• Disease
  • Oral
  • Oral Lichen
  • Oral Lichen Planus
  • Anastasios K Markopoulos

    Prominent publications by Anastasios K Markopoulos

    KOL Index score: 9443

    One of the factors involved in the pathogenesis of recurrent aphthous stomatitis (RAS) is a cell-mediated immune response in which several cytokines seem to play a major role. The aim of this study was to detect, enumerate and characterize T helper cells which are secreting type 1 cytokines (interleukin [IL]-2, IL-12, interferon [IFN]-gamma, and tumor necrosis factor [TNF]-alpha) and type 2 cytokines (IL-4, IL-5, IL-6, and IL-10) in the peripheral blood of patients with RAS. Thirty-two ...

    Also Ranks for: Recurrent Aphthous Stomatitis |  patients ras |  aphthous tlymphocytes |  peripheral blood |  cellmediated immune response
    KOL Index score: 8886

    OBJECTIVE: The purpose of the present study was to determine the prevalence of oral lichen planus (OLP) in a population of patients with diabetes mellitus (DM) as compared with a control population.

    DESIGN: A clinicopathologic study.

    SUBJECTS AND METHODS: One hundred and thirty-nine patients with type I DM, 353 patients with type II DM and 274 controls were examined for clinical evidence of OLP. The clinical evidence of OLP in the diabetic and control patients was confirmed by ...

    Also Ranks for: Lichen Planus |  diabetes mellitus |  prevalence olp |  dm patients |  oral male
    KOL Index score: 7788

    OBJECTIVE: The purpose of this study was to detect and enumerate T cells secreting type 1 and 2 cytokines in the peripheral blood of patients with oral lichen planus (OLP) and in healthy controls.

    SUBJECTS AND METHODS: The study group consisted of 80 OLP patients and 80 healthy individuals. Cytokine secreting T cells were detected using ELISPOT assay.

    RESULTS: There was a statistically significant decrease (p<0.05) in the number of IFN- and IL-12 secreting cells in the peripheral blood ...

    Also Ranks for: Olp Patients |  oral lichen planus |  controls p005 |  peripheral blood |  type 1
    KOL Index score: 7181

    OBJECTIVES: To evaluate the role of HPV in oral carcinogenesis, we examined the prevalence of HPV in malignant, potentially malignant and normal oral epithelium and studied the relation of HPV prevalence with other factors obtained from the patient's records.

    MATERIALS AND METHODS: Our material consisted of 291 tissue specimens from 258 individuals. From every individual formalin fixed and paraffin embedded tissues were examined by nested Polymerase Chain Reaction (NPCR) for the ...

    Also Ranks for: Chain Reaction |  oral carcinogenesis |  hpv dna |  viral load |  aged mouth
    KOL Index score: 6676

    Mast cell contribution to neoangiogenesis during tumorigenesis in oral squamous cell carcinoma is not determined yet.

    OBJECTIVES: To associate numerical mast cell density (MCD) to numerical microvessel density (MVD) during the progression of oral leukoplakia without dysplasia and leukoplakia with dysplasia to squamous cell carcinoma (OSCC).

    MATERIALS AND METHODS: MVD was analysed immunohistochemically (mouse monoclonal anti-human CD34) in 49 paraffin-embedded specimens, 35 OSCCs, 9 ...

    Also Ranks for: Mast Cells |  mcd mvd |  leukoplakia dysplasia |  normal oral mucosa |  premalignant lesions
    KOL Index score: 6443

    Vascular endothelial growth factor (VEGF) is an angiogenic cytokine and mast cells play a role in neoangiogenesis in various malignancies. The aim of the present study was to elucidate the role of VEGF and mast cells in the early stages of tumorigenesis in oral squamous cell carcinoma (OSCC). Immunohistochemistry was conducted to study VEGF expression and microvessel density (MVD) in 49 tissue samples, 31 OSCCs, 13 leukoplakias (8 with and 5 without dysplasia) and 5 samples from normal ...

    Also Ranks for: Vegf Expression |  mast cells |  cell density |  oral squamous |  endothelial growth
    KOL Index score: 6171

    PURPOSE: The purpose of this study was to determine the clinical and histologic features of 9 simple lipomas, 2 fibrolipomas, and 2 infiltrating lipomas of the oral cavity. In addition, 10 cases of infiltrating lipoma of the oral cavity previously reported in the literature were reviewed.

    MATERIALS AND METHODS: All cases were retrieved from the archives of the Department of Oral Medicine/Pathology of the University of Thessaloniki, Greece. Data on age, sex, location, clinical appearance, ...

    Also Ranks for: Oral Cavity |  adipose tissue |  3 cases |  clinicopathologic study |  infiltrating lipomas
    KOL Index score: 6024

    326 patients with oral lichen planus were followed for periods ranging from 6 months to 10 years (mean 4.8 years), in an attempt to clarify the malignant potential of this disease which is still controversial. Malignant transformation occurred in 4 patients (1.3%) in a mean time of 6.5 years after the onset of lichen planus. Before cancer development, 3 of these patients manifested the erosive form of oral lichen planus, while the others, a combination of the papular/atrophic form. ...

    Also Ranks for: Lichen Planus |  malignant potential |  patients oral |  cell transformation |  cancer development
    KOL Index score: 5493

    The purpose of this study was to investigate the presence of epidermal growth factor (EGF) in patients receiving cyclosporin therapy who had gingival overgrowth and to determine whether there were any differences between these patients and normal healthy controls. Seventeen patients with cyclosporin-induced gingival overgrowth and seventeen age- and sex-matched controls who were taking cyclosporin but had healthy gingiva were used for this study. Unstimulated whole saliva was collected ...

