• Disease
  • Multiple
  • Multiple Myeloma
  • Hitoji Uchiyama

    Prominent publications by Hitoji Uchiyama

    KOL Index score: 10589

    PURPOSE: beta-catenin is the downstream effector of the Wnt signaling pathway, and it regulates cell proliferation. beta-catenin overexpression correlates positively with prognosis in several types of malignancies. We herein assessed its effects on growth of multiple myeloma cells using a xenograft model.

    EXPERIMENTAL DESIGN: We first investigated the expression of beta-catenin in multiple myeloma cell lines and multiple myeloma cells obtained from patients. Next, we investigated the ...

    Also Ranks for: Multiple Myeloma |  small interfering |  mouse model |  beta catenin |  inbred balb mice
    KOL Index score: 8870

    PURPOSE: To evaluate intraocular pressure (IOP) change through hemodialysis and examine other factors to affect IOP change in patients treated with hemodialysis.

    DESIGN: Prospective, observational case series.

    METHODS: IOP, blood pressure, and plasma colloid osmotic pressure (COP) were measured in 188 eyes of 95 patients receiving hemodialysis in Nantan General Hospital.

    RESULTS: IOP significantly decreased after hemodialysis (P = 0.006). Body weight, systolic and diastolic blood ...

    Also Ranks for: Intraocular Pressure |  hemodialysis patients |  renal dialysis |  iop blood |  female glaucoma
    KOL Index score: 8359

    In the opinion of the European LeukemiaNet (ELN), nucleophosmin member 1 gene mutation (NPM1 mut)-positive acute myeloid leukemia (AML) with an fms-like kinase 3-internal tandem duplication (FLT3-ITD) allele ratio (AR) <0.5 (low AR) has a favorable prognosis, and allogeneic hematopoietic stem cell transplant (allo-HSCT) in the first complete remission (CR1) period is not actively recommended. We studied 147 patients with FLT3-ITD gene mutation-positive AML, dividing them into those with ...

    Also Ranks for: Prognostic Impact |  myeloid leukemia |  npm1 mutation |  allohsct cr1 |  tyrosine kinase
    KOL Index score: 8172

    Recently, the ligand for c-mpl has been cloned and initial studies have shown it to be the platelet regulatory factor, thrombopoietin (TPO). To elucidate the role of TPO in the reconstitution of megakaryopoiesis and platelet production after stem cell transplantation, we measured serum TPO levels in nine patients undergoing autologous peripheral blood stem cell transplantation (PBSCT) and in healthy volunteers. Serum TPO levels significantly correlated with the degree of peripheral ...

    Also Ranks for: Stem Cell |  thrombopoietin levels |  platelet count |  autologous peripheral |  serum tpo
    KOL Index score: 7777

    To improve the selection of donors for allogeneic stem cell transplantation, it is important to identify reliable parameters that predict CD34+-cell yields after granulocyte-colony stimulating factor (G-CSF)-induced peripheral blood stem cell (PBSC) mobilization. We retrospectively investigated the peripheral blood (PB) kinetics of white blood cells (WBCs), CD34+ cells, matrix metalloproteinases (MMP)-9 and -2, and tissue inhibitors of metalloproteinases (TIMP)-1 and -2 in 15 healthy ...

    Also Ranks for: Stem Cell |  peripheral blood |  stimulating factor |  granulocyte colony |  gcsf treatment
    KOL Index score: 7740

    Autologous hematopoietic cell transplantation (HCT) has not gained universal popularity in the treatment of acute myeloid leukemia (AML), and its status remains unclear. To determine the implementation status and outcomes of autologous HCT for adults with AML in Japan, we analyzed data from 1,174 patients (including 446 with acute promyelocytic leukemia [APL]) who underwent autologous HCT between 1992 and 2016 consecutively reported to the Japanese nationwide transplantation registry. ...

    Also Ranks for: Acute Myeloid Leukemia |  cell transplantation |  autologous hematopoietic |  myeloid aml |  complete remission
    KOL Index score: 7699

    High-dose chemotherapy (HDT) supported by autologous stem cell transplantation (ASCT) has long been one of the standards of care for younger patients with multiple myeloma (MM). Cyclophosphamide (CY) plus granulocyte colony-stimulating factor (G-CSF) has been the conventional preparation for hematopoietic progenitor cell (HPC) mobilization, although the optimal dosage of CY in this setting has not yet been clearly defined. This study investigated the efficacy and safety of low-dose ...

    Also Ranks for: Multiple Myeloma |  cell mobilization |  stimulating factor |  granulocyte colony |  patients mm
    KOL Index score: 7226

    Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML/MDS) represent severe late effects in patients receiving hematopoietic cell transplantation (HCT) for lymphoma. The choice between high-dose therapy with autologous HCT and allogeneic HCT with reduced-intensity conditioning remains controversial in patients with relapsed lymphoma. We retrospectively analyzed incidence and risk factors for the development of t-AML/MDS in lymphoma patients treated with autologous or ...

    Also Ranks for: Myelodysplastic Syndrome |  autologous hct |  cell transplantation |  acute myeloid |  patients risk
    KOL Index score: 6571

    OBJECTIVE: We retrospectively investigated the efficacy and predictive factors for the treatment outcomes of bortezomib plus dexamethasone (BD) as second-line induction therapy prior to high-dose chemotherapy supported by autologous stem cell transplantation (HDT/ASCT) in multiple myeloma (MM) patients.

