Tsubota Laboratory, Inc., Tokyo 160-0016, Japan | Tsubota Laboratory, Inc | Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, ...

KOL Resume for Tsubota TSUBOTA  (birth, ichthyosis, congenital, defect, congenital ichthyosis)


Tsubota Laboratory, Inc., Tokyo 160-0016, Japan


Tsubota Laboratory, Inc., Shinjuku-ku, Tokyo 160-0016, Japan

Department of Ophthalmology, Keio University School of Medicine.


Tsubota Laboratory, Inc., Tokyo 160-8582, Japan


Prominent publications by Tsubota TSUBOTA

KOL Index score: 19568

Chronic graft-versus-host disease (cGVHD), a serious complication following allogeneic HSCT (hematopoietic stem cell transplantation), is characterized by systemic fibrosis. The tissue renin-angiotensin system (RAS) is involved in the fibrotic pathogenesis, and an angiotensin II type 1 receptor (AT1R) antagonist can attenuate fibrosis. Tissue RAS is present in the lacrimal gland, lung, and liver, and is known to be involved in the fibrotic pathogenesis of the lung and liver. This study ...

Known for Lacrimal Gland |  Liver Fibrosis |  Host Disease |  1 Receptor |  Murine Model
KOL Index score: 19369

PURPOSE: To describe MUC5AC alterations and the ocular surface disorder in atopic patients with or without corneal ulcers.

METHODS: Atopic patients' eyes were divided into two groups according to the presence and absence of corneal ulceration. The subjects underwent corneal sensitivity measurements, Schirmer test, tear film break-up time (BUT), fluorescein and Rose Bengal staining of the ocular surface and conjunctival impression cytology and brush cytology. Impression cytology samples ...

Known for Ocular Surface |  Eyes Corneal Ulcers |  Atopic Patients |  Brush Cytology |  Akc Vkc
KOL Index score: 18755

PURPOSE: To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU).

METHODS: The localization of AT1R and AT2R was shown by immunohistochemistry. EIU was induced by intraperitoneal injection of lipopolysaccharide (LPS). Animals were treated with telmisartan for 2 days and were evaluated 24 hours later. Expression levels of ...

Known for Retinal Inflammation |  Type 1 |  Neuroprotective Effects |  Treatment Telmisartan |  Receptor Angiotensin
KOL Index score: 18524

PURPOSE: To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation.

METHODS: Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) daily for 1 week. Retinal mRNA and protein levels of the RAS components ...

Known for Type 1 |  Nuclear Factor |  Induced Retinal |  Messenger Receptor |  Protein Levels
KOL Index score: 17924

BACKGROUND: The demographic structure of a country changes dramatically with increasing trends toward general population aging and declining birth rates. In Japan, the percentage of the elderly population (aged ≥65 years) reached 25% in 2013; it is expected to exceed 30% in 2025 and reach 39.9% in 2060. The national total population has been decreasing steadily since its peak reached in 2008, and it is expected to fall to the order of 80 million in 2060. Of the total population, those ...

Known for Paradigm Shift |  Geriatric Medicine |  Quality Life |  Medical Nursing |  Elderly Population
KOL Index score: 15584

Purpose: To evaluate the association between iris damage and cytokine levels in the aqueous humor (AqH).

Methods: A total of 201 AqH samples from 201 consecutive patients (mean age 73.7 ± 10.6) were collected at the beginning of corneal transplantation or cataract surgery. Iris damage of each case was assessed from preoperative slit-lamp findings based on its severity. The subjects were classified into three groups: eyes without iris damage (126 eyes), eyes with mild iris damage (51 ...

Known for Iris Damage |  Cytokine Levels |  Aqueous Humor Aqh |  Sicam1 Eyes |  Corneal Transplantation
KOL Index score: 15380

PURPOSE: To examine whether the angiotensin II type 1 receptor (AT1-R) signaling plays a role in ocular inflammation in endotoxin-induced uveitis (EIU).

