• Disease
  • Venous
  • Venous Stasis
  • Gian Cesare Guidi

    Prominent publications by Gian Cesare Guidi

    KOL Index score: 21580

    BACKGROUND: The study is aimed at evaluating the performance of the predictive model ROMA (Risk of Ovarian Malignancy Algorithm), which utilizes the combination of human epididymis protein 4 (HE4) and CA125 values to assess the risk of epithelial ovarian cancer (EOC) in women with a pelvic mass.

    METHODS: One hundred and four women diagnosed with a pelvic mass (55 EOC and 49 benign cases) and scheduled to have surgery were enrolled, along with 49 healthy females. Preoperative serum ...

    Also Ranks for: Pelvic Mass |  epithelial ovarian |  ca125 roma |  95 he4 |  sensitivity specificity
    KOL Index score: 10484

    In order to describe the haemostatic role of a variation in inhibitor reactivity with different factor VIII (FVIII) concentrates, we have compared inhibitor titres against a panel of FVIII concentrates and correlated titre with the capacity to inhibit thrombin generation. Three plasma-derived concentrates were tested in vitro in mixing experiments with inhibitor plasmas from 11 patients with severe haemophilia A: Fanhdi, which contains von Willebrand factor (VWF) with a final ratio of ...

    Also Ranks for: Thrombin Generation |  factor viii |  kogenate bayer |  inhibitor titres |  vwf ratio
    KOL Index score: 10382

    INTRODUCTION: The validation process is essential in accredited clinical laboratories. Aim of this study was to validate five kinds of serum vacuum tubes for routine clinical chemistry laboratory testing.

    MATERIALS AND METHODS: Blood specimens from 100 volunteers in five different serum vacuum tubes (Tube I: VACUETTE, Tube II: LABOR IMPORT, Tube III: S-Monovette, Tube IV: SST and Tube V: SST II) were collected by a single, expert phlebotomist. The routine clinical chemistry tests were ...

    Also Ranks for: Vacuum Tubes |  preanalytical management |  clinical chemistry |  sst tube |  statistical significance
    KOL Index score: 10156

    BACKGROUND: Preanalytical factors are the main source of variation in clinical chemistry testing and among the major determinants of preanalytical variability, sample hemolysis can exert a strong influence on result reliability. Hemolytic samples are a rather common and unfavorable occurrence in laboratory practice, as they are often considered unsuitable for routine testing due to biological and analytical interference. However, definitive indications on the analytical and clinical ...

    Also Ranks for: Clinical Chemistry |  hemolysis blood |  ldh potassium |  hemolyzed specimens |  preanalytical variability
    KOL Index score: 9891

    INTRODUCTION: The activities involving phlebotomy, a critical task for obtaining diagnostic blood samples, are poorly studied as regards the major sources of errors and the procedures related to laboratory quality control. The aim of this study was to verify the compliance with CLSI documents of clinical laboratories from South America and to assess whether teaching phlebotomists to follow the exact procedure for blood collection by venipuncture from CLSI/NCCLS H03-A6 - Procedures for ...

    Also Ranks for: Diagnostic Blood |  clsi h03a6 document |  phlebotomy training |  procedures collection |  venipuncture quality
    KOL Index score: 9546

    Recent Genome-Wide Association Studies (GWAS) have pinpointed different single nucleotide polymorphisms consistently associated with blood pressure (BP) and hypertension prevalence. However, little data exist regarding single nucleotide polymorphisms predicting BP variation over time and hypertension incidence. The aim of this study was to confirm the association of a genetic risk score (GRS), based on 29 independent single nucleotide polymorphisms, with cross-sectional BP and ...

    Also Ranks for: Genetic Risk Score |  blood pressure |  mm hg |  hypertension incidence |  traditional risk factors
    KOL Index score: 9373

    BACKGROUND: Tumour-released DNA in blood represents a promising biomarker for cancer detection. Although epigenetic alterations such as aberrant promoter methylation represent an appealing perspective, the discordance existing between frequencies of alterations found in DNA extracted from tumour tissue and cell-free DNA (cfDNA) has challenged their practical clinical application. With the aim to explain this bias of agreement, we investigated whether protocadherin 10 (PCDH10) promoter ...

    Also Ranks for: Colorectal Cancer |  promoter methylation |  plasma samples |  epigenetic alteration |  dna cfdna
    KOL Index score: 9345

    AIM: Although CA125 is the most widely used cancer marker in the diagnostic approach of pelvic masses in women, its clinical usefulness is limited because it lacks expression of the antigen in the early stages of disease. The human epididymis protein 4 (HE4) is frequently over-expressed in ovarian cancer, whereas its expression in normal tissues, including the ovary, is low. The aim of this study was to assess the concentration of both HE4 and CA125 in patients with different forms of ...

    Also Ranks for: Pelvic Mass |  he4 patients |  human epididymis protein |  diagnostic approach |  benign disease
    KOL Index score: 9284

    OBJECTIVE: Although there is information on biochemical markers of muscle and cardiac damage following strenuous exercise, little is known about the kinetics of these markers in athletes performing sub-maximal exercise.

    MATERIAL AND METHODS: Fifteen healthy, trained, Caucasian males took part in a 21-km run. Blood samples were collected before the run, immediately after (post), and 3 h, 6 h and 24 h thereafter. Biochemical markers of muscle and cardiac damage were evaluated on the ...