    METHODS: Sixty-six transplant eligible MM patients treated by the Kyoto Clinical Hematology Study Group between 2006 and 2011 were investigated. Conventional induction chemotherapy, ...

    Also Ranks for: Multiple Myeloma |  stem cell |  induction therapy |  partial response |  asct patients
    KOL Index score: 6385

    We conducted a multicenter prospective study for evaluating the utility and prognostic markers of recombinant human soluble thrombomodulin (rTM) treatment for acute disseminated intravascular coagulation (DIC) by various types of hematologic malignancies. The study comprised 30 patients with DIC due to hematologic diseases without severe infection. DIC improved in 15 patients and 20 were alive on day 28. Univariate analyses showed that, in comparison with patients who had survived on day ...

    Also Ranks for: Disseminated Intravascular |  rtm dic |  adamts13 activity |  human soluble |  severe infection
    KOL Index score: 6200

    Subcutaneous panniculitis-like T cell lymphoma (SPTL) is a rare subtype of non-Hodgkin lymphoma for which a definitive therapeutic strategy has not been established yet. We report a case of chemotherapy-resistant SPTL with hemophagocytic syndrome (HPS) which was successfully treated with cyclosporine A (CsA) plus methylprednisolone (mPSL), and also reviewed 11 SPTL cases treated with CsA, previously reported in the literature. Our patient was a 38-year-old female with SPTL. The disease ...

    Also Ranks for: Cell Lymphoma |  hemophagocytic syndrome |  subcutaneous panniculitis |  2 weeks |  complete remission
    KOL Index score: 6106

    The prognostic significance of FLT3-tyrosine kinase domain (TKD) mutations remains unknown. To investigate the prognostic impact of FLT3-TKD, 676 de novo acute myeloid leukemia (AML), we retrospectively analyzed cases and conducted a review of the literature. Of the 676 de novo AML cases, 34 (5.0%) were FLT3-TKD-positive; both FLT3-TKD and FLT3-ITD were noted in only two cases (0.3%). Although no significant differences in relapse-free survival (RFS) were noted, FLT3-TKD-positive cases ...

    Also Ranks for: Tyrosine Kinase |  acute myeloid |  flt3 tkd |  prognostic significance |  leukemia aml
    KOL Index score: 6043

    INTRODUCTION: The most common cause of central pontine myelinolysis is an overly rapid correction of hyponatremia, although it can also occur in patients with any condition leading to nutritional or electrolyte stress. We report a case of diffuse large B-cell lymphoma with central pontine myelinolysis developing at the onset of disease. To the best of our knowledge, hematological malignancies presenting with central pontine myelinolysis have been rarely reported, especially in previously ...

    Also Ranks for: Central Pontine |  cell lymphoma |  diffuse large |  resonance imaging |  brain magnetic


    Hitoji Uchiyama: Influence Statistics

    Sample of concepts for which Hitoji Uchiyama is among the top experts in the world.
    Concept World rank
    68yearold female aitl #7
    pbpct leukemia #7
    clot fcm #7
    pbpct neutrophil counts #7
    aitl csa #7
    il3 rose #7
    transiently pbpct #7
    bm involvement detection #7
    reconstitution megakaryopoiesis #7
    dlbcl prevalent #7
    amelioration systemic symptoms #7
    rose pbpct #7
    haematological malignancies pbpct #7
    34 154 patients #7
    serum levels pbpct #7
    tumors amelioration #7
    pbpct serum levels #7
    platelet regulatory factor #7
    firstline rchop regimen #7
    fcm prognostically #7
    rasrelated protein pathways #7
    chemotherapy refractory aitl #7
    pcgdtcl female genome #7
    kinetics serum cytokines #7
    female aitl #7
    combination bm biopsy #7
    serum tpo pbsct #7
    aitl conventional #7
    2500 fmoles #7
    pbpct il1 #7
    tp53related signaling #7
    bm biopsy fcm #7
    fcm bm smear #7
    tpo critical role #7
    cyclosporin aitl #7
    pbpct serum #7
    tcl gene cluster #7
    221 dlbcl patients #7
    purified pbsct #7
    bm clot fcm #7
    elisa 14 patients #8
    del13q 25 patients #8
    metaphase spreads predictor #8
    detection −13 #8
    t1416 1q21 #8
    monosomy −13 #8
    pontine aged #8
    detection gbanding #8
    −13 detected #8
    spreads predictor #8

    Key People For Multiple Myeloma

    Top KOLs in the world
    Kenneth Carl Anderson
    multiple myeloma mm cells board directors
    Robert A Kyle
    multiple myeloma undetermined significance consultancy funding
    Sundararajan Vincent Rajkumar
    multiple myeloma consultancy funding undetermined significance
    Paul Gerard Guy Richardson
    multiple myeloma board directors advisory committees
    JesusFernando San San Miguel
    multiple myeloma consultancy honoraria board directors
    Bart Barlogie
    multiple myeloma total therapy gene expression

    Hitoji Uchiyama:Expert Impact

    Concepts for whichHitoji Uchiyamahas direct influence:Multiple myeloma,  Large bcell,  Cell lymphoma,  Prognostic impact,  Platelet engraftment,  Cell transplantation,  Diffuse large,  Myeloid leukemia.

    Hitoji Uchiyama:KOL impact

    Concepts related to the work of other authors for whichfor which Hitoji Uchiyama has influence:Multiple myeloma,  Acute myeloid leukemia,  Stem cell,  Intraocular pressure,  Peripheral blood,  Flt3 inhibitors,  Stimulating factor.



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    Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan; | Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan | Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan