Prominent publications by Izumi Komoto

KOL Index score: 15472

Purpose: Patients with pancreatic neuroendocrine neoplasm grade-3 (PanNEN-G3) show variable responses to platinum-based chemotherapy. Recent studies indicated that PanNEN-G3 includes well-differentiated neuroendocrine tumor with G3 (NET-G3). Here, we examined the clinicopathologic and molecular features of PanNEN-G3 and assessed the responsiveness to chemotherapy and survival.Experimental Design: A total of 100 patients with PanNEN-G3 were collected from 31 institutions, and after ...

के लिए जाना जाता है Rb Loss |  pancreatic neuroendocrine |  kras mutation |  net g3 |  response chemotherapy
KOL Index score: 13781

AIM: To search for the optimal surgery for gastrinoma and duodenopancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1.

METHODS: Sixteen patients with genetically confirmed multiple endocrine neoplasia type 1 (MEN 1) and Zollinger-Ellison syndrome (ZES) underwent resection of both gastrinomas and duodenopancreatic neuroendocrine tumors (NETs) between 1991 and 2009. For localization of gastrinoma, selective arterial secretagogue injection test (SASI test) ...

के लिए जाना जाता है Multiple Endocrine |  type 1 |  gastrinoma patients |  sasi test |  biochemical cure
KOL Index score: 11366


Although neuroendocrine tumors (NETs) are rare, the number of patients with NET is increasing. However, in Japan, there have been no epidemiological studies on NET since 2005; thus, the prevalence of NET remains unknown.Methods

We reported the epidemiology of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) [pancreatic neuroendocrine tumors (PNETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005. Here, we conducted the second nationwide survey on ...

के लिए जाना जाता है Nationwide Survey |  gastrointestinal neuroendocrine |  epidemiological trends |  patients net |  distant metastasis
KOL Index score: 10703

Aims/hypothesisG protein-coupled receptor 40 (GPR40) is abundantly expressed in pancreatic beta cells in rodents, where it facilitates glucose-induced insulin secretion in response to mid- to long-chain fatty acids in vitro. However, GPR40 gene expression in humans has not been fully investigated, and little is known about the physiological and pathophysiological roles of GPR40 in humans. The aim of this study, therefore, was to examine GPR40 expression and its clinical implications in ...

के लिए जाना जाता है Gpr40 Expression |  insulin secretion |  pancreatic beta cells |  islet cell |  neoplastic humans
KOL Index score: 9995


The current study evaluated efficacy of

the intravenous calcium injection test as a new diagnostic approach to

clarify the existence of gastrinoma, which often goes undetected with

routine testing. Twenty-six patients with hypergastrinemia were

studied. For the calcium injection test, blood samples were taken from

12 patients with hypergastrinemia (HG), and three healthy volunteers,

and one patient with nonfunctioning endocrine tumor in the pancreas

(control). We compared ...

के लिए जाना जाता है Differential Diagnosis |  calcium injection |  secretin test |  zes patients |  blood samples
KOL Index score: 8933

BackgroundThere have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan.MethodsWe examined the epidemiology of GEP-NETs [pancreatic endocrine tumors (PETs) and gastrointestinal neuroendocrine tumors (GI-NETs)] in Japan in 2005 using a nationwide stratified random sampling method.ResultsA total of 2,845 individuals received treatment for PETs. Prevalence was estimated as 2.23/100,000 with an annual onset incidence of 1.01/100,000. ...

के लिए जाना जाता है Neuroendocrine Tumors |  ginets japan |  tumor size |  distant metastases |  annual onset incidence
KOL Index score: 8113

More than 50% of patients with multiple endocrine neoplasia type 1 (MEN1) develop gastroenteropancreatic neuroendocrine tumors (GEPNETs), and insulinoma is the second most common functioning GEPNET. Compared to other functioning and nonfunctioning GEPNETs in MEN1, insulinoma is considered to develop at a younger age. To clarify the clinical features of insulinoma developed in Japanese patients with MEN1, a recently constructed database of Japanese MEN1 patients was analyzed. Among 560 ...

के लिए जाना जाता है Multiple Endocrine |  men1 patients |  type 1 |  age diagnosis |  pancreatic neoplasms
KOL Index score: 7552

BackgroundThe worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroendocrine Tumor Society (JNETS) planned to investigate the recent incidence and distribution of these tumors using data from the national cancer registry started in 2016. This study examined the incidence and distribution of primary sites as well as rate of advanced disease ...

