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    • Williams Williams
    • Williams Williams: Influence Statistics

      Williams Williams

      Williams Williams

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      Institute of Hepatology, Foundation for Liver Research, London, United Kingdom | Institute of Hepatology, Foundation for Liver Research, King's College London, London, UK | ...

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      Williams Williams:Expert Impact

      Concepts for whichWilliams Williamshas direct influence:Liver transplantation,Fulminant hepatic failure,Hepatocellular carcinoma,Liver disease,Acute liver failure,Primary biliary cirrhosis,Chronic hepatitis,Liver failure.

      Williams Williams:KOL impact

      Concepts related to the work of other authors for whichfor which Williams Williams has influence:Liver transplantation,Hepatocellular carcinoma,Chronic hepatitis,Hepatic encephalopathy,Cirrhotic patients,Primary biliary cirrhosis,Portal hypertension.

      KOL Resume for Williams Williams

      Year
      2021

      Institute of Hepatology, Foundation for Liver Research, London, United Kingdom

      Faculty of Life Sciences and Medicine, King’s College London, London, UK

      2020

      Foundation for Liver Research, The Institute of Hepatology London, London, UK

      Institute of Hepatology, London, United Kingdom.

      Faculty of Life Sciences & Medicine, King’s College London, London, United Kingdom

      2019

      The Institute of Hepatology London, Foundation for Liver Research, 111 Coldharbour Lane, SE5 9NT, London, UK

      Institute for Hepatology London, Foundation for Liver Research, London, United Kingdom.

      2018

      Faculty of Life Sciences & Medicine, King’s College, London, UK

      Life Sciences and Medicine, Kings College London, Kings College Hospital, London, United Kingdom, .

      2017

      Regeneration and Repair Group, The Institute of Hepatology, Foundation for Liver Research, London, UK.

      Foundation for Liver Research, The Institute of Hepatology, London, UK

      Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

      2016

      I Jane Cox, Antonio Riva, Roger Williams, Institute of Hepatology, London, Foundation for Liver Research, London WC1E 6HX, United Kingdom.

      2015

      Institute of Hepatology, London & Foundation for Liver Research, United Kingdom

      Division of Transplantation Immunology and Mucosal Biology, King's College London, UK

      2014

      Institute of Hepatology, Foundation for Liver Research, London, United Kingdom, .

      2013

      The Foundation for Liver Research, The Institute of Hepatology, London, UK

      Institute of Hepatology and Foundation for Liver Research, London, United Kingdom

      2012

      The Institute of Hepatology, Foundation for Liver Research, 69-75 Chenies Mews, London, WC1E 6HX, UK

      Institute of Hepatology and Foundation for Liver Research, London

      2011

      Liver Unit, King's College Hospital and School of Medicine and Dentistry, Denmark Hill, London SE5 8RX, UK

      2010

      Institute of Hepatology, University College London Medical School, and University College London Hospitals, London (R.W.).

      2009

      Institute of Hepatology, UCL Medical School, London.

      2008

      Institute of Liver Studies, King's College School of Medicine and Dentistry, London, England

      Gastrointestinal and Liver Unit, The Prince of Wales Hospital and University of New South Wales, Sydney, Australia

      2007

      Institute of Hepatology, University College London Medical School, 69-75 Chenies Mews, London, WC1E 6HX, UK.

      Sign-in to see all concepts, it's free!
      Sample of concepts for which Williams Williams is among the top experts in the world.
      Concept World rank
      haemodilution anaemia #1
      halothane‐induced neoantigens #1
      oral embolization #1
      grade encephalopathy #1
      acute hepatic necrosis #1
      encephalopathy weeks #1
      hla‐dr8‐dqb10402 haplotype #1
      paracetamol mice #1
      suppressorcell function #1
      cytotoxicity patients #1
      susceptibility cirrhosis #1
      acetaminophen adolescent #1
      remission autoimmune hepatitis #1
      aldosterone secretion cirrhosis #1
      sensitization hbsag #1
      semen hbvdna #1
      diseases azathioprine #1
      titres antibodies #1
      olt il6 #1
      withthrombin #1
      low dose dopamine #1
      intrahepatic expression hbcag #1
      gastric iron #1
      experimental hepatic necrosis #1
      oral k1 #1
      chronic active hepatitis #1
      hcv autoimmune hepatitis #1
      intravenous nitroglycerin vasopressin #1
      alf hepatic infiltration #1
      twodimensional infusions #1
      transplantation years #1
      patients haemoperfusion #1
      wit 180 minutes #1
      hla‐c genes #1
      fk506 methylprednisolone #1
      lbp encephalapp #1
      intrahepatic calcium carcinoma #1
      suppressorcell #1
      liver disease1 #1
      continuous bipolar recording #1
      diabetes haemochromatosis #1
      240 × #1
      hplc paria #1
      bromosulphthalein #1
      liver disease incidence #1
      series treatment #1
      disturbed brain tryptophan #1
      therapeutic option children #1
      hplc intravenous cyclosporine #1
      chronic kidney hbsag #1
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      Prominent publications by Williams Williams

      KOL-Index: 17561

      BACKGROUND/AIMS: To investigate the impact of hepatitis B (HBV) and C (HCV) infections on hepatocellular carcinoma (HCC) in Europe.

