Prominent publications by Roberto Broccoletti

KOL Index score: 13318

OBJECTIVE: To evaluate the efficacy of a combination of topical corticosteroids with topical antimycotic drugs in the therapy of atrophic-erosive forms of oral lichen planus (OLP).

PATIENTS AND METHODS: The study population consisted of 60 patients with OLP subdivided into three groups matched for sex and age. The first group (25 patients) and the second group (24 patients) received respectively 0.05% clobetasol propionate ointment or 0.05% fluocinonide ointment in an adhesive medium (4% ...

Known for Topical Corticosteroids |  Lichen Planus |  Olp Patients |  6 Months |  Clobetasol Placebo
KOL Index score: 12868

BackgroundSeveral studies in the past have investigated the expression of micro RNAs (miRNAs) in saliva as potential biomarkers. Since miRNAs associated with extracellular vesicles (EVs) are known to be protected from enzymatic degradation, we evaluated whether salivary EVs from patients with oral squamous cell carcinoma (OSCC) were enriched with specific subsets of miRNAs.MethodsOSCC patients and controls were matched with regards to age, gender and risk factors. Total RNA was extracted ...

Known for Potential Biomarkers |  Oscc Patients |  Squamous Cell |  Salivary Evs |  Differential Expression
KOL Index score: 11120

BACKGROUND: Oral lichen planus (OLP) is a chronic inflammatory disease that can be painful, especially in the atrophic and erosive forms. Several drugs have been used with varying results, but most treatments are empirical, and do not have adequate control groups or correct study designs.

OBJECTIVES: To compare the effectiveness of clobetasol and ciclosporin in the topical management of OLP and to evaluate which is more cost-effective and which gives the longest remission from signs and ...

Known for Lichen Planus |  Topical Management |  Randomized Controlled Trial |  2 Months |  Glucocorticoids Humans
KOL Index score: 10896

Most lymphocytes in the lamina propria of oral lichen planus (OLP) lesions express and secrete interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), whereas they do not secret interleukin-4 and -10 or transforming growth factor-beta. We analyzed whether the polymorphisms of several cytokines may influence the susceptibility to OLP. Cytokine typing was performed by a sequence-specific PCR assay. Thirteen cytokine genes with 22 single-nucleotide polymorphisms were ...

Known for Lichen Planus |  Necrosis Factor |  Olp Patients |  Frequency Genetic |  Polymorphisms Susceptibility
KOL Index score: 10458

The most important complication of oral lichen planus (OLP) is the development of oral squamous cell carcinoma (OSCC) but this is a very controversial matter. The aim of the study was to estimate in a Northern Italian cohort of OLP patients the risk for OSCC. Four hundred and two patients with histologically confirmed OLP diagnosed from January 1988 to July 1999, were followed-up to the end of February 2001. The standardized incidence ratio (SIR) of OSCC was calculated for the entire ...

Known for Lichen Planus |  Squamous Cell |  Patients Olp |  Hcv Infection |  Risk Oscc
KOL Index score: 10198

To assess the aetiology of liver disease associated with lichen planus, we prospectively studied 70 consecutive newly diagnosed patients with oral lichen planus (OLP) living in northwest Italy (Piemonte) and 70 controls matched for age and sex with other oral keratoses coming from the same district. Twenty-two patients with OLP (31.4%) and 9 controls (12.9%) were found to be affected by chronic liver disease (CLD) (P = 0.014). In sixteen of the 22 OLP patients with CLD the liver disease ...

Known for Oral Lichen Planus |  Italian Patients |  Liver Disease |  Olp Hcv |  Virus Infection
KOL Index score: 10076

BACKGROUND: Mucous membrane pemphigoid (MMP) includes a range of variants frequently having oral, particularly gingival, lesions. It has been suggested that MMP exclusively involving the oral cavity could be a distinct subset, but the immunological status of patients with predominantly oral lesions has received little attention.

METHODS: Indirect immunofluorescence (IIF) on normal human skin and normal human salt-split skin (SSS) as a substrate and immunoblotting on extracts of human ...

Known for Mucous Membrane |  Oral Cavity |  Iga Antibodies |  Patients Mmp |  Bullous Pemphigoid
KOL Index score: 9251

OBJECTIVE: Even though diagnostic oral exfoliative cytology is a useful, economical and practical tool in the diagnosis of oral dysplasia and carcinoma, it is not yet extensively used. The results of conventional exfoliative and liquid-based diagnostic cytology in oral potentially malignant lesions (PML) are herein reported and compared with the histological diagnosis.

METHODS: Either conventional (89) or liquid-based (384) exfoliative cytology was used for the diagnosis of oral ...

Known for Oral Cytology |  Sensitivity Specificity |  Histological Diagnosis |  Situ Carcinoma |  Liquid Based
KOL Index score: 8487

AIM: To assess the prevalence of oral mucosal lesions (OML) and evaluate its association with tobacco and alcohol consumption and the wearing of removable dentures in an adult population from the Turin area, Italy.

MATERIALS AND METHODS: A retrospective study, based on an invitational self-selected screening, was performed on 4098 subjects. It included clinical examination plus biopsies when necessary. Patient history included age, sex, denture wearing and risk habits. Internationally ...

