• Disease
  • Pancreatic
  • Pancreatic Cancer
  • Markus Wolfgang Büchler†

    Prominent publications by Markus Wolfgang Büchler†

    KOL Index score: 18327

    BACKGROUND: Postoperative surgical site infections are one of the most frequent complications after open abdominal surgery, and triclosan-coated sutures were developed to reduce their occurrence. The aim of the PROUD trial was to obtain reliable data for the effectiveness of triclosan-coated PDS Plus sutures for abdominal wall closure, compared with non-coated PDS II sutures, in the prevention of surgical site infections.

    METHODS: This multicentre, randomised controlled group-sequential ...

    Also Ranks for: Surgical Site |  abdominal wall closure |  coated pds |  randomised controlled |  infection sutures
    KOL Index score: 18072

    BACKGROUND: The ESPAC-3 trial showed that adjuvant gemcitabine is the standard of care based on similar survival to and less toxicity than adjuvant 5-fluorouracil/folinic acid in patients with resected pancreatic cancer. Other clinical trials have shown better survival and tumour response with gemcitabine and capecitabine than with gemcitabine alone in advanced or metastatic pancreatic cancer. We aimed to determine the efficacy and safety of gemcitabine and capecitabine compared with ...

    Also Ranks for: Adjuvant Gemcitabine |  resected pancreatic cancer |  3 trial |  aged pancreatic |  toxicity patients
    KOL Index score: 17818

    CONTEXT: Adjuvant fluorouracil has been shown to be of benefit for patients with resected pancreatic cancer. Gemcitabine is known to be the most effective agent in advanced disease as well as an effective agent in patients with resected pancreatic cancer.

    OBJECTIVE: To determine whether fluorouracil or gemcitabine is superior in terms of overall survival as adjuvant treatment following resection of pancreatic cancer.

    DESIGN, SETTING, AND PATIENTS: The European Study Group for Pancreatic ...

    Also Ranks for: Folinic Acid |  pancreatic cancer |  fluorouracil gemcitabine |  adjuvant chemotherapy |  randomized controlled trial
    KOL Index score: 17405

    OBJECTIVE: To assess the influence of resection margins on survival for patients with resected pancreatic cancer treated within the context of the adjuvant European Study Group for Pancreatic Cancer-1 (ESPAC-1) study.

    SUMMARY BACKGROUND DATA: Pancreatic cancer is associated with a poor long-term survival rate of only 10% to 15% after resection. Patients with positive microscopic resection margins (R1) have a worse survival, but it is not known how they fare in adjuvant studies.

    METHODS: ...

    Also Ranks for: Resection Margins |  adjuvant chemoradiation |  pancreatic cancer |  chemotherapy patients |  randomized controlled trial
    KOL Index score: 16705

    OBJECTIVE: Pancreatic cancer is characterised by invasive tumour spread and early metastasis formation. During epithelial-mesenchymal transition, loss of the cell adhesion molecule E-cadherin is frequent and can be caused by genetic or epigenetic modifications, recruitment of transcriptional activators/repressors or post-translational modifications. A study was undertaken to investigate how E-cadherin expression in human pancreatic adenocarcinoma and pancreatic cancer cell lines is ...

    Also Ranks for: Pancreatic Cancer |  histone deacetylase |  cadherin expression |  hdac1 hdac2 |  somatic mutations
    KOL Index score: 16704

    ErbB3 is a transmembrane signaling molecule that shares close structural homology with epidermal growth factor receptor (EGFR), erbB2, and erbB4. They have all been implicated in cell transformation and tumor pathogenesis, but very little is known about the role of erbB3 in normal colon and colorectal cancer. Therefore, in the current study, we determined whether erbB3 is found in normal human colon and whether its expression is altered in colorectal cancer. Because of some evidence that ...