      METHODS: Five hundred and three patients with HCC, from six liver centers, were included. All 503 sera and 80 liver samples were tested for HBV DNA and HCV RNA by polymerase chain reaction. GBV-C/HGV RNA was also tested in 57 sera.

      RESULTS: HBsAg and anti-HCV were detected in 19% and 40.1% of the patients, respectively. Serum and liver HBV DNA were detected ...

      Known for Hbv Hcv | Hepatocellular Carcinoma | Patients Hcc | Gbvc Hgv | Viral Human Humans
      KOL-Index: 15766

      BACKGROUND & AIMS: Susceptibility to bacterial infection is a feature of alcohol-related liver disease. Programmed cell death 1 (PD1), the T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3, also known as hepatitis A virus cellular receptor 2), and their respective ligands-CD274 (also known as PD ligand 1 [PDL1]) and galectin-9-are inhibitory receptors that regulate the balance between protective immunity and host immune-mediated damage. However, their sustained ...

      Known for Adaptive Immunity | Patients Aah | Pd1 Tim3 | Alcoholic Hepatitis | Interferon Gamma
      KOL-Index: 14618

      The liver is the major source of circulating insulinlike growth factor-I (IGF-I) and has been suggested as a major source of at least two of the major binding proteins that modify its bioavailability. We aimed to assess the direct effects of liver dysfunction on serum levels of IGF-1 and its major binding proteins by measuring fasting levels of growth hormone, IGF-1, IGFBP-1, IGFBP-3, insulin, C peptide, and glucose in 35 patients with cirrhosis and during an oral glucose tolerance test ...

      Known for Binding Protein | Growth Hormone | Igfbp1 Levels | Liver Disease | Major Source
      KOL-Index: 14157

      BACKGROUND: End-stage cirrhosis related to hepatitic C virus (HCV) is a common reason for liver transplantation, although viremia ia known to persist in most cases. We investigated the impact of persistent HCV infection after liver transplantation on patient and graft survival and the effects of the HCV genotype and the degree of HLA matching between donor and recipient on the severity of recurrent hepatitis.

      METHODS: A group of 149 patients with HCV infection who received liver ...

      Known for Liver Transplantation | Hepatitis Infection | Hcv Genotype | Cirrhosis Median | Months Graft
      KOL-Index: 13621

      BACKGROUND: In most patients with autoimmune hepatitis, remission can be maintained with prednisolone, usually in combination with azathioprine, but the majority of patients have a relapse when treatment is stopped and therefore require long-term therapy. Because prolonged corticosteroid therapy may have serious toxic effects, in 1984 we undertook a controlled trial of maintenance therapy with azathioprine alone. None of the 25 patients in that trial had relapses during the follow-up ...

      Known for Autoimmune Hepatitis | Azathioprine Patients | Prednisolone Remission | Term Maintenance | Higher Dose
      KOL-Index: 13450

      OBJECTIVE: To evaluate the outcome of liver transplantation in patients with alcoholic cirrhosis with respect to selection criteria, survival, and evidence suggesting a return to harmful drinking.

      DESIGN: Nine year retrospective study.

      SETTING: Cambridge and King's College Hospital liver transplant programme.

      SUBJECTS: 24 Patients (three women, 21 men) with alcoholic cirrhosis.

      MAIN OUTCOME MEASURES: Survival, rehabilitation, and clinical and laboratory evidence of a return to harmful ...

      Known for Alcoholic Cirrhosis | Liver Transplantation | Harmful Drinking | Patients Transplants | Hepatocellular Carcinoma
      KOL-Index: 13192

      BACKGROUND/AIMS: To investigate whether the measurement of HBV DNA by quantitative polymerase chain reaction (PCR) is helpful in monitoring response to interferon treatment in chronic hepatitis B virus infection, we have determined sequentially serum levels of HBV DNA during and up to 18 months after treatment, in 10 patients with a sustained response (all anti-HBe positive, five also HBsAg negative and anti-HBs positive) and, as controls, in 12 non-responders.

