Prominent publications by Chikako Nishigori

KOL Index score: 15125

The transcription factor signal transducer and activator of transcription 3 (STAT3) has two important phosphorylation sites, Tyr705 and Ser727, for its activation. Ser727 phosphorylation has been considered to be a secondary event after Tyr705 phosphorylation. In this study, the role and regulation of Ser727 phosphorylation in STAT3 in melanocytic cells were examined. STAT3 was phosphorylated on Ser727 in the absence of Tyr705 phosphorylation in melanocytes. ...

Known for Melanoma Cells |  Stat3 Phosphorylation |  Nuclear Translocation |  Cell Survival |  Tyr705 Ser727
KOL Index score: 13078

Hand-foot skin reaction is a most common multi-kinase inhibitor-related adverse event. This study aimed to examine whether the toxicity of sorafenib and sunitinib for human keratinocytes was associated with inhibiting signal transduction and activator of transcription 3 (STAT3). We studied whether STAT3 activity affects sorafenib- and sunitinib-induced cell growth inhibition in HaCaT cells by WST-8 assay. Stattic enhanced the cell-growth inhibitory and apoptotic effects of sorafenib and ...

Known for Sorafenib Sunitinib |  Signal Transduction |  Hacat Cells |  Transcription 3 |  Wst8 Assay
KOL Index score: 12344

BACKGROUND: Current treatment with biologics has produced dramatic therapeutic effects in patients with psoriasis, although these agents occasionally decrease in efficacy. One of the main factors responsible for this attenuation is attributed to the development of antidrug antibodies (ADAs).

OBJECTIVES: To analyse the relationship between serum drug concentrations, the presence of ADAs and treatment efficacy of adalimumab and infliximab, and to determine the optimal use of these ...

Known for Adalimumab Infliximab |  Monoclonal Antibodies |  Treatment Psoriasis |  Patients Adas |  Drug Concentrations
KOL Index score: 12315

CD4(+)CD25(+) T cells are an important population that plays a crucial role in the maintenance of peripheral self-tolerance. Recently, it was shown that the elimination of these cells by in vivo administration of anti-CD25 monoclonal antibody (mAb) caused the regression of highly immunogenic tumors in syngeneic mice. In this study, we examined whether B16F10 melanoma cells regressed with the elimination of CD25(+) regulatory T cells. We found the melanoma cells were not affected at all ...

Known for Tumor Cells |  B16f10 Melanoma |  Cell Depletion |  Skin Neoplasms |  Anticd25 Mab
KOL Index score: 11743

Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) is a member of the signal regulatory protein family in which the extracellular region interacts with its ligand, CD47. Recent studies have demonstrated that SHPS-1 plays an important role in cell migration and cell adhesion. We demonstrate in this study, using immunohistochemical and flow cytometric analyses, that murine Langerhans cells (LCs) express SHPS-1. Treatment of mice ears with ...

Known for Langerhans Cells |  Lymph Nodes |  Monoclonal Antigens |  Tyrosine Phosphatase |  Src Homology
KOL Index score: 11172

BACKGROUND: It has been reported that patients with cholinergic urticaria have a type 1 allergy to autologous sweat; however, the pathogenesis of that disorder has not been fully elucidated.

OBJECTIVE: We investigated the responsiveness to autologous sweat and serum in patients with cholinergic urticaria in relation to their clinical characteristics. We further classified the clinical subtypes that are clearly characterized by responsiveness to in vivo and in vitro tests as well as their ...

Known for Autologous Sweat |  Cholinergic Urticaria |  Serum Patients |  Positive Reactions |  Histamine Release
KOL Index score: 10522

Xeroderma pigmentosum (XP) patients in Tunisia who belong to the genetic complementation group A (XPA) have milder skin symptoms than do Japanese XPA patients. Such difference in the clinical features might be caused by the difference in the site of mutation in the XP A-complementing (XPAC) gene. The purpose of this study is to identify the genetic alterations in the XPAC gene in the Tunisian XPA patients and to investigate the relationship between the clinical symptoms and the genetic ...

Known for Point Mutation |  Xeroderma Pigmentosum |  Xpa Patients |  Exon 6 |  Genetic Complementation
KOL Index score: 10317

The hepatocyte growth factor (HGF) signaling pathway was examined in human normal melanocytes and three malignant melanoma cell lines. HGF-induced activation of c-Met, its receptor-tyrosine kinase, was observed in both melanocytes and melanoma cells, whereas phosphatidylinositol 3-kinase (PI3K), a downstream target of c-Met, was not activated in the melanocytes but enhanced in the melanoma cell lines. The electrophoretic mobility of Gab1, the scaffolding adapter protein that couples ...

Known for Melanoma Cells |  Protein Kinase |  Hepatocyte Growth |  Phosphatidylinositol 3 |  Factor Induced
KOL Index score: 9916

UV exposure induces skin cancer, in part, by inducing immune suppression. Repairing DNA damage, neutralizing the activity of cis-urocanic acid, and reversing oxidative stress abrogate UV-induced immune suppression and skin cancer induction, suggesting that DNA, UCA, and lipid photo-oxidation serve as UV photoreceptors. What is not clear is whether signaling through each of these different photoreceptors activates independent pathways to induce biological effects or whether there is a ...

Known for Dna Repair |  Immune Suppression |  Oxidative Stress |  Skin Cancer |  5 Ht
KOL Index score: 9757

We identified seven novel germline mutations of the PTCH gene in eight unrelated Japanese patients with nevoid basal cell carcinoma syndrome (NBCCS). In order to ensure genetic diagnosis, all 23 coding exons of the PTCH gene were amplified from genomic DNA by polymerase chain reaction (PCR) and sequenced. Mutations were found in all eight patients with NBCCS. The mutations detected in this study include one insertion/deletion mutation, one 1-bp insertion, two 1-bp deletions, one nonsense ...