    Also Ranks for: Colorectal Cancer |  erbb2 erbb3 |  increased expression |  messenger receptor |  mrna levels
    KOL Index score: 16439

    BACKGROUND: Resections of the pancreatic body and tail reaching to the left of the superior mesenteric vein are defined as distal pancreatectomy. Most distal pancreatectomies are elective treatments for chronic pancreatitis, benign or malignant diseases, and they have high morbidity rates of up to 40%. Pancreatic fistula formation is the main source of postoperative morbidity, associated with numerous further complications. Researchers have proposed several surgical resection and closure ...

    Also Ranks for: Distal Pancreatectomy |  pancreatic remnant |  scalpel resection |  hand‐sewn closure |  stapler versus
    KOL Index score: 16300

    BACKGROUND: It has been proven that bariatric surgery affects weight loss. Patients with morbid obesity have a significantly lower quality of life (QOL) and body image compared with the general population.

    OBJECTIVE: To evaluate QOL, body image, and general self-efficacy (GSE) in patients with morbid obesity undergoing bariatric surgery within clinical parameters.

    SETTINGS: Monocentric, prospective, longitudinal cohort study.

    METHODS: Patients completed the short form 36 (SF-36) for QOL, ...

    Also Ranks for: Body Image |  bariatric surgery |  24 months |  life qol |  prospective cohort study
    KOL Index score: 16184

    OBJECTIVE: To determine benefits of conservative versus surgical treatment in patients with necrotizing pancreatitis.

    SUMMARY BACKGROUND DATA: Infection of pancreatic necrosis is the most important risk factor contributing to death in severe acute pancreatitis, and it is generally accepted that infected pancreatic necrosis should be managed surgically. In contrast, the management of sterile pancreatic necrosis accompanied by organ failure is controversial. Recent clinical experience has ...

    Also Ranks for: Necrotizing Pancreatitis |  infected necrosis |  pancreatic infection |  surgery patients |  treatment strategy
    KOL Index score: 15448

    BACKGROUND & AIMS: Bone morphogenetic proteins (BMPs) belong to the transforming growth factor beta superfamily of signaling molecules. We characterized the expression of BMP-2 and its receptors in human pancreatic tissues and pancreatic cancer cell lines and examined the effects of BMP-2 on mitogenesis.

    METHODS: Expression of BMP-2 and its receptors was determined by Northern blot analysis using specific complementary DNA probes. Distribution of BMP-2 in pancreatic cancers was examined ...

    Also Ranks for: Cell Growth |  morphogenetic protein |  human pancreatic cancer |  expression bmp2 |  situ hybridization
    KOL Index score: 15305

    OBJECTIVE: To compare growth factor receptor expression in papilla of Vater cancer and pancreatic cancer.

    SUMMARY BACKGROUND DATA: Cancer of the papilla of Vater has a much better prognosis than pancreatic cancer. Earlier symptoms may result in earlier diagnosis, but different biologic growth behaviors and genetic alterations might also be explanations.

    PATIENTS AND METHODS: Surgical specimens from papilla of Vater cancers (24 patients) and pancreatic cancers (80 patients), normal ...

    Also Ranks for: Vater Cancer |  growth factor |  erbb2 receptor |  situ hybridization |  mrna expression
    KOL Index score: 15149

    Pancreatic cancer cells are usually resistant to apoptosis mediated by tumor necrosis factor (TNF)-alpha or FasL, and their toxicity towards normal cells hampers their application for therapeutic use. TNF-related apoptosis-inducing ligand (TRAIL), a novel member of the TNF family, triggers apoptosis in a variety of malignant cells, but exhibits less cytotoxicity in normal cells. To investigate the therapeutic potential of TRAIL, we analyzed the expression of TRAIL and its ...

    Also Ranks for: Dr4 Dr5 |  pancreatic cancer |  expression trail |  tumor necrosis factor |  messenger receptors
    KOL Index score: 15025

    PURPOSE: Up to 25% of patients with node-negative colorectal cancer (CRC) on conventional histopathologic analysis ultimately die of recurrent disease. We performed a systematic review with meta-analyses to clarify whether molecular detection of isolated tumor cells or micrometastases in regional lymph nodes indicates high risk of disease recurrence and poor survival in node-negative CRC.

