takao Suzuki
    depressive symptoms mild cognitive impairment cognitive function
    Hideyo Yoshida
    knee pain urinary incontinence geriatric syndrome
    Toru Akune
    road study knee pain locomotive syndrome

    Hiroshi Kawaguchi:Expert Impact

    Concepts for whichHiroshi Kawaguchihas direct influence:Road study,  Knee pain,  Knee osteoarthritis,  Wakayama spine study,  Lumbar spondylosis,  Bone formation,  Fibroblast growth factor,  Growth factor.

    Hiroshi Kawaguchi:KOL impact

    Concepts related to the work of other authors for whichfor which Hiroshi Kawaguchi has influence:Knee osteoarthritis,  Growth factor,  Stem cells,  Gene expression,  Bone formation,  Articular cartilage,  Osteoblast differentiation.



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    Department of Orthopaedics and Spine, Tokyo Neurological Centre, Minato-ku, Tokyo, Japan | Department of Orthopaedic Surgery, Tokyo Neurological Center, Tokyo, Japan | Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Med