METHODS: EIU was induced in C57BL/6 mice by a single intraperitoneal injection of 150 mug lipopolysaccharide (LPS). Tissue localization, mRNA expression, and protein levels of AT1-R in murine retinas were examined by immunohistochemistry, RT-PCR, and Western blot analyses, respectively. Telmisartan, an AT1-R antagonist widely used as an ...

Known for Ocular Inflammation |  Type 1 |  Induced Uveitis |  Leukocyte Adhesion |  Protein Levels
KOL Index score: 15299

PURPOSE: To investigate the applicability of tear meniscus height (TMH) measurement using Visante optical coherence tomography (OCT) in the diagnosis of dry eye disease.

DESIGN: Prospective, controlled, single-center study.

PARTICIPANTS: Twenty-four right eyes of 24 patients (6 males, 18 females; mean age, 63.14±13.4 years) with definite dry eye according to the Japanese dry eye diagnostic criteria and 27 right eyes of 27 control subjects (12 males, 15 females; mean age, 56.04±14.22 ...

Known for Dry Eye Disease |  Coherence Tomography |  Tear Meniscus Height |  Sensitivity Specificity |  Strip Meniscometry
KOL Index score: 15024

PURPOSE: A recent study revealed that angiotensin receptor signaling mediates ocular inflammation and neovascularization. It was also found that prorenin undergoes nonproteolytic activation leading to upregulation of the renin-angiotensin system (RAS) when prorenin receptor interacts specifically with the handle region of prorenin. The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in ...

Known for Ocular Inflammation |  Prorenin Receptor |  Nonproteolytic Activation |  Induced Uveitis |  Leukocyte Adhesion
KOL Index score: 14691

PURPOSE: To evaluate structural changes in the cornea and anterior chamber (AC) after LASIK for myopia.

DESIGN: Retrospective nonrandomized study.

PARTICIPANTS: One hundred sixty-one eyes of 83 patients (mean age, 34.5+/-8.3 years) who underwent uneventful LASIK for myopia and myopic astigmatism. The preoperative refractive error (spherical equivalent) and corneal thickness were -6.02+/-2.10 diopters (D) and 549.9+/-29.3 mum, respectively.

METHODS: The AC volume (ACV), AC depth (ACD), ...

Known for Posterior Corneal |  Forward Shift |  Acv Lasik |  Anterior Chamber |  1 Month
KOL Index score: 14571

BACKGROUND: Conditions that destroy the limbal area of the peripheral cornea, such as the Stevens-Johnson syndrome, ocular pemphigoid, and chemical and thermal injuries, can deplete stem cells of the corneal epithelium. The result is scarring and opacification of the normally clear cornea. Standard corneal transplantation cannot treat this form of functional blindness.

METHODS: We performed and evaluated 70 transplantations of corneal epithelial stem cells from cadaveric eyes into 43 ...

Known for Corneal Epithelial |  Visual Acuity |  Severe Ocular |  Surface Disorders |  Transplantation Stem
KOL Index score: 14498

PURPOSE: To evaluate the efficacy of autologous serum eye drops for dry eye after LASIK in a prospective, randomized study.

METHODS: Fifty-four eyes of 27 male patients who underwent LASIK were divided into two groups; patients who used autologous serum eye drops and those who used artificial tears postoperatively. Schirmer test with anesthesia, tear break-up time (BUT), and rose bengal and fluorescein staining for the ocular surface were prospectively compared between the groups. All ...

Known for Serum Eye |  Artificial Tears |  Schirmer Test |  1 Month |  Bengal Score
KOL Index score: 14487

PURPOSE: To evaluate and grade the extent and severity of chronic ocular manifestations in Stevens-Johnson syndrome (SJS).

DESIGN: Prospective multicenter case series.

PARTICIPANTS: We enrolled 73 patients (138 eyes) with SJS seen between April 2003 and March 2005 at 3 tertiary referral centers.

METHODS: Patients with a confirmed history of SJS and chronic ocular complications that persisted for at least 1 year from the onset of SJS were included. Their detailed medical history and ...