    METHODS: The following databases were searched in August 2011 to identify studies on the prognostic ...

    Also Ranks for: Regional Lymph Nodes |  disease recurrence |  poor survival |  molecular detection |  tumor cells
    KOL Index score: 14781

    INTRODUCTION: The microenvironment of low oxygen that is present in human pancreatic cancer in vivo may actively influence tumor growth as well as neovascularization.

    AIMS: To determine whether hypoxia-inducible factor 1 (HIF-1) is specifically activated by hypoxia in vitro in pancreatic cancer cells and correlated these findings with tumor specimens.

    METHODOLOGY: Hypoxic regulation of vascular endothelial growth factor (VEGF) was studied by northern blot analysis and enzyme-linked ...

    Also Ranks for: Growth Factor |  pancreatic cancer |  vascular endothelial |  tumor hypoxia |  hif1 vegf


    Markus Wolfgang Büchler†: Influence Statistics

    Sample of concepts for which Markus Wolfgang Büchler† is among the top experts in the world.
    Concept World rank
    arterial involvement type #1
    fxyd3 pancreatic cancer #1
    receptors bmp2 #1
    cvbc #1
    persisting elevation #1
    scalpel resection #1
    isgps pph #1
    colon anastomoses rats #1
    skin antisepsis ssi #1
    classical whipple #1
    procapb #1
    blotting northern carcinoma #1
    patients pylorus resection #1
    female humans length #1
    microarray analysen #1
    cent drainage #1
    ppw cw #1
    gastric venous congestion #1
    drks00013997 #1
    pct gcsf #1
    tbetar ctgf #1
    resection primary #1
    infection acute pancreatitis #1
    alcoholic idiopathic pancreatitis #1
    activin stage #1
    hypertrophy pca #1
    retrocolic reconstruction #1
    vascular stapler #1
    pancreatic resection #1
    hand sewn #1
    edc liver transplantation #1
    pankreasinsuffizienz #1
    ret ext #1
    patients r1 #1
    tgf beta day #1
    emergency pancreatoduodenectomy #1
    fewer adhesions #1
    levels alk5 #1
    survival review authors #1
    messenger receptors immunohistochemistry #1
    pyloruspreserving #1
    expression hip #1
    erbb‐4 mrna expression #1
    pancreatic remnant #1
    antecolic reconstruction #1
    patients tumor resection #1
    nomaedc #1
    acute colonic volvulus #1
    cda mrna #1
    pla2ii pancreatic cancer #1

    Key People For Pancreatic Cancer

    Top KOLs in the world
    Ralpha H Hruban†
    pancreatic cancer gene expression tumor carcinoma
    Ahmedin M Jemal
    united states breast cancer addis ababa
    Rebecca L Siegel
    united states colorectal cancer incidence rates
    Anirban Maitra
    pancreatic cancer precursor lesions early detection
    Markus Wolfgang Büchler†
    pancreatic cancer chronic pancreatitis liver transplantation
    Helmut M Friess†
    pancreatic cancer chronic pancreatitis growth factor

    Markus Wolfgang Büchler†:Expert Impact

    Concepts for whichMarkus Wolfgang Büchler†has direct influence:Pancreatic cancer,  Chronic pancreatitis,  Acute pancreatitis,  Pancreatic surgery,  Liver transplantation,  Distal pancreatectomy,  Growth factor,  Rectal cancer.

    Markus Wolfgang Büchler†:KOL impact

    Concepts related to the work of other authors for whichfor which Markus Wolfgang Büchler† has influence:Pancreatic cancer,  Acute pancreatitis,  Hepatocellular carcinoma,  Tumor cells,  Liver transplantation,  Growth factor,  Postoperative complications.



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    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, INF 110, Heidelberg 69120, Germany | Clinic for General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany; | Klinik für Allgemei