के लिए जाना जाता है Neuroendocrine Neoplasms |  japan nens |  tumors pancreatic |  primary sites |  cancer registry
KOL Index score: 7520

Ghrelin is a 28-amino acid peptide that regulates GH release together with GHRH and somatostatin. The expression of ghrelin has been detected in the stomach, small intestine, hypothalamus, pituitary gland, kidney, placenta, and testis. Recently it was reported that ghrelin is present in pancreatic alpha-cells and that it stimulates insulin secretion. In this study, we examined the ghrelin expression in two cases of glucagonoma and two cases of insulinoma by Northern blot analysis and ...

के लिए जाना जाता है Ghrelin Expression |  multiple endocrine |  islet cell |  insulin secretion |  pituitary gland
KOL Index score: 7451

BackgroundThe role of surgery in pancreatic neuroendocrine neoplasm grade 3 (pNEN-G3) treatment remains unclear. We aimed to clarify the role of surgery for pNEN-G3, which has recently been reclassified as pancreatic neuroendocrine tumor-G3 (pNET-G3) and pancreatic neuroendocrine carcinoma-G3 (pNEC-G3), with and without metastases, respectively.MethodsWe analyzed a subgroup of patients from the Japanese pancreatic NEC study, a Japanese multicenter case-series study of pNEN-G3. ...

के लिए जाना जाता है Pancreatic Neuroendocrine |  carcinoma g3 |  aged neoplasm |  surgical procedures |  patients pnet
KOL Index score: 7308

BackgroundWe conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004.MethodsData on 1541 patients, 514 pancreatic endocrine tumors (PETs) and 1027 gastrointestinal carcinoids (GICs), were collected and analyzed.ResultsNonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and ...

के लिए जाना जाता है Nationwide Survey |  pets 74 |  nets japan |  neuroendocrine tumors |  multiple endocrine
KOL Index score: 7014

Background Lanreotide is a long-acting somatostatin analog with demonstrated efficacy against enteropancreatic neuroendocrine tumor (NET) in the phase III (CLARINET) study. Materials and Methods In this single-arm study, Japanese patients with grade (G) 1/G2 NET received lanreotide (120 mg/4 weeks) for 48 weeks. Those who completed the study were enrolled in a long-term extension study. The primary endpoint was the clinical benefit rate (CBR) defined as a complete response, partial ...

के लिए जाना जाता है Japanese Patients |  neuroendocrine tumors |  lanreotide autogel |  neoplasms peptides |  cbr orr

के लिए प्रमुख लोग Multiple Endocrine

दुनिया में शीर्ष kols
Stephen * ******
multiple endocrine men1 gene primary hyperparathyroidism
Samuel * *****
multiple endocrine parathyroid glands carcinoembryonic antigen
Rajesh * *******
multiple endocrine neoplasia type mutational analysis
Britt * ********
multiple endocrine men1 gene neoplasia type
Maria ***** ******
multiple endocrine estrogen receptor postmenopausal women
Bruce ******* **** ******
breast cancer multiple endocrine neoplasia type
एक खोज वाक्यांश का चयन करें   multiple endocrine , multiple endocrine neoplasia , multiple endocrine men1 , multiple endocrine neoplasias , multiple endocrine tumors

Izumi Komoto:विशेषज्ञ प्रभाव

जिसके लिए अवधारणाएंIzumi Komotoप्रत्यक्ष प्रभाव है:Multiple endocrine,  Gastric carcinoma,  Rb loss,  Neuroendocrine tumors,  Human pancreas,  Ghrelin expression,  Primary hepatic gastrinoma,  Japanese patients.

Izumi Komoto:कोल इम्पैक्ट

अन्य लेखकों के काम से संबंधित अवधारणाएं जिनके लिएfor which Izumi Komoto प्रभाव है:Neuroendocrine tumors,  Multiple endocrine,  Insulin secretion,  Lymph node metastasis,  Esophageal cancer,  Chemokine receptors,  Neoplasia type.



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Kansai Electric Power Medical Research Institute, Osaka 553-0003, Japan | Department of Surgery, Kansai Electric Power Hospital, Osaka 553-0003, Japan;,, (I.K.);,, (M.I.) | Department of Surgery