Known for Ptch Gene |  Germline Mutations |  Cell Carcinoma |  Nevoid Basal |  Patients Nbccs
KOL Index score: 9601

UV irradiation interferes with the induction of T cell-mediated immune responses, in part by causing cells in the skin to produce immunoregulatory cytokines. Recent evidence implicates UV-induced DNA damage as a trigger for the cascade of events leading to systemic immune suppression in vivo. However, to date, there has been no direct evidence linking DNA damage and cytokine production in UV-irradiated cells. Here we provide such evidence by showing that treatment of UV-irradiated murine ...

Known for Dna Damage |  Inbred Balb Mice |  Murine Keratinocytes |  Cells Skin |  Uv Irradiation
KOL Index score: 9334

BackgroundSignal transducer and activator of transcription (STAT)3 is a reported mediator of molecular-targeted drug-induced keratinocyte toxicity.AimOur purpose was to assess the association of single nucleotide polymorphisms (SNPs) in STAT3 with hand-foot skin reactions (HFSR) in patients with metastatic renal cell carcinoma (mRCC) treated with multiple tyrosine kinase inhibitors (mTKIs).Patients and MethodsSixty-five Japanese patients with clear cell renal cell carcinoma who were ...

Known for Cell Carcinoma |  Single Nucleotide Polymorphisms |  Retrospective Analysis |  Kinase Inhibitors |  Japanese Patients
KOL Index score: 9144

Keratinocytes are the major target of sunlight, and they produce prostaglandin (PG) E2 upon ultraviolet (UV) exposure. Although indomethacin, one of cyclooxygenase inhibitors, is known to suppress UV-induced acute skin inflammation, it remains uncertain whether endogenous PGE2 is responsible for UV-induced skin inflammation, and which subtype of PGE2 receptors mediates this process. UV-induced skin inflammation was investigated by using genetically and pharmacologically PGE2 ...

Known for Induced Skin |  Ep4 Receptors |  Blood Flow |  Uv Exposure |  Ultraviolet Rays
KOL Index score: 8838

Phototherapy with narrow-band UVB (NB-UVB), with a peak exclusively at 311 nm wavelength, has been found to be more effective in treating a variety of skin diseases than conventional broad-band UVB (BB-UVB). To assess the difference in carcinogenic activity between NB-UVB and BB-UVB, we investigated skin tumor formation by irradiating albino hairless, Ogg1 knockout mice and C57BL/6J wild counterparts with these two UV sources. We found that the ratio of malignant skin tumors induced by ...

Known for Cyclobutane Pyrimidine Dimer |  Nb Uvb |  Cpd Formation |  Skin Tumor |  C57bl Mice


Chikako Nishigori: Influence Statistics

Sample of concepts for which Chikako Nishigori is among the top experts in the world.
Concept World rank
cyclosporine antagonists histamine #1
direct base sequencing #1
japanese xpa patients #1
cutis dyschromica #1
effects ascorbyl2phosphate magnesium #1
transcription creb activity #1
66 oligomer probes #1
extramammary polymorphism carcinoma #1
ser727 phosphorylation stat3 #1
xp status #1
continued blockade #1
potential new trigger #1
sorafenib hacat cells #1
satellite wheals lack #1
initial intense exposure #1
conventional sat #1
snhl xpadeficient mice #1
japan xp complementation #1
cancer extramammary #1
mpc wnt #1
sweat allergy‐type #1
protein animals immunosorbent #1
action spectrum disorder #1
hcs surfacebound ige #1
cholinergic urticaria subtypes #1
tpa phosphorylated stat3 #1
serum factornegative patients #1
tgfβr2 contrast #1
cellular melanocytes melanoma #1
patients xpv #1
cholinergic urticaria epidemiology #1
outer stressors #1
japan pcr amplification #1
hive formation subtypes #1
grade 3 sccs #1
xpaxp #1
urticaria unresponsive #1
unique ros levels #1
uv mouse #1
xp cells killing #1
appearance trial adapalene #1
8oxoguanine epidermal cells #1
apoptosis hsc1 cells #1
hardening serum #1
hair follicle melanocyte #1
sat conventional #1
mrna abnormal splicings #1
skin toxicity sorafenib #1
topical moisturizer sides #1
stat3 src inhibitor #1

Key People For Xeroderma Pigmentosum

Top KOLs in the world
Kenneth H Kraemer
xeroderma pigmentosum dna repair skin cancer
Alan Robert LEHMANN
xeroderma pigmentosum dna repair cockayne syndrome
James E Cleaver
xeroderma pigmentosum dna repair ultraviolet light
Dirk Bootsma
xeroderma pigmentosum dna repair human chromosome
Jay H Robbins
xeroderma pigmentosum dna repair cockayne syndrome
Jan H J Hoeijmakers
dna repair xeroderma pigmentosum cockayne syndrome

Chikako Nishigori:Expert Impact

Concepts for whichChikako Nishigorihas direct influence:Xeroderma pigmentosum,  Cholinergic urticaria,  P53 gene,  Autologous sweat,  Skin cancer,  Melanoma cells,  Japanese patients,  Chemical peeling.

Chikako Nishigori:KOL impact

Concepts related to the work of other authors for whichfor which Chikako Nishigori has influence:Xeroderma pigmentosum,  Dna damage,  Oxidative stress,  Skin cancer,  Blau syndrome,  Ultraviolet radiation,  Melanoma cells.



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Division of Research on Intractable Dermatological Disease, Department of iPS cell Applications, Kobe University Graduate School of Medicine, Kobe, Japan | Division of Dermatology, Kobe University Graduate School of Medicine, Kobe, Japan | Division o

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