    Also Ranks for: Muscle Damage |  biochemical markers |  creatine kinase |  ast ldh |  ck mb
    KOL Index score: 9196

    BACKGROUND: While the promotion of health-related fitness is thereby widespread, less focus is currently being given on the biological influence that physical activity might exert on results of laboratory testing. As such, this study was undertaken to assess the kinetics of liver injury markers following physical exercise.

    DESIGN AND METHODS: Total and direct bilirubin as well as the activity of biochemical markers of liver injury including aspartate aminotransferase (AST), alanine ...

    Also Ranks for: Liver Injury |  creatine kinase |  ast ldh |  physical activity |  total direct bilirubin
    KOL Index score: 9159

    CONTEXT: Preanalytical factors influencing the reliability of laboratory testing are commonplace. It is traditionally accepted that hemolytic samples are unsuitable for coagulation assays because of the release of hemoglobin, intracellular components, and thromboplastic substances from damaged blood cells.

    OBJECTIVE: To evaluate the influence of blood cell lysis on routine coagulation testing.

    DESIGN: Twelve aliquots prepared by serial dilutions of homologous lysated samples collected ...

    Also Ranks for: Routine Coagulation Testing |  cell lysis |  prothrombin time |  fibrinogen samples |  blood coagulation
    KOL Index score: 9094

    BACKGROUND: Elevated levels of uric acid in serum (SUA) or plasma (PUA) are increasingly related to cardiovascular disease. It is unclear whether they are independent risk factors or simply markers, reflecting association with other traditional risk factors.

    METHODS: We retrospectively assessed results of a lipid profile, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, total cholesterol to HDL-C ratio ...

    Also Ranks for: Uric Acid |  lipid profile |  hdl cholesterol |  plasma aip |  cardiovascular disease
    KOL Index score: 8980

    Obstructive sleep apnea syndrome (OSAS) is a chronic disease characterized by recurrent episodes of partial or complete upper airway collapse and obstruction during sleep, associated with intermittent oxygen desaturation, sleep fragmentation, and symptoms of disruptive snoring and daytime sleepiness. Increasing focus is being placed on the relationship between OSAS and all-cause and cardiovascular disease-related mortality, but it still largely unclear whether this association is ...

    Also Ranks for: Sleep Apnea |  cardiovascular disease |  heart failure |  relationship osas |  atrial fibrillation


    Gian Cesare Guidi: Influence Statistics

    Sample of concepts for which Gian Cesare Guidi is among the top experts in the world.
    Concept World rank
    laboratory manufacturers #1
    assays nitrogen measurement #1
    clinical biochemistry assays #1
    peripheral sampling sites #1
    hemolysis increases #1
    arbitrary limits manufacturers #1
    experiments vivo demonstrate #1
    physiology laboratory process #1
    nitrogen concentration output #1
    preanalytical interferences #1
    youngest erythrocytes selenium #1
    clinical chemistry reagents #1
    routine haematological #1
    laboratory prescriptions #1
    laboratory urgent #1
    data lipemia interference #1
    minutes homogenisation #1
    selenium availability #1
    testing interferences #1
    nira comparison #1
    laboratory immunoassays age #1
    manufacturers declarations manufacturers #1
    mother child concordances #1
    gshpx italian #1
    factors selenium concentration #1
    lipemia interference urgent #1
    reticulocyte gshpx activity #1
    clinical biochemistry analyses #1
    constrained economic context #1
    youngest erythrocytes #1
    nitrogen stools #1
    matrix serum plasma #1
    selenium enzyme activity #1
    biosynthesis systemic prostacyclin #1
    vitro variations #1
    dependent gshpx #1
    lipemia laboratory #1
    arbitrary limits #1
    stools infrared reflectance #1
    04272 #1
    stool collection minutes #1
    rbc gshpx activity #1
    consequence selenium imbalance #1
    infrared reflectance measurement #1
    insufficient availability selenium #1
    gshpx defects #1
    chemical methods nitrogen #1
    selenium pregancy #1
    selenium imbalance #1
    concurrent malondialdehyde #1

    Key People For Venous Stasis

    Top KOLs in the world
    A Nicolaides Nicolaides
    carotid artery duplex scanning varicose veins
    David M Bergqvist
    venous thromboembolism abdominal aortic aneurysm vascular surgery
    Henriksen Henriksen
    blood flow magnetic resonance subcutaneous tissue
    carotid endarterectomy fibrinolytic activity carbon monoxide
    Per Sejrsen
    blood flow capillary permeability eccentric exercise
    John A Heit
    venous thromboembolism pulmonary embolism alcohol dependence

    Gian Cesare Guidi:Expert Impact

    Concepts for whichGian Cesare Guidihas direct influence:Venous stasis,  Laboratory testing,  Routine coagulation testing,  Venous thromboembolism,  Large cohort,  Blood doping,  Hdl cholesterol,  Laboratory medicine.

    Gian Cesare Guidi:KOL impact

    Concepts related to the work of other authors for whichfor which Gian Cesare Guidi has influence:Cell distribution width,  Ovarian cancer,  Blood pressure,  Venous thromboembolism,  Obstructive sleep apnea,  Laboratory medicine,  Platelet volume.



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    Scientific Direction, University Hospital of Verona, Italy. | Section of Clinical Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy; ; Latin American Working Group for Preanalytical Phas