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    • Craig James McClain

      Craig James McClain

      Robley Rex VAMC, Louisville, KY | University of Louisville Alcohol Research Center, Louisville, KY, USA | Hepatobiology & Toxicology Center, University of Louisville, ...



      KOL Resume for Craig James McClain


      Robley Rex VAMC, Louisville, KY

      Hepatobiology and Toxicology Program, University of Louisville, Louisville, Kentucky, USA

      Department of Medicine, University of Louisville, Louisville, United States


      Department of Medicine, University of Louisville, Louisville, KY 40202 USA

      University of Louisville Alcohol Research Center



      Craig James McClain: Influence Statistics

      Sample of concepts for which Craig James McClain is among the top experts in the world.
      Concept World rank
      hepatocytes tnfalpha killing #1
      hnf4alpha depletion liver #1
      etoh lps treatment #1
      fatty acids oxlams #1
      oxlams liver #1
      ptca inbred balb #1
      monocytes ald #1
      dietary fats ingestion #1
      humans nash #1
      severe aah igg #1
      diets active yogurt #1
      cpt1α expression #1
      frequency apoptotic nuclei #1
      endotoxin liver #1
      enhanced pde4b expression #1
      betaine hepatic steatosis #1
      synthesis bdl #1
      p05 antioxidants #1
      monocyte nuclear #1
      stable cirrhosis otz #1
      upregulation pde4 expression #1
      inflammatory cytokines zinc #1
      acrolein epithelial cells #1
      lowering alcohol #1
      cellular oxidative injury #1
      human ald #1
      role copperfructose interactions #1
      copper fructose intake #1
      normal subjects mcp1 #1
      hepatotoxicity tash #1
      rna chx #1
      oxlam diet #1
      rosiglitazone ethanol exposure #1
      deuterium tgs #1
      alcohol dietary fat #1
      mice sadenosylmethionine #1
      lpsstimulated il6 production #1
      ald adomet #1
      acrolein epigenetic modifications #1
      hcv acrolein #1
      lps pancreatic injury #1
      craving domains aud #1
      exogenous administration il6 #1
      associations vocs #1
      itf cramp #1
      urinary zinc excretion #1
      upregulation hdac class #1
      zinc deficiency anorexia #1
      ptca hne #1
      activation proteins plcγ1 #1


      Prominent publications by Craig James McClain

      KOL-Index: 15779

      Nuclear receptors are transcription factors which sense changing environmental or hormonal signals and effect transcriptional changes to regulate core life functions including growth, development, and reproduction. To support this function, following ligand-activation by xenobiotics, members of subfamily 1 nuclear receptors (NR1s) may heterodimerize with the retinoid X receptor (RXR) to regulate transcription of genes involved in energy and xenobiotic metabolism and inflammation. Several ...

      Known for Nuclear Receptors | New Tricks | Liver Disease | Alcoholic Fatty | Insulin Resistance
      KOL-Index: 15690

      BACKGROUND: Interactions between the gut, immune system, and the liver, as well as the type of fat in the diet, are critical components of alcoholic liver disease (ALD). The goal of the present study was to determine the effects of saturated fat (SF) and unsaturated fat (USF) on ethanol (EtOH)-induced gut-liver interactions in a mouse model of ALD.

      METHODS: C57BL/6N mice were fed Lieber-DeCarli liquid diets containing EtOH and enriched in USF (corn oil) or SF (medium chain ...

      Known for Mouse Model | Dietary Fat | Alcoholic Liver Disease | Tight Junction | Intestinal Permeability
      KOL-Index: 14835

      BACKGROUND: Heavy alcohol consumption frequently causes liver inflammation/injury, and certain fatty acids (FAs) may be involved in this liver pathology. In this study, we evaluated the association of heavy drinking and the changes in the FA levels involved in the ω-6 (pro-inflammatory) and ω-3 (anti-inflammatory) state in alcohol-dependent (AD) patients who had no clinical manifestations of liver injury. We aimed to identify sex-based differences in patients with mild or no biochemical ...

