• KOL
    • Liver Failure
    • Rajiv Jalan
    • Rajiv Jalan: Influence Statistics

      Rajiv Jalan

      Rajiv Jalan

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      Liver Failure Group, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, United Kingdom. Electronic address: r.jalan@ucl.ac.uk. | ...

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      Rajiv Jalan:Expert Impact

      Concepts for whichRajiv Jalanhas direct influence:Liver failure,Hepatic encephalopathy,Liver transplantation,Acute liver failure,Patients cirrhosis,Chronic liver,Patients aclf,Acute liver.

      Rajiv Jalan:KOL impact

      Concepts related to the work of other authors for whichfor which Rajiv Jalan has influence:Hepatic encephalopathy,Liver failure,Cirrhotic patients,Portal hypertension,Hepatorenal syndrome,Alcoholic hepatitis,Acute kidney injury.

      KOL Resume for Rajiv Jalan

      Year
      2022

      Liver Failure Group, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, United Kingdom. Electronic address:

      University College London, London, United Kingdom of Great Britain and Northern Ireland

      2021

      University College London – Liver Failure Group, Institute for Liver and Digestive Health London, London, United Kingdom

      European Foundation for the Study of Chronic Liver Failure (EF Clif), 08021 Barcelona, Spain; Liver Failure Group, Institute for Liver and Digestive Health, UCL Medical School, London, UK.

      UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK

      2020

      Liver Failure Group, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, United Kingdom; European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain. Electronic address:

      Translational Hepatology, Department of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany

      University College London, Royal Free Hospital, London, UK

      UCL Medical School, London, United Kingdom.

      Royal Free Hospital, London, United Kingdom

      2019

      The EASL-CLIF Consortium, European Foundation-CLIF, Barcelona, Spain

      Liver failure unit, UCL, London

      2018

      Liver Failure Group, UCL Institute for Liver and Digestive Health, UCL Medical School, London, UK

      ILDH, Division of Medicine, University College London Medical School, London, United Kingdom

      2017

      Karolin Thiel, Wilfried Klingert, Alfred Königsrainer, Martin Schenk, Christian Thiel, Department of General, Visceral and Transplant Surgery, Tuebingen University Hospital, Tuebingen 72076, Germany

      ILDH, Division of Medicine, University College London Medical School, London, UK

      From the *Centre for Medical Imaging, Division of Medicine, and †Institute for Liver and Digestive Health, Division of Medicine, University College London; ‡Department of Medical Physics, University College London Hospitals NHS Trust; and §Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom.

      Pamela Leckie, Yalda Sharifi, Nathan A Davies, Rajiv Jalan, Institute for Liver and Digestive Health, University College London, London NW3 2PF, United Kingdom

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      Sample of concepts for which Rajiv Jalan is among the top experts in the world.
      Concept World rank
      obesity infection risk #1
      cytoplasmic expression hepatitis #1
      uncontrolled intracranial #1
      3 months tipss #1
      skeletal portasystemic shunt #1
      cirrhotic patients csfsg #1
      cps1 activity #1
      posttransplant survival illness #1
      model alf #1
      techniques encephalopathy humans #1
      concept ammonia removal #1
      activity uces #1
      coma ammonia #1
      alf lornithine phenylacetate #1
      impact hyperammonaemia #1
      hrv remote monitoring #1
      increase arterial lps #1
      plf preventive measures #1
      larginine supplementation disease #1
      nafld hyperammonemia #1
      exitus #1
      mol pigs #1
      ammonia lornithine #1
      study cirrhosis #1
      cirrhosis variceal haemorrhage #1
      upper bleed hypoisoleucinemia #1
      ammonia major role #1
      syndrome acute decompensation #1
      aclf meld #1
      infection risk esld #1
      bdl arterial ammonia #1
      ddah1 immunohistochemistry #1
      pathophysiological basis #1
      aldaclf specific management #1
      infection ohe #1
      meldna score aclf3 #1
      aclf tlr4 #1
      cell death tak242 #1
      biological muscle lornithine #1
      albumin female hepatitis #1
      improved enos #1
      caspase3 expression vascularisation #1
      ammoniagenic diet #1
      simulated bleed fgroup #1
      gfr flow renin #1
      presence encephalopathy #1
      receptor liver cirrhosis #1
      function uces #1
      25 bid emricasan #1
      psychometric hepatic mhe #1
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      Prominent publications by Rajiv Jalan

      KOL-Index: 17938

      BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is a syndrome that occurs in cirrhosis characterized by organ failure(s) and high mortality rate. There are no biomarkers of ACLF. The LCN2 gene and its product, neutrophil gelatinase-associated lipocalin (NGAL), are upregulated in experimental models of liver injury and cultured hepatocytes as a result of injury by toxins or proinflammatory cytokines, particularly Interleukin-6. The aim of this study was to investigate whether ...

