• KOLs
  • P19 Cells
  • Ilona Sylvia Skerjanc
Ilona Sylvia Skerjanc

Ilona Sylvia Skerjanc

From The Department Of Biochemistry, University Of Western Ontario, London, Ontario N6a 5c1, Canada

Direct Impact

Concepts for which Ilona Sylvia Skerjanc has direct influence:

p19 cells
skeletal myogenesis
retinoic acid
premyogenic mesoderm
cardiac muscle
myod activity
mef2c expression

External impact

Concepts related to the work of other authors for which Ilona Sylvia Skerjanc has influence:

p19 cells
calcium transient
sox2 expression
pluripotent stem
centrosomal localization
lens vesicle
alphaiib gene

Prominent publications by Ilona Sylvia Skerjanc

KOL-Index: 31 OBJECTIVES: We needed to sort expressed sequence tags (ESTs) from human cardiac expression libraries. DESIGN AND METHODS: We annotated DNA sequence text files of 35,152 cardiac ESTs using our search and annotation tool called Multiblast.pl. We generated lists of the most prevalent ESTs in each library, and using a novel Venn tool, we grouped ESTs that were common to all or exclusive to ...
Known for
Dna Sequence Text Files | Fetal Cardiac Libraries | Lists | Hypothetical Protein Kiaa0553
KOL-Index: 26 Embryonic stem (ES) cell-based cardiac muscle repair using tissue-engineered scaffolds is an attractive prospective treatment option for patients suffering from heart disease. In this study, our aim was to characterize mouse ES cell-derived cardiomyocytes growing on collagen I/III scaffolds, modified with the adhesion peptides arginine-glycine-aspartic acid (RGD). Mouse ES-derived embryoid ...
Known for
Cardiomyogenesis Ebs | Cells Differentiated | Stem Cardiac | Scaffolds Addition
KOL-Index: 25 Very little is known about SET- and MYND-containing protein 2 (SMYD2), a member of the SMYD protein family. However, the interest in better understanding the roles of SMYD2 has grown because of recent reports indicating that SMYD2 methylates p53 and histone H3. In this study, we present a combined proteomics and genomics study of SMYD2 designed to elucidate its molecular roles. We report the ...
Known for
Roles Smyd2 | Throughput Chromatin | Immunoprecipitation Coupled | Methylates
KOL-Index: 21 Since a previous study (Goldman-Johnson et al., 2008 [4]) has shown that androgens can stimulate increased differentiation of mouse embryonic stem (mES) cells into cardiomyocytes using a genomic pathway, the aim of our study is to elucidate the molecular mechanisms regulating testosterone-enhanced cardiomyogenesis. Testosterone upregulated cardiomyogenic transcription factors, including ...
Known for
Increased Histone Acetylation | P19 Embryonal Carcinoma Cells | Testosterone-Enhanced Cardiomyogenesis | Cardiomyogenic Transcription Factor
KOL-Index: 21 In this study, we have identified novel roles for Sox15 and Sox7 as regulators of muscle precursor cell fate in P19 cells. To examine the role of Sox15 and Sox7 during skeletal myogenesis, we isolated populations of P19 cells with either gene stably integrated into the genome, termed P19[Sox15] and P19[Sox7]. Both SOX proteins were sufficient to upregulate the expression of the muscle ...
Known for
Myogenic Regulatory Factor | Myod | Stable Expression | Muscle Myogenesis
KOL-Index: 20 BACKGROUND: Understanding stem cell differentiation is essential for the future design of cell therapies. While retinoic acid (RA) is the most potent small molecule enhancer of skeletal myogenesis in stem cells, the stage and mechanism of its function has not yet been elucidated. Further, the intersection of RA with other signalling pathways that stimulate or inhibit myogenesis (such as Wnt ...
Known for
Bmp4 Expression | Wnt3a | Myogenesis Stem | Myod
KOL-Index: 19 Human embryonic stem cells (hESCs) are a potential source of material for cell therapy of muscle diseases. To date, it has proven difficult to generate skeletal muscle from hESCs in high yields and within a reasonable timeframe. Further, a hESC-derived Pax3/7-positive skeletal muscle progenitor population has not yet been described. Previous studies have shown that Pax3/7-positive progenitor ...
Known for
Cells Hescs | Directed Culture Method | Skeletal Muscle Progenitor | Myod
KOL-Index: 19 The Sonic Hedgehog (Shh) signaling pathway is important for neurogenesis in vivo. Gli transcription factors, effector proteins of the Shh signaling pathway, have neurogenic properties in vivo, which are still poorly understood. To study the molecular basis of neurogenic properties of Gli2, we used a well-established embryonic stem cell model, the P19 embryonal carcinoma (EC) cell line, which ...
Known for
Sonic Hedgehog Shh | P19 Embryonal Carcinoma | Well-Established Embryonic Stem Model | Directly Upregulating Ascl1
KOL-Index: 19 The myogenic regulatory factors (MRFs), MyoD and myogenin, can induce myogenesis in a variety of cell lines but not efficiently in monolayer cultures of P19 embryonal carcinoma stem cells. Aggregation of cells expressing MRFs, termed P19[MRF] cells, results in an approximately 30-fold enhancement of myogenesis. Here we examine molecular events occurring during P19 cell aggregation to ...
Known for
P19 Embryonal Carcinoma Stem | Monolayer Cultures | Lineage-Specific Manner | Bmp-4 Signaling
KOL-Index: 18 Aberrant or elevated levels of reactive oxygen species (ROS) can mediate deleterious cellular effects, including neuronal toxicity and degeneration observed in the etiology of a number of pathological conditions, including Alzheimer’s and Parkinson’s diseases. Nevertheless, ROS can be generated in a controlled manner and can regulate redox sensitive transcription factors such as NFκB, AP-1 ...
Known for
Neurogenesis Literature | Fate Neural | Ros Signaling | Species Neuronal

From the Department of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada

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