Prominent publications by Claudio Ortolani

KOL Index score: 14949

BACKGROUND: Allergy to fresh fruits and vegetables is mostly observed in subjects with pollinosis, especially from birch, because of cross-reacting allergens in vegetable foods and pollens. However, allergic reactions to fruits, specifically Rosaceae fruits, have been reported in subjects without pollinosis.

OBJECTIVE: This study evaluated the pattern of IgE reactivity, identifying the allergen responsible in 2 groups of patients with oral allergy syndrome to peach with or without birch ...

Also Ranks for: Major Allergen |  lipid transfer protein |  prunus persica |  plant blotting |  birch pollinosis
KOL Index score: 14685

BACKGROUND: Only a few food allergens have as yet been identified, mainly because of the difficulty of obtaining a sufficient number of patients who are clinically sensitized to a given food. This is more feasible in the case of the oral allergy syndrome (OAS), a common form of food allergy, which is especially prevalent in patients with pollinosis.

OBJECTIVE: We designed a study to identify the allergens of kiwi fruit (Actinidia chinensis) by analyzing the sera of patients with OAS for ...

Also Ranks for: Kiwi Fruit |  birch pollen |  allergenic components |  cross reactivity |  major allergen
KOL Index score: 12978

BACKGROUND: Only a few studies have investigated the clinical role of food allergens, especially the relationship between sensitization to a given allergen and occurrence of adverse reactions when eating the relevant food item.

OBJECTIVE: This study evaluated the clinical role of the allergens of Brazil nut by comparing the patterns of IgE binding in sera from 11 patients with anaphylaxis after eating Brazil nuts with those from 10 subjects with no symptoms to this food item. Both groups ...

Also Ranks for: Brazil Nut |  major allergen |  2s albumin |  clinical expression |  ige binding
KOL Index score: 12921

One hundred adult patients with a history of oral allergy syndrome (OAS) after ingestion of fruits and vegetables, 77 patients with hay fever and 13 with skin prick tests and RAST positive to pollens but without seasonal symptoms, and 32 normal nonallergic control subjects, had Phadebas RAST and skin prick tests with commercial extracts (CSPT) and with fresh foods (FFSPT) to assess the reliability of these three tests. Sensitivity was better with FFSPT for carrot, celery, cherry, apple, ...

Also Ranks for: Skin Prick Tests |  fresh foods |  oral allergy syndrome |  apple carrot |  food extracts
KOL Index score: 12491

BACKGROUND: Few allergic reactions to grape are reported in the literature. In some cases an association with peach and cherry allergy was observed. No IgE-mediated reactions to wine have been described, and no grape major allergens have yet been identified.

OBJECTIVE: We describe several severe reactions to grape or wine. We characterized the grape major allergens and tried to identify the allergen in wine.

METHODS: We collected documented histories of allergic reactions to grape and ...

Also Ranks for: Grape Wine |  allergic reactions |  transfer protein |  peach ltp |  major allergen
KOL Index score: 12491

BACKGROUND: Oral allergy syndrome in response to fruits and vegetables frequently occurs as clusters of hypersensitivity to members of the same botanical family, for which the immunologic basis lies in a number of common allergens, most of them still unidentified.

OBJECTIVE: This study was designed to assess the in vivo and in vitro cross-reactivity between fruits of the Prunoideae subfamily (i.e., peach, cherry, apricot, and plum) and to identify their major allergens and the ...

Also Ranks for: Oral Allergy Syndrome |  cross reactivity |  major allergens |  vivo study |  pollen skin tests
KOL Index score: 12356

BACKGROUND: Allergy to apple is commonly associated with birch pollinosis because the two share homologous allergens. However, some patients have apple allergy but no birch pollinosis, suggesting that there are allergens that do not cross-react with birch.

OBJECTIVE: The aim of the study was to evaluate the IgE reactivity pattern to an apple extract in subjects with allergic reactions to apple, with and without birch hay fever.

METHODS: Forty-three patients with oral allergy syndrome for ...

Also Ranks for: Lipid Transfer Protein |  birch pollinosis |  clinical role |  patients apple allergy |  gel chromatography
KOL Index score: 11413

BACKGROUND: Apricots are widely grown in Europe, and allergic reactions are becoming more common, especially oral allergy syndrome. Apricot belongs to the botanical subfamily of Prunoideae, which includes peach, the major allergen of which was identified as a 9-kd protein, a lipid transfer protein (LTP).

OBJECTIVE: The aim of the study was to evaluate the IgE reactivity pattern to an apricot extract in subjects with allergic reactions to apricot, as demonstrated by a positive oral ...

