Rafael Andrade

OBJECTIVE: To assess the age at menopause (AM) in Latin America urban areas.

DESIGN: A total of 17,150 healthy women, aged 40 to 59 years, accompanying patients to healthcare centers in 47 cities of 15 Latin American countries, were surveyed regarding their age, educational level, healthcare coverage, history of gynecological surgery, smoking habit, presence of menses, and the use of contraception or hormone therapy at menopause. The AM was calculated using logit analysis.

RESULTS: The ...

PURPOSE: To compare the safety and efficacy of hook wire versus microcoil localization of pulmonary nodules prior to video-assisted thoracoscopic resection (VATS).

MATERIALS AND METHODS: A retrospective comparative review was conducted of 46 patients (26 hook wire and 20 microcoil) who underwent computed tomography fluoroscopic-guided nodule localizations prior to VATS in a single center between January 2012 and August 2016. Nodule characteristics, procedural details, clinical outcomes, ...

BACKGROUND: Papular urticaria caused by flea bite presents clinical symptoms of hypersensitive reaction accompanied by skin lesions. Diagnostic and therapeutic approaches to the disease often go unrewarded, partly because of our incomplete understanding of the underlying immunopathogenesis.

OBJECTIVE: To characterize the immune response to the flea bite in patients with papular urticaria.

METHODS: This study included 45 randomly selected patients and 17 controls. Cutaneous allergy tests ...

Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder with clinical and genetic heterogeneity. This syndrome was first described by Laurence and Moon in 1866 and additional cases were described by Bardet and Biedl between 1920 and 1922. The main features are obesity, polydactyly, pigmentary retinopathy, learning disabilities, various degrees of intellectual impairment, hypogonadism, and renal abnormalities. Bardet-Biedl syndrome is both phenotypically and genetically ...

Background: Hepatic angiosarcoma is a rare tumor of endothelial origin that accounts for up to 2% of all primary neoplasms of the liver. It is uncommon in young adults and acute liver failure is a very unusual presentation of this disease. Case Presentation: We report the cases of two young male adults who presented with acute liver failure. One of them was diagnosed with primary hepatic angiosarcoma after transplantation based on the complete evaluation of the heaptectomy specimen; ...

Digital fibrokeratomas are benign acquired lesions. They are firm, more or less hyperkeratotic projections arising out of a collarette of slightly raised skin. Clinically, they resemble rudimentary supernumerary digits. Microscopically, a fibrokeratoma is composed of a core of normal appearing connective tissue covered with an acanthotic epidermis which produces a dense enveloping hyperkeratosis.

Histone deacetylase (HDAC) proteins, which regulate the acetylation state of proteins, are the targets of multiple clinical drugs for cancer treatment. Due to the heterogeneity of tumors, HDAC proteins play different roles in the progression of various cancer types. For example, MDA-MB-468 and MDA-MB-231 cells are both triple negative breast cancer cells but belong to different subtypes that display different response to HDAC inhibitor drugs. To investigate the role of HDAC proteins in ...

A man 60 years old suddenly developed hard nodules in a tattoo that had been placed 45 years ago. The interest of the case lies in the following points: (1) the histopathology of a biopsied specimen was that of a sarcoid reaction; (2) lung changes were subsequently found that were interpreted as pulmonary sarcoidosis; and (3) the cutaneous lesions began to flatten after the biopsy was taken, and within four months both they and the lung changes had disappeared.

Abstract Purpose Employ fuzzy logic to auxiliary in identification and diagnosis the gravity of diabetic retinopathy (DR). Methods A cross-sectional study was performed, being assessed 100 diabetes mellitus patients with DR. The following ultrasound findings were measured employing a semi-quantitative punctuation method: vitreous hemorrhage, posterior vitreous detachment, epiretinal fibrosis, retinal detachment. The fundus photography (FP) aspects evaluated for diagnosis of DR were at ...

Homosexual conjugality and the struggle for sexual and reproductive rights divides the homosexual movement and is quite a challenge to understand the conceptions that support the passionate defenses and the opposite positions to the 'gay marriage' and/or the sexual and reproductive rights. The purpose of the present paper is to understand how conjugality and parenthood are represented and accepted (or not). Careful research has been conducted among homosexual groups, showing that they ...