Akihiro Kawauchi

Akihiro Kawauchi

From The Section Of Laparoscopic And Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio And The Department Of Urology, ...

Direct Impact

Concepts for which Akihiro Kawauchi has direct influence:

prostate cancer
nocturnal enuresis
cyclin d1b
bladder capacity
vesicoureteral reflux
salvage chemotherapy
penile erection

External impact

Concepts related to the work of other authors for which Akihiro Kawauchi has influence:

prostate cancer
benign prostatic hyperplasia
erectile function
lower urinary tract symptoms
vesicoureteral reflux
urinary tract infection
γ-glutamyl cyclotransferase

Prominent publications by Akihiro Kawauchi

KOL-Index: 136 Previous studies show that gamma-glutamylcyclotransferase (GGCT) is expressed at high levels in various cancer tissues and that its knockdown inhibits MCF7 cancer cell growth via upregulation of p21WAF1/CIP1 (p21). However, the detailed underlying mechanism is unclear. Here, we used yeast two-hybrid screening and co-immunoprecipitation to identify Prohibitin-2 (PHB2) as a novel protein that ...
Known for
P21 Promoter | Nuclear Expression | Deregulated Proliferation | Upregulation Ggct
KOL-Index: 121 Voiding cystourethrography is the most important fluoroscopic examination in pediatric urology for the investigation of lower urogenital tract diseases, such as vesicoureteral reflux or urethral stricture. However, this invasive procedure imposes a significant burden on children and their parents, and recently there has been a paradigm shift in the diagnosis and treatment of vesicoureteral ...
Known for
Routine Continuous Antibiotic Prophylaxis | Children Vesicoureteral | Invasive Procedure | Febrile Urinary Tract Infection
KOL-Index: 87 The Japanese Urological Association has developed Clinical Guidelines for Benign Prostatic Hyperplasia (BPH) for men with suspected BPH. This article is an English translation of the abridged version of the Guidelines. The Guidelines were formulated on the basis of evidence retrieved from the PubMed database between 1995 and 2009, as well as other relevant sources. The target patients of ...
Known for
Guidelines Benign | Bladder Symptom | Bph Target | Overactive
KOL-Index: 53 Inhibition of gamma-glutamylcyclotransferase (GGCT), which is highly expressed in various cancer tissues, exerts anticancer effects both in vitro and in vivo. Previous studies have shown that depletion of GGCT blocks the growth of MCF7 breast cancer cells via upregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21); in addition, induction of autophagy plays a role in the ...
Known for
Cells Upregulation | Inhibition Cancer | Marked Attenuation | Foxo3a Phosphorylation
KOL-Index: 53 The present article is the abbreviated English translation of the Japanese guidelines for male lower urinary tract symptoms and benign prostatic hyperplasia updated as of the end of 2016. The target patients are men aged >50 years complaining of lower urinary tract symptoms, with or without benign prostatic hyperplasia, and the target readers are non-urological general physicians and ...
Known for
Urologists Symptoms | Serum Prostate-Specific Antigen | 5 Inhibitors | Bladder Outlet Obstruction
KOL-Index: 51 Patients with a history of non-muscle-invasive bladder cancer sometimes have recurrence of tumors after transurethral resection of bladder tumor treatment. To find factors related to the recurrence of non-muscle-invasive bladder cancer, we examined tissue specimens taken at transurethral resection of bladder tumor as an initial treatment. We revealed the association between prognosis of ...
Known for
Transurethral | Resection Bladder | Intratumoral Foxp3 | Rfs Rate
KOL-Index: 43 Metabolic reprogramming leading to aerobic glycolysis, termed the “Warburg effect,” is a critical property of cancer cells. However, the precise mechanisms underlying this phenomenon are not fully understood. A growing body of evidence indicates that γ-glutamylcyclotransferase (GGCT), an enzyme involved in glutathione homeostasis that is highly expressed in many types of cancer, represents a ...
Known for
Hypoxia-Inducible Factor-1α | Metabolomic | Cells Ggct | “warburg
KOL-Index: 43 BACKGROUND: Enuresis is an extremely common condition, which, although somatically benign, poses long-term psychosocial risks if untreated. There are still many misconceptions regarding the proper management of these children. AIM: A cross-professional team of experts affiliated with the International Children's Continence Society (ICCS) undertook to update the previous guidelines for the ...
Known for
Child Dry | Continence Iccs | Voiding | Document International
KOL-Index: 34 Müllerianosis of the urinary bladder is an extremely rare benign condition, characterized by the presence of a mixture of at least two müllerian-derived components, and endosalpingiosis is also an extremely rare condition, characterized by the presence of tubal-type epithelium. In this report, we describe the 17(th) case of müllerianosis and 5(th) case of endosalpingiosis of the urinary ...
Known for
Extremely Rare Benign | Variably-Sized Dilated Tubular Glands | Covered Ciliated | 37-Year-Old Japanese Female
KOL-Index: 33 γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers-glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma-and promotes cancer progression; its depletion leads to the suppression of proliferation, invasion, and migration of ...
Known for
Cancer-Bearing Xenograft Mice | Ovarian Cancers | Inhibition Ggct | Cancer Depletion

From the Section of Laparoscopic and Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio and the Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan

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