      Known for Liver Injury | Heavy Drinking | Fatty Acids | Clinical Manifestations | Gr2 Patients
      KOL-Index: 14519

      Increased plasma and hepatic TNF-alpha activity has been implicated in the pathogenesis of alcoholic liver disease (ALD). We previously reported that monocytes from alcoholic patients show enhanced constitutive as well as LPS-inducible NF-kappaB activation and TNF-alpha production. Studies in monocytes have shown that cAMP plays an important role in regulating TNF-alpha expression, and elevation of cellular cAMP suppresses TNF-alpha production. The effects of chronic ethanol exposure on ...

      Known for Tnf Expression | Alcoholic Liver | Chronic Ethanol | Cellular Camp | Inducible Nf
      KOL-Index: 14328

      Endotoxemia is a contributing cofactor to alcoholic liver disease (ALD), and alcohol-induced increased intestinal permeability is one of the mechanisms of endotoxin absorption. Probiotic bacteria have been shown to promote intestinal epithelial integrity and protect barrier function in inflammatory bowel disease (IBD) and in ALD. Although it is highly possible that some common molecules secreted by probiotics contribute to this action in IBD, the effect of probiotic culture supernatant ...

      Known for Liver Injury | Intestinal Permeability | Culture Supernatant | Lactobacillus Rhamnosus | Acute Alcohol
      KOL-Index: 13982

      BACKGROUND: High-level occupational exposures to some industrial chemicals have been associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD). However, the potential role of low-level environmental pollution on liver disease in the general population has not been evaluated.

      OBJECTIVE: We determined whether environmental pollutants are associated with an elevation in serum alanine aminotransferase (ALT) activity and suspected NAFLD in U.S. adults.

      METHODS: This ...

      Known for Liver Disease | Polychlorinated Biphenyls | Nhanes 2003–2004 | Lead Mercury | Environmental Pollutants
      KOL-Index: 13507

      Increased plasma and hepatic TNF-alpha expression is well documented in patients with alcoholic hepatitis and is implicated in the pathogenesis of alcoholic liver disease. We have previously shown that monocytes from patients with alcoholic hepatitis show increased constitutive and LPS-induced NF-kappaB activation and TNF-alpha production. Our recent studies showed that chronic ethanol exposure significantly decreased cellular cAMP levels in both LPS-stimulated and unstimulated monocytes ...

      Known for Alcoholic Liver Disease | Tnf Expression | Monocytes Macrophages | Cellular Camp | Lps Inducible
      KOL-Index: 13498

      Although altered cytokine homeostasis has been implicated in the pathogenesis of alcoholic liver disease, the relationship between cytokines and metabolic consequences of alcoholic liver disease is unknown. We, therefore, sought to correlate circulating concentrations of tumor necrosis factor-alpha, interleukin-1 and interleukin-6 to clinical and biochemical parameters of liver disease in chronic alcoholic patients. We used an enzyme-linked immunosorbent assay to measure plasma tumor ...

      Known for Alcoholic Patients | Tumor Necrosis Factor | Liver Disease | Cytokine Concentrations | Interleukin1 Interleukin6
      KOL-Index: 13037

      BACKGROUND & AIMS: Alcoholic liver disease (ALD) is characterized by gut dysbiosis and increased gut permeability. Hypoxia inducible factor 1α (HIF-1α) has been implicated in transcriptional regulation of intestinal barrier integrity and inflammation. We aimed to test the hypothesis that HIF-1α plays a critical role in gut microbiota homeostasis and the maintenance of intestinal barrier integrity in a mouse model of ALD.

      METHODS: Wild-type (WT) and intestinal epithelial-specific Hif1a ...

      Known for Alcoholic Liver Disease | Intestinal Dysbiosis | Barrier Dysfunction | Liver Steatosis | Alanine Aminotransferase
      KOL-Index: 12762

      Green tea polyphenols are potent antioxidants. They have both anti-cancer and anti-inflammatory effects. However, their mechanisms of actions remain unclear. In inflammation, tumor necrosis factor-alpha(TNFalpha) plays a pivotal role. NF-KB, an oxidative stress -sensitive nuclear transcription factor, controls the expression of many genes including the TNFalpha gene. We postulated that green tea polyphenols regulate TNFalpha gene expression by modulating NF-KB activation through their ...

