Fergus Neil Doubal: Influence Statistics

Fergus Neil Doubal

Fergus Neil Doubal

Stroke Clinic, National Health Service Lothian, Edinburgh, United Kingdom | Centre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, ...

Fergus Neil Doubal: Expert Impact

Concepts for which Fergus Neil Doubal has direct influence: Lacunar stroke , Antiplatelet therapy , Perivascular spaces , Small vessel , Small vessel disease , Cerebral small , Specific abilities .

Fergus Neil Doubal: KOL impact

Concepts related to the work of other authors for which for which Fergus Neil Doubal has influence: Cognitive impairment , White matter , Cerebral microbleeds , Ischemic stroke , Small vessel , Magnetic resonance , Perivascular spaces .

KOL Resume for Fergus Neil Doubal

Year
2022

Stroke Clinic, National Health Service Lothian, Edinburgh, United Kingdom

Centre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK

2021

Brain Research Imaging Centre, Centre for Clinical Brain Sciences, UK Dementia Research Institute Centre at the University of Edinburgh, Edinburgh, United Kingdom

for the RESTART Collaboration

2020

From the Centre for Clinical Brain Sciences (A.C.C.J., G.W.B., M.S.S., M.J.T., U.C., F.M.C., R.B., D.J.G., O.K.L.H., A.G.M., I.M., K.H., S.W., T.M., M.C.V.-H., F.N.D., J.M.W.), University of Edinburgh, Scotland.

Centre for Clinical Brain Science, University of Edinburgh, United Kingdom (C.M., G.W.B., F.M.C., F.D.).

UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK

2019

Neuroimaging Sciences and Brain Research Imaging Center, Division of Neuroimaging Sciences, Center for Clinical Brain Sciences, UK Dementia Research Institute at the University of Edinburgh, UK

Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom

2018

Centre for Clinical Brain Sciences, University of Edinburgh, UK.

2017

Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK

Department of Medicine, Elderly Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

2016

Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, Edinburgh, UK

2015

From the Centre for Clinical Brain Sciences, Western General Hospital, Edinburgh, United Kingdom.

Centre for Clinical Brain Sciences, University of Edinburgh, Glasgow, UK

2014

From the Centre for Clinical Brain Sciences (S.D.J.M., F.N.D., M.S.D., J.M.W.), University of Edinburgh, UK; and Department of Neurology and Cardiovascular Research Institute Maastricht (J.S.), Maastricht University Medical Centre, the Netherlands.

2013

From the NEUROFARBA Department, Neuroscience Section, University of Florence, Italy (A.D.B., D.I.); and Divisions of Neuroimaging Sciences (S.D.J.M., J.M.W.) and Geriatric Medicine (F.N.D.), Western General Hospital, University of Edinburgh, Edinburgh, UK.

Division of Clinical Neurosciences and SINAPSE Collaboration, University of Edinburgh, Western General Hospital, Edinburgh, UK

2012

Division of Clinical Neurosciences, Brain Research Imaging Centre, University of Edinburgh, Edinburgh, UK

2011

From the Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK.

2010

Scottish Imaging Network, a Platform for Scientific Excellence (SINAPSE) Collaboration, SFC Brain Imaging Research Centre, Edinburgh, UK

2009

Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, United Kingdom

2008

From the Division of Clinical Neurosciences (F.N.D., M.S.D., J.M.W.) and the Princess Alexandra Eye Pavilion (B.D.), University of Edinburgh, Edinburgh, UK.

Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK

2007

Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK

Prominent publications by Fergus Neil Doubal

KOL-Index: 20128 . BACKGROUND: The cause of cerebral small vessel disease is not fully understood, yet it is important, accounting for about 25% of all strokes. It also increases the risk of having another stroke and contributes to about 40% of dementias. Various processes have been implicated, including microatheroma, endothelial dysfunction and inflammation. A previous review investigated endothelial ...
Known for Lacunar Stroke | Endothelial Dysfunction | Blood Markers | Tnf Α
KOL-Index: 17824 . BACKGROUND: Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be used ...
Known for Antiplatelet Therapy | Intracerebral Haemorrhage | Participants Median | Label Trial
KOL-Index: 17395 . BACKGROUND: Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral ...
Known for Antiplatelet Therapy | Intracerebral Haemorrhage | Stroke Risk | Small Vessel
KOL-Index: 13008 . BACKGROUND AND AIMS: Enlarged perivascular spaces (also known as Virchow-Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their etiology, and specificity to small vessel as opposed to general cerebrovascular disease or ageing, is unclear. We tested the association between enlarged perivascular spaces and ischemic stroke subtype, other markers of small vessel ...
Known for Enlarged Perivascular Spaces | Small Vessel | Centrum Semiovale | White Matter Lesions
KOL-Index: 11477 . BACKGROUND AND PURPOSE: Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensities, markers of established small vessel disease. MATERIALS AND METHODS: ...
Known for Perivascular Spaces | White Matter Hyperintensities | Vascular Risk Factors | Cerebral Small
KOL-Index: 10762 . Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can ...
Known for Features Svd | Small Vessel | Neurodegenerative Disease | Image Acquisition
KOL-Index: 9985 . OBJECTIVES: In this cross-sectional study, we tested the construct validity of a "total SVD score," which combines individual MRI features of small-vessel disease (SVD) in one measure, by testing associations with vascular risk factors and stroke subtype. METHODS: We analyzed data from patients with lacunar or nondisabling cortical stroke from 2 prospective stroke studies. Brain MRI was ...
Known for Vascular Risk Factors | Total Mri | Brain Small | Cerebral Atrophy
KOL-Index: 9945 . OBJECTIVE: Lacunar stroke is common (25% of ischemic strokes) and mostly because of an intrinsic cerebral microvascular disease of unknown cause. Although considered primarily to be an ischemic process, the vessel and tissue damage could also be explained by dysfunctional endothelium or blood-brain barrier (BBB) leak, not just ischemia. We tested for subtle generalized BBB leakiness in ...
Known for Lacunar Stroke | Barrier Dysfunction | White Matter | Bbb Leak
KOL-Index: 9817 . Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. It is the most common incidental finding on brain scans. To summarize evidence on the diagnosis and management of silent cerebrovascular disease to prevent stroke, the Stroke Council of the American Heart Association convened a writing ...
Known for Silent Cerebrovascular Disease | Stroke Patients | Cerebral Microbleeds | Heart Association
KOL-Index: 9521 . Purpose: Semiautomated software applications derive quantitative retinal vascular parameters from fundus camera images. However, the extent of agreement between measurements from different applications is unclear. We evaluate the agreement between retinal measures from two software applications, the Singapore "I" Vessel Assessment (SIVA) and the Vessel Assessment and Measurement Platform ...
Known for Vampire Measurements | Retinal Vascular | Vessel Assessment | Cohort 1936
KOL-Index: 9427 . BACKGROUND: White matter lesions (WML) are commonly seen on brain MRI and are generally considered a marker of tissue damage from cerebral small vessel disease. WML are associated with increasing age and vascular risk factors, but their precise cause is unknown. A role for carotid artery atherothromboemboli has been suggested. If this is the case, more WML would be expected ipsilateral to ...
Known for Carotid Stenosis | White Matter Lesions | Vascular Risk Factors | Increasing Age
KOL-Index: 9317 . Rationale The pathophysiology of most lacunar stroke, a form of small vessel disease, is thought to differ from large artery atherothrombo- or cardio-embolic stroke. Licensed drugs, isosorbide mononitrate and cilostazol, have promising mechanisms of action to support their testing to prevent stroke recurrence, cognitive impairment, or radiological progression after lacunar stroke. Aim ...
Known for Isosorbide Mononitrate | Small Vessel | Cognitive Decline | Lacunar Stroke
KOL-Index: 9047 . PURPOSE: To assess the suitability of retinal images held in the UK Biobank--the largest retinal data repository in a prospective population-based cohort--for computer assisted vascular morphometry, generating measures that are commonly investigated as candidate biomarkers of systemic disease. METHODS: Non-mydriatic fundus images from both eyes of 2,690 participants--people with a ...
Known for Uk Biobank | Retinal Images | Myocardial Infarction | Vascular Morphometry
KOL-Index: 8935 . BACKGROUND AND PURPOSE: Lacunar infarction is attributable to a perforating arteriolar abnormality. Possible causes include embolism, atheromatosis, or intrinsic disease. We examined whether the size, shape, or location of the lacunar infarct varied with embolic sources, systemic atheroma, or vascular risk factors. METHODS: We examined data from 3 prospective studies of patients with ...
Known for Basal Ganglia | Infarct Size | Centrum Semiovale | Stroke Lacunar
KOL-Index: 8901 . Background: Lacunar stroke, a frequent clinical manifestation of small vessel disease (SVD), differs pathologically from other ischaemic stroke subtypes and has no specific long-term secondary prevention. Licenced drugs, isosorbide mononitrate (ISMN) and cilostazol, have relevant actions to prevent SVD progression. Methods: We recruited independent patients with clinically confirmed ...
Known for Isosorbide Mononitrate | Lacunar Stroke | Cilostazol Ismn | Cognitive Impairment

Key People For Lacunar Stroke

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Stroke Clinic, National Health Service Lothian, Edinburgh, United Kingdom | Centre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK | Centre for Clinical Brain Sciences, University of Edinburgh | Cen