    Also Ranks for: Gingival Overgrowth |  epidermal growth factor |  egf concentrations |  immunosuppressive agents |  immunosorbent assay
    KOL Index score: 5417

    OBJECTIVE: The aim of the current study was to investigate any association of Helicobacter Pylori (HP) in recurrent aphthous stomatitis (RAS) and the effect of eradication of the microorganism in the clinical course of the disease.

    STUDY DESIGN: Forty-eight patients with RAS were included in the study. Twenty-six were women and 22 men, of average age 41.3 +/- 2.44. Thirty-four out of these 48 patients were HP positive and the rest 14 who were negative were used as a control group. The ...

    Also Ranks for: Helicobacter Pylori |  ras patients |  aphthous stomatitis |  eradication therapy |  square distribution
    KOL Index score: 5415

    The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-A, -B and -DR alleles were typed in 29 families, 27 nuclear and two extended (121 subjects). HLA haplotypes of all family members with RAS were compared with those who were ...

    Also Ranks for: Recurrent Aphthous Stomatitis |  hla haplotypes |  ras alleles |  genetic association
    KOL Index score: 5351

    OBJECTIVE: The purpose of the present study was to investigate the presence of insulin-like growth factor-I (IGF-I) in the labial salivary glands of patients with Sjögren's syndrome and healthy controls and to determine if there are any differences between these two groups.

    DESIGN: An immunohistochemical study.

    SUBJECTS AND METHODS: Twenty-five patients with Sjögren's syndrome, 20 healthy controls and 20 patients with mucoceles of the lip were used in this study. All individuals ...

    Also Ranks for: Salivary Glands |  insulin‐like growth |  sjögrens syndrome |  immunohistochemical study |  factor igf
    KOL Index score: 5151

    BACKGROUND: In the current study the presence of extracellular IL-1B, IL-8, OAZ and SAT mRNAs in the saliva was evaluated as a tool in the early detection of oral squamous cell carcinoma.

    METHODS: 34 patients with primary oral squamous cell carcinoma stage T1N0M0/T2N0M0, 20 patients with oral leukoplakia and dysplasia (15 patients with mild dysplasia and 5 with severe dysplasia/in situ carcinoma) and 31 matched healthy-control subjects were included in the study. The presence of IL-1B, ...

    Also Ranks for: Squamous Cell |  tumor carcinoma |  saliva biomarkers |  early detection |  patients oral
    KOL Index score: 4964

    Congenital absence of major salivary glands, especially the parotid gland, is a rare entity. It is usually monolateral and is not correlated with accessory salivary gland tissue. Aplasia of parotid gland may occur alone or in association with abnormalities of other salivary glands, first branchial arch developmental disturbances or other congenital anomalies.We report an interesting case of bilateral aplasia of the parotid glands together with bilateral accessory parotid tissue, without ...

    Also Ranks for: Parotid Gland |  developmental anomalies |  congenital absence |  rare entity |  choristoma female
    KOL Index score: 4709

    OBJECTIVE: The purpose of this study was to determine the clinical and histopathologic presentation of actinic cheilitis.

    STUDY DESIGN: A retrospective study on 65 patients attending an Oral Medicine clinic in Greece over a 10 year period. For each case the demographic, clinical and histopathologic information were evaluated.

    RESULTS: The mean age at the time of diagnosis was 53.1 +/- 11.4 years. Thirty-nine patients (60%) used tobacco in any form. An outdoor occupation was indicated for ...

    Also Ranks for: Actinic Cheilitis |  squamous cell carcinoma |  connective tissue |  epithelial dysplasia |  lower lip


    Anastasios K Markopoulos: Influence Statistics

    Sample of concepts for which Anastasios K Markopoulos is among the top experts in the world.
    Concept World rank
    uremic stomatitis #6

    Key People For Oral Lichen Planus

    Top KOLs in the world
    Crispian M Scully
    oral cancer lichen planus recurrent aphthous stomatitis
    Marco Carrozzo
    lichen planus mucous membrane oral medicine
    Isaa¨c van der Waal
    oral leukoplakia squamous cell carcinoma lichen planus
    Philip B Sugerman
    lichen planus oral cancer mast cell degranulation
    Kobkan Thongprasom
    lichen planus thai patients oral medicine
    Palle Holmstrup
    lichen planus autogenous bone nude mice

    Anastasios K Markopoulos:Expert Impact

    Concepts for whichAnastasios K Markopouloshas direct influence:Oral lichen planus,  Desquamative gingivitis,  Actinic cheilitis,  Lichen planus,  Oral leukoplakia,  Parotid gland,  Oral cavity,  Pemphigus vegetans.

    Anastasios K Markopoulos:KOL impact

    Concepts related to the work of other authors for whichfor which Anastasios K Markopoulos has influence:Actinic cheilitis,  Oral lichen planus,  Squamous cell,  Malignant transformation,  Recurrent aphthous stomatitis,  Diabetes mellitus,  Salivary glands.



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    Department of Oral Medicineand Oral Pathology, School of Dentistry, Aristotle University, 54124 Thessaloniki, Greece | Aristotle University, School of Dentistry, Department of Oral Medicine and Oral Pathology | Department of Stomatology, School of De