Known for New Grading |  Chronic Ocular |  Patients Sjs |  –johnson Syndrome |  Corneal Diseases
KOL Index score: 14452

PURPOSE: Angiotensin-converting enzyme (ACE), also known as kininase II, functions not only to convert angiotensin I to angiotensin II, but also to cleave bradykinin into inactive fragments. Thus, ACE inhibition causes the tissue accumulation of bradykinin, exerting either of two opposite effects: anti- or proangiogenic. The purpose of the present study was to investigate the role of bradykinin in the development of choroidal neovascularization (CNV), with or without ACE ...

Known for Choroidal Neovascularization |  Converting Enzyme |  Cnv Vegf |  Receptor Angiotensin |  Inbred C57bl Microscopy
KOL Index score: 14412

PURPOSE: Resveratrol is known as one of the antioxidant polyphenols contained in red wine and grape skin. The purpose of the present study was to investigate the role of resveratrol in ocular inflammation in endotoxin-induced uveitis (EIU).

METHODS: EIU was induced in male C57/B6 mice at the age of 6 weeks by a single intraperitoneal injection of lipopolysaccharide (LPS). Animals had received oral supplementation of resveratrol at the doses of 5, 50, 100, or 200 mg/kg for 5 days until ...

Known for Nuclear Factor |  Ocular Inflammation |  Oxidative Damage |  Induced Uveitis |  Lps Administration


Tsubota TSUBOTA: Influence Statistics

Sample of concepts for which Tsubota TSUBOTA is among the top experts in the world.
Concept World rank
dhmeq angiotensin #1
aquaporin 5 distribution #1
mvcs severity #1
bioengineered lacrimal #1
cytobrushs #1
corneal sensory experience #1
jogging board #1
staining score #1
epithelial cells ring #1
fluorescein rose bengal #1
improvements sleep quality #1
heterophilic adhesion alphaebeta7 #1
fluorescein rose #1
cgvhd fk506 #1
glands middle #1
keratoconjunctivitis patients #1
eosinophils receptor crth2 #1
treatment mgd #1
lacrimal punctal cauterization #1
amt lat #1
ectrodactylyectodermal #1
mgd normal subjects #1
corneal epithelium keratoplasty #1
vfq25 score psqi #1
fva 1 week #1
techniques epithelial #1
fellow eyes fva #1
predpensvmbasic #1
tears muc5ac concentration #1
limbal phenotype #1
95 risk factors #1
orgahexa eye #1
dlk laser #1
nonplug #1
short tear #1
crocetin administration #1
future mvcs patients #1
postoperative spherical #1
fibrotic pathogenesis lung #1
limbal fibroblasts #1
eye cessation #1
ovd injection #1
warming eye mask #1
moist inserts #1
improvement tear #1
sleep quality ded #1
definite ded ded #1
dryup #1
icd mgald #1
acuity measurement #1

Key People For Dry Eye

Top KOLs in the world
dry eye ocular surface lacrimal gland
Stephen Carl Pflugfelder
dry eye ocular surface sjögren syndrome
Debra Ann Schaumberg
dry eye macular degeneration tear osmolarity
David A Sullivan
gene expression meibomian gland secretory component
Murat Dogru
dry eye ocular surface tear function
Kelly Kinney Nichols
dry eye tear film meibomian gland dysfunction

Tsubota TSUBOTA:Expert Impact

Concepts for whichTsubota TSUBOTAhas direct influence:Dry eye,  Ocular surface,  Dry eye disease,  Lacrimal gland,  Visual acuity,  Oxidative stress,  Situ keratomileusis,  Cataract surgery.

Tsubota TSUBOTA:KOL impact

Concepts related to the work of other authors for whichfor which Tsubota TSUBOTA has influence:Dry eye,  Ocular surface,  Oxidative stress,  Tear film,  Amniotic membrane,  Stem cells,  Visual acuity.



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Tsubota Laboratory, Inc., Tokyo 160-0016, Japan | Tsubota Laboratory, Inc | Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;, ofuji.yoshiko413@keio.jp, (Y.O.);, yusakukatada@z2.keio

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