Izumi Komoto

Izumi Komoto

Japan Neuroendocrine Tumor Society, Kyoto, Japan Department Of Surgery, Kansai Electric Power Hospital, Osaka, Japan Division Of Neuroendocrine Tumor Science, Kansai Electric ...

Direct Impact

Concepts for which Izumi Komoto has direct influence:

insulinoma cells
east asian
platinum-based chemotherapy
hot water
rb loss
endocrine neoplasia
calcium injection test

External impact

Concepts related to the work of other authors for which Izumi Komoto has influence:

platinum-based chemotherapy
repeat hepatectomy
rb loss
sstr2 expression
kras mutation
pancreatic neuroendocrine neoplasm
2 diabetes

Prominent publications by Izumi Komoto

KOL-Index: 48 Somatostatin analogues (SSAs) are widely used to treat gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Somatostatin receptor 2 (SSTR2) immunoreactivity serves as a predictive marker of the therapeutic efficacy of SSAs in pancreatic NETs. However, SSTR2 expression profiles in tumor cells and their association with the therapeutic efficacy of SSAs remains virtually unknown in ...
Known for
Neuroendocrine Cells | Gastrointestinal Nets | Primary Sites | Sstr2 Status
KOL-Index: 45 BACKGROUND/OBJECTIVES: Pancreatic neuroendocrine carcinoma (PanNEC)-G3 often presents along with genetic abnormalities such as KRAS, RB1, and TP53 mutations. However, the association between these genetic findings and response to chemotherapy and prognosis has not been clarified. This study aimed to clarify the clinicopathological features of PanNEC-G3. METHODS: We performed a subgroup ...
Known for
Pannen-G3 | 49 | Mutation Groups | Pannec Classified
KOL-Index: 43 Functioning pancreaticoduodenal neuroendocrine tumors (PD-NETs) are popular in a textbook, but they are still unfamiliar to a general clinician, and delay of diagnosis or misdiagnosis has been reported even today. It is a consensus that sporadic functioning PD-NET is cured only by surgical resection. So, early detection and early resection is the gold standard for the treatment of ...
Known for
Tumors Functioning | Resection Early | Pancreaticoduodenal
KOL-Index: 30 We overviewed the recent development of curative surgery for gastrinoma that has been rapidly improved since the development of new localization techniques, especially the selective arterial secretagogue injection test (SASI test) and somatostatin receptor scintigraphy (SRS). A number of new pathological findings of gastrinomas in patients with Zollinger-Ellison syndrome have been ...
Known for
Somatostatin Receptor Scintigraphy | Zollinger Ellison | Strategy Gastrinoma
KOL-Index: 29 Aims/hypothesisG protein-coupled receptor 40 (GPR40) is abundantly expressed in pancreatic beta cells in rodents, where it facilitates glucose-induced insulin secretion in response to mid- to long-chain fatty acids in vitro. However, GPR40 gene expression in humans has not been fully investigated, and little is known about the physiological and pathophysiological roles of GPR40 in humans. ...
Known for
Insulinoma Tissues | Sulfonylurea Receptor | Gpr40 Mrna | Expression Gene
KOL-Index: 28 Purpose: Patients with pancreatic neuroendocrine neoplasm grade-3 (PanNEN-G3) show variable responses to platinum-based chemotherapy. Recent studies indicated that PanNEN-G3 includes well-differentiated neuroendocrine tumor with G3 (NET-G3). Here, we examined the clinicopathologic and molecular features of PanNEN-G3 and assessed the responsiveness to chemotherapy and survival.Experimental ...
Known for
Chemotherapy Response | Japanese Multicenter | Chemotherapeutic | Net Pancreatic
KOL-Index: 22 Background Lanreotide is a long-acting somatostatin analog with demonstrated efficacy against enteropancreatic neuroendocrine tumor (NET) in the phase III (CLARINET) study. Materials and Methods In this single-arm study, Japanese patients with grade (G) 1/G2 NET received lanreotide (120 mg/4 weeks) for 48 weeks. Those who completed the study were enrolled in a long-term extension study. The ...
Known for
Phase Lanreotide | Cbr Pfs | Orr Safety
KOL-Index: 21 BackgroundThere have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan.MethodsWe examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sampling method.ResultsA total of 2,845 individuals received treatment for PETs. ...
Known for
Gep Nets | Methodswe | Pets Estimated | Nationwide Stratified Sampling Method
KOL-Index: 21 PurposeStreptozocin (STZ) is a key agent for treating advanced pancreatic neuroendocrine tumors (pNET). Most STZ regimens for pNET are daily and also include 5-fluorouracil (5FU), whereas STZ monotherapy and weekly regimens have also been applied in daily practice in Japan. The present study aimed to evaluate responses to weekly regimens and to STZ monotherapy, and to identify a predictive ...
Known for
Regimens Stz | Key Agent | Ki67 Proliferation | Monotherapy Pnet
KOL-Index: 19 OBJECTIVE: Human macrophage metalloelastase is referred to as matrix metalloproteinase (MMP-12), its function in tumors is contradictory. The current study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (SCC). PATIENTS AND METHODS: We analyzed the levels of MMP-12 mRNA expression in 67 patients with primary esophageal SCC by Northern blot analysis and ...
Known for
Situ Hybridization Immunohistochemical Staining | Mmp- 12 Subgroup | 27 67 Esophageal Scc | Expression Esophageal

Japan Neuroendocrine Tumor Society, Kyoto, Japan Department of Surgery, Kansai Electric Power Hospital, Osaka, Japan Division of Neuroendocrine Tumor Science, Kansai Electric Power Medical Research Institute, Osaka, Japan

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