      Known for Green Tea Polyphenols | Necrosis Factor | Murine Model | Induced Tumor | Catechin Cell
      KOL-Index: 12568

      Alcoholic liver disease is associated with zinc decrease in the liver. Therefore, we examined whether dietary zinc supplementation could provide protection from alcoholic liver injury. Metallothionein-knockout and wild-type 129/Sv mice were pair-fed an ethanol-containing liquid diet for 12 weeks, and the effects of zinc supplementation on ethanol-induced liver injury were analyzed. Zinc supplementation attenuated ethanol-induced hepatic zinc depletion and liver injury as measured by ...

      Known for Zinc Supplementation | Oxidative Stress | Alcoholic Liver | Ethanol Glutathione | Reactive Oxygen Species
      KOL-Index: 12453

      Increased tumor necrosis factor-a activity has been reported in patients with alcoholic hepatitis and is implicated in its pathogenesis. The aim of this study was to investigate potential mechanisms of increased tumor necrosis factor-a activity in alcoholic hepatitis. Monocyte nuclear factor-kB activity was assessed by electrophoretic mobility shift assay, monocyte tumor necrosis factor-a mRNA was semi-quantitatively assessed by reverse transcriptase polymerase chain reaction, and tumor ...

      Known for Alcoholic Hepatitis | Necrosis Factor | Monocytes Patients | Increased Tumor | Κb Activation
      KOL-Index: 12444

      BACKGROUND: Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that are detectable in the serum of all American adults. Amongst PCB congeners, PCB 153 has the highest serum level. PCBs have been dose-dependently associated with obesity, metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) in epidemiological studies.

      OBJECTIVE: The purpose of this study is to determine mechanisms by which PCB 153 worsens diet-induced obesity and NAFLD in male mice fed a ...

      Known for Fatty Liver | Pcb Pcb 153 | Polychlorinated Biphenyl | Hepatic Steatosis | Highfat Disease Models
      KOL-Index: 12277

      Alcoholic liver disease (ALD) ranks among major causes of morbidity and mortality. Diet and crosstalk between the gut and liver are important determinants of ALD. We evaluated the effects of different types of dietary fat and ethanol on the gut microbiota composition and metabolic activity and the effect of these changes on liver injury in ALD. Compared with ethanol and a saturated fat diet (medium chain triglycerides enriched), an unsaturated fat diet (corn oil enriched) exacerbated ...

      Known for Dietary Fat | Gut Microbiome | Alcoholic Liver | Mouse Model | Disease Ald
      KOL-Index: 12248

      Acrolein is a common environmental, food and water pollutant and a major component of cigarette smoke. Also, it is produced endogenously via lipid peroxidation and cellular metabolism of certain amino acids and drugs. Acrolein is cytotoxic to many cell types including hepatocytes; however the mechanisms are not fully understood. We examined the molecular mechanisms underlying acrolein hepatotoxicity in primary human hepatocytes and hepatoma cells. Acrolein, at pathophysiological ...

      Known for Oxidative Stress | Mitochondrial Dysfunction | Endoplasmic Reticulum | Cell Death | Exposure Acrolein

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      Craig James McClain:Expert Impact

      Concepts for whichCraig James McClainhas direct influence:Liver injury,  Alcoholic liver disease,  Liver disease,  Alcoholic hepatitis,  Alcoholic liver,  Zinc deficiency,  Tumor necrosis factor,  Tumor necrosis.

      Craig James McClain:KOL impact

      Concepts related to the work of other authors for whichfor which Craig James McClain has influence:Liver disease,  Oxidative stress,  Gut microbiota,  Alcoholic hepatitis,  Insulin resistance,  Kupffer cells,  Zinc deficiency.



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      Robley Rex VAMC, Louisville, KY | University of Louisville Alcohol Research Center, Louisville, KY, USA | Hepatobiology & Toxicology Center, University of Louisville, Louisville, KY, USA | University of Louisville Hepatobiology and Toxicology Center,

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