Also Ranks for: Major Allergen |  lipid transfer protein |  apricot ltp |  allergic reactions |  oral allergy syndrome
KOL Index score: 11405

BACKGROUND: The hazelnut major allergens identified to date are an 18-kd protein homologous to Bet v 1 and a 14-kd allergen homologous to Bet v 2. No studies have reported hazelnut allergens recognized in patients with positive double-blind, placebo-controlled food challenge (DBPCFC) results or in patients allergic to hazelnut but not to birch.

OBJECTIVE: We characterized the hazelnut allergens by studying the IgE reactivity of 65 patients with positive DBPCFC results and 7 patients with ...

Also Ranks for: Major Allergen |  patients hazelnut |  controlled food |  ige reactivity |  positive dbpcfc
KOL Index score: 11393

BACKGROUND: The detection of specific IgE antibodies to environmental allergens does not always coincide with a diagnosis of clinically evident allergic disease, because some patients with positive skin and/or in vitro test results have no symptoms related to the allergen or allergens that induced the antibodies.

OBJECTIVE: In a multicenter study the optimal cutoff values for specific IgE antibody levels and skin test results that could discriminate between patients with symptomatic and ...

Also Ranks for: Specific Ige |  skin test |  seasonal sensitivity |  allergy patients |  cutoff values
KOL Index score: 11031

BACKGROUND: Three main problems hamper the identification of wheat food allergens: (1) lack of a standardized procedure for extracting all of the wheat protein fractions; (2) absence of double-blind, placebo-controlled food challenge studies that compare the allergenic profile of Osborne's three protein fractions in subjects with real wheat allergy, and (3) lack of data on the differences in IgE-binding capacity between raw and cooked wheat.

METHODS: Sera of 16 wheat-challenge-positive ...

Also Ranks for: Food Allergy |  lipid transfer proteins |  amylase inhibitors |  grass pollen |  wheat allergens
KOL Index score: 10866

BACKGROUND: Tree nuts are a common cause of food allergy in Europe. However, few studies deal with real food allergy to hazelnuts in subjects believed to be allergic to this food.

OBJECTIVE: We sought to select subjects with a history of allergic reactions on ingestion of hazelnut and determine how many of these have true allergy by means of the double-blind, placebo-controlled food challenge (DBPCFC).

METHODS: Eighty-six subjects with a history of symptoms after hazelnut ingestion were ...

Also Ranks for: Hazelnut Allergy |  skin tests |  food challenge |  sensitivity positive predictive |  positive dbpcfc
KOL Index score: 10577

The reliability and safety of the oral challenge procedure were evaluated in the diagnosis and prevention of intolerance to nonsteroidal anti-inflammatory drugs (NSAIDs). 112 NSAID-intolerant patients were submitted to oral challenge with aspirin (acetylsalicylic acid), dipyrone, paracetamol, imidazole-hydroxybenzoate or nimesulide to confirm historic intolerance and to evaluate tolerance to other NSAIDs. A significant correlation was demonstrated between history of intolerance and the ...

Also Ranks for: Oral Challenge |  patients intolerant |  alternative nsaids |  nonsteroidal anti |  nsaid intolerance
KOL Index score: 10566

BACKGROUND: Cereals are the most important nutritional component in the human diet. Food-induced allergic reactions to these substances therefore have serious implications, and exhaustive diagnosis is required. Such diagnosis is still difficult because of the incomplete knowledge about major cereal allergens. In particular, few food-induced allergic reactions to maize have been reported, and no information on the allergenic proteins is available.

OBJECTIVE: Having observed several ...

Also Ranks for: Major Allergen |  lipid transfer protein |  nterminal sequence |  isoelectric point |  maize ltp

Key People For Major Allergen

Top KOLs in the world
Rudolf *******
grass pollen allergic patients allergenic activity
Thomas * * ************
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Dietrich *****
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Martin * *******
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Christof *****
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Heimo ***********
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Claudio Ortolani:Expert Impact

Concepts for whichClaudio Ortolanihas direct influence:Major allergen,  Food allergy,  Kiwi fruit,  Oral challenge,  Sodium cromoglycate,  Amino acid,  Lipid transfer protein,  Asymptomatic allergy.

Claudio Ortolani:KOL impact

Concepts related to the work of other authors for whichfor which Claudio Ortolani has influence:Food allergy,  Allergic rhinitis,  Specific ige,  Atopic dermatitis,  Major allergen,  Skin tests,  Birch pollen.



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Istituto Allergologico Lombardo. Casa Di Cura Ambrosiana, Cesano Boscone, Milano, Italy | Allergy Unit. Istituto Sacra Famiglia. Casa di Cura Ambrosiana, Cesano Boscone, Italy | Unit of Allergology and Clinical Immunology, A.O. Niguarda Hospital, Mil