      METHODS: Serum HBV DNA was ...

      Known for Hbv Dna | Quantitative Pcr | Chronic Hepatitis | Interferon Treatment | Virus Infection
      KOL-Index: 12947

      After nearly 18 years of research, the association between human leukocyte antigens A1-B8-DR3 and autoimmune chronic active hepatitis still provokes debate. The principal reasons for this are disease heterogeneity and racial variation in the distribution of human leukocyte antigens between populations. The aim of the present study was to reexamine the relationship between these antigens and autoimmune chronic active hepatitis in a well-characterized series of patients. Ninety-six ...

      Known for Human Leukocyte | Autoimmune Chronic | Active Hepatitis | Hla Antigens | Liver Transplantation
      KOL-Index: 12867

      BACKGROUND/AIMS: Patients with chronic hepatitis B infection have elevated plasma tumor necrosis factor (TNF) alpha levels. Two TNF-alpha receptors have been identified, each responsible for distinct TNF-alpha activities. The aim of this study was to evaluate the biological function of the elevated TNF-alpha in chronic hepatitis B virus infection by examining the two TNF signaling pathways in the evolution of hepatitis B-related liver injury.

      METHODS: The hepatic expression of the two ...

      Known for Necrosis Factor | Tnf Receptors | Chronic Hepatitis | Virus Replication | Viral Clearance
      KOL-Index: 12825

      BACKGROUND: A newly described DNA virus, named transfusion-transmitted virus (TTV), was recently detected with high prevalence in Japanese patients with fulminant hepatitis and chronic liver disease of unknown aetiology. We investigated the presence of this virus in patients with liver disease in the UK to find out whether TTV infection is associated with liver damage.

      METHODS: We used semi-nested PCR to amplify TTV DNA from serum samples from 126 adults, of whom 72 were patients with a ...

      Known for Ttv Dna Patients | Viral Hepatitis | Dna Virus | Liver Damage | Reaction Prevalence
      KOL-Index: 12598

      Activation of macrophages by endotoxin is assumed responsible for increased circulating tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor (sTNFR) levels in cirrhosis. Relevant to this is expression of Toll-like receptor (TLR) 4 and TLR2, which is critically involved in production of TNF-alpha in response to endotoxin and Gram-positive microbial stimuli, respectively. The first studies on this in cirrhosis are reported here. In 36 cirrhotic patients and 32 controls, we ...

      Known for Tlr2 Tlr4 | Tnf Alpha | Mononuclear Cell | Peripheral Blood | Toll Receptors
      KOL-Index: 12555

      Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes by HBV-specific CD8 cells has been assumed to be the central mechanism causing both liver damage and virus control. To understand the role of cytotoxic T cells in the pathogenesis of HBV infection, we used functional assays that require T cell expansion in vitro and human histocompatibility leukocyte antigen (HLA)-peptide tetramers that allow direct ex vivo quantification of circulating and ...

      Known for Liver Damage | Specific Cd8 | Hbv Replication | Viral Control | Persistent Hepatitis
      KOL-Index: 12446

      Interleukin-12 (IL-12) is an immunomodulatory cytokine that promotes cellular immunity. Pre-clinical data suggest that IL-12 inhibits hepatitis B virus (HBV) replication by stimulating interferon-gamma (IFN-gamma) production. We investigated whether a combination treatment with lamivudine plus recombinant human interleukin-12 (rhIL-12) will result in a greater and prolonged suppression of HBV replication in comparison with lamivudine monotherapy. Fifteen patients with HBeAg-positive ...

      Known for Hbv Replication | Chronic Hepatitis | Combination Therapy | Ifn Gamma | Positive Lymphocytes
      KOL-Index: 12376

      BACKGROUND & AIMS: Impaired T-cell reactivity is believed to be the dominant cause of chronic hepatitis B virus (HBV) infection. We characterized HBV-specific T-cell responses in chronic hepatitis B surface antigen carriers who received bone marrow from HLA-identical donors with natural immunity to HBV and seroconverted to antibody to hepatitis B surface antigen.

      METHODS: T-cell reactivity to HBV antigens and peptides was assessed in a proliferation assay, the frequency of HBV core- and ...

      Known for Chronic Hepatitis | Core Antigen | Adoptive Transfer | Cd4 Cells | Bone Marrow

      Key People For Liver Transplantation

      Top KOLs in the world
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      Williams Williams
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      Institute of Hepatology, Foundation for Liver Research, London, United Kingdom | Institute of Hepatology, Foundation for Liver Research, King's College London, London, UK | Faculty of Life Sciences and Medicine, King’s College London, London, UK | Fa

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