Known for Oral Mucosal Lesions |  Prevalence Omls |  Alcohol Drinking Candidiasis |  Risk Habits |  Aged Mouth
KOL Index score: 8003

Comparison between low-level laser therapy (LLLT) and clonazepam for treating burning mouth syndrome (BMS) patients has never been documented; the aim of this study was to assess the effects of LLLT photobiomodulation versus medical therapy with clonazepam on BMS. Thirty-three patients (25 female, 8 male, mean age = 67.12) were randomly allocated to two different groups: the first one (group A, 18 patients) underwent two laser irradiation sessions weekly for 5 weeks, whereas the second ...

Known for Mouth Syndrome |  Level Laser |  Groups Lllt |  Patients Bms |  Anxiety Depression
KOL Index score: 7903

BACKGROUND: Mucous membrane pemphigoid (MMP) used to be considered as a single entity but it is now evident that a range of variants exists. Among them, pure ocular cicatricial pemphigoid (OCP) and pure oral pemphigoid (OP) appear to be very different subsets. Previous immunogenetics studies have found increased occurrence of the DQB1*0301 allele mainly in patients with OCP whereas in patients with OP the data are more open to doubt.

OBJECTIVES: To analyse HLA predisposition in a group ...

Known for Oral Cavity |  Mucous Membrane |  Patients Mmp |  Hla Dqb10301 |  Mucosa Pemphigoid
KOL Index score: 7899

To date there are still no reliable biomarkers for oral potentially malignant disorders (PMDs) to predict the risk of progression to squamous cell carcinoma (SCC). Within a prospective clinical trial of patients with PMDs, DNA content flow cytometry (DNA FCM) was evaluated for 60 PMDs using fresh samples obtained by a dermatological curette. There were 6/42 PMDs without dysplasia, but with DNA aneuploidy, versus 8/18 with both dysplasia and aneuploidy (p=0.02). When the tongue and the ...

Known for Dna Aneuploidy |  Malignant Disorders |  Aged Mouth |  Dermatological Curette |  Oral Carcinogenesis
KOL Index score: 7556

Oral lichen planus (OLP) is a chronic inflammatory disease that can be painful, mainly in the atrophic and erosive forms. Numerous drugs have been used with dissimilar results, but most treatments are empirical and do not have adequate control groups or correct study designs. However, to date, the most commonly employed and useful agents for the treatment of LP are topical corticosteroids. A randomized, double-blind, placebo-controlled trial has been designed to compare the efficacy and ...

Known for Lichen Planus |  Topical Clobetasol |  Randomized Controlled |  2 Months |  Numerous Drugs
KOL Index score: 7519

OBJECTIVES: To evaluate the degree and causes of underdiagnosis of incisional biopsy in oral potentially malignant lesions (PML).

DESIGN: Cross-sectional retrospective study.

MATERIALS AND METHODS: All pathology slides (incisional biopsy and resection specimen) from 46 patients with oral PML were reviewed and scored blind. The provisional diagnosis was considered in order to provide underdiagnosis or overdiagnosis according to whether this score was lower or higher than the final ...

Known for Incisional Biopsy |  Squamous Cell |  Aged Mouth |  Provisional Diagnosis |  Oral Mucosal


Roberto Broccoletti: Influence Statistics

Sample of concepts for which Roberto Broccoletti is among the top experts in the world.
Concept World rank
olp topical #1
atrophic erosive forms #1
gingival lesions #1
clobetasol treated #1
diagnosis liquid #1
atrophic‐erosive oral #1
semiconductor lichen planus #1
4 hydroxyethyl #1
planus prospective #1
semiconductor lichen #1
atrophic erosive #1
atrophic‐erosive #1
atrophicerosive olp #1
carbonate spray #2
succeeding 24 weeks #2
thirteen cytokine genes #2
eortc qlqhn35 controls #2
gingival vulgaris #2
finger rub application #2
lissone #2
white hyperkeratotic lesions #2
cariex surgical #2
area osteochemonecrosis #2
oral cavity patients #2
cvds familiarity #2
prevalence linked #2
habits denture #2
patients traditional scalpel #2
kir2dl2 hcvve #2
alcohol drinking candidiasis #2
olp kir #2
mouth plaque score #2
interleukin4 young adult #2
dried lesion #2
oxygenenriched oil #2
turin area prevalence #2
unresponsive olp #2
gingival localisation #2
increased incidence cvds #2
dm980 #2
dg patients mmp1 #2
09mm spot size #2
cariex #2
xylitol spray #2
patients desquamative gingivitis #2

Key People For Lichen Planus

Top KOLs in the world
Crispian M Scully
oral cancer lichen planus recurrent aphthous stomatitis
Marco Carrozzo
lichen planus mucous membrane oral medicine
Stephen Ross Porter
lichen planus oral health human herpesvirus
Philip B Sugerman
lichen planus oral cancer mast cell degranulation
Palle Holmstrup
lichen planus autogenous bone nude mice
Drore Eisen
lichen planus psoriatic arthritis topical cyclosporine

Roberto Broccoletti:Expert Impact

Concepts for whichRoberto Broccolettihas direct influence:Lichen planus,  Oral lichen planus,  Desquamative gingivitis,  Oral lichen,  Oral hygiene,  Yag laser,  Italian patients,  Gingival lesions.

Roberto Broccoletti:KOL impact

Concepts related to the work of other authors for whichfor which Roberto Broccoletti has influence:Oral lichen planus,  Malignant transformation,  Squamous cell,  Patients olp,  Mucous membrane,  Hcv infection.



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Department of Surgical Sciences, CIR‐Dental School, University of Turin, Turin, Italy | University of Turin - CIR-Dental School | Department of Surgical Science, Oral Medicine Section, CIR-Dental School, University of Turin, 10126 Turin, Italy;, ales

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