Localized heat urticaria

Title:

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Known for:

Localized Heat Urticaria | Heat Challenge| Mast Cells| Plasma Histamine Levels| Hot Temperature

Authors:

Phil L Lieberman LAUREN A Daman KEN HASHIMOTO MITCHELL GANIER

Year:

1978

Times cited:

Expert Impact

Concepts for whichthey havehas direct influence:Localized heat urticaria,Heat urticaria,Localized heat,Heat challenge,Mast cells,Plasma histamine levels,Skin urticaria,Mast cell.

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Localized heat urticaria

Abstract

The pathophysiology of localized heat urticaria was studied by performing a heat challenge on a patient with this disease. Serum levels of total hemolytic complement, C3, and factor B decreased following heat challenge, whereas levels of C4 and C5 did not. Plasma histamine levels remained unchanged. Electron microscopic studies of affected tissue revealed endothelial cell damage and neutrophilic degranulation in the affected area. Mast cells remained intact. These data imply that activation of the alternative complement pathway is involved in the pathogenesis of localized heat urticaria and that mast cell histamine release does not play a significant role in this disease.

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