      Known for Liver Failure | Aclf Ngal | Lcn2 Gene | Prognosis Cirrhosis | Neutrophil Gelatinase
      KOL-Index: 16610

      BACKGROUND & AIMS: Patients with acute-on-chronic liver failure (ACLF) can be listed for liver transplantation (LT) because LT is the only curative treatment option. We evaluated whether the clinical course of ACLF, particularly ACLF-3, between the time of listing and LT affects 1-year post-transplant survival.

      METHODS: We identified patients from the United Network for Organ Sharing database who were transplanted within 28 days of listing and categorized them by ACLF grade at waitlist ...

      Known for Liver Failure | Aclf Aclf3 | Transplantation Patients | Post Survival | Acute Chronic
      KOL-Index: 14998

      BACKGROUND & AIMS: Antibiotic resistance has been increasingly reported in patients with decompensated cirrhosis in single-center studies. Prospective investigations reporting broad epidemiological data are scarce. We aimed to analyze epidemiological changes in bacterial infections in patients with decompensated cirrhosis.

      METHODS: This was a prospective evaluation of 2 series of patients hospitalized with decompensated cirrhosis. The Canonic series included 1,146 patients from Northern, ...

      Known for Bacterial Infections | Resistant Bacteria | Liver Failure | Decompensated Cirrhosis | Antibiotic Resistance
      KOL-Index: 14615

      BACKGROUND & AIMS: Liver transplantation (LT) has been proposed as an effective salvage therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large collaborative study was designed to assess the current clinical practice and outcomes of patients with ACLF who are wait-listed for LT in Europe.

      METHODS: This was a retrospective study including 308 consecutive patients with ACLF, listed in 20 centres across 8 European countries, from January 2018 to ...

      Known for Liver Transplantation | Patients Aclf | Acute Chronic | Decompensated Cirrhosis | 1 Year
      KOL-Index: 14609

      BACKGROUND & AIMS: Patients with cirrhosis hospitalized for an acute decompensation (AD) and organ failure are at risk for imminent death and considered to have acute-on-chronic liver failure (ACLF). However, there are no established diagnostic criteria for ACLF, so little is known about its development and progression. We aimed to identify diagnostic criteria of ACLF and describe the development of this syndrome in European patients with AD.

      METHODS: We collected data from 1343 ...

      Known for Aclf Patients | Liver Failure | Acute Decompensation | Distinct Syndrome | 28day Mortality Rate
      KOL-Index: 13766

      BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is a syndrome of systemic inflammation and organ failures. Obesity, also characterized by chronic inflammation, is a risk factor among patients with cirrhosis for decompensation, infection, and mortality. Our aim was to test the hypothesis that obesity predisposes patients with decompensated cirrhosis to the development of ACLF.

      METHODS: We examined the United Network for Organ Sharing (UNOS) database, from 2005-2016, ...

      Known for Class Iii Obesity | Liver Failure | Aclf Patients | Decompensated Cirrhosis | Acute Chronic
      KOL-Index: 13728

      In the post-absorptive state, ammonia is produced in equal amounts in the small and large bowel. Small intestinal synthesis of ammonia is related to amino acid breakdown, whereas large bowel ammonia production is caused by bacterial breakdown of amino acids and urea. The contribution of the gut to the hyperammonemic state observed during liver failure is mainly due to portacaval shunting and not the result of changes in the metabolism of ammonia in the gut. Patients with liver disease ...

      Known for Liver Failure | Ammonia Metabolism | Experimental Animals | Kidneys Major Role | Reduced Capacity
      KOL-Index: 12878

      BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is a frequent syndrome (30% prevalence), characterized by acute decompensation of cirrhosis, organ failure(s) and high short-term mortality. This study develops and validates a specific prognostic score for ACLF patients.

      METHODS: Data from 1349 patients included in the CANONIC study were used. First, a simplified organ function scoring system (CLIF Consortium Organ Failure score, CLIF-C OFs) was developed to diagnose ACLF using ...

      Known for Prognostic Score | Liver Failure | Clifc Aclfs | Aclf Diagnosis | Illness Chronic
      KOL-Index: 12868

      BACKGROUND & AIMS: Cirrhotic patients with acute decompensation frequently develop acute-on-chronic liver failure (ACLF), which is associated with high mortality rates. Recently, a specific score for these patients has been developed using the CANONIC study database. The aims of this study were to develop and validate the CLIF-C AD score, a specific prognostic score for hospitalised cirrhotic patients with acute decompensation (AD), but without ACLF, and to compare this with the ...

      Known for Cirrhotic Patients | Acute Decompensation | Clifc Ads | Chronic Liver | Aclf Childpugh
      KOL-Index: 12597

      BACKGROUND & AIMS: This randomized controlled trial compared variceal band ligation (VBL), propranolol (PPL), and isosorbide-5-mononitrate (ISMN) in the prevention of first esophageal variceal bleed.

      METHODS: Over a 6-year period, 172 patients with cirrhosis, grade II or III esophageal varices that had never bled, were recruited; 44 into VBL, 66 into PPL, and 62 into ISMN. Baseline patient characteristics: age, 55 +/- 11 years; Child-Pugh score, 8 +/- 2; 65% alcohol-induced cirrhosis; ...

      Known for Vbl Ppl | Variceal Hemorrhage | Band Ligation | Controlled Trial | Isosorbide Mononitrate
      KOL-Index: 12514

      BACKGROUND & AIMS: Liver transplantation for patients with acute-on-chronic liver failure (ACLF) with 3 or more failing organs (ACLF-3) is controversial. We compared liver waitlist mortality or removal according to model for end-stage liver disease (MELD) score vs ACLF category. We also studied factors associated with reduced odds of survival for 1 year after liver transplantation in patients with ACLF-3.

      METHODS: We analyzed data from the United Network for Organ Sharing (UNOS) from ...

      Known for Liver Transplantation | Patients Aclf3 | Meld Score | 1 Year | Mechanical Ventilation
      KOL-Index: 12496

      BACKGROUND/AIMS: The aim of this study was to analyse prognostic variables predicting mortality, shunt insufficiency, variceal rebleeding and encephalopathy following transjugular intrahepatic portosystemic stent-shunt for variceal haemorrhage.

      METHODS: Sixty-eight patients with cirrhosis who successfully underwent transjugular intrahepatic portosystemic stent-shunt for variceal haemorrhage were studied. Mean age was 54.8 years (s.e. 1.5); 41 were males and 27 were females. Mean Child ...

      Known for Variceal Haemorrhage | Prognostic Variables | Stent Shunt | Encephalopathy Transjugular | Intrahepatic Portosystemic
      KOL-Index: 12482

      BACKGROUND & AIMS: Research on vasopressin (AVP) in cirrhosis and its role in the assessment of prognosis has been hindered by the difficulty of measuring AVP levels accurately. Copeptin, a 39-aminoacid glycopeptide, is released from the neurohypophysis together with AVP. Copeptin could have a role as biomarker of prognosis in cirrhosis as it may reflect circulatory dysfunction. The aim of this study is to investigate the role of copeptin as biomarker of disease progression and prognosis ...

      Known for Plasma Copeptin | Patients Cirrhosis | Liver Disease | Glycopeptides Humans | Vasopressin Avp
      KOL-Index: 12275

      BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF), which develops in patients with cirrhosis, is characterized by intense systemic inflammation and organ failure(s). Because systemic inflammation is energetically expensive, its metabolic costs may result in organ dysfunction/failure. Therefore, we aimed to analyze the blood metabolome in patients with cirrhosis, with and without ACLF.

      METHODS: We performed untargeted metabolomics using liquid chromatography coupled to ...

      Known for Mitochondrial Dysfunction | Patients Aclf | Organ Failures | Potential Mechanism | Systemic Inflammation
      KOL-Index: 12262

      The aims of this study were to determine the role of cell death in patients with cirrhosis and acute decompensation (AD) and acute on chronic liver failure (ACLF) using plasma-based biomarkers. The patients studied were part of the CANONIC (CLIF Acute-on-Chronic Liver Failure in Cirrhosis) study (N = 337; AD, 258; ACLF, 79); additional cohorts included healthy volunteers, stable patients with cirrhosis, and a group of 16 AD patients for histological studies. Caspase-cleaved keratin 18 ...

      Known for Cell Death | Acute Decompensation | Patients Aclf | Ck18 K18 | Liver Failure

      Key People For Liver Failure

      Top KOLs in the world
      #1
      Williams Williams
      liver transplantation fulminant hepatic failure hepatocellular carcinoma
      #2
      Julia Alexis Wendon
      acute liver failure liver transplantation patients alf
      #3
      Rajiv Jalan
      liver failure hepatic encephalopathy patients cirrhosis
      #4
      William Martens Lee
      acute liver failure chronic hepatitis liver injury
      #5
      Didier Samuel
      liver transplantation hepatocellular carcinoma hepatitis virus
      #6
      William Bernal
      acute liver failure liver transplantation hospital mortality

      Liver Failure Group, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, United Kingdom. Electronic address: r.jalan@ucl.ac.uk. | Liver Failure Group, UCL Institute for Liver and Digestive Health, UCL Medic

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